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GO:0000086 G2/M transition of mitotic cell cycle

Term Information

ID GO:0000086
Name G2/M transition of mitotic cell cycle
Ontology Biological Process
Definition The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
GONUTS GO:0000086 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact mitotic G2/M transition

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000278 mitotic cell cycle only_in_taxon 2759 Eukaryota
GO:0044770 cell cycle phase transition only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000086:
Relationship To GO:0000086 Child Term Child Term Name
Part of GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle
Regulates GO:0010389 regulation of G2/M transition of mitotic cell cycle
Negatively regulates GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
Positively regulates GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Part of GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle
Part of GO:0090419 negative regulation of transcription involved in G2/M transition of mitotic cell cycle
Regulates GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
Regulates GO:0031661 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
Regulates GO:0031662 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle

Protein Annotation

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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000086. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000086 based on the entire annotation set Co-occurrence statistics for GO:0000086 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-04-24 Added RELATION part of GO:0000278 (mitotic cell cycle)
2014-03-07 Added SYNONYM mitotic G2/M transition
2014-03-07 Added RELATION is a GO:0044839 (cell cycle G2/M phase transition)
2013-03-03 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (e.g. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2013-03-03 Added DEFINITION The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2013-03-03 Deleted RELATION part of GO:0051329 (mitotic interphase)
2013-03-03 Deleted RELATION is a GO:0022402 (cell cycle process)
2013-03-03 Added RELATION is a GO:0044772 (mitotic cell cycle phase transition)
2012-11-07 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (i.e. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2012-11-07 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (e.g. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2012-11-05 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2012-11-05 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (i.e. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2008-05-13 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2008-05-12 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2008-04-01 Updated RELATION is a GO:0022402 (cell cycle process)
2008-04-01 Updated RELATION part of GO:0051329 (mitotic interphase)
2004-10-13 Updated DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2002-02-06 Updated TERM G2/M transition of mitotic cell cycle
2001-08-06 Added DEFINITION Progression from G2 phase to M phase of the standard mitotic cell cycle.
2001-04-03 Updated TERM G2/M transition of mitotic cell cycle
2001-03-30 Added TERM G2/M transition of mitotic cell cycle

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM G2/M transition of mitotic cell cycle
2001-04-03 Updated TERM G2/M transition of mitotic cell cycle
2001-03-30 Added TERM G2/M transition of mitotic cell cycle

Definition/synonyms

Timestamp Action Category Detail
2014-03-07 Added SYNONYM mitotic G2/M transition
2013-03-03 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (e.g. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2013-03-03 Added DEFINITION The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2012-11-07 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (i.e. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2012-11-07 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (e.g. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2012-11-05 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2012-11-05 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle. The molecular event responsible for this transition is the activation of the major cell cycle cyclin-dependent kinase (i.e. Cdc2 in S. pombe, CDC28 in S. cerevisiae, Cdk1 in human).
2008-05-13 Added DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2008-05-12 Deleted DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2004-10-13 Updated DEFINITION Progression from G2 phase to M phase of the mitotic cell cycle.
2001-08-06 Added DEFINITION Progression from G2 phase to M phase of the standard mitotic cell cycle.

Relationships

Timestamp Action Category Detail
2015-04-24 Added RELATION part of GO:0000278 (mitotic cell cycle)
2014-03-07 Added RELATION is a GO:0044839 (cell cycle G2/M phase transition)
2013-03-03 Deleted RELATION part of GO:0051329 (mitotic interphase)
2013-03-03 Deleted RELATION is a GO:0022402 (cell cycle process)
2013-03-03 Added RELATION is a GO:0044772 (mitotic cell cycle phase transition)
2008-04-01 Updated RELATION is a GO:0022402 (cell cycle process)
2008-04-01 Updated RELATION part of GO:0051329 (mitotic interphase)
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