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GO:0002314 germinal center B cell differentiation

The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).

Term Information

ID GO:0002314
Name germinal center B cell differentiation
Ontology Biological Process
Definition The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
Comment

Synonyms

Type Synonym
exact germinal center B lymphocyte differentiation
exact germinal center B-cell differentiation
exact germinal center B-lymphocyte differentiation

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0002376 immune system process
GO:0050896 response to stimulus
GO:0009987 cellular process
GO:0032501 multicellular organismal process
GO:0032502 developmental process
GO:0001775 cell activation
GO:0048856 anatomical structure development
GO:0006955 immune response
GO:0007275 multicellular organismal development
GO:0048869 cellular developmental process
GO:0045321 leukocyte activation
GO:0030154 cell differentiation
GO:0048731 system development
GO:0046649 lymphocyte activation
GO:0042113 B cell activation
GO:0002263 cell activation during immune response
GO:0048513 organ development
GO:0002520 immune system development
GO:0002366 leukocyte activation during immune response
GO:0048534 hemopoietic or lymphoid organ development
GO:0002285 lymphocyte activation during immune response
GO:0030097 hemopoiesis
GO:0002312 B cell activation during immune response
GO:0002521 leukocyte differentiation
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0002335 mature B cell differentiation
GO:0002313 mature B cell differentiation during immune response
GO:0002314 germinal center B cell differentiation

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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