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GO:0003917 DNA topoisomerase type I activity

Term Information

ID GO:0003917
Name DNA topoisomerase type I activity
Ontology Molecular Function
Definition Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
PMID:8811192
Comment Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
GONUTS GO:0003917 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact type I DNA topoisomerase activity
exact type I topoisomerase activity
narrow DNA topoisomerase I activity
related untwisting enzyme activity
broad deoxyribonucleate topoisomerase
related swivelase activity
related relaxing enzyme activity
related omega-protein activity
related nicking-closing enzyme activity
broad topoisomerase

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.99.1.2
InterPro IPR000380
InterPro IPR001631
InterPro IPR005733
InterPro IPR008336
InterPro IPR009054
InterPro IPR013030
InterPro IPR013034
InterPro IPR013499
InterPro IPR014711
InterPro IPR014727
InterPro IPR018521
InterPro IPR023406
MetaCyc 5.99.1.2-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003917:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003917. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003917 based on the entire annotation set Co-occurrence statistics for GO:0003917 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2008-05-12 Deleted DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2008-04-01 Updated RELATION is a GO:0003916 (DNA topoisomerase activity)
2007-11-08 Added SYNONYM deoxyribonucleate topoisomerase
2007-11-08 Added SYNONYM topoisomerase
2007-09-06 Added SYNONYM nicking-closing enzyme activity
2007-09-06 Added SYNONYM omega-protein activity
2007-09-06 Added SYNONYM relaxing enzyme activity
2007-09-06 Added SYNONYM swivelase activity
2007-09-06 Added SYNONYM untwisting enzyme activity
2007-08-09 Added SYNONYM DNA topoisomerase I activity
2007-08-09 Added SYNONYM type I DNA topoisomerase activity
2007-08-09 Added SYNONYM type I topoisomerase activity
2007-08-09 Deleted SYNONYM type I DNA topoisomerase activity
2007-08-09 Deleted SYNONYM type I topoisomerase activity
2007-08-09 Deleted SYNONYM DNA topoisomerase I activity
2007-06-17 Added SYNONYM type I DNA topoisomerase activity
2007-06-17 Added SYNONYM type I topoisomerase activity
2004-04-19 Added SYNONYM DNA topoisomerase I activity
2004-04-16 Deleted SYNONYM DNA topoisomerase I activity
2003-10-27 Added SYNONYM DNA topoisomerase I activity
2003-10-27 Added XREF MetaCyc:5.99.1.2-RXN
2003-08-18 Deleted SYNONYM DNA topoisomerase I activity
2003-08-06 Updated DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2003-04-15 Added SYNONYM DNA topoisomerase I activity
2003-04-15 Updated DEFINITION Catalysis of DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2003-04-15 Updated TERM DNA topoisomerase type I activity
2003-03-19 Updated TERM DNA topoisomerase I activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
2002-02-06 Updated TERM DNA topoisomerase I
2001-04-03 Updated TERM DNA topoisomerase I
2001-03-30 Added XREF EC:5.99.1.2
2001-03-30 Added TERM DNA topoisomerase I

Term

Timestamp Action Category Detail
2003-04-15 Updated TERM DNA topoisomerase type I activity
2003-03-19 Updated TERM DNA topoisomerase I activity
2002-02-06 Updated TERM DNA topoisomerase I
2001-04-03 Updated TERM DNA topoisomerase I
2001-03-30 Added TERM DNA topoisomerase I

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2008-05-12 Deleted DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2007-11-08 Added SYNONYM deoxyribonucleate topoisomerase
2007-11-08 Added SYNONYM topoisomerase
2007-09-06 Added SYNONYM nicking-closing enzyme activity
2007-09-06 Added SYNONYM omega-protein activity
2007-09-06 Added SYNONYM relaxing enzyme activity
2007-09-06 Added SYNONYM swivelase activity
2007-09-06 Added SYNONYM untwisting enzyme activity
2007-08-09 Added SYNONYM DNA topoisomerase I activity
2007-08-09 Added SYNONYM type I DNA topoisomerase activity
2007-08-09 Added SYNONYM type I topoisomerase activity
2007-08-09 Deleted SYNONYM type I DNA topoisomerase activity
2007-08-09 Deleted SYNONYM type I topoisomerase activity
2007-08-09 Deleted SYNONYM DNA topoisomerase I activity
2007-06-17 Added SYNONYM type I DNA topoisomerase activity
2007-06-17 Added SYNONYM type I topoisomerase activity
2004-04-19 Added SYNONYM DNA topoisomerase I activity
2004-04-16 Deleted SYNONYM DNA topoisomerase I activity
2003-10-27 Added SYNONYM DNA topoisomerase I activity
2003-08-18 Deleted SYNONYM DNA topoisomerase I activity
2003-08-06 Updated DEFINITION Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2003-04-15 Added SYNONYM DNA topoisomerase I activity
2003-04-15 Updated DEFINITION Catalysis of DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003916 (DNA topoisomerase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:5.99.1.2-RXN
2001-03-30 Added XREF EC:5.99.1.2
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