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GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity

Term Information

ID GO:0000252
Name C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
Ontology Molecular Function
Definition Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
PMID:9811880
Comment Note that zymosterol is cholesta-8,24-dien-3-ol.
GONUTS GO:0000252 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related C-3 sterol dehydrogenase (C-4 decarboxylase) activity
exact 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
related sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
related sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
related sterol 4alpha-carboxylic decarboxylase activity
related C-3 sterol dehydrogenase activity
related 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
related 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
related 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.-

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000252:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000252. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000252 based on the entire annotation set Co-occurrence statistics for GO:0000252 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-26 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-26 Deleted SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-11-26 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Deleted SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-11-26 Deleted SYNONYM C-3 sterol dehydrogenase activity
2007-11-26 Deleted SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-26 Added SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-11-26 Added SYNONYM C-3 sterol dehydrogenase activity
2007-11-26 Added SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-11-26 Added SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-11-08 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase
2007-11-08 Deleted SYNONYM sterol 4alpha-carboxylic decarboxylase
2007-11-08 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-08 Added SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase
2007-09-06 Added SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-09-06 Added SYNONYM C-3 sterol dehydrogenase activity
2007-09-06 Added SYNONYM sterol 4alpha-carboxylic decarboxylase
2007-09-06 Added SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-08-09 Added SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2007-08-09 Deleted SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2004-09-25 Added XREF EC:1.1.1.-
2004-09-25 Added SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2004-09-24 Updated DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2003-03-19 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
2002-11-27 Updated DEFINITION Catalysis of the removal of the 3-alpha hydrogen from the 3-ketocarboxylic acid sterol intermediate, resulting in the decarboxylation of the 3-ketocarboxylic acid: acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2002-02-06 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)
2001-08-06 Added DEFINITION Enzyme that catalyzes the removal of the 3-alpha hydrogen from the 3-ketocarboxylic acid sterol intermediate, resulting in the decarboxylation of the 3-ketocarboxylic acid: acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2001-04-03 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)
2001-03-30 Added TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
2002-02-06 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)
2001-04-03 Updated TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)
2001-03-30 Added TERM C-3 sterol dehydrogenase (C-4 sterol decarboxylase)

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2007-11-26 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-26 Deleted SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-11-26 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Deleted SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-11-26 Deleted SYNONYM C-3 sterol dehydrogenase activity
2007-11-26 Deleted SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-11-26 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-26 Added SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-11-26 Added SYNONYM C-3 sterol dehydrogenase activity
2007-11-26 Added SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-11-26 Added SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-11-08 Deleted SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase
2007-11-08 Deleted SYNONYM sterol 4alpha-carboxylic decarboxylase
2007-11-08 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
2007-11-08 Added SYNONYM sterol 4alpha-carboxylic decarboxylase activity
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2007-09-06 Added SYNONYM 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase
2007-09-06 Added SYNONYM C-3 sterol dehydrogenase (C-4 decarboxylase) activity
2007-09-06 Added SYNONYM C-3 sterol dehydrogenase activity
2007-09-06 Added SYNONYM sterol 4alpha-carboxylic decarboxylase
2007-09-06 Added SYNONYM sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
2007-08-09 Added SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2007-08-09 Deleted SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2004-09-25 Added SYNONYM sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
2004-09-24 Updated DEFINITION Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.
2002-11-27 Updated DEFINITION Catalysis of the removal of the 3-alpha hydrogen from the 3-ketocarboxylic acid sterol intermediate, resulting in the decarboxylation of the 3-ketocarboxylic acid: acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.
2001-08-06 Added DEFINITION Enzyme that catalyzes the removal of the 3-alpha hydrogen from the 3-ketocarboxylic acid sterol intermediate, resulting in the decarboxylation of the 3-ketocarboxylic acid: acts in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol in ergosterol biosynthesis.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2004-09-25 Added XREF EC:1.1.1.-
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