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GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding

Term Information

ID GO:0000980
Name RNA polymerase II distal enhancer sequence-specific DNA binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
Comment Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers.
GONUTS GO:0000980 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink
Considerations when annotating from ChiP assay resultsLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000980:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000980. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000980 based on the entire annotation set Co-occurrence statistics for GO:0000980 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-04 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-09-04 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-09-04 Updated TERM RNA polymerase II distal enhancer sequence-specific DNA binding
2011-02-15 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-02-15 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-01-30 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer.
2011-01-30 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-01-30 Added RELATION is a GO:0001158 (enhancer sequence-specific DNA binding)
2011-01-30 Deleted RELATION is a GO:0035326 (enhancer binding)
2010-10-24 Added RELATION has part GO:0003705 (RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity)
2010-09-03 Added TERM RNA polymerase II enhancer sequence-specific DNA binding
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer.
2010-09-03 Added RELATION is a GO:0035326 (enhancer binding)
2010-09-03 Added RELATION is a GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)

Term

Timestamp Action Category Detail
2011-09-04 Updated TERM RNA polymerase II distal enhancer sequence-specific DNA binding
2010-09-03 Added TERM RNA polymerase II enhancer sequence-specific DNA binding

Definition/synonyms

Timestamp Action Category Detail
2011-09-04 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-09-04 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-02-15 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-02-15 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2011-01-30 Deleted DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer.
2011-01-30 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a RNA polymerase II (Pol II) enhancer.

Relationships

Timestamp Action Category Detail
2011-01-30 Added RELATION is a GO:0001158 (enhancer sequence-specific DNA binding)
2011-01-30 Deleted RELATION is a GO:0035326 (enhancer binding)
2010-10-24 Added RELATION has part GO:0003705 (RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity)
2010-09-03 Added RELATION is a GO:0035326 (enhancer binding)
2010-09-03 Added RELATION is a GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
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