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GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

Term Information

ID GO:0000184
Name nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Ontology Biological Process
Definition The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Comment

Synonyms

Type Synonym
exact mRNA catabolism, nonsense-mediated
exact mRNA breakdown, nonsense-mediated decay
exact mRNA catabolic process, nonsense-mediated
exact mRNA degradation, nonsense-mediated decay
exact nuclear mRNA catabolic process, nonsense-mediated decay
exact nonsense-mediated mRNA decay

Cross-references associated with this term:

Database ID
Wikipedia Nonsense-mediated_mRNA_decay
Wikipedia Nonsense-mediated_decay
INTERPRO IPR018999

Web service: term information

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0043170 macromolecule metabolic process
GO:0044238 primary metabolic process
GO:0009056 catabolic process
GO:0043283 biopolymer metabolic process
GO:0044237 cellular metabolic process
GO:0009057 macromolecule catabolic process
GO:0044260 cellular macromolecule metabolic process
GO:0044248 cellular catabolic process
GO:0043285 biopolymer catabolic process
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0034960 cellular biopolymer metabolic process
GO:0044265 cellular macromolecule catabolic process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0034962 cellular biopolymer catabolic process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
I GO:0070479 nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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