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GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Term Information

ID GO:0003755
Name peptidyl-prolyl cis-trans isomerase activity
Ontology Molecular Function
Definition Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Secondary IDs GO:0004752 GO:0042028
GONUTS GO:0003755 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related peptidyl-prolyl isomerase B reaction
exact peptide bond isomerase activity
exact peptidylproline cis-trans-isomerase activity
exact peptidylprolyl isomerase activity
exact PPIase activity
related cyclophilin activity
exact peptidylprolyl cis-trans isomerase activity
exact rotamase activity
narrow juglone-sensitive cis-trans proline isomerase activity
narrow juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
related parvulin
related immunophilin
narrow cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
narrow FK506-sensitive peptidyl-prolyl cis-trans isomerase
exact cis-trans proline isomerase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.2.1.8
InterPro IPR002130
InterPro IPR008104
InterPro IPR016304
InterPro IPR020892
InterPro IPR023034
InterPro IPR023059
InterPro IPR024936
InterPro IPR026257
InterPro IPR026951
MetaCyc PEPTIDYLPROLYL-ISOMERASE-RXN
UniProtKB-KW Rotamase

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004600 cyclophilin CONSIDER GO:0003755
GO:0006460 peptidyl-prolyl isomerase B reaction CONSIDER GO:0003755
GO:0030053 immunophilin CONSIDER GO:0003755
GO:0042027 cyclophilin-type peptidyl-prolyl cis-trans isomerase activity CONSIDER GO:0003755
GO:0030051 FK506-sensitive peptidyl-prolyl cis-trans isomerase REPLACEDBY GO:0003755
GO:0030052 parvulin REPLACEDBY GO:0003755

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003755:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003755. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003755 based on the entire annotation set Co-occurrence statistics for GO:0003755 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-04-07 Added RELATION part of GO:0000413 (protein peptidyl-prolyl isomerization)
2009-04-29 Added SECONDARY GO:0042028 (juglone-sensitive peptidyl-prolyl cis-trans isomerase activity)
2009-04-29 Added SYNONYM juglone-sensitive cis-trans proline isomerase activity
2009-04-29 Added SYNONYM juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2008-04-01 Updated RELATION is a GO:0016859 (cis-trans isomerase activity)
2007-12-14 Added SYNONYM peptide bond isomerase activity
2007-12-14 Added SYNONYM peptidylproline cis-trans-isomerase activity
2007-12-14 Added SYNONYM peptidylprolyl isomerase activity
2007-09-06 Added SYNONYM PPIase activity
2007-09-06 Added SYNONYM cyclophilin activity
2007-09-06 Added SYNONYM peptidylprolyl cis-trans isomerase activity
2007-09-06 Added SYNONYM rotamase activity
2007-09-06 Deleted SYNONYM PPIase
2007-09-06 Deleted SYNONYM cyclophilin
2007-09-06 Deleted SYNONYM rotamase
2007-08-09 Added SYNONYM cis-trans proline isomerase activity
2007-08-09 Added SYNONYM cyclophilin
2007-08-09 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Added SYNONYM immunophilin
2007-08-09 Added SYNONYM parvulin
2007-08-09 Added SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Added SYNONYM rotamase
2007-08-09 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Added SYNONYM PPIase
2007-08-09 Deleted SYNONYM cis-trans proline isomerase activity
2007-08-09 Deleted SYNONYM cyclophilin
2007-08-09 Deleted SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Deleted SYNONYM immunophilin
2007-08-09 Deleted SYNONYM parvulin
2007-08-09 Deleted SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Deleted SYNONYM rotamase
2007-08-09 Deleted SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Deleted SYNONYM PPIase
2006-09-29 Added SYNONYM cis-trans proline isomerase activity
2005-08-10 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2005-08-10 Added SYNONYM cyclophilin
2005-08-10 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2005-08-10 Added SYNONYM immunophilin
2005-08-10 Added SYNONYM parvulin
2005-08-10 Added SYNONYM peptidyl-prolyl isomerase B reaction
2004-04-19 Added SYNONYM rotamase
2004-04-19 Added SYNONYM PPIase
2004-04-16 Deleted SYNONYM PPIase
2004-04-16 Deleted SYNONYM rotamase
2003-10-27 Added SYNONYM PPIase
2003-10-27 Added SYNONYM rotamase
2003-10-27 Added XREF MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
2003-08-21 Deleted SYNONYM PPIase
2003-08-21 Deleted SYNONYM rotamase
2003-03-19 Updated TERM peptidyl-prolyl cis-trans isomerase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2002-06-05 Added TERM peptidyl-prolyl cis-trans isomerase
2002-06-05 Added SECONDARY GO:0004752 (rotamase)
2002-06-05 Added XREF EC:5.2.1.8
2002-06-05 Added SYNONYM PPIase
2002-06-05 Added SYNONYM rotamase
2002-05-30 Deleted SYNONYM PPIase
2002-05-30 Deleted XREF EC:5.2.1.8
2002-05-30 Deleted SECONDARY GO:0004752 (rotamase)
2002-05-30 Deleted TERM peptidylprolyl cis-trans isomerase
2002-05-30 Deleted SYNONYM rotamase
2002-02-13 Updated TERM peptidylprolyl cis-trans isomerase
2002-02-06 Updated TERM peptidyl-prolyl isomerase
2001-11-07 Updated TERM peptidyl-prolyl isomerase
2001-06-21 Added SYNONYM PPIase
2001-06-21 Added SYNONYM rotamase
2001-06-21 Added SECONDARY GO:0004752 (rotamase)
2001-04-03 Updated TERM peptidylprolyl isomerase
2001-03-30 Added XREF EC:5.2.1.8
2001-03-30 Added TERM peptidylprolyl isomerase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM peptidyl-prolyl cis-trans isomerase activity
2002-06-05 Added TERM peptidyl-prolyl cis-trans isomerase
2002-05-30 Deleted TERM peptidylprolyl cis-trans isomerase
2002-02-13 Updated TERM peptidylprolyl cis-trans isomerase
2002-02-06 Updated TERM peptidyl-prolyl isomerase
2001-11-07 Updated TERM peptidyl-prolyl isomerase
2001-04-03 Updated TERM peptidylprolyl isomerase
2001-03-30 Added TERM peptidylprolyl isomerase

