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GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Term Information

ID GO:0002460
Name adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Ontology Biological Process
Definition An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
GONUTS GO:0002460 Wiki Page

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0002376 immune system process never_in_taxon 4895 Schizosaccharomyces
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002460:
Relationship To GO:0002460 Child Term Child Term Name
Regulates GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Negatively regulates GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Positively regulates GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Is a GO:0002456 T cell mediated immunity
Is a GO:0002461 tolerance induction dependent upon immune response
Is a GO:0002467 germinal center formation
Is a GO:0019724 B cell mediated immunity
Is a GO:0042088 T-helper 1 type immune response
Is a GO:0072538 T-helper 17 type immune response
Is a GO:0090717 adaptive immune memory response involving T cells and B cells
Is a GO:0090719 adaptive immune effector response involving T cells and B lineage cells
Is a GO:0090721 primary adaptive immune response involving T cells and B cells

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0002460. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0002460 based on the entire annotation set Co-occurrence statistics for GO:0002460 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-11-13 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
2016-11-13 Added DEFINITION An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
2009-06-11 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2009-06-11 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
2009-06-11 Deleted SYNONYM adaptive immune response (sensu Gnathostomata)
2008-05-13 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2008-05-12 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2008-04-01 Updated RELATION is a GO:0002250 (adaptive immune response)
2007-08-09 Added SYNONYM adaptive immune response (sensu Gnathostomata)
2007-08-09 Deleted SYNONYM adaptive immune response (sensu Gnathostomata)
2007-04-20 Updated DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2007-04-06 Added SYNONYM adaptive immune response (sensu Gnathostomata)
2007-04-06 Updated TERM adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2007-01-18 Updated TERM adaptive immune response (sensu Gnathostomata)
2007-01-15 Updated TERM adaptive immune response (sensu the Gnathostomata research community)
2006-09-22 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory), as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776).
2006-09-21 Added TERM adaptive immune response (sensu Gnathostomata)

Term

Timestamp Action Category Detail
2007-04-06 Updated TERM adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2007-01-18 Updated TERM adaptive immune response (sensu Gnathostomata)
2007-01-15 Updated TERM adaptive immune response (sensu the Gnathostomata research community)
2006-09-21 Added TERM adaptive immune response (sensu Gnathostomata)

Definition/synonyms

Timestamp Action Category Detail
2016-11-13 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
2016-11-13 Added DEFINITION An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
2009-06-11 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2009-06-11 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
2009-06-11 Deleted SYNONYM adaptive immune response (sensu Gnathostomata)
2008-05-13 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2008-05-12 Deleted DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2007-08-09 Added SYNONYM adaptive immune response (sensu Gnathostomata)
2007-08-09 Deleted SYNONYM adaptive immune response (sensu Gnathostomata)
2007-04-20 Updated DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).
2007-04-06 Added SYNONYM adaptive immune response (sensu Gnathostomata)
2006-09-22 Added DEFINITION An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory), as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776).

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002250 (adaptive immune response)
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