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GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding

Term Information

ID GO:0000977
Name RNA polymerase II regulatory region sequence-specific DNA binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
Comment The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
GONUTS GO:0000977 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink
Considerations when annotating from ChiP assay resultsLink

Cross-references

Database ID
InterPro IPR027770
InterPro IPR029830
InterPro IPR030430

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000977:
Relationship To GO:0000977 Child Term Child Term Name
Is a GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Is a GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
Is a GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
Is a GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
Capable of GO:1990907 beta-catenin-TCF complex
Capable of GO:1990589 ATF4-CREB1 transcription factor complex
Capable of GO:1990590 ATF1-ATF4 transcription factor complex
Capable of GO:1990617 CHOP-ATF4 complex
Regulates GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Negatively regulates GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Capable of GO:1990378 upstream stimulatory factor complex
Capable of GO:1990647 C/EBP complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000977. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000977 based on the entire annotation set Co-occurrence statistics for GO:0000977 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-31 Deleted DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2010-10-31 Added DEFINITION Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2010-10-24 Added RELATION has part GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
2010-09-03 Added TERM RNA polymerase II regulatory region sequence-specific DNA binding
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2010-09-03 Added RELATION is a GO:0001012 (RNA polymerase II regulatory region DNA binding)
2010-09-03 Added RELATION is a GO:0000976 (transcription regulatory region sequence-specific DNA binding)

Term

Timestamp Action Category Detail
2010-09-03 Added TERM RNA polymerase II regulatory region sequence-specific DNA binding

Definition/synonyms

Timestamp Action Category Detail
2010-10-31 Deleted DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2010-10-31 Added DEFINITION Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

Relationships

Timestamp Action Category Detail
2010-10-24 Added RELATION has part GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
2010-09-03 Added RELATION is a GO:0001012 (RNA polymerase II regulatory region DNA binding)
2010-09-03 Added RELATION is a GO:0000976 (transcription regulatory region sequence-specific DNA binding)
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