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GO:0003905 alkylbase DNA N-glycosylase activity

Term Information

ID GO:0003905
Name alkylbase DNA N-glycosylase activity
Ontology Molecular Function
Definition Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
PMID:10872450 PMID:9224623
Secondary IDs GO:0004036
GONUTS GO:0003905 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related deoxyribonucleate 3-methyladenine glycosidase II
exact alkylbase DNA glycosidase activity
exact DNA glycosidase II activity
exact DNA-3-methyladenine glycosidase II activity
related 3-methyladenine DNA glycosylase II
related AlkA
related DNA-3-methyladenine glycosylase II
broad alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.2.2.21
InterPro IPR000035
InterPro IPR003180
MetaCyc 3.2.2.21-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003905:
Relationship To GO:0003905 Child Term Child Term Name
Is a GO:0043916 DNA-7-methylguanine glycosylase activity
Is a GO:0043733 DNA-3-methylbase glycosylase activity
Is a GO:0052820 DNA-1,N6-ethenoadenine N-glycosylase activity
Is a GO:0052821 DNA-7-methyladenine glycosylase activity
Is a GO:1990053 DNA-5-methylcytosine glycosylase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003905. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003905 based on the entire annotation set Co-occurrence statistics for GO:0003905 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-10-30 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site.
2011-10-30 Added DEFINITION Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
2010-09-03 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site.
2010-09-03 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2008-04-01 Updated RELATION is a GO:0019104 (DNA N-glycosylase activity)
2007-12-14 Added SECONDARY GO:0004036 (alkylbase DNA glycosidase activity)
2007-12-14 Added SYNONYM alkylbase DNA glycosidase activity
2007-11-08 Added SYNONYM 3-methyladenine DNA glycosylase II
2007-11-08 Added SYNONYM AlkA
2007-11-08 Added SYNONYM DNA-3-methyladenine glycosylase II
2007-11-08 Added SYNONYM alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
2007-11-08 Added SYNONYM deoxyribonucleate 3-methyladenine glycosidase II
2007-09-06 Added SYNONYM DNA glycosidase II activity
2007-08-09 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2007-08-09 Deleted SYNONYM DNA-3-methyladenine glycosidase II activity
2004-04-19 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2004-04-16 Deleted SYNONYM DNA-3-methyladenine glycosidase II activity
2003-10-27 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2003-10-27 Added XREF MetaCyc:3.2.2.21-RXN
2003-08-18 Deleted SYNONYM DNA-3-methyladenine glycosidase II
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2003-03-19 Updated TERM alkylbase DNA N-glycosylase activity
2002-11-27 Added DEFINITION Recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2002-05-17 Updated TERM alkylbase DNA N-glycosylase
2002-05-17 Added SYNONYM DNA-3-methyladenine glycosidase II
2002-02-06 Updated TERM DNA-3-methyladenine glycosidase II
2001-04-03 Updated TERM DNA-3-methyladenine glycosidase II
2001-03-30 Added XREF EC:3.2.2.21
2001-03-30 Added TERM DNA-3-methyladenine glycosidase II

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM alkylbase DNA N-glycosylase activity
2002-05-17 Updated TERM alkylbase DNA N-glycosylase
2002-02-06 Updated TERM DNA-3-methyladenine glycosidase II
2001-04-03 Updated TERM DNA-3-methyladenine glycosidase II
2001-03-30 Added TERM DNA-3-methyladenine glycosidase II

Definition/synonyms

Timestamp Action Category Detail
2011-10-30 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site.
2011-10-30 Added DEFINITION Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
2010-09-03 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site.
2010-09-03 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2007-12-14 Added SYNONYM alkylbase DNA glycosidase activity
2007-11-08 Added SYNONYM 3-methyladenine DNA glycosylase II
2007-11-08 Added SYNONYM AlkA
2007-11-08 Added SYNONYM DNA-3-methyladenine glycosylase II
2007-11-08 Added SYNONYM alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
2007-11-08 Added SYNONYM deoxyribonucleate 3-methyladenine glycosidase II
2007-09-06 Added SYNONYM DNA glycosidase II activity
2007-08-09 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2007-08-09 Deleted SYNONYM DNA-3-methyladenine glycosidase II activity
2004-04-19 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2004-04-16 Deleted SYNONYM DNA-3-methyladenine glycosidase II activity
2003-10-27 Added SYNONYM DNA-3-methyladenine glycosidase II activity
2003-08-18 Deleted SYNONYM DNA-3-methyladenine glycosidase II
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2002-11-27 Added DEFINITION Recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
2002-05-17 Added SYNONYM DNA-3-methyladenine glycosidase II

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019104 (DNA N-glycosylase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.2.2.21-RXN
2001-03-30 Added XREF EC:3.2.2.21

Other

Timestamp Action Category Detail
2007-12-14 Added SECONDARY GO:0004036 (alkylbase DNA glycosidase activity)
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