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GO Term History: Displaying 107 audit records for all terms for the date 2012-06-24

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added XREF VZ:554
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added XREF VZ:803
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added XREF VZ:665
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added XREF VZ:815
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added SYNONYM suppression by virus of host PKR activity by binding to dsRNA
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by nuclear sequestration of PKR
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by sequestering of PKR in nucleus
2012-06-24 GO:1901039 regulation of peptide antigen transport Added TERM regulation of peptide antigen transport
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added TERM negative regulation of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added TERM positive regulation of peptide antigen transport
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added TERM suppression by virus of host PKR activity
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added TERM suppression by virus of host PKR activity via double-stranded RNA binding
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added TERM suppression by virus of host PKR activity by positive regulation of PKR nuclear localization
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added TERM suppression by virus of host PKR activity by positive regulation of PKR catabolic process
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added TERM suppression by virus of host protein kinase activity
2012-06-24 GO:0039585 PKR signal transduction Added TERM PKR signal transduction
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added TERM modulation by virus of host PP1 activity
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added TERM suppression by virus of host tetherin activity
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added TERM suppression by virus of host antigen processing and presentation
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added TERM suppression by virus of host TYK2 activity
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added TERM suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added TERM suppression by virus of host JAK1 activity
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added TERM suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added TERM suppression by virus of host JAK1 activity via JAK1 binding
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added TERM suppression by virus of host ISG15 activity
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.
2012-06-24 GO:1901039 regulation of peptide antigen transport Added DEFINITION Any process that modulates the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding.
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits.
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive.
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha).
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added DEFINITION Any process that activates or increases the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added DEFINITION The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response.
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added DEFINITION Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex.
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2.
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1.
2012-06-24 GO:0039585 PKR signal transduction Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR.
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added SYNONYM downregulation of PKR by degradation through proteosome
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added SYNONYM inhibition of host BST2/Tetherin by virus
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM inhibition of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM up-regulation of peptide antigen transport
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added SYNONYM suppression by virus of host EIF2AK2 activity
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM up regulation of peptide antigen transport
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added SYNONYM inhibition by virus of host TYK2 phosphorylation
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added SYNONYM promotion by virus of proteosome-dependent PKR degradation
2012-06-24 GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Added RELATION is a GO:0039588 (suppression by virus of host antigen processing and presentation)
2012-06-24 GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Deleted RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added RELATION is a GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added RELATION is a GO:0039574 (suppression by virus of host TYK2 activity)
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added RELATION is a GO:0039514 (suppression by virus of host JAK-STAT cascade)
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added RELATION is a GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added RELATION is a GO:0039576 (suppression by virus of host JAK1 activity)
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added RELATION is a GO:0039576 (suppression by virus of host JAK1 activity)
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added RELATION is a GO:0039507 (suppression by virus of host molecular function)
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added RELATION is a GO:0039584 (suppression by virus of host protein kinase activity)
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added RELATION is a GO:1900182 (positive regulation of protein localization to nucleus)
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added RELATION is a GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added RELATION is a GO:0039513 (suppression by virus of host catalytic activity)
2012-06-24 GO:0039585 PKR signal transduction Added RELATION is a GO:0035556 (intracellular signal transduction)
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added RELATION is a GO:0039517 (modulation by virus of host protein serine/threonine phosphatase activity)
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added RELATION is a GO:0039506 (modulation by virus of host molecular function)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION is a GO:0090087 (regulation of peptide transport)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION is a GO:0002583 (regulation of antigen processing and presentation of peptide antigen)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION is a GO:1901039 (regulation of peptide antigen transport)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION is a GO:0051051 (negative regulation of transport)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION negatively regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION is a GO:1901039 (regulation of peptide antigen transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION is a GO:0051050 (positive regulation of transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION positively regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added SYNONYM modulation of host PP1 activity by virus
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added SYNONYM inhibition of host proteasome antigen processing by virus
2012-06-24 GO:0039585 PKR signal transduction Added SYNONYM PKR signaling pathway
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM downregulation of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM activation of peptide antigen transport
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added SYNONYM inhibition by virus of host TYK2 activation
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added SYNONYM regulation by virus of host PP1 activity
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM upregulation of peptide antigen transport
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus
2012-06-24 GO:0039585 PKR signal transduction Added SYNONYM signaling through PKR
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM down regulation of peptide antigen transport
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added SYNONYM suppression by virus of host BST-2 activity
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM down-regulation of peptide antigen transport
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039505 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Added RELATION is a GO:0039588 (suppression by virus of host antigen processing and presentation)
2012-06-24 GO:0039505 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Deleted RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039512 suppression by virus of host protein tyrosine kinase activity Added RELATION is a GO:0039584 (suppression by virus of host protein kinase activity)
2012-06-24 GO:0039512 suppression by virus of host protein tyrosine kinase activity Deleted RELATION is a GO:0039513 (suppression by virus of host catalytic activity)
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0019901 protein kinase binding Added RELATION has part GO:0039578 (suppression by virus of host JAK1 activity via JAK1 binding)
2012-06-24 GO:0003725 double-stranded RNA binding Added RELATION has part GO:0039581 (suppression by virus of host PKR activity via double-stranded RNA binding)
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added XREF VZ:720
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added XREF VZ:784
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added XREF VZ:723

