spacer

GO:0000077 DNA damage checkpoint

Term Information

ID GO:0000077
Name DNA damage checkpoint
Ontology Biological Process
Definition A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
GONUTS GO:0000077 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow DNA damage response, signal transduction resulting in cell cycle arrest

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
cell cycleLink

Cross-references

Database ID
InterPro IPR003011
InterPro IPR007150
InterPro IPR007268
InterPro IPR015519
InterPro IPR016256
InterPro IPR016580
InterPro IPR016587
InterPro IPR026584
InterPro IPR027011
InterPro IPR029293
InterPro IPR029546
Wikipedia DNA_damage_checkpoint
Wikipedia Postreplication_checkpoint

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000077:
Relationship To GO:0000077 Child Term Child Term Name
Is a GO:0031572 G2 DNA damage checkpoint
Negatively regulates GO:2000002 negative regulation of DNA damage checkpoint
Positively regulates GO:2000003 positive regulation of DNA damage checkpoint
Regulates GO:2000001 regulation of DNA damage checkpoint
Part of GO:0072421 detection of DNA damage stimulus involved in DNA damage checkpoint
Part of GO:0072422 signal transduction involved in DNA damage checkpoint
Is a GO:0044783 G1 DNA damage checkpoint
Is a GO:0044773 mitotic DNA damage checkpoint

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000077. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000077 based on the entire annotation set Co-occurrence statistics for GO:0000077 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-12-10 Added RELATION is a GO:0006974 (cellular response to DNA damage stimulus)
2010-12-10 Deleted RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2010-12-10 Added DEFINITION A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
2010-12-10 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2010-09-26 Deleted RELATION is a GO:0007165 (signal transduction)
2010-04-16 Added RELATION is a GO:0007165 (signal transduction)
2009-02-25 Added XREF Wikipedia:Postreplication_checkpoint
2009-02-25 Added XREF Wikipedia:DNA_damage_checkpoint
2008-05-13 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2008-05-12 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2008-04-01 Updated RELATION is a GO:0031570 (DNA integrity checkpoint)
2008-04-01 Updated RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2007-08-09 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2007-08-09 Deleted SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-07-22 Updated TERM DNA damage checkpoint
2004-07-22 Deleted SYNONYM DNA damage checkpoint
2004-07-22 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-04-19 Added SYNONYM DNA damage checkpoint
2004-04-16 Deleted SYNONYM DNA damage checkpoint
2003-06-21 Updated TERM DNA damage response, signal transduction resulting in cell cycle arrest
2003-06-21 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2003-06-21 Added SYNONYM DNA damage checkpoint
2002-02-06 Updated TERM DNA damage checkpoint
2001-04-03 Updated TERM DNA damage checkpoint
2001-03-30 Added TERM DNA damage checkpoint

Term

Timestamp Action Category Detail
2004-07-22 Updated TERM DNA damage checkpoint
2003-06-21 Updated TERM DNA damage response, signal transduction resulting in cell cycle arrest
2002-02-06 Updated TERM DNA damage checkpoint
2001-04-03 Updated TERM DNA damage checkpoint
2001-03-30 Added TERM DNA damage checkpoint

Definition/synonyms

Timestamp Action Category Detail
2010-12-10 Added DEFINITION A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
2010-12-10 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2008-05-13 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2008-05-12 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2007-08-09 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2007-08-09 Deleted SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-07-22 Deleted SYNONYM DNA damage checkpoint
2004-07-22 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-04-19 Added SYNONYM DNA damage checkpoint
2004-04-16 Deleted SYNONYM DNA damage checkpoint
2003-06-21 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2003-06-21 Added SYNONYM DNA damage checkpoint

Relationships

Timestamp Action Category Detail
2010-12-10 Added RELATION is a GO:0006974 (cellular response to DNA damage stimulus)
2010-12-10 Deleted RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2010-09-26 Deleted RELATION is a GO:0007165 (signal transduction)
2010-04-16 Added RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0031570 (DNA integrity checkpoint)
2008-04-01 Updated RELATION is a GO:0042770 (signal transduction in response to DNA damage)

Cross-references

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Postreplication_checkpoint
2009-02-25 Added XREF Wikipedia:DNA_damage_checkpoint
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms