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GO:0033743 peptide-methionine (R)-S-oxide reductase activity

Term Information

ID GO:0033743
Name peptide-methionine (R)-S-oxide reductase activity
Ontology Molecular Function
Definition Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
Secondary IDs GO:0000318
GONUTS GO:0033743 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related selenoprotein R
exact protein-methionine-R-oxide reductase activity
exact peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity
related pMSR
related pMRsr
broad methionine sulfoxide reductase activity
narrow methionine sulfoxide reductase B activity
broad methionine S-oxide reductase activity
exact methionine S-oxide reductase (R-form oxidizing) activity
related SelX
related SelR
related PilB
related MsrB

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.8.4.-
EC 1.8.4.12
InterPro IPR002579
KEGG R07607
MetaCyc 1.8.4.12-RXN
RHEA 24167

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0033743:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0033743. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0033743 based on the entire annotation set Co-occurrence statistics for GO:0033743 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-17 Deleted DEFINITION Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin.
2012-10-17 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
2012-10-17 Added SYNONYM protein-methionine-R-oxide reductase activity
2012-10-17 Added XREF EC:1.8.4.-
2012-10-17 Added SECONDARY GO:0000318 (protein-methionine-R-oxide reductase activity)
2010-10-11 Added DEFINITION Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2010-10-11 Added XREF KEGG:R07607
2010-10-11 Added XREF RHEA:24167
2009-05-21 Added XREF MetaCyc:1.8.4.12-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2008-04-01 Updated RELATION is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)
2007-12-06 Deleted SYNONYM peptide-methionine (R)-S-oxide reductase activity
2007-11-27 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2007-11-08 Added TERM peptide-methionine (R)-S-oxide reductase activity
2007-11-08 Added SYNONYM MsrB
2007-11-08 Added SYNONYM methionine S-oxide reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase B activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM pMRsr
2007-11-08 Added SYNONYM PilB
2007-11-08 Added SYNONYM SelR
2007-11-08 Added SYNONYM SelX
2007-11-08 Added SYNONYM methionine S-oxide reductase (R-form oxidizing) activity
2007-11-08 Added SYNONYM pMSR
2007-11-08 Added SYNONYM peptide-methionine (R)-S-oxide reductase activity
2007-11-08 Added SYNONYM peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity
2007-11-08 Added SYNONYM selenoprotein R
2007-11-08 Added XREF EC:1.8.4.12

Term

Timestamp Action Category Detail
2007-11-08 Added TERM peptide-methionine (R)-S-oxide reductase activity

Definition/synonyms

Timestamp Action Category Detail
2012-10-17 Deleted DEFINITION Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin.
2012-10-17 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
2012-10-17 Added SYNONYM protein-methionine-R-oxide reductase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2008-05-13 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2007-12-06 Deleted SYNONYM peptide-methionine (R)-S-oxide reductase activity
2007-11-27 Added DEFINITION Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
2007-11-08 Added SYNONYM MsrB
2007-11-08 Added SYNONYM methionine S-oxide reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase B activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM pMRsr
2007-11-08 Added SYNONYM PilB
2007-11-08 Added SYNONYM SelR
2007-11-08 Added SYNONYM SelX
2007-11-08 Added SYNONYM methionine S-oxide reductase (R-form oxidizing) activity
2007-11-08 Added SYNONYM pMSR
2007-11-08 Added SYNONYM peptide-methionine (R)-S-oxide reductase activity
2007-11-08 Added SYNONYM peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity
2007-11-08 Added SYNONYM selenoprotein R

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)

Cross-references

Timestamp Action Category Detail
2012-10-17 Added XREF EC:1.8.4.-
2010-10-11 Added XREF KEGG:R07607
2010-10-11 Added XREF RHEA:24167
2009-05-21 Added XREF MetaCyc:1.8.4.12-RXN
2007-11-08 Added XREF EC:1.8.4.12

Other

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0000318 (protein-methionine-R-oxide reductase activity)
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