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GO Term History: Displaying 158 audit records for all terms for the date 2012-01-18

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This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2012-01-18 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand.
2012-01-18 GO:0007215 glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Deleted DEFINITION Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.
2012-01-18 GO:0003154 BMP signaling pathway involved in determination of left/right symmetry Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry.
2012-01-18 GO:0071893 BMP signaling pathway involved in nephric duct formation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to nephric duct formation.
2012-01-18 GO:0038007 netrin-activated signaling pathway Deleted DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 GO:0008101 decapentaplegic signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors.
2012-01-18 GO:0061353 BMP signaling pathway involved in Malpighian tubule cell chemotaxis Deleted DEFINITION The series of molecular signals generated as a consequence of a BMP receptor binding to one of its physiological ligands leading to the directed movement of a Malpighian tubule cells toward a stimulus and contributing to the shaping of the tubule.
2012-01-18 GO:0035385 Roundabout signaling pathway Deleted DEFINITION The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell.
2012-01-18 GO:0003130 BMP signaling pathway involved in heart induction Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction.
2012-01-18 GO:0033209 tumor necrosis factor-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2012-01-18 GO:0003269 BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
2012-01-18 GO:0060869 transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission.
2012-01-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0035771 interleukin-4-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-4 binding to a cell surface receptor.
2012-01-18 GO:0038026 reelin-mediated signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a cell surface receptor binding to reelin, a secreted glycoprotein, to initiate a change in cell activity.
2012-01-18 GO:0038043 interleukin-5-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-5 binding to a cell surface receptor.
2012-01-18 GO:0003303 BMP signaling pathway involved in heart jogging Deleted DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
2012-01-18 GO:0061149 BMP signaling pathway involved in ureter morphogenesis Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
2012-01-18 GO:0038042 dimeric G-protein coupled receptor signaling pathway Deleted DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
2012-01-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate.
2012-01-18 GO:0061057 peptidoglycan recognition protein signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides.
2012-01-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0008063 Toll signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell.
2012-01-18 GO:0035235 ionotropic glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex.
2012-01-18 GO:0007168 receptor guanylyl cyclase signaling pathway Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity.
2012-01-18 GO:0061151 BMP signaling pathway involved in renal system segmentation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the segmentation of the renal system.
2012-01-18 GO:0038025 reelin receptor activity Deleted DEFINITION Combining with the secreted glycoprotein reelin, and transmitting the signal to initiate a change in cell activity.
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added TERM NIK/NF-kappaB cascade
2012-01-18 GO:0007215 glutamate receptor signaling pathway Updated TERM glutamate receptor signaling pathway
2012-01-18 GO:0035723 interleukin-15-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0060797 transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate.
2012-01-18 GO:0060803 BMP signaling pathway involved in mesodermal cell fate specification Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate.
2012-01-18 GO:0003154 BMP signaling pathway involved in determination of left/right symmetry Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
2012-01-18 GO:0003434 BMP signaling pathway involved in growth plate cartilage chondrocyte development Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
2012-01-18 GO:0007215 glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007224 smoothened signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 GO:0007249 I-kappaB kinase/NF-kappaB signaling Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 GO:0007249 I-kappaB kinase/NF-kappaB signaling Deleted DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 GO:0060835 transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis.
2012-01-18 GO:0060797 transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate.
2012-01-18 GO:0007216 G-protein coupled glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins.
2012-01-18 GO:0030509 BMP signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0033210 leptin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2012-01-18 GO:0035463 transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves.
2012-01-18 GO:0060826 transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern.
2012-01-18 GO:0061312 BMP signaling pathway involved in heart development Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.
2012-01-18 GO:0070106 interleukin-27-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0070757 interleukin-35-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0032924 activin receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035235 ionotropic glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035655 interleukin-18-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035772 interleukin-13-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061149 BMP signaling pathway involved in ureter morphogenesis Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
2012-01-18 GO:0071847 TNFSF11-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007168 receptor guanylyl cyclase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0035385 Roundabout signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035771 interleukin-4-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038058 TNFSF11 receptor activity Added DEFINITION Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.
2012-01-18 GO:0045500 sevenless signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0048861 leukemia inhibitory factor signaling pathway Added DEFINITION Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061057 peptidoglycan recognition protein signaling pathway Added DEFINITION A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
2012-01-18 GO:0003302 transforming growth factor beta receptor signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
2012-01-18 GO:0035655 interleukin-18-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
2012-01-18 GO:0007179 transforming growth factor beta receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
2012-01-18 GO:0007224 smoothened signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 GO:0070757 interleukin-35-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor.