Definition/synonyms

Timestamp Action Category Detail
2009-04-29 Added SYNONYM juglone-sensitive cis-trans proline isomerase activity
2009-04-29 Added SYNONYM juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2007-12-14 Added SYNONYM peptide bond isomerase activity
2007-12-14 Added SYNONYM peptidylproline cis-trans-isomerase activity
2007-12-14 Added SYNONYM peptidylprolyl isomerase activity
2007-09-06 Added SYNONYM PPIase activity
2007-09-06 Added SYNONYM cyclophilin activity
2007-09-06 Added SYNONYM peptidylprolyl cis-trans isomerase activity
2007-09-06 Added SYNONYM rotamase activity
2007-09-06 Deleted SYNONYM PPIase
2007-09-06 Deleted SYNONYM cyclophilin
2007-09-06 Deleted SYNONYM rotamase
2007-08-09 Added SYNONYM cis-trans proline isomerase activity
2007-08-09 Added SYNONYM cyclophilin
2007-08-09 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Added SYNONYM immunophilin
2007-08-09 Added SYNONYM parvulin
2007-08-09 Added SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Added SYNONYM rotamase
2007-08-09 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Added SYNONYM PPIase
2007-08-09 Deleted SYNONYM cis-trans proline isomerase activity
2007-08-09 Deleted SYNONYM cyclophilin
2007-08-09 Deleted SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2007-08-09 Deleted SYNONYM immunophilin
2007-08-09 Deleted SYNONYM parvulin
2007-08-09 Deleted SYNONYM peptidyl-prolyl isomerase B reaction
2007-08-09 Deleted SYNONYM rotamase
2007-08-09 Deleted SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2007-08-09 Deleted SYNONYM PPIase
2006-09-29 Added SYNONYM cis-trans proline isomerase activity
2005-08-10 Added SYNONYM FK506-sensitive peptidyl-prolyl cis-trans isomerase
2005-08-10 Added SYNONYM cyclophilin
2005-08-10 Added SYNONYM cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
2005-08-10 Added SYNONYM immunophilin
2005-08-10 Added SYNONYM parvulin
2005-08-10 Added SYNONYM peptidyl-prolyl isomerase B reaction
2004-04-19 Added SYNONYM rotamase
2004-04-19 Added SYNONYM PPIase
2004-04-16 Deleted SYNONYM PPIase
2004-04-16 Deleted SYNONYM rotamase
2003-10-27 Added SYNONYM PPIase
2003-10-27 Added SYNONYM rotamase
2003-08-21 Deleted SYNONYM PPIase
2003-08-21 Deleted SYNONYM rotamase
2002-11-27 Added DEFINITION Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2002-06-05 Added SYNONYM PPIase
2002-06-05 Added SYNONYM rotamase
2002-05-30 Deleted SYNONYM PPIase
2002-05-30 Deleted SYNONYM rotamase
2001-06-21 Added SYNONYM PPIase
2001-06-21 Added SYNONYM rotamase

Relationships

Timestamp Action Category Detail
2011-04-07 Added RELATION part of GO:0000413 (protein peptidyl-prolyl isomerization)
2008-04-01 Updated RELATION is a GO:0016859 (cis-trans isomerase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
2002-06-05 Added XREF EC:5.2.1.8
2002-05-30 Deleted XREF EC:5.2.1.8
2001-03-30 Added XREF EC:5.2.1.8

Other

Timestamp Action Category Detail
2009-04-29 Added SECONDARY GO:0042028 (juglone-sensitive peptidyl-prolyl cis-trans isomerase activity)
2002-06-05 Added SECONDARY GO:0004752 (rotamase)
2002-05-30 Deleted SECONDARY GO:0004752 (rotamase)
2001-06-21 Added SECONDARY GO:0004752 (rotamase)
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