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GO:0016592 mediator complex

Term Information

ID GO:0016592
Name mediator complex
Ontology Cellular Component
Definition A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
PMID:11454195 PMID:16168358 PMID:17870225
Secondary IDs GO:0000119
GONUTS GO:0016592 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact L mediator complex
narrow TRAP complex
exact Srb-mediator complex
related CDK8-containing TRAP/mediator complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR007018
InterPro IPR008626
InterPro IPR008831
InterPro IPR009244
InterPro IPR009332
InterPro IPR009401
InterPro IPR011425
InterPro IPR013921
InterPro IPR013942
InterPro IPR013947
InterPro IPR014801
InterPro IPR016530
InterPro IPR016532
InterPro IPR016612
InterPro IPR016820
InterPro IPR018174
InterPro IPR019035
InterPro IPR019087
InterPro IPR019095
InterPro IPR019145
InterPro IPR019258
InterPro IPR019313
InterPro IPR019364
InterPro IPR019403
InterPro IPR019404
InterPro IPR019680
InterPro IPR020998
InterPro IPR021018
InterPro IPR021989
InterPro IPR028367
Wikipedia Mediator_(coactivator)

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016592:
Relationship To GO:0016592 Child Term Child Term Name
Has part GO:0070847 core mediator complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016592. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016592 based on the entire annotation set Co-occurrence statistics for GO:0016592 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-03-17 Added RELATION has part GO:0002929 (MECO complex)
2009-08-06 Added SECONDARY GO:0000119 (mediator complex)
2009-08-06 Added XREF Wikipedia:Mediator_(coactivator)
2009-08-06 Added SYNONYM Srb-mediator complex
2009-08-06 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2009-08-06 Added SYNONYM CDK8-containing TRAP/mediator complex
2009-08-06 Added SYNONYM TRAP complex
2009-08-06 Added DEFINITION A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
2009-08-06 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2009-08-06 Updated TERM mediator complex
2008-06-07 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-06-07 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-13 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-12 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-04-01 Updated RELATION is a GO:0044451 (nucleoplasm part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM CDK8-containing TRAP/mediator complex
2007-08-09 Added SYNONYM L mediator complex
2007-08-09 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2007-08-09 Deleted SYNONYM L mediator complex
2007-07-23 Added SYNONYM CDK8-containing TRAP/mediator complex
2007-07-23 Added SYNONYM L mediator complex
2004-12-01 Updated DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2004-11-26 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16�polypeptides: Srb2, -4,�-5,�-6,�and -7, Med1, -2,�-4,�-6,�-7,�and -8,�Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2002-02-06 Updated TERM Srb-mediator complex
2001-04-03 Updated TERM Srb-mediator complex
2001-03-30 Added TERM Srb-mediator complex

Term

Timestamp Action Category Detail
2009-08-06 Updated TERM mediator complex
2002-02-06 Updated TERM Srb-mediator complex
2001-04-03 Updated TERM Srb-mediator complex
2001-03-30 Added TERM Srb-mediator complex

Definition/synonyms

Timestamp Action Category Detail
2009-08-06 Added SYNONYM Srb-mediator complex
2009-08-06 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2009-08-06 Added SYNONYM CDK8-containing TRAP/mediator complex
2009-08-06 Added SYNONYM TRAP complex
2009-08-06 Added DEFINITION A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
2009-08-06 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-06-07 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-06-07 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-13 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-12 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2007-08-09 Added SYNONYM CDK8-containing TRAP/mediator complex
2007-08-09 Added SYNONYM L mediator complex
2007-08-09 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2007-08-09 Deleted SYNONYM L mediator complex
2007-07-23 Added SYNONYM CDK8-containing TRAP/mediator complex
2007-07-23 Added SYNONYM L mediator complex
2004-12-01 Updated DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2004-11-26 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16�polypeptides: Srb2, -4,�-5,�-6,�and -7, Med1, -2,�-4,�-6,�-7,�and -8,�Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.

Relationships

Timestamp Action Category Detail
2012-03-17 Added RELATION has part GO:0002929 (MECO complex)
2008-04-01 Updated RELATION is a GO:0044451 (nucleoplasm part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)

Cross-references

Timestamp Action Category Detail
2009-08-06 Added XREF Wikipedia:Mediator_(coactivator)

Other

Timestamp Action Category Detail
2009-08-06 Added SECONDARY GO:0000119 (mediator complex)
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