Terms

Timestamp GO ID GO Term Name Action Category Detail
2012-06-24 GO:1901039 regulation of peptide antigen transport Added TERM regulation of peptide antigen transport
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added TERM negative regulation of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added TERM positive regulation of peptide antigen transport
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added TERM suppression by virus of host PKR activity
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added TERM suppression by virus of host PKR activity via double-stranded RNA binding
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added TERM suppression by virus of host PKR activity by positive regulation of PKR nuclear localization
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added TERM suppression by virus of host PKR activity by positive regulation of PKR catabolic process
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added TERM suppression by virus of host protein kinase activity
2012-06-24 GO:0039585 PKR signal transduction Added TERM PKR signal transduction
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added TERM modulation by virus of host PP1 activity
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added TERM suppression by virus of host tetherin activity
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added TERM suppression by virus of host antigen processing and presentation
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added TERM suppression by virus of host TYK2 activity
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added TERM suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added TERM suppression by virus of host JAK1 activity
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added TERM suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added TERM suppression by virus of host JAK1 activity via JAK1 binding
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added TERM suppression by virus of host ISG15 activity

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added SYNONYM suppression by virus of host PKR activity by binding to dsRNA
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by nuclear sequestration of PKR
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by sequestering of PKR in nucleus
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.
2012-06-24 GO:1901039 regulation of peptide antigen transport Added DEFINITION Any process that modulates the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding.
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits.
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive.
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha).
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added DEFINITION Any process that activates or increases the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added DEFINITION The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response.
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added DEFINITION Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex.
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport.
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2.
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1.
2012-06-24 GO:0039585 PKR signal transduction Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added DEFINITION Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR.
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added SYNONYM downregulation of PKR by degradation through proteosome
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added SYNONYM inhibition of host BST2/Tetherin by virus
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM inhibition of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM up-regulation of peptide antigen transport
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added SYNONYM suppression by virus of host EIF2AK2 activity
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM up regulation of peptide antigen transport
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added SYNONYM inhibition by virus of host TYK2 phosphorylation
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added SYNONYM promotion by virus of proteosome-dependent PKR degradation
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added SYNONYM modulation of host PP1 activity by virus
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added SYNONYM inhibition of host proteasome antigen processing by virus
2012-06-24 GO:0039585 PKR signal transduction Added SYNONYM PKR signaling pathway
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM downregulation of peptide antigen transport
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM activation of peptide antigen transport
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added SYNONYM inhibition by virus of host TYK2 activation
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added SYNONYM regulation by virus of host PP1 activity
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added SYNONYM upregulation of peptide antigen transport
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added SYNONYM suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus
2012-06-24 GO:0039585 PKR signal transduction Added SYNONYM signaling through PKR
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM down regulation of peptide antigen transport
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added SYNONYM suppression by virus of host BST-2 activity
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added SYNONYM down-regulation of peptide antigen transport

