spacer

GO:0000253 3-keto sterol reductase activity

Term Information

ID GO:0000253
Name 3-keto sterol reductase activity
Ontology Molecular Function
Definition Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
PMID:9811880
Comment Note that zymosterol is cholesta-8,24-dien-3-ol.
Secondary IDs GO:0050576
GONUTS GO:0000253 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
exact 3-keto-steroid reductase activity
exact 3-KSR activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.270
MetaCyc 1.1.1.270-RXN
MetaCyc RXN3O-4110
MetaCyc RXN66-19
MetaCyc RXN66-24
MetaCyc RXN66-314
MetaCyc RXN66-319
RHEA 18412

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000253:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000253. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000253 based on the entire annotation set Co-occurrence statistics for GO:0000253 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Deleted DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.
2011-09-16 Added DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
2011-09-16 Added XREF RHEA:18412
2009-11-15 Deleted DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2009-11-15 Added DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.
2009-11-15 Added SYNONYM 3-keto-steroid reductase activity
2009-11-15 Added XREF MetaCyc:RXN66-19
2009-11-15 Added XREF MetaCyc:RXN3O-4110
2009-11-15 Added XREF MetaCyc:RXN66-24
2009-11-15 Added XREF MetaCyc:RXN66-319
2009-11-15 Added XREF MetaCyc:1.1.1.270-RXN
2009-11-15 Added XREF EC:1.1.1.270
2009-11-15 Deleted XREF EC:1.1.1.-
2009-11-15 Added SYNONYM 3-KSR activity
2009-11-15 Added SECONDARY GO:0050576 (3-keto-steroid reductase activity)
2009-05-21 Added XREF MetaCyc:RXN66-314
2008-05-13 Added DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-26 Added SYNONYM 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
2004-09-25 Added XREF EC:1.1.1.-
2004-09-24 Updated DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2003-03-19 Updated TERM 3-keto sterol reductase activity
2002-11-27 Updated DEFINITION Catalysis of the conversion of the 3-keto sterol intermediate to the 3-beta-hydroxy; acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2002-02-06 Updated TERM 3-keto sterol reductase
2001-08-06 Added DEFINITION Enzyme that converts the 3-keto sterol intermediate to the 3-beta-hydroxy; acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2001-04-03 Updated TERM 3-keto sterol reductase
2001-03-30 Added TERM 3-keto sterol reductase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM 3-keto sterol reductase activity
2002-02-06 Updated TERM 3-keto sterol reductase
2001-04-03 Updated TERM 3-keto sterol reductase
2001-03-30 Added TERM 3-keto sterol reductase

Definition/synonyms

Timestamp Action Category Detail
2011-09-16 Deleted DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.
2011-09-16 Added DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
2009-11-15 Deleted DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2009-11-15 Added DEFINITION Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.
2009-11-15 Added SYNONYM 3-keto-steroid reductase activity
2009-11-15 Added SYNONYM 3-KSR activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2007-11-26 Added SYNONYM 3beta-hydroxy-steroid:NADP+ 3-oxidoreductase
2004-09-24 Updated DEFINITION Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+.
2002-11-27 Updated DEFINITION Catalysis of the conversion of the 3-keto sterol intermediate to the 3-beta-hydroxy; acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2001-08-06 Added DEFINITION Enzyme that converts the 3-keto sterol intermediate to the 3-beta-hydroxy; acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:18412
2009-11-15 Added XREF MetaCyc:RXN66-19
2009-11-15 Added XREF MetaCyc:RXN3O-4110
2009-11-15 Added XREF MetaCyc:RXN66-24
2009-11-15 Added XREF MetaCyc:RXN66-319
2009-11-15 Added XREF MetaCyc:1.1.1.270-RXN
2009-11-15 Added XREF EC:1.1.1.270
2009-11-15 Deleted XREF EC:1.1.1.-
2009-05-21 Added XREF MetaCyc:RXN66-314
2004-09-25 Added XREF EC:1.1.1.-

Other

Timestamp Action Category Detail
2009-11-15 Added SECONDARY GO:0050576 (3-keto-steroid reductase activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
14ms