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GO:0000724 double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

Term Information

ID GO:0000724
Name double-strand break repair via homologous recombination
Ontology Biological Process
Definition The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
Comment

Synonyms

Type Synonym
exact Rad51-dependent recombinational repair
exact homology-directed repair
exact homologous recombinational repair
exact HRR
exact Rhp51-dependent recombinational repair
exact HDR

Cross-references associated with this term:

Database ID
INTERPRO IPR015252

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0050896 response to stimulus
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0043170 macromolecule metabolic process
GO:0006950 response to stress
GO:0044238 primary metabolic process
GO:0006974 response to DNA damage stimulus
GO:0043283 biopolymer metabolic process
GO:0051716 cellular response to stimulus
GO:0044237 cellular metabolic process
GO:0033554 cellular response to stress
GO:0044260 cellular macromolecule metabolic process
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0034984 cellular response to DNA damage stimulus
GO:0034960 cellular biopolymer metabolic process
GO:0006259 DNA metabolic process
GO:0006310 DNA recombination
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0000725 recombinational repair
GO:0000724 double-strand break repair via homologous recombination

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0043150 DNA synthesis during double-strand break repair via homologous recombination
I GO:0000727 double-strand break repair via break-induced replication
I GO:0045003 double-strand break repair via synthesis-dependent strand annealing
R GO:0010569 regulation of double-strand break repair via homologous recombination

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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