spacer

GO:0003714 transcription corepressor activity

Term Information

ID GO:0003714
Name transcription corepressor activity
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
PMID:10213677 PMID:16858867
GONUTS GO:0003714 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact transcription co-repressor activity

Cross-references

Database ID
InterPro IPR016607
InterPro IPR017298
InterPro IPR022709
InterPro IPR024106
InterPro IPR028376
InterPro IPR028762

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003714:
Relationship To GO:0003714 Child Term Child Term Name
Is a GO:0001106 RNA polymerase II transcription corepressor activity
Has part GO:0070491 repressing transcription factor binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003714. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003714 based on the entire annotation set Co-occurrence statistics for GO:0003714 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-03-18 Deleted RELATION part of GO:0016481 (negative regulation of transcription)
2011-01-23 Added DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
2011-01-23 Deleted DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2010-12-02 Added RELATION part of GO:0016481 (negative regulation of transcription)
2010-12-02 Deleted DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2010-12-02 Added DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2010-12-01 Deleted RELATION is a GO:0016564 (transcription repressor activity)
2008-05-13 Added DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2008-05-12 Deleted DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2008-04-01 Updated RELATION is a GO:0016564 (transcription repressor activity)
2008-04-01 Updated RELATION is a GO:0003712 (transcription cofactor activity)
2007-08-09 Added SYNONYM transcription co-repressor activity
2007-08-09 Deleted SYNONYM transcription co-repressor activity
2004-04-19 Added SYNONYM transcription co-repressor activity
2004-04-16 Deleted SYNONYM transcription co-repressor activity
2004-01-09 Added SYNONYM transcription co-repressor activity
2004-01-09 Updated TERM transcription corepressor activity
2003-03-19 Updated TERM transcription co-repressor activity
2002-11-27 Updated DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2002-02-06 Updated TERM transcription co-repressor
2001-08-06 Added DEFINITION The function of a transcription co-factor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2001-04-03 Updated TERM transcription co-repressor
2001-03-30 Added TERM transcription co-repressor

Term

Timestamp Action Category Detail
2004-01-09 Updated TERM transcription corepressor activity
2003-03-19 Updated TERM transcription co-repressor activity
2002-02-06 Updated TERM transcription co-repressor
2001-04-03 Updated TERM transcription co-repressor
2001-03-30 Added TERM transcription co-repressor

Definition/synonyms

Timestamp Action Category Detail
2011-01-23 Added DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
2011-01-23 Deleted DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2010-12-02 Deleted DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2010-12-02 Added DEFINITION Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2008-05-13 Added DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2008-05-12 Deleted DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2007-08-09 Added SYNONYM transcription co-repressor activity
2007-08-09 Deleted SYNONYM transcription co-repressor activity
2004-04-19 Added SYNONYM transcription co-repressor activity
2004-04-16 Deleted SYNONYM transcription co-repressor activity
2004-01-09 Added SYNONYM transcription co-repressor activity
2002-11-27 Updated DEFINITION The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.
2001-08-06 Added DEFINITION The function of a transcription co-factor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself.

Relationships

Timestamp Action Category Detail
2011-03-18 Deleted RELATION part of GO:0016481 (negative regulation of transcription)
2010-12-02 Added RELATION part of GO:0016481 (negative regulation of transcription)
2010-12-01 Deleted RELATION is a GO:0016564 (transcription repressor activity)
2008-04-01 Updated RELATION is a GO:0016564 (transcription repressor activity)
2008-04-01 Updated RELATION is a GO:0003712 (transcription cofactor activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms