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GO:0001200 metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity

Term Information

ID GO:0001200
Name metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
PMID:12829264 PMID:12829265 PMID:2674688
Comment This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
GONUTS GO:0001200 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription factor activitiesLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001200:
Relationship To GO:0001200 Child Term Child Term Name
Is a GO:0001201 metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0001200. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0001200 based on the entire annotation set Co-occurrence statistics for GO:0001200 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-04-07 Added DEFINITION Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
2012-04-07 Deleted DEFINITION Interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a specific DNA sequence, or by regulating some other function of the transcription factor, in order to modulate transcription by RNA polymerase II.
2011-11-26 Added TERM metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
2011-11-26 Added DEFINITION Interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a specific DNA sequence, or by regulating some other function of the transcription factor, in order to modulate transcription by RNA polymerase II.
2011-11-26 Added RELATION is a GO:0001199 (metal ion regulated sequence-specific DNA binding transcription factor activity)
2011-11-26 Added RELATION is a GO:0000981 (sequence-specific DNA binding RNA polymerase II transcription factor activity)

Term

Timestamp Action Category Detail
2011-11-26 Added TERM metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity

Definition/synonyms

Timestamp Action Category Detail
2012-04-07 Added DEFINITION Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.
2012-04-07 Deleted DEFINITION Interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a specific DNA sequence, or by regulating some other function of the transcription factor, in order to modulate transcription by RNA polymerase II.
2011-11-26 Added DEFINITION Interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a specific DNA sequence, or by regulating some other function of the transcription factor, in order to modulate transcription by RNA polymerase II.

Relationships

Timestamp Action Category Detail
2011-11-26 Added RELATION is a GO:0001199 (metal ion regulated sequence-specific DNA binding transcription factor activity)
2011-11-26 Added RELATION is a GO:0000981 (sequence-specific DNA binding RNA polymerase II transcription factor activity)
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