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GO:0000250 lanosterol synthase activity

Term Information

ID GO:0000250
Name lanosterol synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
GONUTS GO:0000250 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact OSC
exact oxidosqualene-lanosterol cyclase activity
exact squalene 2,3-epoxide:lanosterol cyclase activity
exact lanosterol 2,3-oxidosqualene cyclase activity
exact 2,3-oxidosqualene-lanosterol cyclase activity
exact 2,3-epoxysqualene-lanosterol cyclase activity
exact 2,3-epoxysqualene lanosterol cyclase activity
exact (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
broad squalene epoxidase-cyclase activity
broad 2,3-oxidosqualene sterol cyclase activity
exact squalene-2,3-oxide-lanosterol cyclase activity
exact oxidosqualene:lanosterol cyclase activity
exact 2,3-epoxysqualene--lanosterol cyclase activity
exact oxidosqualene--lanosterol cyclase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.4.99.7
KEGG R03199
MetaCyc LANOSTEROL-SYNTHASE-RXN
RHEA 14624

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000250:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000250. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000250 based on the entire annotation set Co-occurrence statistics for GO:0000250 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:14624
2010-10-11 Added XREF KEGG:R03199
2009-11-08 Deleted SYNONYM 2,3-oxidosqualene sterol cyclase activity
2009-11-08 Deleted SYNONYM squalene epoxidase-cyclase activity
2009-11-08 Deleted SYNONYM 2,3-oxidosqualene cyclase activity
2009-11-08 Added SYNONYM 2,3-oxidosqualene sterol cyclase activity
2009-11-08 Added SYNONYM squalene epoxidase-cyclase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2008-04-01 Updated RELATION is a GO:0031559 (oxidosqualene cyclase activity)
2008-01-10 Added SYNONYM oxidosqualene:lanosterol cyclase activity
2007-11-08 Added SYNONYM (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
2007-11-08 Added SYNONYM 2,3-epoxysqualene lanosterol cyclase activity
2007-11-08 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene sterol cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM lanosterol 2,3-oxidosqualene cyclase activity
2007-11-08 Added SYNONYM oxidosqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM squalene 2,3-epoxide:lanosterol cyclase activity
2007-11-08 Added SYNONYM squalene epoxidase-cyclase activity
2007-11-08 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-11-08 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2007-09-06 Added SYNONYM 2,3-epoxysqualene--lanosterol cyclase activity
2007-09-06 Added SYNONYM oxidosqualene--lanosterol cyclase activity
2007-09-06 Added SYNONYM squalene-2,3-oxide-lanosterol cyclase activity
2007-08-09 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-08-09 Added SYNONYM OSC
2007-08-09 Added SYNONYM oxidosqualene-lanosterol cyclase
2007-08-09 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-08-09 Deleted SYNONYM OSC
2007-08-09 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2004-09-24 Updated DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2004-04-19 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2004-04-19 Added SYNONYM OSC
2004-04-19 Added SYNONYM oxidosqualene-lanosterol cyclase
2004-04-16 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2004-04-16 Deleted SYNONYM OSC
2004-04-16 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2003-10-27 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2003-10-27 Added SYNONYM OSC
2003-10-27 Added SYNONYM oxidosqualene-lanosterol cyclase
2003-10-27 Added XREF MetaCyc:LANOSTEROL-SYNTHASE-RXN
2003-08-21 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2003-08-21 Deleted SYNONYM OSC
2003-08-21 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2003-03-19 Updated TERM lanosterol synthase activity
2003-03-19 Deleted SYNONYM 2,3-epoxysqualene--lanosterol cyclase
2003-03-19 Deleted SYNONYM oxidosqualene--lanosterol cyclase
2002-11-27 Updated DEFINITION Catalysis of the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
2002-02-06 Updated TERM lanosterol synthase
2001-11-07 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2001-11-07 Added SYNONYM oxidosqualene-lanosterol cyclase
2001-08-06 Added DEFINITION Enzyme that catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
2001-04-03 Updated TERM lanosterol synthase
2001-03-30 Added XREF EC:5.4.99.7
2001-03-30 Added SYNONYM oxidosqualene--lanosterol cyclase
2001-03-30 Added SYNONYM 2,3-epoxysqualene--lanosterol cyclase
2001-03-30 Added SYNONYM OSC
2001-03-30 Added TERM lanosterol synthase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM lanosterol synthase activity
2002-02-06 Updated TERM lanosterol synthase
2001-04-03 Updated TERM lanosterol synthase
2001-03-30 Added TERM lanosterol synthase

