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GO:0003916 DNA topoisomerase activity

Term Information

ID GO:0003916
Name DNA topoisomerase activity
Ontology Molecular Function
Definition Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
PMID:8811192
Secondary IDs GO:0009387
GONUTS GO:0003916 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.99.1.-
InterPro IPR002631
InterPro IPR003491
InterPro IPR003601
InterPro IPR003602
InterPro IPR005736
InterPro IPR005738
InterPro IPR005739
InterPro IPR006691
InterPro IPR013497
InterPro IPR013498
InterPro IPR015346
InterPro IPR028612
MetaCyc 5.99.1.2-RXN
UniProtKB-KW Topoisomerase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003916:
Relationship To GO:0003916 Child Term Child Term Name
Is a GO:0003917 DNA topoisomerase type I activity
Is a GO:0061505 DNA topoisomerase II activity
Has part GO:0003677 DNA binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003916. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003916 based on the entire annotation set Co-occurrence statistics for GO:0003916 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-06-22 Deleted RELATION is a GO:0003677 (DNA binding)
2009-05-21 Added XREF MetaCyc:5.99.1.2-RXN
2008-05-13 Added DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-05-12 Deleted DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-04-01 Updated RELATION is a GO:0003677 (DNA binding)
2008-04-01 Updated RELATION is a GO:0016853 (isomerase activity)
2008-03-20 Deleted SYNONYM DNA supercoiling activity
2008-03-11 Updated DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-02-10 Deleted SYNONYM DNA supercoiling activity
2008-02-10 Added SYNONYM DNA supercoiling activity
2007-08-09 Added SYNONYM DNA supercoiling activity
2007-08-09 Deleted SYNONYM DNA supercoiling activity
2004-09-18 Added SECONDARY GO:0009387 (DNA supercoiling activity)
2004-09-18 Added SYNONYM DNA supercoiling activity
2004-09-17 Updated DEFINITION Catalysis of a topological transformation in double-stranded DNA by a covalent or non-covalent mechanism.
2003-04-16 Updated DEFINITION Catalysis of a topological transformation in double-stranded DNA.
2003-04-15 Added DEFINITION atalysis of a topological transformation in double-stranded DNA.
2003-03-19 Updated TERM DNA topoisomerase activity
2002-02-06 Updated TERM DNA topoisomerase
2001-04-03 Updated TERM DNA topoisomerase
2001-03-30 Added XREF EC:5.99.1.-
2001-03-30 Added TERM DNA topoisomerase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM DNA topoisomerase activity
2002-02-06 Updated TERM DNA topoisomerase
2001-04-03 Updated TERM DNA topoisomerase
2001-03-30 Added TERM DNA topoisomerase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-05-12 Deleted DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-03-20 Deleted SYNONYM DNA supercoiling activity
2008-03-11 Updated DEFINITION Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
2008-02-10 Deleted SYNONYM DNA supercoiling activity
2008-02-10 Added SYNONYM DNA supercoiling activity
2007-08-09 Added SYNONYM DNA supercoiling activity
2007-08-09 Deleted SYNONYM DNA supercoiling activity
2004-09-18 Added SYNONYM DNA supercoiling activity
2004-09-17 Updated DEFINITION Catalysis of a topological transformation in double-stranded DNA by a covalent or non-covalent mechanism.
2003-04-16 Updated DEFINITION Catalysis of a topological transformation in double-stranded DNA.
2003-04-15 Added DEFINITION atalysis of a topological transformation in double-stranded DNA.

Relationships

Timestamp Action Category Detail
2013-06-22 Deleted RELATION is a GO:0003677 (DNA binding)
2008-04-01 Updated RELATION is a GO:0003677 (DNA binding)
2008-04-01 Updated RELATION is a GO:0016853 (isomerase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:5.99.1.2-RXN
2001-03-30 Added XREF EC:5.99.1.-

Other

Timestamp Action Category Detail
2004-09-18 Added SECONDARY GO:0009387 (DNA supercoiling activity)
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