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GO:0000165 MAPK cascade

Term Information

ID GO:0000165
Name MAPK cascade
Ontology Biological Process
Definition An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
PMID:20811974 PMID:9561267
Comment MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
GONUTS GO:0000165 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact MAPK signal transduction
related MAPK signaling
related MAPK signalling
exact MAP kinase kinase kinase cascade
exact MAP kinase cascade
narrow MAPKKK cascade during sporulation
exact mitogen-activated protein kinase cascade
exact MAPKKK cascade
narrow ERK/MAPK cascade

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000015 GO:0000165 MAPK cascade only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
Wikipedia MAPK_cascade
Wikipedia Mitogen-activated_protein_kinase

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000165:
Relationship To GO:0000165 Child Term Child Term Name
Is a GO:0051403 stress-activated MAPK cascade
Is a GO:0000161 MAPK cascade involved in osmosensory signaling pathway
Part of GO:0000189 MAPK import into nucleus
Is a GO:0000196 MAPK cascade involved in cell wall organization or biogenesis
Is a GO:0071507 MAPK cascade involved in conjugation with cellular fusion
Is a GO:0070371 ERK1 and ERK2 cascade
Is a GO:0070375 ERK5 cascade
Is a GO:0035420 MAPK cascade involved in innate immune response
Regulates GO:0043408 regulation of MAPK cascade
Negatively regulates GO:0043409 negative regulation of MAPK cascade
Positively regulates GO:0043410 positive regulation of MAPK cascade
Part of GO:0004707 MAP kinase activity
Part of GO:0004708 MAP kinase kinase activity
Part of GO:0004709 MAP kinase kinase kinase activity
Part of GO:0008349 MAP kinase kinase kinase kinase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000165. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000165 based on the entire annotation set Co-occurrence statistics for GO:0000165 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM MAPK signal transduction
2013-12-04 Added RELATION is a GO:0035556 (intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2013-11-15 Added RELATION is a GO:0023014 (signal transduction by phosphorylation)
2012-01-29 Added SYNONYM mitogen-activated protein kinase cascade
2012-01-27 Added SYNONYM MAPKKK cascade
2012-01-27 Added SYNONYM ERK/MAPK cascade
2012-01-27 Deleted SYNONYM MAPK cascade
2012-01-27 Deleted SYNONYM ERK/MAPK cascade
2012-01-27 Updated TERM MAPK cascade
2012-01-27 Added DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2012-01-27 Deleted DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2011-09-11 Added RELATION has part GO:0038030 (non-canonical Wnt signaling pathway via MAPK cascade)
2011-09-11 Added RELATION has part GO:0038029 (epidermal growth factor receptor signaling pathway via MAPK cascade)
2011-05-12 Added DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2011-05-12 Deleted DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2010-01-07 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2010-01-07 Added DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2009-07-06 Added SYNONYM MAPKKK cascade during sporulation
2009-02-25 Added XREF Wikipedia:Mitogen-activated_protein_kinase
2009-02-25 Added XREF Wikipedia:MAPK_cascade
2008-05-13 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-05-12 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-04-18 Added SYNONYM MAPK signaling
2008-04-18 Added SYNONYM MAPK signalling
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
2007-08-09 Added SYNONYM ERK/MAPK cascade
2007-08-09 Added SYNONYM MAP kinase cascade
2007-08-09 Added SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM MAPK cascade
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Deleted SYNONYM ERK/MAPK cascade
2007-08-09 Deleted SYNONYM MAP kinase cascade
2007-08-09 Deleted SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM MAPK cascade
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2006-03-25 Added SYNONYM ERK/MAPK cascade
2005-06-27 Added SYNONYM MAP kinase cascade
2005-06-27 Added SYNONYM MAP kinase kinase kinase cascade
2005-06-27 Added SYNONYM MAPK cascade
2002-02-06 Updated TERM MAPKKK cascade
2001-08-06 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2001-04-03 Updated TERM MAPKKK cascade
2001-03-30 Added TERM MAPKKK cascade

Term

Timestamp Action Category Detail
2012-01-27 Updated TERM MAPK cascade
2002-02-06 Updated TERM MAPKKK cascade
2001-04-03 Updated TERM MAPKKK cascade
2001-03-30 Added TERM MAPKKK cascade

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM MAPK signal transduction
2012-01-29 Added SYNONYM mitogen-activated protein kinase cascade
2012-01-27 Added SYNONYM MAPKKK cascade
2012-01-27 Added SYNONYM ERK/MAPK cascade
2012-01-27 Deleted SYNONYM MAPK cascade
2012-01-27 Deleted SYNONYM ERK/MAPK cascade
2012-01-27 Added DEFINITION An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2012-01-27 Deleted DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2011-05-12 Added DEFINITION A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK.
2011-05-12 Deleted DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2010-01-07 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2010-01-07 Added DEFINITION A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2009-07-06 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2009-07-06 Added SYNONYM MAPKKK cascade during sporulation
2008-05-13 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-05-12 Deleted DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
2008-04-18 Added SYNONYM MAPK signaling
2008-04-18 Added SYNONYM MAPK signalling
2007-08-09 Added SYNONYM ERK/MAPK cascade
2007-08-09 Added SYNONYM MAP kinase cascade
2007-08-09 Added SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Added SYNONYM MAPK cascade
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-08-09 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-08-09 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-08-09 Deleted SYNONYM ERK/MAPK cascade
2007-08-09 Deleted SYNONYM MAP kinase cascade
2007-08-09 Deleted SYNONYM MAP kinase kinase kinase cascade
2007-08-09 Deleted SYNONYM MAPK cascade
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-04-21 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2006-03-25 Added SYNONYM ERK/MAPK cascade
2005-06-27 Added SYNONYM MAP kinase cascade
2005-06-27 Added SYNONYM MAP kinase kinase kinase cascade
2005-06-27 Added SYNONYM MAPK cascade
2001-08-06 Added DEFINITION Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.

Relationships

Timestamp Action Category Detail
2013-12-04 Added RELATION is a GO:0035556 (intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2013-11-15 Added RELATION is a GO:0023014 (signal transduction by phosphorylation)
2011-09-11 Added RELATION has part GO:0038030 (non-canonical Wnt signaling pathway via MAPK cascade)
2011-09-11 Added RELATION has part GO:0038029 (epidermal growth factor receptor signaling pathway via MAPK cascade)
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)

Cross-references

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Mitogen-activated_protein_kinase
2009-02-25 Added XREF Wikipedia:MAPK_cascade
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