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GO:0003905 alkylbase DNA N-glycosylase activityCatalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
Term Information
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| Type | Synonym |
| related | DNA-3-methyladenine glycosylase II |
| related | AlkA |
| related | 3-methyladenine DNA glycosylase II |
| exact | DNA glycosidase II activity |
| exact | DNA-3-methyladenine glycosidase II activity |
| broad | alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) |
| exact | alkylbase DNA glycosidase activity |
| related | deoxyribonucleate 3-methyladenine glycosidase II |
| Database | ID |
| MetaCyc | 3.2.2.21-RXN |
| INTERPRO | IPR003180 |
| INTERPRO | IPR000035 |
| EC | 3.2.2.21 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||
![]() | GO:0003824 catalytic activity | |||||
![]() | ![]() | GO:0016787 hydrolase activity | ||||
![]() | ![]() | ![]() | GO:0016798 hydrolase activity, acting on glycosyl bonds | |||
![]() | ![]() | ![]() | ![]() | GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds | ||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0019104 DNA N-glycosylase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0003905 alkylbase DNA N-glycosylase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0008725 DNA-3-methyladenine glycosylase I activity |
| I | GO:0043916 DNA-7-methylguanine glycosylase activity |
| I | GO:0043733 DNA-3-methyladenine glycosylase III activity |
| I | GO:0043736 DNA-3-methyladenine glycosylase IV activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |