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GO:0003810 protein-glutamine gamma-glutamyltransferase activity

Term Information

ID GO:0003810
Name protein-glutamine gamma-glutamyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
GONUTS GO:0003810 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related factor XIIIa
related fibrin stabilizing factor
exact protein-glutamine:amine gamma-glutamyltransferase
narrow tissue transglutaminase
exact glutaminylpeptide gamma-glutamyltransferase activity
exact fibrinoligase activity
exact transglutaminase activity
related polyamine transglutaminase activity
exact R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
exact TGase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.3.2.13
InterPro IPR008958
InterPro IPR020916
MetaCyc 2.3.2.13-RXN
RESID AA0124

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003810:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003810. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003810 based on the entire annotation set Co-occurrence statistics for GO:0003810 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2008-04-01 Updated RELATION is a GO:0016755 (transferase activity, transferring amino-acyl groups)
2007-11-08 Added SYNONYM R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
2007-11-08 Added SYNONYM factor XIIIa
2007-11-08 Added SYNONYM fibrin stabilizing factor
2007-11-08 Added SYNONYM protein-glutamine:amine gamma-glutamyltransferase
2007-11-08 Added SYNONYM tissue transglutaminase
2007-09-06 Added SYNONYM glutaminylpeptide gamma-glutamyltransferase activity
2007-09-06 Added SYNONYM polyamine transglutaminase activity
2007-08-09 Added SYNONYM TGase activity
2007-08-09 Added SYNONYM fibrinoligase activity
2007-08-09 Added SYNONYM transglutaminase activity
2007-08-09 Deleted SYNONYM TGase activity
2007-08-09 Deleted SYNONYM fibrinoligase activity
2007-08-09 Deleted SYNONYM transglutaminase activity
2006-01-07 Added SYNONYM TGase activity
2006-01-07 Added SYNONYM fibrinoligase activity
2006-01-07 Added SYNONYM transglutaminase activity
2006-01-05 Updated DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2005-02-24 Added XREF RESID:AA0124
2003-10-27 Added XREF MetaCyc:2.3.2.13-RXN
2003-03-26 Updated DEFINITION Catalysis of the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2003-03-19 Updated TERM protein-glutamine gamma-glutamyltransferase activity
2002-11-27 Added DEFINITION Cross-links polypeptide chains by the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2002-02-06 Updated TERM protein-glutamine gamma-glutamyltransferase
2001-04-03 Updated TERM protein-glutamine gamma-glutamyltransferase
2001-03-30 Added XREF EC:2.3.2.13
2001-03-30 Added TERM protein-glutamine gamma-glutamyltransferase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM protein-glutamine gamma-glutamyltransferase activity
2002-02-06 Updated TERM protein-glutamine gamma-glutamyltransferase
2001-04-03 Updated TERM protein-glutamine gamma-glutamyltransferase
2001-03-30 Added TERM protein-glutamine gamma-glutamyltransferase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2007-11-08 Added SYNONYM R-glutaminyl-peptide:amine gamma-glutamyl transferase activity
2007-11-08 Added SYNONYM factor XIIIa
2007-11-08 Added SYNONYM fibrin stabilizing factor
2007-11-08 Added SYNONYM protein-glutamine:amine gamma-glutamyltransferase
2007-11-08 Added SYNONYM tissue transglutaminase
2007-09-06 Added SYNONYM glutaminylpeptide gamma-glutamyltransferase activity
2007-09-06 Added SYNONYM polyamine transglutaminase activity
2007-08-09 Added SYNONYM TGase activity
2007-08-09 Added SYNONYM fibrinoligase activity
2007-08-09 Added SYNONYM transglutaminase activity
2007-08-09 Deleted SYNONYM TGase activity
2007-08-09 Deleted SYNONYM fibrinoligase activity
2007-08-09 Deleted SYNONYM transglutaminase activity
2006-01-07 Added SYNONYM TGase activity
2006-01-07 Added SYNONYM fibrinoligase activity
2006-01-07 Added SYNONYM transglutaminase activity
2006-01-05 Updated DEFINITION Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2003-03-26 Updated DEFINITION Catalysis of the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
2002-11-27 Added DEFINITION Cross-links polypeptide chains by the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016755 (transferase activity, transferring amino-acyl groups)

Cross-references

Timestamp Action Category Detail
2005-02-24 Added XREF RESID:AA0124
2003-10-27 Added XREF MetaCyc:2.3.2.13-RXN
2001-03-30 Added XREF EC:2.3.2.13
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