2012-01-18 GO:0061372 activin receptor signaling pathway involved in heart jogging Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor and contributing to the process of heart jogging.
2012-01-18 GO:0003434 BMP signaling pathway involved in growth plate cartilage chondrocyte development Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time.
2012-01-18 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
2012-01-18 GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak.
2012-01-18 GO:0032924 activin receptor signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor.
2012-01-18 GO:0003302 transforming growth factor beta receptor signaling pathway involved in heart jogging Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
2012-01-18 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
2012-01-18 GO:0070106 interleukin-27-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor.
2012-01-18 GO:0060337 type I interferon signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2012-01-18 GO:0031663 lipopolysaccharide-mediated signaling pathway Deleted DEFINITION The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0060826 transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern.
2012-01-18 GO:0033210 leptin-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2012-01-18 GO:0038058 TNFSF11 receptor activity Deleted DEFINITION Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal within the cell to initiate a change in cell activity or function.
2012-01-18 GO:0038042 dimeric G-protein coupled receptor signaling pathway Added DEFINITION A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
2012-01-18 GO:0038043 interleukin-5-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0060337 type I interferon signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a type I interferon binding to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2012-01-18 GO:0060835 transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis.
2012-01-18 GO:0060869 transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission.
2012-01-18 GO:0061372 activin receptor signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging.
2012-01-18 GO:0070102 interleukin-6-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0003269 BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
2012-01-18 GO:0007167 enzyme linked receptor protein signaling pathway Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007216 G-protein coupled glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035772 interleukin-13-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-13 binding to a cell surface receptor.
2012-01-18 GO:0071847 TNFSF11-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor ligand superfamily member 11 (TNFSF11) binding to a cell surface receptor.
2012-01-18 GO:0007186 G-protein coupled receptor signaling pathway Deleted DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007250 activation of NF-kappaB-inducing kinase activity Added RELATION part of GO:0038061 (NIK/NF-kappaB signaling)
2012-01-18 GO:0007254 JNK cascade Added RELATION is a GO:0051403 (stress-activated MAPK cascade)
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added RELATION is a GO:0035556 (intracellular signal transduction)
2012-01-18 GO:0046330 positive regulation of JNK cascade Deleted RELATION is a GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046330 positive regulation of JNK cascade Deleted RELATION is a GO:0043410 (positive regulation of MAPK cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Added RELATION is a GO:0032872 (regulation of stress-activated MAPK cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Deleted RELATION is a GO:0070302 (regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Deleted RELATION is a GO:0043408 (regulation of MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Added RELATION is a GO:0032873 (negative regulation of stress-activated MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Deleted RELATION is a GO:0043409 (negative regulation of MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Deleted RELATION is a GO:0070303 (negative regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046330 positive regulation of JNK cascade Added RELATION is a GO:0032874 (positive regulation of stress-activated MAPK cascade)
2012-01-18 GO:0007254 JNK cascade Deleted RELATION is a GO:0000165 (MAPK cascade)
2012-01-18 GO:0007254 JNK cascade Deleted RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Added RELATION is a GO:0005230 (extracellular ligand-gated ion channel activity)
2012-01-18 GO:0004704 NF-kappaB-inducing kinase activity Added RELATION part of GO:0038061 (NIK/NF-kappaB signaling)
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM non-canonical NF-KB signaling
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM p52-dependent NF-kappaB signaling
2012-01-18 GO:0007215 glutamate receptor signaling pathway Added SYNONYM glutamate signaling pathway
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM noncanonical NF-kappaB signaling
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM noncanonical nuclear factor kappaB (NF-kappaB) pathway
2012-01-18 GO:0007186 G-protein coupled receptor signaling pathway Added DEFINITION A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008063 Toll signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008101 decapentaplegic signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061353 BMP signaling pathway involved in Malpighian tubule cell chemotaxis Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule.
2012-01-18 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2012-01-18 GO:0035691 macrophage migration inhibitory factor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038026 reelin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. The cascade begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
2012-01-18 GO:0061151 BMP signaling pathway involved in renal system segmentation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system.
2012-01-18 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007229 integrin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008293 torso signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0031663 lipopolysaccharide-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0071893 BMP signaling pathway involved in nephric duct formation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation.
2012-01-18 GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak.
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Added DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
2012-01-18 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007219 Notch signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate.
