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GO:0001913 T cell mediated cytotoxicity

Term Information

ID GO:0001913
Name T cell mediated cytotoxicity
Ontology Biological Process
Definition The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
PMID:11911826
Comment Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
GONUTS GO:0001913 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact T-cell mediated apoptosis
exact T-cell mediated cell death
exact T-cell mediated cell killing
exact T-cell mediated cytotoxicity
exact T cell mediated apoptosis
exact T lymphocyte mediated cytotoxicity
related T cell mediated cytolysis
exact T cell mediated cell killing
exact T cell mediated cell death
exact T-lymphocyte mediated cytotoxicity

Cross-Ontology Relations

Relation Other Ontology ID Term
mediated_by CL CL:0000084 T cell

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001913:
Relationship To GO:0001913 Child Term Child Term Name
Part of GO:0043316 cytotoxic T cell degranulation
Regulates GO:0001914 regulation of T cell mediated cytotoxicity
Negatively regulates GO:0001915 negative regulation of T cell mediated cytotoxicity
Positively regulates GO:0001916 positive regulation of T cell mediated cytotoxicity
Is a GO:0002419 T cell mediated cytotoxicity directed against tumor cell target

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0001913. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0001913 based on the entire annotation set Co-occurrence statistics for GO:0001913 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-12-23 Added RELATION is a GO:0044699 (single-organism process)
2012-09-28 Deleted RELATION is a GO:0006917 (induction of apoptosis)
2008-05-13 Added DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-05-12 Deleted DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-04-01 Updated RELATION is a GO:0002456 (T cell mediated immunity)
2008-04-01 Updated RELATION is a GO:0006917 (induction of apoptosis)
2008-04-01 Updated RELATION is a GO:0001909 (leukocyte mediated cytotoxicity)
2007-08-09 Added SYNONYM T cell mediated apoptosis
2007-08-09 Added SYNONYM T cell mediated cell death
2007-08-09 Added SYNONYM T cell mediated cell killing
2007-08-09 Added SYNONYM T cell mediated cytolysis
2007-08-09 Added SYNONYM T lymphocyte mediated cytotoxicity
2007-08-09 Added SYNONYM T-cell mediated apoptosis
2007-08-09 Added SYNONYM T-cell mediated cell death
2007-08-09 Added SYNONYM T-cell mediated cell killing
2007-08-09 Added SYNONYM T-cell mediated cytotoxicity
2007-08-09 Added SYNONYM T-lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-cell mediated cell killing
2007-08-09 Deleted SYNONYM T-cell mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T cell mediated apoptosis
2007-08-09 Deleted SYNONYM T cell mediated cell death
2007-08-09 Deleted SYNONYM T cell mediated cell killing
2007-08-09 Deleted SYNONYM T cell mediated cytolysis
2007-08-09 Deleted SYNONYM T lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-cell mediated apoptosis
2007-08-09 Deleted SYNONYM T-cell mediated cell death
2005-06-02 Deleted SYNONYM T-cell mediated cytolysis
2005-06-02 Deleted SYNONYM T cell mediated cytotoxicity
2005-06-02 Added SYNONYM T cell mediated cytolysis
2005-06-02 Added SYNONYM T lymphocyte mediated cytotoxicity
2005-06-02 Added SYNONYM T-cell mediated cytotoxicity
2005-06-02 Added SYNONYM T-lymphocyte mediated cytotoxicity
2005-06-02 Updated TERM T cell mediated cytotoxicity
2005-05-26 Updated DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2004-10-29 Added SYNONYM T cell mediated apoptosis
2004-10-29 Added SYNONYM T cell mediated cell death
2004-10-29 Deleted SYNONYM T cell mediated apoptosis
2004-10-29 Deleted SYNONYM T cell mediated cell death
2004-10-29 Deleted SYNONYM T cell mediated cell killing
2004-10-29 Deleted SYNONYM T cell mediated cytotoxicity
2004-10-29 Deleted SYNONYM T-cell mediated apoptosis
2004-10-29 Deleted SYNONYM T-cell mediated cytolysis
2004-10-29 Added SYNONYM T cell mediated cell killing
2004-10-29 Added SYNONYM T cell mediated cytotoxicity
2004-10-29 Added SYNONYM T-cell mediated apoptosis
2004-10-29 Added SYNONYM T-cell mediated cytolysis
2004-10-28 Added SYNONYM T cell mediated apoptosis
2004-10-28 Added SYNONYM T cell mediated cell death
2004-10-28 Added SYNONYM T cell mediated cell killing
2004-10-28 Added SYNONYM T cell mediated cytotoxicity
2004-10-28 Added SYNONYM T-cell mediated apoptosis
2004-10-28 Added SYNONYM T-cell mediated cell death
2004-10-28 Added SYNONYM T-cell mediated cell killing
2004-10-28 Added DEFINITION The directed killing of a target cell by a T-cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2004-10-28 Added TERM T-cell mediated cytotoxicity
2004-10-28 Added SYNONYM T-cell mediated cytolysis

