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GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity

Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Term Information

ID GO:0003906
Name DNA-(apurinic or apyrimidinic site) lyase activity
Ontology Molecular Function
Definition Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Comment Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.

Synonyms

Type Synonym
related endonuclease VIII activity
broad phage-T4 UV endonuclease
narrow micrococcus luteus UV endonuclease
related X-ray endonuclease III
narrow E. coli endonuclease III activity
exact DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity
related E. coli endonuclease III
narrow AP endonuclease class I activity
exact AP lyase activity
narrow Micrococcus luteus UV endonuclease activity
narrow Phage-T(4) UV endonuclease activity
narrow Phage-T4 UV endonuclease activity
exact deoxyribonuclease (apurinic or apyrimidinic) activity
exact AP site-DNA 5'-phosphomonoester-lyase activity
exact endodeoxyribonuclease (apurinic or apyrimidinic) activity

Cross-references associated with this term:

Database ID
INTERPRO IPR012092
INTERPRO IPR000191
INTERPRO IPR015886
INTERPRO IPR012319
INTERPRO IPR000214
INTERPRO IPR015887
INTERPRO IPR005759
MetaCyc 4.2.99.18-RXN
EC 4.2.99.18

This term can be used instead of these obsolete terms:

GO:0008845 endonuclease VIII activity (consider GO:0003906)

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activity
I GO:0000704 pyrimidine dimer DNA N-glycosylase activity
I GO:0008534 oxidized purine base lesion DNA N-glycosylase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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