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GO:0004930 G-protein coupled receptor activity

Term Information

ID GO:0004930
Name G-protein coupled receptor activity
Ontology Molecular Function
Definition Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Secondary IDs GO:0001622 GO:0001623 GO:0001624 GO:0001625 GO:0016526
GONUTS GO:0004930 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow G-protein coupled receptor activity, unknown ligand
exact ligand-dependent GPCR activity
narrow orphan G protein coupled receptor activity
exact receptor activity, G-protein coupled
narrow Mas proto-oncogene receptor activity
exact GPCR activity
exact G-protein-coupled receptor activity
exact G-protein linked receptor activity
exact G protein linked receptor activity
exact G protein coupled receptor activity
narrow orphan G-protein coupled receptor activity
narrow EBV-induced receptor
narrow SREB receptor
narrow Epstein-Barr Virus-induced receptor activity
narrow super conserved receptor expressed in brain receptor activity
narrow RDC1 receptor activity
narrow orphan GPCR activity

Cross-references

Database ID
InterPro IPR000068
InterPro IPR000276
InterPro IPR000337
InterPro IPR000344
InterPro IPR000820
InterPro IPR000832
InterPro IPR000848
InterPro IPR000935
InterPro IPR001740
InterPro IPR001793
InterPro IPR001879
InterPro IPR002144
InterPro IPR002258
InterPro IPR002276
InterPro IPR002280
InterPro IPR003051
InterPro IPR003052
InterPro IPR003053
InterPro IPR003056
InterPro IPR003288
InterPro IPR003289
InterPro IPR003334
InterPro IPR003904
InterPro IPR003910
InterPro IPR003924
InterPro IPR004073
InterPro IPR005464
InterPro IPR007960
InterPro IPR008078
InterPro IPR008103
InterPro IPR008112
InterPro IPR010596
InterPro IPR011500
InterPro IPR017978
InterPro IPR017979
InterPro IPR017983
InterPro IPR022335
InterPro IPR022347
InterPro IPR022348
InterPro IPR026221
InterPro IPR026228
InterPro IPR026230
InterPro IPR026232
InterPro IPR026233
InterPro IPR026234
InterPro IPR026919
InterPro IPR027336
InterPro IPR027338
InterPro IPR027341
InterPro IPR027344
InterPro IPR028016
InterPro IPR028017
UniProtKB-KW G-protein coupled receptor
Wikipedia GPCR

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016527 brain-specific angiogenesis inhibitor activity CONSIDER GO:0004930

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004930:
Relationship To GO:0004930 Child Term Child Term Name
Is a GO:0001647 G-protein coupled cytokinin receptor activity
Is a GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
Is a GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity
Is a GO:0004953 icosanoid receptor activity
Is a GO:0004991 parathyroid hormone receptor activity
Is a GO:0004992 platelet activating factor receptor activity
Is a GO:0004949 cannabinoid receptor activity
Is a GO:0042654 ecdysis-triggering hormone receptor activity
Is a GO:0004997 thyrotropin-releasing hormone receptor activity
Is a GO:0004999 vasoactive intestinal polypeptide receptor activity
Is a GO:0008020 G-protein coupled photoreceptor activity
Is a GO:0008227 G-protein coupled amine receptor activity
Is a GO:0008502 melatonin receptor activity
Is a GO:0008527 taste receptor activity
Is a GO:0008528 G-protein coupled peptide receptor activity
Is a GO:0015055 secretin receptor activity
Is a GO:0015056 corticotrophin-releasing factor receptor activity
Is a GO:0016500 protein-hormone receptor activity
Is a GO:0016519 gastric inhibitory peptide receptor activity
Is a GO:0016520 growth hormone-releasing hormone receptor activity
Is a GO:0045125 bioactive lipid receptor activity
Is a GO:0001608 G-protein coupled nucleotide receptor activity
Is a GO:0001616 growth hormone secretagogue receptor activity
Is a GO:0016503 pheromone receptor activity
Is a GO:0001609 G-protein coupled adenosine receptor activity
Is a GO:0070553 nicotinic acid receptor activity
Is a GO:0038022 G-protein coupled olfactory receptor activity
Is a GO:0038182 G-protein coupled bile acid receptor activity
Is a GO:0004965 G-protein coupled GABA receptor activity
Is a GO:0038054 G-protein coupled estrogen receptor activity
Is a GO:0004952 dopamine neurotransmitter receptor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004930. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004930 based on the entire annotation set Co-occurrence statistics for GO:0004930 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-10-24 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2011-10-24 Added DEFINITION Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2011-10-24 Added XREF Wikipedia:GPCR
2011-10-24 Added SYNONYM receptor activity, G-protein coupled
2010-10-07 Added SYNONYM Mas proto-oncogene receptor activity
2010-10-07 Added SYNONYM orphan G protein coupled receptor activity
2010-10-07 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2010-10-07 Deleted SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Deleted SYNONYM orphan GPCR activity
2010-10-07 Deleted SYNONYM orphan G protein coupled receptor activity
2010-10-07 Added SYNONYM orphan GPCR activity
2010-10-07 Added SYNONYM Epstein-Barr Virus-induced receptor activity
2010-10-07 Added SYNONYM SREB receptor
2010-10-07 Added SYNONYM RDC1 receptor activity
2010-10-07 Added SYNONYM super conserved receptor expressed in brain receptor activity
2010-10-07 Added SYNONYM EBV-induced receptor
2010-10-07 Added SECONDARY GO:0001625 (Epstein-Barr Virus-induced receptor activity)
2010-10-07 Added SECONDARY GO:0001624 (RDC1 receptor activity)
2010-10-07 Added SECONDARY GO:0001623 (Mas proto-oncogene receptor activity)
2010-10-07 Added SECONDARY GO:0001622 (super conserved receptor expressed in brain receptor activity)
2010-10-07 Added SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2010-06-15 Added RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2010-06-09 Updated TERM G-protein coupled receptor activity
2010-06-08 Added RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2010-06-08 Updated TERM G-protein coupled receptor activity
2008-10-10 Added SYNONYM ligand-dependent GPCR activity
2008-05-13 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2008-05-12 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2008-04-01 Updated RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2007-08-09 Added SYNONYM G protein coupled receptor activity
2007-08-09 Added SYNONYM G protein linked receptor activity
2007-08-09 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Added SYNONYM G-protein linked receptor activity
2007-08-09 Added SYNONYM G-protein-coupled receptor activity
2007-08-09 Added SYNONYM GPCR activity
2007-08-09 Added SYNONYM orphan G protein coupled receptor activity
2007-08-09 Added SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Added SYNONYM orphan GPCR activity
2007-08-09 Deleted SYNONYM G protein coupled receptor activity
2007-08-09 Deleted SYNONYM G protein linked receptor activity
2007-08-09 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Deleted SYNONYM G-protein linked receptor activity
2007-08-09 Deleted SYNONYM G-protein-coupled receptor activity
2007-08-09 Deleted SYNONYM GPCR activity
2007-08-09 Deleted SYNONYM orphan G protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan GPCR activity
2006-11-02 Added SECONDARY GO:0016526 (G-protein coupled receptor activity, unknown ligand)
2006-11-02 Added SYNONYM orphan GPCR activity
2006-11-02 Added SYNONYM orphan G-protein coupled receptor activity
2006-11-02 Added SYNONYM orphan G protein coupled receptor activity
2006-11-02 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2005-06-27 Added SYNONYM G protein coupled receptor activity
2005-06-27 Added SYNONYM G protein linked receptor activity
2005-06-27 Added SYNONYM G-protein linked receptor activity
2005-06-27 Added SYNONYM G-protein-coupled receptor activity
2005-06-27 Added SYNONYM GPCR activity
2005-06-27 Deleted SYNONYM G-protein linked receptor
2005-06-27 Deleted SYNONYM GPCR
2004-04-19 Added SYNONYM G-protein linked receptor
2004-04-19 Added SYNONYM GPCR
2004-04-16 Deleted SYNONYM G-protein linked receptor
2004-04-16 Deleted SYNONYM GPCR
2003-03-19 Updated TERM G-protein coupled receptor activity
2002-11-27 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2002-02-06 Updated TERM G-protein coupled receptor
2001-04-03 Updated TERM G-protein coupled receptor
2001-03-30 Added SYNONYM G-protein linked receptor
2001-03-30 Added SYNONYM GPCR
2001-03-30 Added TERM G-protein coupled receptor

