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GO:0000165 MAPKKK cascadeCascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
Term Information
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| Type | Synonym |
| exact | MAP kinase kinase kinase cascade |
| related | MAPK signaling |
| related | MAPK signalling |
| exact | ERK/MAPK cascade |
| exact | MAPK cascade |
| narrow | MAPKKK cascade during sporulation |
| exact | MAP kinase cascade |
| Database | ID |
| Wikipedia | Mitogen-activated_protein_kinase |
| INTERPRO | IPR015749 |
| Wikipedia | MAPK_cascade |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | |||||||||
![]() | GO:0009987 cellular process | ||||||||
![]() | ![]() | GO:0065007 biological regulation | |||||||
![]() | ![]() | ![]() | GO:0007154 cell communication | ||||||
![]() | ![]() | ![]() | ![]() | GO:0050789 regulation of biological process | |||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0050794 regulation of cellular process | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0007165 signal transduction | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0007242 intracellular signaling cascade | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0007243 protein kinase cascade | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0000165 MAPKKK cascade |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| P | GO:0051389 inactivation of MAPKK activity |
| P | GO:0051390 inactivation of MAPKKK activity |
| I | GO:0051403 stress-activated MAPK cascade |
| I | GO:0000161 MAPKKK cascade involved in osmosensory signaling pathway |
| P | GO:0000185 activation of MAPKKK activity |
| P | GO:0000186 activation of MAPKK activity |
| P | GO:0000188 inactivation of MAPK activity |
| P | GO:0000189 nuclear translocation of MAPK |
| I | GO:0000196 MAPKKK cascade during cell wall biogenesis |
| P | GO:0000187 activation of MAPK activity |
| I | GO:0007254 JNK cascade |
| I | GO:0070371 ERK1 and ERK2 cascade |
| I | GO:0070375 BMK cascade |
| R | GO:0043408 regulation of MAPKKK cascade |
| NR | GO:0043409 negative regulation of MAPKKK cascade |
| PR | GO:0043410 positive regulation of MAPKKK cascade |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |