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GO:0002542 Factor XII activation

Term Information

ID GO:0002542
Name Factor XII activation
Ontology Biological Process
Definition Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
GONUTS GO:0002542 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Hageman factor activation

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002542:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0002542. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0002542 based on the entire annotation set Co-occurrence statistics for GO:0002542 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-02-06 Deleted RELATION is a GO:0045862 (positive regulation of proteolysis)
2009-05-21 Added RELATION is a GO:0010954 (positive regulation of protein processing)
2009-05-11 Added RELATION is a GO:0002673 (regulation of acute inflammatory response)
2009-05-03 Added RELATION positively regulates GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2009-05-03 Deleted RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2009-05-03 Added RELATION is a GO:0045862 (positive regulation of proteolysis)
2008-05-13 Added DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2008-05-12 Deleted DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2008-04-01 Updated RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2008-04-01 Updated RELATION part of GO:0002353 (plasma kallikrein-kinin cascade)
2007-08-09 Added SYNONYM Hageman factor activation
2007-08-09 Deleted SYNONYM Hageman factor activation
2006-09-22 Added DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2006-09-21 Added SYNONYM Hageman factor activation
2006-09-21 Added TERM Factor XII activation

Term

Timestamp Action Category Detail
2006-09-21 Added TERM Factor XII activation

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2008-05-12 Deleted DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2007-08-09 Added SYNONYM Hageman factor activation
2007-08-09 Deleted SYNONYM Hageman factor activation
2006-09-22 Added DEFINITION Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
2006-09-21 Added SYNONYM Hageman factor activation

Relationships

Timestamp Action Category Detail
2010-02-06 Deleted RELATION is a GO:0045862 (positive regulation of proteolysis)
2009-05-21 Added RELATION is a GO:0010954 (positive regulation of protein processing)
2009-05-11 Added RELATION is a GO:0002673 (regulation of acute inflammatory response)
2009-05-03 Added RELATION positively regulates GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2009-05-03 Deleted RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2009-05-03 Added RELATION is a GO:0045862 (positive regulation of proteolysis)
2008-04-01 Updated RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2008-04-01 Updated RELATION part of GO:0002353 (plasma kallikrein-kinin cascade)
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