Term

Timestamp Action Category Detail
2005-06-02 Updated TERM T cell mediated cytotoxicity
2004-10-28 Added TERM T-cell mediated cytotoxicity

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-05-12 Deleted DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2007-08-09 Added SYNONYM T cell mediated apoptosis
2007-08-09 Added SYNONYM T cell mediated cell death
2007-08-09 Added SYNONYM T cell mediated cell killing
2007-08-09 Added SYNONYM T cell mediated cytolysis
2007-08-09 Added SYNONYM T lymphocyte mediated cytotoxicity
2007-08-09 Added SYNONYM T-cell mediated apoptosis
2007-08-09 Added SYNONYM T-cell mediated cell death
2007-08-09 Added SYNONYM T-cell mediated cell killing
2007-08-09 Added SYNONYM T-cell mediated cytotoxicity
2007-08-09 Added SYNONYM T-lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-cell mediated cell killing
2007-08-09 Deleted SYNONYM T-cell mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T cell mediated apoptosis
2007-08-09 Deleted SYNONYM T cell mediated cell death
2007-08-09 Deleted SYNONYM T cell mediated cell killing
2007-08-09 Deleted SYNONYM T cell mediated cytolysis
2007-08-09 Deleted SYNONYM T lymphocyte mediated cytotoxicity
2007-08-09 Deleted SYNONYM T-cell mediated apoptosis
2007-08-09 Deleted SYNONYM T-cell mediated cell death
2005-06-02 Deleted SYNONYM T-cell mediated cytolysis
2005-06-02 Deleted SYNONYM T cell mediated cytotoxicity
2005-06-02 Added SYNONYM T cell mediated cytolysis
2005-06-02 Added SYNONYM T lymphocyte mediated cytotoxicity
2005-06-02 Added SYNONYM T-cell mediated cytotoxicity
2005-06-02 Added SYNONYM T-lymphocyte mediated cytotoxicity
2005-05-26 Updated DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2004-10-29 Added SYNONYM T cell mediated apoptosis
2004-10-29 Added SYNONYM T cell mediated cell death
2004-10-29 Deleted SYNONYM T cell mediated apoptosis
2004-10-29 Deleted SYNONYM T cell mediated cell death
2004-10-29 Deleted SYNONYM T cell mediated cell killing
2004-10-29 Deleted SYNONYM T cell mediated cytotoxicity
2004-10-29 Deleted SYNONYM T-cell mediated apoptosis
2004-10-29 Deleted SYNONYM T-cell mediated cytolysis
2004-10-29 Added SYNONYM T cell mediated cell killing
2004-10-29 Added SYNONYM T cell mediated cytotoxicity
2004-10-29 Added SYNONYM T-cell mediated apoptosis
2004-10-29 Added SYNONYM T-cell mediated cytolysis
2004-10-28 Added SYNONYM T cell mediated apoptosis
2004-10-28 Added SYNONYM T cell mediated cell death
2004-10-28 Added SYNONYM T cell mediated cell killing
2004-10-28 Added SYNONYM T cell mediated cytotoxicity
2004-10-28 Added SYNONYM T-cell mediated apoptosis
2004-10-28 Added SYNONYM T-cell mediated cell death
2004-10-28 Added SYNONYM T-cell mediated cell killing
2004-10-28 Added DEFINITION The directed killing of a target cell by a T-cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2004-10-28 Added SYNONYM T-cell mediated cytolysis

Relationships

Timestamp Action Category Detail
2012-12-23 Added RELATION is a GO:0044699 (single-organism process)
2012-09-28 Deleted RELATION is a GO:0006917 (induction of apoptosis)
2008-04-01 Updated RELATION is a GO:0002456 (T cell mediated immunity)
2008-04-01 Updated RELATION is a GO:0006917 (induction of apoptosis)
2008-04-01 Updated RELATION is a GO:0001909 (leukocyte mediated cytotoxicity)
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