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GO:0000165 MAPKKK cascade

Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.

Term Information

ID GO:0000165
Name MAPKKK cascade
Ontology Biological Process
Definition Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
Comment

Synonyms

Type Synonym
exact MAP kinase kinase kinase cascade
related MAPK signaling
related MAPK signalling
exact ERK/MAPK cascade
exact MAPK cascade
narrow MAPKKK cascade during sporulation
exact MAP kinase cascade

Cross-references associated with this term:

Database ID
Wikipedia Mitogen-activated_protein_kinase
INTERPRO IPR015749
Wikipedia MAPK_cascade

Web service: term information

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0065007 biological regulation
GO:0007154 cell communication
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0007165 signal transduction
GO:0007242 intracellular signaling cascade
GO:0007243 protein kinase cascade
GO:0000165 MAPKKK cascade

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0051389 inactivation of MAPKK activity
P GO:0051390 inactivation of MAPKKK activity
I GO:0051403 stress-activated MAPK cascade
I GO:0000161 MAPKKK cascade involved in osmosensory signaling pathway
P GO:0000185 activation of MAPKKK activity
P GO:0000186 activation of MAPKK activity
P GO:0000188 inactivation of MAPK activity
P GO:0000189 nuclear translocation of MAPK
I GO:0000196 MAPKKK cascade during cell wall biogenesis
P GO:0000187 activation of MAPK activity
I GO:0007254 JNK cascade
I GO:0070371 ERK1 and ERK2 cascade
I GO:0070375 BMK cascade
R GO:0043408 regulation of MAPKKK cascade
NR GO:0043409 negative regulation of MAPKKK cascade
PR GO:0043410 positive regulation of MAPKKK cascade

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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