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GO:0003905 alkylbase DNA N-glycosylase activity

Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.

Term Information

ID GO:0003905
Name alkylbase DNA N-glycosylase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
Comment

Synonyms

Type Synonym
related DNA-3-methyladenine glycosylase II
related AlkA
related 3-methyladenine DNA glycosylase II
exact DNA glycosidase II activity
exact DNA-3-methyladenine glycosidase II activity
broad alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
exact alkylbase DNA glycosidase activity
related deoxyribonucleate 3-methyladenine glycosidase II

Cross-references associated with this term:

Database ID
MetaCyc 3.2.2.21-RXN
INTERPRO IPR003180
INTERPRO IPR000035
EC 3.2.2.21

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
GO:0003905 alkylbase DNA N-glycosylase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0008725 DNA-3-methyladenine glycosylase I activity
I GO:0043916 DNA-7-methylguanine glycosylase activity
I GO:0043733 DNA-3-methyladenine glycosylase III activity
I GO:0043736 DNA-3-methyladenine glycosylase IV activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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