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GO:0003712 transcription cofactor activity

Term Information

ID GO:0003712
Name transcription cofactor activity
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
PMID:10213677 PMID:16858867
GONUTS GO:0003712 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact transcriptional co-regulator
exact transcriptional cofactor activity

Cross-references

Database ID
InterPro IPR000197
InterPro IPR002691
InterPro IPR003101
InterPro IPR012587
InterPro IPR016861
InterPro IPR021950
InterPro IPR026649
InterPro IPR027113
InterPro IPR028314

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003712:
Relationship To GO:0003712 Child Term Child Term Name
Has part GO:0001098 basal transcription machinery binding
Is a GO:0001104 RNA polymerase II transcription cofactor activity
Is a GO:0003713 transcription coactivator activity
Is a GO:0003714 transcription corepressor activity

Protein Annotation

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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003712. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003712 based on the entire annotation set Co-occurrence statistics for GO:0003712 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-01-23 Deleted DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2011-01-23 Added DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
2010-12-01 Added RELATION is a GO:0000989 (transcription factor binding transcription factor activity)
2010-12-01 Deleted RELATION is a GO:0030528 (transcription regulator activity)
2010-12-01 Deleted RELATION is a GO:0008134 (transcription factor binding)
2010-12-01 Deleted DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2010-12-01 Added DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2008-05-13 Added DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2008-05-12 Deleted DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2008-04-01 Updated RELATION is a GO:0030528 (transcription regulator activity)
2008-04-01 Updated RELATION is a GO:0008134 (transcription factor binding)
2007-08-09 Added SYNONYM transcriptional co-regulator
2007-08-09 Added SYNONYM transcriptional cofactor activity
2007-08-09 Deleted SYNONYM transcriptional cofactor activity
2007-08-09 Deleted SYNONYM transcriptional co-regulator
2007-07-22 Added SYNONYM transcriptional cofactor activity
2003-03-19 Updated TERM transcription cofactor activity
2002-11-27 Updated DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2002-05-21 Updated TERM transcription cofactor
2002-02-06 Updated TERM transcription co-factor
2001-08-06 Added DEFINITION The function of a protein that links a sequence-specific transcription factor to the core RNA polymerase II complex; does not bind DNA itself.
2001-04-03 Updated TERM transcription co-factor
2001-03-30 Added SYNONYM transcriptional co-regulator
2001-03-30 Added TERM transcription co-factor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM transcription cofactor activity
2002-05-21 Updated TERM transcription cofactor
2002-02-06 Updated TERM transcription co-factor
2001-04-03 Updated TERM transcription co-factor
2001-03-30 Added TERM transcription co-factor

Definition/synonyms

Timestamp Action Category Detail
2011-01-23 Deleted DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2011-01-23 Added DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
2010-12-01 Deleted DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2010-12-01 Added DEFINITION Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the transcription machinery.
2008-05-13 Added DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2008-05-12 Deleted DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2007-08-09 Added SYNONYM transcriptional co-regulator
2007-08-09 Added SYNONYM transcriptional cofactor activity
2007-08-09 Deleted SYNONYM transcriptional cofactor activity
2007-08-09 Deleted SYNONYM transcriptional co-regulator
2007-07-22 Added SYNONYM transcriptional cofactor activity
2002-11-27 Updated DEFINITION The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself.
2001-08-06 Added DEFINITION The function of a protein that links a sequence-specific transcription factor to the core RNA polymerase II complex; does not bind DNA itself.
2001-03-30 Added SYNONYM transcriptional co-regulator

Relationships

Timestamp Action Category Detail
2010-12-01 Added RELATION is a GO:0000989 (transcription factor binding transcription factor activity)
2010-12-01 Deleted RELATION is a GO:0030528 (transcription regulator activity)
2010-12-01 Deleted RELATION is a GO:0008134 (transcription factor binding)
2008-04-01 Updated RELATION is a GO:0030528 (transcription regulator activity)
2008-04-01 Updated RELATION is a GO:0008134 (transcription factor binding)
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