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GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activity

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

Term Information

ID GO:0000703
Name oxidized pyrimidine base lesion DNA N-glycosylase activity
Ontology Molecular Function
Definition Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
Comment Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.

Synonyms

Type Synonym
broad DNA glycosylase/beta-lyase
related endonuclease VIII activity
broad DNA glycosylase/AP-lyase
related pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
broad bifunctional DNA glycosylase
related endodeoxyribonuclease III
related endonuclease III

This term can be used instead of these obsolete terms:

GO:0008845 endonuclease VIII activity (consider GO:0000703)

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016835 carbon-oxygen lyase activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0034042 5-formyluracil DNA N-glycosylase activity
I GO:0034043 5-hydroxymethyluracil DNA N-glycosylase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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