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GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Term Information

ID GO:0000703
Name oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Ontology Molecular Function
Definition Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
PMID:11554296
Comment Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
Secondary IDs GO:0019004
GONUTS GO:0000703 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact oxidized pyrimidine base lesion DNA N-glycosylase activity
broad bifunctional DNA glycosylase
related pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
related endonuclease VIII activity
related endonuclease III
broad DNA glycosylase/AP-lyase
broad DNA glycosylase/beta-lyase
related endodeoxyribonuclease III

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008845 endonuclease VIII activity CONSIDER GO:0000703

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000703:
Relationship To GO:0000703 Child Term Child Term Name
Is a GO:0034042 5-formyluracil DNA N-glycosylase activity
Is a GO:0034043 5-hydroxymethyluracil DNA N-glycosylase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000703. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000703 based on the entire annotation set Co-occurrence statistics for GO:0000703 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-07-22 Updated TERM oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
2012-07-22 Added SYNONYM oxidized pyrimidine base lesion DNA N-glycosylase activity
2009-06-27 Deleted DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2009-06-27 Added DEFINITION Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
2009-06-27 Deleted RELATION is a GO:0004520 (endodeoxyribonuclease activity)
2008-05-13 Added DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2008-05-12 Deleted DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2008-04-01 Updated RELATION is a GO:0004520 (endodeoxyribonuclease activity)
2008-04-01 Updated RELATION is a GO:0003906 (DNA-(apurinic or apyrimidinic site) lyase activity)
2008-04-01 Updated RELATION is a GO:0000702 (oxidized base lesion DNA N-glycosylase activity)
2007-08-09 Added SYNONYM DNA glycosylase/AP-lyase
2007-08-09 Added SYNONYM DNA glycosylase/beta-lyase
2007-08-09 Added SYNONYM bifunctional DNA glycosylase
2007-08-09 Added SYNONYM endodeoxyribonuclease III
2007-08-09 Added SYNONYM endonuclease III
2007-08-09 Added SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2007-08-09 Deleted SYNONYM DNA glycosylase/AP-lyase
2007-08-09 Deleted SYNONYM DNA glycosylase/beta-lyase
2007-08-09 Deleted SYNONYM bifunctional DNA glycosylase
2007-08-09 Deleted SYNONYM endodeoxyribonuclease III
2007-08-09 Deleted SYNONYM endonuclease III
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2006-10-13 Updated TERM oxidized pyrimidine base lesion DNA N-glycosylase activity
2006-10-13 Added SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2005-08-10 Added SYNONYM endonuclease VIII activity
2004-04-19 Added SYNONYM DNA glycosylase/beta-lyase
2004-04-19 Added SYNONYM bifunctional DNA glycosylase
2004-04-19 Added SYNONYM endodeoxyribonuclease III
2004-04-19 Added SYNONYM endonuclease III
2004-04-19 Added SYNONYM DNA glycosylase/AP-lyase
2004-04-16 Deleted SYNONYM DNA glycosylase/AP-lyase
2004-04-16 Deleted SYNONYM DNA glycosylase/beta-lyase
2004-04-16 Deleted SYNONYM bifunctional DNA glycosylase
2004-04-16 Deleted SYNONYM endodeoxyribonuclease III
2004-04-16 Deleted SYNONYM endonuclease III
2003-11-05 Deleted XREF MetaCyc:4.2.99.18-RXN
2003-11-05 Deleted XREF EC:4.2.99.18
2003-10-27 Added SYNONYM DNA glycosylase/AP-lyase
2003-10-27 Added SYNONYM DNA glycosylase/beta-lyase
2003-10-27 Added SYNONYM bifunctional DNA glycosylase
2003-10-27 Added SYNONYM endodeoxyribonuclease III
2003-10-27 Added SYNONYM endonuclease III
2003-10-27 Added XREF MetaCyc:4.2.99.18-RXN
2003-08-18 Deleted SYNONYM DNA glycosylase/AP-lyase
2003-08-18 Deleted SYNONYM DNA glycosylase/beta-lyase
2003-08-18 Deleted SYNONYM endodeoxyribonuclease III
2003-08-18 Deleted SYNONYM endonuclease III
2003-08-18 Deleted SYNONYM bifunctional DNA glycosylase
2003-08-05 Updated DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2003-03-19 Updated TERM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2002-11-27 Added DEFINITION Recognizes and removes oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
2002-05-17 Added SYNONYM endonuclease III
2002-05-17 Added SYNONYM endodeoxyribonuclease III
2002-05-17 Added SYNONYM bifunctional DNA glycosylase
2002-05-17 Added SYNONYM DNA glycosylase/beta-lyase
2002-05-17 Added SYNONYM DNA glycosylase/AP-lyase
2002-05-17 Added SECONDARY GO:0019004 (endodeoxyribonuclease III)
2002-05-17 Added TERM pyrimidine-specific oxidized base lesion DNA N-glycosylase
2002-05-17 Added XREF EC:4.2.99.18