2012-01-18 GO:0038007 netrin-activated signaling pathway Added DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 GO:0038025 reelin receptor activity Added DEFINITION Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2012-01-18 GO:0035463 transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to determination of organismal asymmetry with respect to the left and right halves.
2012-01-18 GO:0070102 interleukin-6-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.
2012-01-18 GO:0001875 lipopolysaccharide receptor activity Deleted DEFINITION Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0035723 interleukin-15-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-15 binding to a cell surface receptor.
2012-01-18 GO:0008293 torso signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the transmembrane receptor tyrosine kinase torso binding to its physiological ligand.
2012-01-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2012-01-18 GO:0060803 BMP signaling pathway involved in mesodermal cell fate specification Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate.
2012-01-18 GO:0035691 macrophage migration inhibitory factor signaling pathway Deleted DEFINITION Any series of molecular signals generated as a consequence of macrophage migration inhibitory factor binding to a cell surface receptor.
2012-01-18 GO:0007167 enzyme linked receptor protein signaling pathway Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.
2012-01-18 GO:0061312 BMP signaling pathway involved in heart development Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the progression of the heart over time.
2012-01-18 GO:0007229 integrin-mediated signaling pathway Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2012-01-18 GO:0045500 sevenless signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the receptor sevenless binding to one of its physiological ligands.
2012-01-18 GO:0007219 Notch signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2012-01-18 GO:0048861 leukemia inhibitory factor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
2012-01-18 GO:0030509 BMP signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
2012-01-18 GO:0001875 lipopolysaccharide receptor activity Added DEFINITION Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0003130 BMP signaling pathway involved in heart induction Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
2012-01-18 GO:0003303 BMP signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
2012-01-18 GO:0007179 transforming growth factor beta receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0033209 tumor necrosis factor-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Terms

Timestamp GO ID GO Term Name Action Category Detail
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added TERM NIK/NF-kappaB cascade
2012-01-18 GO:0007215 glutamate receptor signaling pathway Updated TERM glutamate receptor signaling pathway

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2012-01-18 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand.
2012-01-18 GO:0007215 glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Deleted DEFINITION Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.
2012-01-18 GO:0003154 BMP signaling pathway involved in determination of left/right symmetry Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry.
2012-01-18 GO:0071893 BMP signaling pathway involved in nephric duct formation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to nephric duct formation.
2012-01-18 GO:0038007 netrin-activated signaling pathway Deleted DEFINITION The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 GO:0008101 decapentaplegic signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors.
2012-01-18 GO:0061353 BMP signaling pathway involved in Malpighian tubule cell chemotaxis Deleted DEFINITION The series of molecular signals generated as a consequence of a BMP receptor binding to one of its physiological ligands leading to the directed movement of a Malpighian tubule cells toward a stimulus and contributing to the shaping of the tubule.
2012-01-18 GO:0035385 Roundabout signaling pathway Deleted DEFINITION The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell.
2012-01-18 GO:0003130 BMP signaling pathway involved in heart induction Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction.
2012-01-18 GO:0033209 tumor necrosis factor-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
2012-01-18 GO:0003269 BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
2012-01-18 GO:0060869 transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission.
2012-01-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0035771 interleukin-4-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-4 binding to a cell surface receptor.
2012-01-18 GO:0038026 reelin-mediated signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a cell surface receptor binding to reelin, a secreted glycoprotein, to initiate a change in cell activity.
2012-01-18 GO:0038043 interleukin-5-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-5 binding to a cell surface receptor.
2012-01-18 GO:0003303 BMP signaling pathway involved in heart jogging Deleted DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
2012-01-18 GO:0061149 BMP signaling pathway involved in ureter morphogenesis Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
2012-01-18 GO:0038042 dimeric G-protein coupled receptor signaling pathway Deleted DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
2012-01-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate.
2012-01-18 GO:0061057 peptidoglycan recognition protein signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides.
2012-01-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0008063 Toll signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell.
2012-01-18 GO:0035235 ionotropic glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex.
2012-01-18 GO:0007168 receptor guanylyl cyclase signaling pathway Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity.
2012-01-18 GO:0061151 BMP signaling pathway involved in renal system segmentation Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the segmentation of the renal system.
2012-01-18 GO:0038025 reelin receptor activity Deleted DEFINITION Combining with the secreted glycoprotein reelin, and transmitting the signal to initiate a change in cell activity.
2012-01-18 GO:0035723 interleukin-15-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0060797 transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate.