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM G-protein coupled receptor activity
2010-06-08 Updated TERM G-protein coupled receptor activity
2003-03-19 Updated TERM G-protein coupled receptor activity
2002-02-06 Updated TERM G-protein coupled receptor
2001-04-03 Updated TERM G-protein coupled receptor
2001-03-30 Added TERM G-protein coupled receptor

Definition/synonyms

Timestamp Action Category Detail
2011-10-24 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2011-10-24 Added DEFINITION Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2011-10-24 Added SYNONYM receptor activity, G-protein coupled
2010-10-07 Added SYNONYM Mas proto-oncogene receptor activity
2010-10-07 Added SYNONYM orphan G protein coupled receptor activity
2010-10-07 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2010-10-07 Deleted SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Deleted SYNONYM orphan GPCR activity
2010-10-07 Deleted SYNONYM orphan G protein coupled receptor activity
2010-10-07 Added SYNONYM orphan GPCR activity
2010-10-07 Added SYNONYM Epstein-Barr Virus-induced receptor activity
2010-10-07 Added SYNONYM SREB receptor
2010-10-07 Added SYNONYM RDC1 receptor activity
2010-10-07 Added SYNONYM super conserved receptor expressed in brain receptor activity
2010-10-07 Added SYNONYM EBV-induced receptor
2010-10-07 Added SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2008-10-10 Added SYNONYM ligand-dependent GPCR activity
2008-05-13 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2008-05-12 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2007-08-09 Added SYNONYM G protein coupled receptor activity
2007-08-09 Added SYNONYM G protein linked receptor activity
2007-08-09 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Added SYNONYM G-protein linked receptor activity
2007-08-09 Added SYNONYM G-protein-coupled receptor activity
2007-08-09 Added SYNONYM GPCR activity
2007-08-09 Added SYNONYM orphan G protein coupled receptor activity
2007-08-09 Added SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Added SYNONYM orphan GPCR activity
2007-08-09 Deleted SYNONYM G protein coupled receptor activity
2007-08-09 Deleted SYNONYM G protein linked receptor activity
2007-08-09 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Deleted SYNONYM G-protein linked receptor activity
2007-08-09 Deleted SYNONYM G-protein-coupled receptor activity
2007-08-09 Deleted SYNONYM GPCR activity
2007-08-09 Deleted SYNONYM orphan G protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan GPCR activity
2006-11-02 Added SYNONYM orphan GPCR activity
2006-11-02 Added SYNONYM orphan G-protein coupled receptor activity
2006-11-02 Added SYNONYM orphan G protein coupled receptor activity
2006-11-02 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2005-06-27 Added SYNONYM G protein coupled receptor activity
2005-06-27 Added SYNONYM G protein linked receptor activity
2005-06-27 Added SYNONYM G-protein linked receptor activity
2005-06-27 Added SYNONYM G-protein-coupled receptor activity
2005-06-27 Added SYNONYM GPCR activity
2005-06-27 Deleted SYNONYM G-protein linked receptor
2005-06-27 Deleted SYNONYM GPCR
2004-04-19 Added SYNONYM G-protein linked receptor
2004-04-19 Added SYNONYM GPCR
2004-04-16 Deleted SYNONYM G-protein linked receptor
2004-04-16 Deleted SYNONYM GPCR
2002-11-27 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2001-03-30 Added SYNONYM G-protein linked receptor
2001-03-30 Added SYNONYM GPCR

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0007186 (G-protein coupled receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0004888 (transmembrane signaling receptor activity)

Cross-references

Timestamp Action Category Detail
2011-10-24 Added XREF Wikipedia:GPCR

Other

Timestamp Action Category Detail
2010-10-07 Added SECONDARY GO:0001625 (Epstein-Barr Virus-induced receptor activity)
2010-10-07 Added SECONDARY GO:0001624 (RDC1 receptor activity)
2010-10-07 Added SECONDARY GO:0001623 (Mas proto-oncogene receptor activity)
2010-10-07 Added SECONDARY GO:0001622 (super conserved receptor expressed in brain receptor activity)
2006-11-02 Added SECONDARY GO:0016526 (G-protein coupled receptor activity, unknown ligand)
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