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GO:0000386 second spliceosomal transesterification activity

Term Information

ID GO:0000386
Name second spliceosomal transesterification activity
Ontology Molecular Function
Definition Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
GONUTS GO:0000386 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related lariat formation, 5'-splice site cleavage
broad 3'-splice site cleavage, exon ligation

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006372 obsolete lariat formation, 5'-splice site cleavage CONSIDER GO:0000386
GO:0006373 obsolete 3'-splice site cleavage, exon ligation CONSIDER GO:0000386
GO:0000364 obsolete second U2-type spliceosomal transesterification activity REPLACEDBY GO:0000386
GO:0000367 obsolete second U12-type spliceosomal transesterification activity REPLACEDBY GO:0000386

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000386:
Relationship To GO:0000386 Child Term Child Term Name
Capable of GO:0071013 catalytic step 2 spliceosome

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000386. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000386 based on the entire annotation set Co-occurrence statistics for GO:0000386 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-04-10 Deleted SYNONYM lariat formation, 5'-splice site cleavage
2011-04-10 Added SYNONYM lariat formation, 5'-splice site cleavage
2010-06-15 Added RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2010-06-14 Deleted RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2010-06-08 Added RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2009-11-05 Deleted RELATION is a GO:0031202 (RNA splicing factor activity, transesterification mechanism)
2009-11-05 Added RELATION is a GO:0003824 (catalytic activity)
2008-05-13 Added DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2008-05-12 Deleted DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2008-04-19 Added RELATION is a GO:0031202 (RNA splicing factor activity, transesterification mechanism)
2008-04-19 Deleted RELATION is a GO:0000385 (spliceosomal catalysis)
2008-04-01 Updated RELATION is a GO:0000385 (spliceosomal catalysis)
2007-08-09 Added SYNONYM 3'-splice site cleavage, exon ligation
2007-08-09 Added SYNONYM lariat formation, 5'-splice site cleavage
2007-08-09 Deleted SYNONYM 3'-splice site cleavage, exon ligation
2007-08-09 Deleted SYNONYM lariat formation, 5'-splice site cleavage
2005-08-10 Added SYNONYM lariat formation, 5'-splice site cleavage
2004-04-19 Added SYNONYM 3'-splice site cleavage, exon ligation
2004-04-16 Deleted SYNONYM 3'-splice site cleavage, exon ligation
2003-11-15 Updated TERM second spliceosomal transesterification activity
2003-08-23 Updated DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2003-08-22 Added DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2003-08-22 Added SYNONYM 3'-splice site cleavage, exon ligation
2003-08-22 Added TERM 2nd spliceosomal transesterification activity

Term

Timestamp Action Category Detail
2003-11-15 Updated TERM second spliceosomal transesterification activity
2003-08-22 Added TERM 2nd spliceosomal transesterification activity

Definition/synonyms

Timestamp Action Category Detail
2011-04-10 Deleted SYNONYM lariat formation, 5'-splice site cleavage
2011-04-10 Added SYNONYM lariat formation, 5'-splice site cleavage
2008-05-13 Added DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2008-05-12 Deleted DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2007-08-09 Added SYNONYM 3'-splice site cleavage, exon ligation
2007-08-09 Added SYNONYM lariat formation, 5'-splice site cleavage
2007-08-09 Deleted SYNONYM 3'-splice site cleavage, exon ligation
2007-08-09 Deleted SYNONYM lariat formation, 5'-splice site cleavage
2005-08-10 Added SYNONYM lariat formation, 5'-splice site cleavage
2004-04-19 Added SYNONYM 3'-splice site cleavage, exon ligation
2004-04-16 Deleted SYNONYM 3'-splice site cleavage, exon ligation
2003-08-23 Updated DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2003-08-22 Added DEFINITION Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
2003-08-22 Added SYNONYM 3'-splice site cleavage, exon ligation

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2010-06-14 Deleted RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2010-06-08 Added RELATION part of GO:0000375 (RNA splicing, via transesterification reactions)
2009-11-05 Deleted RELATION is a GO:0031202 (RNA splicing factor activity, transesterification mechanism)
2009-11-05 Added RELATION is a GO:0003824 (catalytic activity)
2008-04-19 Added RELATION is a GO:0031202 (RNA splicing factor activity, transesterification mechanism)
2008-04-19 Deleted RELATION is a GO:0000385 (spliceosomal catalysis)
2008-04-01 Updated RELATION is a GO:0000385 (spliceosomal catalysis)
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