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GO:0003376 sphingosine-1-phosphate signaling pathway

Term Information

ID GO:0003376
Name sphingosine-1-phosphate signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
PMID:22001186
Comment Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
GONUTS GO:0003376 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad sphingolipid signalling pathway
exact S1P signaling pathway
exact S1P-activated GPCR signaling pathway
exact S1P receptor signaling pathway
exact sphingosine-1-phosphate signal transduction
exact S1P-activated G-protein coupled receptor signaling pathway
exact S1P-stimulated signal transduction pathway
broad sphingolipid signaling pathway

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003376:
Relationship To GO:0003376 Child Term Child Term Name
Is a GO:0003377 regulation of apoptosis by sphingosine-1-phosphate signaling pathway
Is a GO:0003378 regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
Part of GO:0038036 sphingosine-1-phosphate receptor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003376. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003376 based on the entire annotation set Co-occurrence statistics for GO:0003376 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM sphingosine-1-phosphate signal transduction
2013-01-09 Added RELATION is a GO:0090520 (sphingolipid mediated signaling pathway)
2012-01-14 Updated TERM sphingosine-1-phosphate signaling pathway
2012-01-14 Deleted DEFINITION A series of molecular signals mediated by a sphingolipid.
2012-01-14 Added DEFINITION A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-14 Deleted SYNONYM sphingolipid signalling pathway
2012-01-14 Added SYNONYM S1P-activated G-protein coupled receptor signaling pathway
2012-01-14 Added SYNONYM sphingolipid signalling pathway
2012-01-14 Added SYNONYM S1P receptor signaling pathway
2012-01-14 Added SYNONYM S1P-stimulated signal transduction pathway
2012-01-14 Added SYNONYM S1P-activated GPCR signaling pathway
2012-01-14 Added SYNONYM S1P signaling pathway
2012-01-14 Added SYNONYM sphingolipid signaling pathway
2012-01-14 Deleted RELATION is a GO:0007165 (signal transduction)
2012-01-14 Added RELATION is a GO:0007186 (G-protein coupled receptor signaling pathway)
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-11-17 Added SYNONYM sphingolipid signalling pathway
2010-07-25 Added RELATION is a GO:0023033 (signaling pathway)
2010-07-25 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-21 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-21 Deleted RELATION is a GO:0007242 (intracellular signaling cascade)
2009-12-14 Added TERM sphingolipid signaling pathway
2009-12-14 Added DEFINITION A series of molecular signals mediated by a sphingolipid.
2009-12-14 Added RELATION is a GO:0007242 (intracellular signaling cascade)

Term

Timestamp Action Category Detail
2012-01-14 Updated TERM sphingosine-1-phosphate signaling pathway
2009-12-14 Added TERM sphingolipid signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM sphingosine-1-phosphate signal transduction
2012-01-14 Deleted DEFINITION A series of molecular signals mediated by a sphingolipid.
2012-01-14 Added DEFINITION A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-14 Deleted SYNONYM sphingolipid signalling pathway
2012-01-14 Added SYNONYM S1P-activated G-protein coupled receptor signaling pathway
2012-01-14 Added SYNONYM sphingolipid signalling pathway
2012-01-14 Added SYNONYM S1P receptor signaling pathway
2012-01-14 Added SYNONYM S1P-stimulated signal transduction pathway
2012-01-14 Added SYNONYM S1P-activated GPCR signaling pathway
2012-01-14 Added SYNONYM S1P signaling pathway
2012-01-14 Added SYNONYM sphingolipid signaling pathway
2010-11-17 Added SYNONYM sphingolipid signalling pathway
2009-12-14 Added DEFINITION A series of molecular signals mediated by a sphingolipid.

Relationships

Timestamp Action Category Detail
2013-01-09 Added RELATION is a GO:0090520 (sphingolipid mediated signaling pathway)
2012-01-14 Deleted RELATION is a GO:0007165 (signal transduction)
2012-01-14 Added RELATION is a GO:0007186 (G-protein coupled receptor signaling pathway)
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-07-25 Added RELATION is a GO:0023033 (signaling pathway)
2010-07-25 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-21 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-21 Deleted RELATION is a GO:0007242 (intracellular signaling cascade)
2009-12-14 Added RELATION is a GO:0007242 (intracellular signaling cascade)
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