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GO:0000257 nitrilase activity

Term Information

ID GO:0000257
Name nitrilase activity
Ontology Molecular Function
Definition Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
GONUTS GO:0000257 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact benzonitrilase activity
exact nitrile aminohydrolase activity
exact acetonitrilase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.5.5.1
KEGG R00540
MetaCyc 3.5.5.1-RXN
RHEA 21727
UM-BBD_enzymeID e0283

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000257:
Relationship To GO:0000257 Child Term Child Term Name
Is a GO:0018761 bromoxynil nitrilase activity
Is a GO:0018762 aliphatic nitrilase activity
Is a GO:0047426 ricinine nitrilase activity
Is a GO:0047427 cyanoalanine nitrilase activity
Is a GO:0047428 arylacetonitrilase activity
Is a GO:0080061 indole-3-acetonitrile nitrilase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000257. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000257 based on the entire annotation set Co-occurrence statistics for GO:0000257 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-02 Added XREF KEGG:R00540
2011-09-16 Added XREF RHEA:21727
2008-05-13 Added DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2008-04-01 Updated RELATION is a GO:0016815 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles)
2007-11-08 Added SYNONYM acetonitrilase activity
2007-11-08 Added SYNONYM benzonitrilase activity
2007-11-08 Added SYNONYM nitrile aminohydrolase activity
2003-10-27 Added XREF UM-BBD_enzymeID:e0283
2003-10-27 Added XREF MetaCyc:3.5.5.1-RXN
2003-03-19 Updated TERM nitrilase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2002-02-06 Updated TERM nitrilase
2001-08-06 Added DEFINITION An enzyme that acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides (from the EC).
2001-04-03 Updated TERM nitrilase
2001-03-30 Added XREF EC:3.5.5.1
2001-03-30 Added TERM nitrilase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM nitrilase activity
2002-02-06 Updated TERM nitrilase
2001-04-03 Updated TERM nitrilase
2001-03-30 Added TERM nitrilase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2007-11-08 Added SYNONYM acetonitrilase activity
2007-11-08 Added SYNONYM benzonitrilase activity
2007-11-08 Added SYNONYM nitrile aminohydrolase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
2001-08-06 Added DEFINITION An enzyme that acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides (from the EC).

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016815 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles)

Cross-references

Timestamp Action Category Detail
2013-10-02 Added XREF KEGG:R00540
2011-09-16 Added XREF RHEA:21727
2003-10-27 Added XREF UM-BBD_enzymeID:e0283
2003-10-27 Added XREF MetaCyc:3.5.5.1-RXN
2001-03-30 Added XREF EC:3.5.5.1
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