2012-01-18 GO:0060803 BMP signaling pathway involved in mesodermal cell fate specification Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate.
2012-01-18 GO:0003154 BMP signaling pathway involved in determination of left/right symmetry Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
2012-01-18 GO:0003434 BMP signaling pathway involved in growth plate cartilage chondrocyte development Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
2012-01-18 GO:0007215 glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007224 smoothened signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 GO:0007249 I-kappaB kinase/NF-kappaB signaling Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 GO:0007249 I-kappaB kinase/NF-kappaB signaling Deleted DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 GO:0060835 transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis.
2012-01-18 GO:0060797 transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate.
2012-01-18 GO:0007216 G-protein coupled glutamate receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins.
2012-01-18 GO:0030509 BMP signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0033210 leptin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2012-01-18 GO:0035463 transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves.
2012-01-18 GO:0060826 transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern.
2012-01-18 GO:0061312 BMP signaling pathway involved in heart development Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.
2012-01-18 GO:0070106 interleukin-27-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0070757 interleukin-35-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0032924 activin receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035235 ionotropic glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035655 interleukin-18-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035772 interleukin-13-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061149 BMP signaling pathway involved in ureter morphogenesis Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
2012-01-18 GO:0071847 TNFSF11-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007168 receptor guanylyl cyclase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0035385 Roundabout signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035771 interleukin-4-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038058 TNFSF11 receptor activity Added DEFINITION Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.
2012-01-18 GO:0045500 sevenless signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0048861 leukemia inhibitory factor signaling pathway Added DEFINITION Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061057 peptidoglycan recognition protein signaling pathway Added DEFINITION A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
2012-01-18 GO:0003302 transforming growth factor beta receptor signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
2012-01-18 GO:0035655 interleukin-18-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
2012-01-18 GO:0007179 transforming growth factor beta receptor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
2012-01-18 GO:0007224 smoothened signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 GO:0070757 interleukin-35-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor.
2012-01-18 GO:0061372 activin receptor signaling pathway involved in heart jogging Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor and contributing to the process of heart jogging.
2012-01-18 GO:0003434 BMP signaling pathway involved in growth plate cartilage chondrocyte development Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time.
2012-01-18 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
2012-01-18 GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak.
2012-01-18 GO:0032924 activin receptor signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor.
2012-01-18 GO:0003302 transforming growth factor beta receptor signaling pathway involved in heart jogging Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
2012-01-18 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
2012-01-18 GO:0070106 interleukin-27-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor.
2012-01-18 GO:0060337 type I interferon signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2012-01-18 GO:0031663 lipopolysaccharide-mediated signaling pathway Deleted DEFINITION The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0060826 transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern.
2012-01-18 GO:0033210 leptin-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2012-01-18 GO:0038058 TNFSF11 receptor activity Deleted DEFINITION Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal within the cell to initiate a change in cell activity or function.
2012-01-18 GO:0038042 dimeric G-protein coupled receptor signaling pathway Added DEFINITION A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
2012-01-18 GO:0038043 interleukin-5-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0060337 type I interferon signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a type I interferon binding to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2012-01-18 GO:0060835 transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis.
2012-01-18 GO:0060869 transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission.
2012-01-18 GO:0061372 activin receptor signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging.
2012-01-18 GO:0070102 interleukin-6-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0003269 BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
2012-01-18 GO:0007167 enzyme linked receptor protein signaling pathway Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007216 G-protein coupled glutamate receptor signaling pathway Added DEFINITION A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0035772 interleukin-13-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-13 binding to a cell surface receptor.
2012-01-18 GO:0071847 TNFSF11-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor ligand superfamily member 11 (TNFSF11) binding to a cell surface receptor.
2012-01-18 GO:0007186 G-protein coupled receptor signaling pathway Deleted DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM non-canonical NF-KB signaling
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM p52-dependent NF-kappaB signaling
2012-01-18 GO:0007215 glutamate receptor signaling pathway Added SYNONYM glutamate signaling pathway
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM noncanonical NF-kappaB signaling
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added SYNONYM noncanonical nuclear factor kappaB (NF-kappaB) pathway
2012-01-18 GO:0007186 G-protein coupled receptor signaling pathway Added DEFINITION A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008063 Toll signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008101 decapentaplegic signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0061353 BMP signaling pathway involved in Malpighian tubule cell chemotaxis Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule.
