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GO:0000398 nuclear mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

Term Information

ID GO:0000398
Name nuclear mRNA splicing, via spliceosome
Ontology Biological Process
Definition The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
Comment Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.

Synonyms

Type Synonym
broad pre-mRNA splicing
broad mRNA splicing
related splicing AT-AC intron
related splicing GT-AG intron
narrow nuclear mRNA splicing via U2-type spliceosome
narrow nuclear mRNA splicing via U12-type spliceosome

Cross-references associated with this term:

Database ID
INTERPRO IPR006973
INTERPRO IPR012592
INTERPRO IPR012591
INTERPRO IPR004015
INTERPRO IPR017862
INTERPRO IPR007022
INTERPRO IPR010491

This term can be used instead of these obsolete terms:

GO:0006371 mRNA splicing (consider GO:0000398)

Web service: term information

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0044238 primary metabolic process
GO:0043170 macromolecule metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0010467 gene expression
GO:0044237 cellular metabolic process
GO:0043283 biopolymer metabolic process
GO:0044260 cellular macromolecule metabolic process
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0034960 cellular biopolymer metabolic process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0000375 RNA splicing, via transesterification reactions
GO:0006397 mRNA processing
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 nuclear mRNA splicing, via spliceosome

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0000245 spliceosome assembly
P GO:0000387 spliceosomal snRNP assembly
P GO:0000390 spliceosome disassembly
P GO:0000393 spliceosomal conformational changes to generate catalytic conformation
I GO:0000365 nuclear mRNA trans splicing, via spliceosome
I GO:0045292 nuclear mRNA cis splicing, via spliceosome
R GO:0048024 regulation of nuclear mRNA splicing, via spliceosome
NR GO:0048025 negative regulation of nuclear mRNA splicing, via spliceosome
PR GO:0048026 positive regulation of nuclear mRNA splicing, via spliceosome
I GO:0000380 alternative nuclear mRNA splicing, via spliceosome

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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