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GO:0000075 cell cycle checkpoint

Term Information

ID GO:0000075
Name cell cycle checkpoint
Ontology Biological Process
Definition A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
Restrictions This term should not be used for direct manual annotation. This term may be used for mapping to external vocabularies in order to create electronic annotations. See comment below for further information.
Comment This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
Secondary IDs GO:0031576 GO:0071779
GONUTS GO:0000075 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow G2/M transition checkpoint
narrow G2/M checkpoint
narrow G1/S transition checkpoint
narrow G1/S checkpoint

Cross-references

Database ID
InterPro IPR026217
InterPro IPR026584
Wikipedia Cell_cycle_checkpoint

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000075:
Relationship To GO:0000075 Child Term Child Term Name
Is a GO:0007093 mitotic cell cycle checkpoint
Is a GO:0031570 DNA integrity checkpoint
Is a GO:0031577 spindle checkpoint
Is a GO:0033313 meiotic cell cycle checkpoint
Part of GO:0072394 detection of stimulus involved in cell cycle checkpoint
Part of GO:0072395 signal transduction involved in cell cycle checkpoint
Regulates GO:1901976 regulation of cell cycle checkpoint
Negatively regulates GO:1901977 negative regulation of cell cycle checkpoint
Positively regulates GO:1901978 positive regulation of cell cycle checkpoint

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Synonym
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Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0000075. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0000075 based on the entire annotation set Co-occurrence statistics for GO:0000075 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-09-14 Added RELATION is a GO:0022402 (cell cycle process)
2013-09-14 Deleted RELATION is a GO:1901988 (negative regulation of cell cycle phase transition)
2013-05-03 Deleted RELATION is a GO:0022402 (cell cycle process)
2013-05-03 Added RELATION is a GO:1901988 (negative regulation of cell cycle phase transition)
2013-05-03 Deleted SYNONYM G1/S checkpoint
2013-05-03 Deleted SYNONYM G2/M transition checkpoint
2013-05-03 Deleted SYNONYM G2/M checkpoint
2013-05-03 Deleted SYNONYM G1/S transition checkpoint
2013-05-03 Added SYNONYM G1/S transition checkpoint
2013-05-03 Added SYNONYM G2/M checkpoint
2013-05-03 Added SYNONYM G2/M transition checkpoint
2013-05-03 Added SYNONYM G1/S checkpoint
2013-04-19 Added SLIM gocheck_do_not_manually_annotate
2013-03-03 Added DEFINITION A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
2013-03-03 Deleted DEFINITION A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
2013-03-03 Added SYNONYM G1/S checkpoint
2013-03-03 Added SYNONYM G1/S transition checkpoint
2013-03-03 Added SYNONYM G2/M transition checkpoint
2013-03-03 Added SYNONYM G2/M checkpoint
2013-03-03 Added RELATION is a GO:0022402 (cell cycle process)
2013-03-03 Deleted RELATION regulates GO:0007050 (cell cycle arrest)
2013-03-03 Deleted RELATION is a GO:0071156 (regulation of cell cycle arrest)
2013-03-03 Added SECONDARY GO:0071779 (G1/S transition checkpoint)
2013-03-03 Added SECONDARY GO:0031576 (G2/M transition checkpoint)
2010-12-10 Deleted DEFINITION A cell cycle regulatory process that delays or stops progression through the cycle until conditions are suitable for the cell to proceed to the next stage.
2010-12-10 Added DEFINITION A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
2010-11-14 Deleted DEFINITION The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2010-11-14 Added DEFINITION A cell cycle regulatory process that delays or stops progression through the cycle until conditions are suitable for the cell to proceed to the next stage.
2010-09-17 Added RELATION is a GO:0071156 (regulation of cell cycle arrest)
2010-09-17 Deleted RELATION is a GO:0051726 (regulation of cell cycle)
2010-09-15 Added RELATION regulates GO:0007050 (cell cycle arrest)
2009-02-25 Added XREF Wikipedia:Cell_cycle_checkpoint
2009-01-12 Added DEFINITION The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2009-01-12 Deleted DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2008-05-13 Added DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2008-05-12 Deleted DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2008-04-01 Updated RELATION is a GO:0051726 (regulation of cell cycle)
2002-02-06 Updated TERM cell cycle checkpoint
2001-08-06 Added DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2001-04-03 Updated TERM cell cycle checkpoint
2001-03-30 Added TERM cell cycle checkpoint

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM cell cycle checkpoint
2001-04-03 Updated TERM cell cycle checkpoint
2001-03-30 Added TERM cell cycle checkpoint

Definition/synonyms

Timestamp Action Category Detail
2013-05-03 Deleted SYNONYM G1/S checkpoint
2013-05-03 Deleted SYNONYM G2/M transition checkpoint
2013-05-03 Deleted SYNONYM G2/M checkpoint
2013-05-03 Deleted SYNONYM G1/S transition checkpoint
2013-05-03 Added SYNONYM G1/S transition checkpoint
2013-05-03 Added SYNONYM G2/M checkpoint
2013-05-03 Added SYNONYM G2/M transition checkpoint
2013-05-03 Added SYNONYM G1/S checkpoint
2013-03-03 Added DEFINITION A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
2013-03-03 Deleted DEFINITION A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
2013-03-03 Added SYNONYM G1/S checkpoint
2013-03-03 Added SYNONYM G1/S transition checkpoint
2013-03-03 Added SYNONYM G2/M transition checkpoint
2013-03-03 Added SYNONYM G2/M checkpoint
2010-12-10 Deleted DEFINITION A cell cycle regulatory process that delays or stops progression through the cycle until conditions are suitable for the cell to proceed to the next stage.
2010-12-10 Added DEFINITION A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
2010-11-14 Deleted DEFINITION The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2010-11-14 Added DEFINITION A cell cycle regulatory process that delays or stops progression through the cycle until conditions are suitable for the cell to proceed to the next stage.
2009-01-12 Added DEFINITION The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2009-01-12 Deleted DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2008-05-13 Added DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2008-05-12 Deleted DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
2001-08-06 Added DEFINITION A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

Relationships

Timestamp Action Category Detail
2013-09-14 Added RELATION is a GO:0022402 (cell cycle process)
2013-09-14 Deleted RELATION is a GO:1901988 (negative regulation of cell cycle phase transition)
2013-05-03 Deleted RELATION is a GO:0022402 (cell cycle process)
2013-05-03 Added RELATION is a GO:1901988 (negative regulation of cell cycle phase transition)
2013-03-03 Added RELATION is a GO:0022402 (cell cycle process)
2013-03-03 Deleted RELATION regulates GO:0007050 (cell cycle arrest)
2013-03-03 Deleted RELATION is a GO:0071156 (regulation of cell cycle arrest)
2010-09-17 Added RELATION is a GO:0071156 (regulation of cell cycle arrest)
2010-09-17 Deleted RELATION is a GO:0051726 (regulation of cell cycle)
2010-09-15 Added RELATION regulates GO:0007050 (cell cycle arrest)
2008-04-01 Updated RELATION is a GO:0051726 (regulation of cell cycle)

Cross-references

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Cell_cycle_checkpoint

Other

Timestamp Action Category Detail
2013-04-19 Added SLIM gocheck_do_not_manually_annotate
2013-03-03 Added SECONDARY GO:0071779 (G1/S transition checkpoint)
2013-03-03 Added SECONDARY GO:0031576 (G2/M transition checkpoint)
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