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GO:0003917 DNA topoisomerase type I activity

Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.

Term Information

ID GO:0003917
Name DNA topoisomerase type I activity
Ontology Molecular Function
Definition Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Comment Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.

Synonyms

Type Synonym
related nicking-closing enzyme activity
related omega-protein activity
related relaxing enzyme activity
broad topoisomerase
exact type I topoisomerase activity
related swivelase activity
related untwisting enzyme activity
broad deoxyribonucleate topoisomerase
exact type I DNA topoisomerase activity
narrow DNA topoisomerase I activity

Cross-references associated with this term:

Database ID
INTERPRO IPR001631
INTERPRO IPR009054
EC 5.99.1.2
MetaCyc 5.99.1.2-RXN
INTERPRO IPR000380
INTERPRO IPR013030
INTERPRO IPR005733
INTERPRO IPR018521
INTERPRO IPR014711
INTERPRO IPR014727
INTERPRO IPR013499
INTERPRO IPR008336

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0005488 binding
GO:0003676 nucleic acid binding
GO:0016853 isomerase activity
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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