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GO:0000988 protein binding transcription factor activity

Term Information

ID GO:0000988
Name protein binding transcription factor activity
Ontology Molecular Function
Definition Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
Restrictions This term should not be used for direct manual annotation. This term may be used for mapping to external vocabularies in order to create electronic annotations. See comment below for further information.
Comment Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of protein binding, e.g. transcription factor binding or RNA polymerase binding. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
GONUTS GO:0000988 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad transcription factor activity

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_generic149
goslim_yeast169
goslim_candida89
goslim_aspergillus85

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016563 transcription activator activity CONSIDER GO:0000988
GO:0016564 transcription repressor activity CONSIDER GO:0000988
GO:0016986 transcription initiation factor activity CONSIDER GO:0000988
GO:0030528 transcription regulator activity CONSIDER GO:0000988

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000988:
Relationship To GO:0000988 Child Term Child Term Name
Is a GO:0000989 transcription factor binding transcription factor activity
Is a GO:0000990 core RNA polymerase binding transcription factor activity
Has part GO:0005515 protein binding

Protein Annotation

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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Name
Synonym
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000988. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000988 based on the entire annotation set Co-occurrence statistics for GO:0000988 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-19 Added SLIM gocheck_do_not_manually_annotate
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-11-05 Added SLIM goslim_candida
2011-10-24 Added RELATION part of GO:2001141 (regulation of RNA biosynthetic process)
2011-10-24 Deleted RELATION part of GO:0006355 (regulation of transcription, DNA-templated)
2011-10-13 Added RELATION part of GO:0006355 (regulation of transcription, DNA-templated)
2011-09-04 Added SYNONYM transcription factor activity
2011-08-21 Deleted DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-08-21 Added DEFINITION Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-08-14 Added SLIM goslim_yeast
2011-06-05 Added DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-06-05 Deleted DEFINITION Interacting selectively and non-covalently with a specific protein in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
2011-03-18 Deleted RELATION part of GO:0006350 (transcription)
2010-10-29 Added RELATION part of GO:0006350 (transcription)
2010-09-03 Added RELATION is a GO:0003674 (molecular_function)
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a specific protein in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
2010-09-03 Added TERM protein binding transcription factor activity

Term

Timestamp Action Category Detail
2010-09-03 Added TERM protein binding transcription factor activity

Definition/synonyms

Timestamp Action Category Detail
2011-09-04 Added SYNONYM transcription factor activity
2011-08-21 Deleted DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-08-21 Added DEFINITION Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-06-05 Added DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
2011-06-05 Deleted DEFINITION Interacting selectively and non-covalently with a specific protein in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a specific protein in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.

Relationships

Timestamp Action Category Detail
2011-10-24 Added RELATION part of GO:2001141 (regulation of RNA biosynthetic process)
2011-10-24 Deleted RELATION part of GO:0006355 (regulation of transcription, DNA-templated)
2011-10-13 Added RELATION part of GO:0006355 (regulation of transcription, DNA-templated)
2011-03-18 Deleted RELATION part of GO:0006350 (transcription)
2010-10-29 Added RELATION part of GO:0006350 (transcription)
2010-09-03 Added RELATION is a GO:0003674 (molecular_function)

Other

Timestamp Action Category Detail
2013-04-19 Added SLIM gocheck_do_not_manually_annotate
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-11-05 Added SLIM goslim_candida
2011-08-14 Added SLIM goslim_yeast
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