Term

Timestamp Action Category Detail
2012-07-22 Updated TERM oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
2006-10-13 Updated TERM oxidized pyrimidine base lesion DNA N-glycosylase activity
2003-03-19 Updated TERM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2002-05-17 Added TERM pyrimidine-specific oxidized base lesion DNA N-glycosylase

Definition/synonyms

Timestamp Action Category Detail
2012-07-22 Added SYNONYM oxidized pyrimidine base lesion DNA N-glycosylase activity
2009-06-27 Deleted DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2009-06-27 Added DEFINITION Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
2008-05-13 Added DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2008-05-12 Deleted DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2007-08-09 Added SYNONYM DNA glycosylase/AP-lyase
2007-08-09 Added SYNONYM DNA glycosylase/beta-lyase
2007-08-09 Added SYNONYM bifunctional DNA glycosylase
2007-08-09 Added SYNONYM endodeoxyribonuclease III
2007-08-09 Added SYNONYM endonuclease III
2007-08-09 Added SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2007-08-09 Deleted SYNONYM DNA glycosylase/AP-lyase
2007-08-09 Deleted SYNONYM DNA glycosylase/beta-lyase
2007-08-09 Deleted SYNONYM bifunctional DNA glycosylase
2007-08-09 Deleted SYNONYM endodeoxyribonuclease III
2007-08-09 Deleted SYNONYM endonuclease III
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2006-10-13 Added SYNONYM pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
2005-08-10 Added SYNONYM endonuclease VIII activity
2004-04-19 Added SYNONYM DNA glycosylase/beta-lyase
2004-04-19 Added SYNONYM bifunctional DNA glycosylase
2004-04-19 Added SYNONYM endodeoxyribonuclease III
2004-04-19 Added SYNONYM endonuclease III
2004-04-19 Added SYNONYM DNA glycosylase/AP-lyase
2004-04-16 Deleted SYNONYM DNA glycosylase/AP-lyase
2004-04-16 Deleted SYNONYM DNA glycosylase/beta-lyase
2004-04-16 Deleted SYNONYM bifunctional DNA glycosylase
2004-04-16 Deleted SYNONYM endodeoxyribonuclease III
2004-04-16 Deleted SYNONYM endonuclease III
2003-10-27 Added SYNONYM DNA glycosylase/AP-lyase
2003-10-27 Added SYNONYM DNA glycosylase/beta-lyase
2003-10-27 Added SYNONYM bifunctional DNA glycosylase
2003-10-27 Added SYNONYM endodeoxyribonuclease III
2003-10-27 Added SYNONYM endonuclease III
2003-08-18 Deleted SYNONYM DNA glycosylase/AP-lyase
2003-08-18 Deleted SYNONYM DNA glycosylase/beta-lyase
2003-08-18 Deleted SYNONYM endodeoxyribonuclease III
2003-08-18 Deleted SYNONYM endonuclease III
2003-08-18 Deleted SYNONYM bifunctional DNA glycosylase
2003-08-05 Updated DEFINITION Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.
2002-11-27 Added DEFINITION Recognizes and removes oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
2002-05-17 Added SYNONYM endonuclease III
2002-05-17 Added SYNONYM endodeoxyribonuclease III
2002-05-17 Added SYNONYM bifunctional DNA glycosylase
2002-05-17 Added SYNONYM DNA glycosylase/beta-lyase
2002-05-17 Added SYNONYM DNA glycosylase/AP-lyase

Relationships

Timestamp Action Category Detail
2009-06-27 Deleted RELATION is a GO:0004520 (endodeoxyribonuclease activity)
2008-04-01 Updated RELATION is a GO:0004520 (endodeoxyribonuclease activity)
2008-04-01 Updated RELATION is a GO:0003906 (DNA-(apurinic or apyrimidinic site) lyase activity)
2008-04-01 Updated RELATION is a GO:0000702 (oxidized base lesion DNA N-glycosylase activity)

Cross-references

Timestamp Action Category Detail
2003-11-05 Deleted XREF MetaCyc:4.2.99.18-RXN
2003-11-05 Deleted XREF EC:4.2.99.18
2003-10-27 Added XREF MetaCyc:4.2.99.18-RXN
2002-05-17 Added XREF EC:4.2.99.18

Other

Timestamp Action Category Detail
2002-05-17 Added SECONDARY GO:0019004 (endodeoxyribonuclease III)
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