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GO:0000976 transcription regulatory region sequence-specific DNA binding

Term Information

ID GO:0000976
Name transcription regulatory region sequence-specific DNA binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
Comment The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
GONUTS GO:0000976 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink
Considerations when annotating from ChiP assay resultsLink

Cross-references

Database ID
InterPro IPR017125
InterPro IPR029521

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000976:
Relationship To GO:0000976 Child Term Child Term Name
Is a GO:0001046 core promoter sequence-specific DNA binding
Is a GO:0001044 mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
Is a GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
Is a GO:0000984 bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
Is a GO:0000987 core promoter proximal region sequence-specific DNA binding
Is a GO:0000992 polymerase III regulatory region sequence-specific DNA binding
Is a GO:0001147 transcription termination site sequence-specific DNA binding
Is a GO:0001158 enhancer sequence-specific DNA binding

Protein Annotation

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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000976. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000976 based on the entire annotation set Co-occurrence statistics for GO:0000976 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-31 Added DEFINITION Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2010-10-31 Deleted DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2010-09-03 Added TERM transcription regulatory region sequence-specific DNA binding
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2010-09-03 Added RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2010-09-03 Added RELATION is a GO:0043565 (sequence-specific DNA binding)
2010-09-03 Added RELATION has part GO:0003700 (sequence-specific DNA binding transcription factor activity)
2010-09-03 Added RELATION has part GO:0000996 (core DNA-dependent RNA polymerase binding promoter specificity activity)

Term

Timestamp Action Category Detail
2010-09-03 Added TERM transcription regulatory region sequence-specific DNA binding

Definition/synonyms

Timestamp Action Category Detail
2010-10-31 Added DEFINITION Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2010-10-31 Deleted DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2010-09-03 Added DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Relationships

Timestamp Action Category Detail
2010-09-03 Added RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2010-09-03 Added RELATION is a GO:0043565 (sequence-specific DNA binding)
2010-09-03 Added RELATION has part GO:0003700 (sequence-specific DNA binding transcription factor activity)
2010-09-03 Added RELATION has part GO:0000996 (core DNA-dependent RNA polymerase binding promoter specificity activity)
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