2012-01-18 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2012-01-18 GO:0035691 macrophage migration inhibitory factor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038026 reelin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. The cascade begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
2012-01-18 GO:0061151 BMP signaling pathway involved in renal system segmentation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system.
2012-01-18 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007229 integrin-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0008293 torso signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2012-01-18 GO:0031663 lipopolysaccharide-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0071893 BMP signaling pathway involved in nephric duct formation Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation.
2012-01-18 GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak.
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Added DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
2012-01-18 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0007219 Notch signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate.
2012-01-18 GO:0038007 netrin-activated signaling pathway Added DEFINITION A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
2012-01-18 GO:0038025 reelin receptor activity Added DEFINITION Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2012-01-18 GO:0035463 transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry Deleted DEFINITION The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to determination of organismal asymmetry with respect to the left and right halves.
2012-01-18 GO:0070102 interleukin-6-mediated signaling pathway Deleted DEFINITION A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.
2012-01-18 GO:0001875 lipopolysaccharide receptor activity Deleted DEFINITION Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0035723 interleukin-15-mediated signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of interleukin-15 binding to a cell surface receptor.
2012-01-18 GO:0008293 torso signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the transmembrane receptor tyrosine kinase torso binding to its physiological ligand.
2012-01-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2012-01-18 GO:0060803 BMP signaling pathway involved in mesodermal cell fate specification Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate.
2012-01-18 GO:0035691 macrophage migration inhibitory factor signaling pathway Deleted DEFINITION Any series of molecular signals generated as a consequence of macrophage migration inhibitory factor binding to a cell surface receptor.
2012-01-18 GO:0007167 enzyme linked receptor protein signaling pathway Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.
2012-01-18 GO:0061312 BMP signaling pathway involved in heart development Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the progression of the heart over time.
2012-01-18 GO:0007229 integrin-mediated signaling pathway Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2012-01-18 GO:0045500 sevenless signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of the receptor sevenless binding to one of its physiological ligands.
2012-01-18 GO:0007219 Notch signaling pathway Deleted DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2012-01-18 GO:0048861 leukemia inhibitory factor signaling pathway Deleted DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
2012-01-18 GO:0030509 BMP signaling pathway Deleted DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
2012-01-18 GO:0001875 lipopolysaccharide receptor activity Added DEFINITION Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2012-01-18 GO:0003130 BMP signaling pathway involved in heart induction Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
2012-01-18 GO:0003303 BMP signaling pathway involved in heart jogging Added DEFINITION A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
2012-01-18 GO:0007179 transforming growth factor beta receptor signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 GO:0033209 tumor necrosis factor-mediated signaling pathway Added DEFINITION A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Relationships

Timestamp GO ID GO Term Name Action Category Detail
2012-01-18 GO:0007250 activation of NF-kappaB-inducing kinase activity Added RELATION part of GO:0038061 (NIK/NF-kappaB signaling)
2012-01-18 GO:0007254 JNK cascade Added RELATION is a GO:0051403 (stress-activated MAPK cascade)
2012-01-18 GO:0038061 NIK/NF-kappaB signaling Added RELATION is a GO:0035556 (intracellular signal transduction)
2012-01-18 GO:0046330 positive regulation of JNK cascade Deleted RELATION is a GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046330 positive regulation of JNK cascade Deleted RELATION is a GO:0043410 (positive regulation of MAPK cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Added RELATION is a GO:0032872 (regulation of stress-activated MAPK cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Deleted RELATION is a GO:0070302 (regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046328 regulation of JNK cascade Deleted RELATION is a GO:0043408 (regulation of MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Added RELATION is a GO:0032873 (negative regulation of stress-activated MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Deleted RELATION is a GO:0043409 (negative regulation of MAPK cascade)
2012-01-18 GO:0046329 negative regulation of JNK cascade Deleted RELATION is a GO:0070303 (negative regulation of stress-activated protein kinase signaling cascade)
2012-01-18 GO:0046330 positive regulation of JNK cascade Added RELATION is a GO:0032874 (positive regulation of stress-activated MAPK cascade)
2012-01-18 GO:0007254 JNK cascade Deleted RELATION is a GO:0000165 (MAPK cascade)
2012-01-18 GO:0007254 JNK cascade Deleted RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2012-01-18 GO:0004970 ionotropic glutamate receptor activity Added RELATION is a GO:0005230 (extracellular ligand-gated ion channel activity)
2012-01-18 GO:0004704 NF-kappaB-inducing kinase activity Added RELATION part of GO:0038061 (NIK/NF-kappaB signaling)
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