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GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Term Information

ID GO:0000184
Name nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Ontology Biological Process
Definition The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
PMID:10025395
GONUTS GO:0000184 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact nonsense-mediated mRNA decay
exact mRNA degradation, nonsense-mediated decay
exact mRNA catabolism, nonsense-mediated
exact mRNA catabolic process, nonsense-mediated
exact nuclear mRNA catabolic process, nonsense-mediated decay
exact mRNA breakdown, nonsense-mediated decay

Cross-references

Database ID
InterPro IPR018999
InterPro IPR019354
InterPro IPR026781
InterPro IPR028802
UniProtKB-KW Nonsense-mediated mRNA decay
Wikipedia Nonsense-mediated_decay
Wikipedia Nonsense-mediated_mRNA_decay

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000184:
Relationship To GO:0000184 Child Term Child Term Name
Is a GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
Is a GO:0070479 nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
Regulates GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Negatively regulates GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Positively regulates GO:2000624 positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000184. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000184 based on the entire annotation set Co-occurrence statistics for GO:0000184 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Nonsense-mediated_mRNA_decay
2009-02-25 Added XREF Wikipedia:Nonsense-mediated_decay
2008-05-13 Added DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2008-05-12 Deleted DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2008-04-30 Added RELATION is a GO:0000956 (nuclear-transcribed mRNA catabolic process)
2008-04-30 Deleted RELATION is a GO:0006402 (mRNA catabolic process)
2008-04-30 Added SYNONYM nuclear mRNA catabolic process, nonsense-mediated decay
2008-04-30 Updated TERM nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
2008-04-27 Updated DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2008-04-01 Updated RELATION is a GO:0006402 (mRNA catabolic process)
2007-08-09 Added SYNONYM mRNA breakdown, nonsense-mediated decay
2007-08-09 Added SYNONYM mRNA catabolic process, nonsense-mediated
2007-08-09 Added SYNONYM mRNA catabolism, nonsense-mediated
2007-08-09 Added SYNONYM mRNA degradation, nonsense-mediated decay
2007-08-09 Added SYNONYM nonsense-mediated mRNA decay
2007-08-09 Deleted SYNONYM mRNA catabolic process, nonsense-mediated
2007-08-09 Deleted SYNONYM nonsense-mediated mRNA decay
2007-08-09 Deleted SYNONYM mRNA breakdown, nonsense-mediated decay
2007-08-09 Deleted SYNONYM mRNA catabolism, nonsense-mediated
2007-08-09 Deleted SYNONYM mRNA degradation, nonsense-mediated decay
2007-01-15 Updated TERM mRNA catabolic process, nonsense-mediated decay
2007-01-15 Added SYNONYM mRNA catabolic process, nonsense-mediated
2005-08-10 Added SYNONYM mRNA breakdown, nonsense-mediated decay
2005-08-10 Added SYNONYM mRNA degradation, nonsense-mediated decay
2004-09-23 Updated TERM mRNA catabolism, nonsense-mediated decay
2004-09-23 Added SYNONYM mRNA catabolism, nonsense-mediated
2004-04-19 Added SYNONYM nonsense-mediated mRNA decay
2004-04-16 Deleted SYNONYM nonsense-mediated mRNA decay
2002-11-27 Updated DEFINITION The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2002-10-02 Updated TERM mRNA catabolism, nonsense-mediated
2002-09-21 Updated TERM nonsense-mediated mRNA catabolism
2002-09-21 Added SYNONYM nonsense-mediated mRNA decay
2002-02-06 Updated TERM nonsense-mediated mRNA decay
2001-08-06 Added DEFINITION The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2001-04-03 Updated TERM nonsense-mediated mRNA decay
2001-03-30 Added TERM nonsense-mediated mRNA decay

Term

Timestamp Action Category Detail
2008-04-30 Updated TERM nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
2007-01-15 Updated TERM mRNA catabolic process, nonsense-mediated decay
2004-09-23 Updated TERM mRNA catabolism, nonsense-mediated decay
2002-10-02 Updated TERM mRNA catabolism, nonsense-mediated
2002-09-21 Updated TERM nonsense-mediated mRNA catabolism
2002-02-06 Updated TERM nonsense-mediated mRNA decay
2001-04-03 Updated TERM nonsense-mediated mRNA decay
2001-03-30 Added TERM nonsense-mediated mRNA decay

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2008-05-12 Deleted DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2008-04-30 Added SYNONYM nuclear mRNA catabolic process, nonsense-mediated decay
2008-04-27 Updated DEFINITION The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2007-08-09 Added SYNONYM mRNA breakdown, nonsense-mediated decay
2007-08-09 Added SYNONYM mRNA catabolic process, nonsense-mediated
2007-08-09 Added SYNONYM mRNA catabolism, nonsense-mediated
2007-08-09 Added SYNONYM mRNA degradation, nonsense-mediated decay
2007-08-09 Added SYNONYM nonsense-mediated mRNA decay
2007-08-09 Deleted SYNONYM mRNA catabolic process, nonsense-mediated
2007-08-09 Deleted SYNONYM nonsense-mediated mRNA decay
2007-08-09 Deleted SYNONYM mRNA breakdown, nonsense-mediated decay
2007-08-09 Deleted SYNONYM mRNA catabolism, nonsense-mediated
2007-08-09 Deleted SYNONYM mRNA degradation, nonsense-mediated decay
2007-01-15 Added SYNONYM mRNA catabolic process, nonsense-mediated
2005-08-10 Added SYNONYM mRNA breakdown, nonsense-mediated decay
2005-08-10 Added SYNONYM mRNA degradation, nonsense-mediated decay
2004-09-23 Added SYNONYM mRNA catabolism, nonsense-mediated
2004-04-19 Added SYNONYM nonsense-mediated mRNA decay
2004-04-16 Deleted SYNONYM nonsense-mediated mRNA decay
2002-11-27 Updated DEFINITION The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
2002-09-21 Added SYNONYM nonsense-mediated mRNA decay
2001-08-06 Added DEFINITION The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

Relationships

Timestamp Action Category Detail
2008-04-30 Added RELATION is a GO:0000956 (nuclear-transcribed mRNA catabolic process)
2008-04-30 Deleted RELATION is a GO:0006402 (mRNA catabolic process)
2008-04-01 Updated RELATION is a GO:0006402 (mRNA catabolic process)

Cross-references

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Nonsense-mediated_mRNA_decay
2009-02-25 Added XREF Wikipedia:Nonsense-mediated_decay
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