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GO:0002755 MyD88-dependent toll-like receptor signaling pathway

Term Information

ID GO:0002755
Name MyD88-dependent toll-like receptor signaling pathway
Ontology Biological Process
Definition Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
PMID:12467241 PMID:12524386 PMID:12855817 PMID:15585605 PMID:15728447
GONUTS GO:0002755 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact MyD88-dependent TLR signaling pathway
exact MyD88-dependent toll-like receptor signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR017281
InterPro IPR026880
InterPro IPR027168
InterPro IPR027175
InterPro IPR027176
InterPro IPR027181
InterPro IPR027182
InterPro IPR027185
InterPro IPR027187
InterPro IPR027190
InterPro IPR027194

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002755:
Relationship To GO:0002755 Child Term Child Term Name
Regulates GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
Negatively regulates GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway
Positively regulates GO:0034126 positive regulation of MyD88-dependent toll-like receptor signaling pathway
Is a GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway
Is a GO:0035661 MyD88-dependent toll-like receptor 2 signaling pathway

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0002755. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0002755 based on the entire annotation set Co-occurrence statistics for GO:0002755 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-02-15 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2011-02-15 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2008-04-01 Updated RELATION is a GO:0002224 (toll-like receptor signaling pathway)
2007-08-09 Deleted SYNONYM MyD88-dependent toll-like receptor signalling pathway
2007-08-09 Added SYNONYM MyD88-dependent TLR signaling pathway
2007-08-09 Added SYNONYM MyD88-dependent toll-like receptor signalling pathway
2007-08-09 Deleted SYNONYM MyD88-dependent TLR signaling pathway
2007-05-13 Added SYNONYM MyD88-dependent toll-like receptor signalling pathway
2006-09-22 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2006-09-21 Added SYNONYM MyD88-dependent TLR signaling pathway
2006-09-21 Added TERM MyD88-dependent toll-like receptor signaling pathway

Term

Timestamp Action Category Detail
2006-09-21 Added TERM MyD88-dependent toll-like receptor signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2011-02-15 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2011-02-15 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2007-08-09 Deleted SYNONYM MyD88-dependent toll-like receptor signalling pathway
2007-08-09 Added SYNONYM MyD88-dependent TLR signaling pathway
2007-08-09 Added SYNONYM MyD88-dependent toll-like receptor signalling pathway
2007-08-09 Deleted SYNONYM MyD88-dependent TLR signaling pathway
2007-05-13 Added SYNONYM MyD88-dependent toll-like receptor signalling pathway
2006-09-22 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2006-09-21 Added SYNONYM MyD88-dependent TLR signaling pathway

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002224 (toll-like receptor signaling pathway)
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