Relationships

Timestamp GO ID GO Term Name Action Category Detail
2012-06-24 GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Added RELATION is a GO:0039588 (suppression by virus of host antigen processing and presentation)
2012-06-24 GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Deleted RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added RELATION is a GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
2012-06-24 GO:0039575 suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation Added RELATION is a GO:0039574 (suppression by virus of host TYK2 activity)
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added RELATION is a GO:0039514 (suppression by virus of host JAK-STAT cascade)
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added RELATION is a GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
2012-06-24 GO:0039577 suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation Added RELATION is a GO:0039576 (suppression by virus of host JAK1 activity)
2012-06-24 GO:0039578 suppression by virus of host JAK1 activity via JAK1 binding Added RELATION is a GO:0039576 (suppression by virus of host JAK1 activity)
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added RELATION is a GO:0039507 (suppression by virus of host molecular function)
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added RELATION is a GO:0039584 (suppression by virus of host protein kinase activity)
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0039581 suppression by virus of host PKR activity via double-stranded RNA binding Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added RELATION is a GO:1900182 (positive regulation of protein localization to nucleus)
2012-06-24 GO:0039582 suppression by virus of host PKR activity by positive regulation of PKR nuclear localization Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added RELATION is a GO:0039580 (suppression by virus of host PKR activity)
2012-06-24 GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process Added RELATION is a GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
2012-06-24 GO:0039584 suppression by virus of host protein kinase activity Added RELATION is a GO:0039513 (suppression by virus of host catalytic activity)
2012-06-24 GO:0039585 PKR signal transduction Added RELATION is a GO:0035556 (intracellular signal transduction)
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added RELATION is a GO:0039517 (modulation by virus of host protein serine/threonine phosphatase activity)
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added RELATION is a GO:0039506 (modulation by virus of host molecular function)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION is a GO:0090087 (regulation of peptide transport)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:1901039 regulation of peptide antigen transport Added RELATION is a GO:0002583 (regulation of antigen processing and presentation of peptide antigen)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION is a GO:1901039 (regulation of peptide antigen transport)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION is a GO:0051051 (negative regulation of transport)
2012-06-24 GO:1901040 negative regulation of peptide antigen transport Added RELATION negatively regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION is a GO:1901039 (regulation of peptide antigen transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION is a GO:0051050 (positive regulation of transport)
2012-06-24 GO:1901041 positive regulation of peptide antigen transport Added RELATION positively regulates GO:0046968 (peptide antigen transport)
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039505 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Added RELATION is a GO:0039588 (suppression by virus of host antigen processing and presentation)
2012-06-24 GO:0039505 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Deleted RELATION is a GO:0019052 (suppression by virus of host intracellular antiviral response)
2012-06-24 GO:0039512 suppression by virus of host protein tyrosine kinase activity Added RELATION is a GO:0039584 (suppression by virus of host protein kinase activity)
2012-06-24 GO:0039512 suppression by virus of host protein tyrosine kinase activity Deleted RELATION is a GO:0039513 (suppression by virus of host catalytic activity)
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added RELATION is a GO:0039512 (suppression by virus of host protein tyrosine kinase activity)
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added RELATION is a GO:0039503 (suppression by virus of host innate immune response)
2012-06-24 GO:0019901 protein kinase binding Added RELATION has part GO:0039578 (suppression by virus of host JAK1 activity via JAK1 binding)
2012-06-24 GO:0003725 double-stranded RNA binding Added RELATION has part GO:0039581 (suppression by virus of host PKR activity via double-stranded RNA binding)

Cross-references

Timestamp GO ID GO Term Name Action Category Detail
2012-06-24 GO:0039580 suppression by virus of host PKR activity Added XREF VZ:554
2012-06-24 GO:0039586 modulation by virus of host PP1 activity Added XREF VZ:803
2012-06-24 GO:0039587 suppression by virus of host tetherin activity Added XREF VZ:665
2012-06-24 GO:0039588 suppression by virus of host antigen processing and presentation Added XREF VZ:815
2012-06-24 GO:0039574 suppression by virus of host TYK2 activity Added XREF VZ:720
2012-06-24 GO:0039576 suppression by virus of host JAK1 activity Added XREF VZ:784
2012-06-24 GO:0039579 suppression by virus of host ISG15 activity Added XREF VZ:723
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