Definition/synonyms

Timestamp Action Category Detail
2009-11-08 Deleted SYNONYM 2,3-oxidosqualene sterol cyclase activity
2009-11-08 Deleted SYNONYM squalene epoxidase-cyclase activity
2009-11-08 Deleted SYNONYM 2,3-oxidosqualene cyclase activity
2009-11-08 Added SYNONYM 2,3-oxidosqualene sterol cyclase activity
2009-11-08 Added SYNONYM squalene epoxidase-cyclase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2008-01-10 Added SYNONYM oxidosqualene:lanosterol cyclase activity
2007-11-08 Added SYNONYM (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
2007-11-08 Added SYNONYM 2,3-epoxysqualene lanosterol cyclase activity
2007-11-08 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene sterol cyclase activity
2007-11-08 Added SYNONYM 2,3-oxidosqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM lanosterol 2,3-oxidosqualene cyclase activity
2007-11-08 Added SYNONYM oxidosqualene-lanosterol cyclase activity
2007-11-08 Added SYNONYM squalene 2,3-epoxide:lanosterol cyclase activity
2007-11-08 Added SYNONYM squalene epoxidase-cyclase activity
2007-11-08 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-11-08 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2007-09-06 Added SYNONYM 2,3-epoxysqualene--lanosterol cyclase activity
2007-09-06 Added SYNONYM oxidosqualene--lanosterol cyclase activity
2007-09-06 Added SYNONYM squalene-2,3-oxide-lanosterol cyclase activity
2007-08-09 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-08-09 Added SYNONYM OSC
2007-08-09 Added SYNONYM oxidosqualene-lanosterol cyclase
2007-08-09 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2007-08-09 Deleted SYNONYM OSC
2007-08-09 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2004-09-24 Updated DEFINITION Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
2004-04-19 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2004-04-19 Added SYNONYM OSC
2004-04-19 Added SYNONYM oxidosqualene-lanosterol cyclase
2004-04-16 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2004-04-16 Deleted SYNONYM OSC
2004-04-16 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2003-10-27 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2003-10-27 Added SYNONYM OSC
2003-10-27 Added SYNONYM oxidosqualene-lanosterol cyclase
2003-08-21 Deleted SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2003-08-21 Deleted SYNONYM OSC
2003-08-21 Deleted SYNONYM oxidosqualene-lanosterol cyclase
2003-03-19 Deleted SYNONYM 2,3-epoxysqualene--lanosterol cyclase
2003-03-19 Deleted SYNONYM oxidosqualene--lanosterol cyclase
2002-11-27 Updated DEFINITION Catalysis of the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
2001-11-07 Added SYNONYM 2,3-epoxysqualene-lanosterol cyclase
2001-11-07 Added SYNONYM oxidosqualene-lanosterol cyclase
2001-08-06 Added DEFINITION Enzyme that catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
2001-03-30 Added SYNONYM oxidosqualene--lanosterol cyclase
2001-03-30 Added SYNONYM 2,3-epoxysqualene--lanosterol cyclase
2001-03-30 Added SYNONYM OSC

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0031559 (oxidosqualene cyclase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:14624
2010-10-11 Added XREF KEGG:R03199
2003-10-27 Added XREF MetaCyc:LANOSTEROL-SYNTHASE-RXN
2001-03-30 Added XREF EC:5.4.99.7
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