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GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activityCatalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
Term Information
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| Type | Synonym |
| broad | DNA glycosylase/beta-lyase |
| related | endonuclease VIII activity |
| broad | DNA glycosylase/AP-lyase |
| related | pyrimidine-specific oxidized base lesion DNA N-glycosylase activity |
| broad | bifunctional DNA glycosylase |
| related | endodeoxyribonuclease III |
| related | endonuclease III |
GO:0008845 endonuclease VIII activity |
(consider GO:0000703) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||||||
![]() | GO:0003824 catalytic activity | |||||||||
![]() | ![]() | GO:0016787 hydrolase activity | ||||||||
![]() | ![]() | ![]() | GO:0016829 lyase activity | |||||||
![]() | ![]() | ![]() | ![]() | GO:0016798 hydrolase activity, acting on glycosyl bonds | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0016835 carbon-oxygen lyase activity | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0019104 DNA N-glycosylase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0000702 oxidized base lesion DNA N-glycosylase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0034042 5-formyluracil DNA N-glycosylase activity |
| I | GO:0034043 5-hydroxymethyluracil DNA N-glycosylase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-21-04-03-45 |