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GO Term History: Displaying 84 audit records for all terms for the date 2011-04-20

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2011-04-20 GO:0051424 corticotropin-releasing hormone binding Added SECONDARY GO:0017047 (adrenocorticotropin-releasing hormone binding)
2011-04-20 GO:0043404 corticotropin-releasing hormone receptor activity Added SECONDARY GO:0031636 (adrenocorticotropin-releasing hormone receptor activity)
2011-04-20 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Added RELATION part of GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
2011-04-20 GO:0035800 deubiquitinase activator activity Added RELATION is a GO:0016504 (peptidase activator activity)
2011-04-20 GO:0035800 deubiquitinase activator activity Added RELATION part of GO:2000158 (positive regulation of ubiquitin-specific protease activity)
2011-04-20 GO:0035801 adrenal cortex development Added RELATION is a GO:0048856 (anatomical structure development)
2011-04-20 GO:0035801 adrenal cortex development Added RELATION part of GO:0030325 (adrenal gland development)
2011-04-20 GO:0035802 adrenal cortex formation Added RELATION part of GO:0035801 (adrenal cortex development)
2011-04-20 GO:0035802 adrenal cortex formation Added RELATION is a GO:0048646 (anatomical structure formation involved in morphogenesis)
2011-04-20 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process Added RELATION part of GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted RELATION is a GO:0017046 (peptide hormone binding)
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted RELATION is a GO:0017047 (adrenocorticotropin-releasing hormone binding)
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:2-methylpropanoate 1-phosphotransferase activity
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Added SYNONYM corticotropin hormone secreting cell development
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Added SYNONYM negative regulation of adrenocorticotropin secretion
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM branched-chain-fatty-acid kinase activity
2011-04-20 GO:0071856 corticotropin receptor binding Added SYNONYM adrenocorticotropin receptor binding
2011-04-20 GO:0035801 adrenal cortex development Added SYNONYM adrenal gland cortex development
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:isobutyrate 1-phosphotransferase activity
2011-04-20 GO:0043404 corticotropin-releasing hormone receptor activity Added SYNONYM adrenocorticotropin-releasing hormone receptor activity
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM isobutyrate kinase activity
2011-04-20 GO:0051458 corticotropin secretion Deleted SYNONYM corticotropin secretion
2011-04-20 GO:0051459 regulation of corticotropin secretion Deleted SYNONYM regulation of corticotropin secretion
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Deleted SYNONYM corticotropin-releasing hormone
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Deleted SYNONYM branched-chain-fatty-acid kinase activity
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Deleted SYNONYM negative regulation of corticotropin secretion
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Deleted SYNONYM isobutyrate kinase activity
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Deleted SYNONYM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Deleted SYNONYM corticotropin hormone secreting cell development
2011-04-20 GO:0004978 corticotropin receptor activity Added SYNONYM adrenocorticotropin receptor activity
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:2-methylpropanoate kinase activity
2011-04-20 GO:0031780 corticotropin hormone receptor binding Added SYNONYM adrenocorticotropin hormone receptor binding
2011-04-20 GO:0051459 regulation of corticotropin secretion Added SYNONYM regulation of adrenocorticotropin secretion
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Added SYNONYM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM branched-chain fatty acid kinase activity
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Added SYNONYM adrenocorticotropin-releasing hormone
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Added SYNONYM positive regulation of adrenocorticotropin secretion
2011-04-20 GO:0051458 corticotropin secretion Added SYNONYM adrenocorticotropin secretion
2011-04-20 GO:0035802 adrenal cortex formation Added SYNONYM adrenal gland cortex formation
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted DEFINITION Interacting selectively and non-covalently with adrenocorticotropin-releasing hormone.
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted DEFINITION Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity.
2011-04-20 GO:0043396 corticotropin-releasing hormone secretion Deleted DEFINITION The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.
2011-04-20 GO:0071856 corticotropin receptor binding Deleted DEFINITION Interacting selectively and non-covalently with an adrenocorticotropin receptor.
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells.
2011-04-20 GO:0051459 regulation of corticotropin secretion Deleted DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Deleted DEFINITION The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2011-04-20 GO:0051458 corticotropin secretion Deleted DEFINITION The regulated release of adrenocorticotropin hormone, also known as corticotropin, by a cell or group of cells. Adrenocorticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.
2011-04-20 GO:0004978 corticotropin receptor activity Deleted DEFINITION Combining with adrenocorticotropin to initiate a change in cell activity.
2011-04-20 GO:0051430 corticotropin-releasing hormone receptor 1 binding Deleted DEFINITION Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
2011-04-20 GO:0031780 corticotropin hormone receptor binding Deleted DEFINITION Interacting selectively and non-covalently with an adrenocorticotropin hormone receptor.
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Deleted DEFINITION The action characteristic of adrenocorticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of adrenocorticotropin secretion by the anterior pituitary.
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Deleted DEFINITION The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Added DEFINITION The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.
2011-04-20 GO:0035801 adrenal cortex development Added DEFINITION The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens).
2011-04-20 GO:0043396 corticotropin-releasing hormone secretion Added DEFINITION The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Added DEFINITION The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.
2011-04-20 GO:0031780 corticotropin hormone receptor binding Added DEFINITION Interacting selectively and non-covalently with an corticotropin hormone receptor.
2011-04-20 GO:0004978 corticotropin receptor activity Added DEFINITION Combining with corticotropin to initiate a change in cell activity.
2011-04-20 GO:0071856 corticotropin receptor binding Added DEFINITION Interacting selectively and non-covalently with a corticotropin receptor.
2011-04-20 GO:0035800 deubiquitinase activator activity Added DEFINITION Increases the activity of a ubiquitin-specific protease, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.
2011-04-20 GO:0051430 corticotropin-releasing hormone receptor 1 binding Added DEFINITION Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Added DEFINITION Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell or group of cells.
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Added DEFINITION The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.
2011-04-20 GO:0035802 adrenal cortex formation Added DEFINITION The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
2011-04-20 GO:0051459 regulation of corticotropin secretion Added DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells.
2011-04-20 GO:0051458 corticotropin secretion Added DEFINITION The regulated release of corticotropin, by a cell or group of cells. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Updated TERM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Updated TERM corticotropin hormone secreting cell development
2011-04-20 GO:0071856 corticotropin receptor binding Updated TERM corticotropin receptor binding
2011-04-20 GO:0035800 deubiquitinase activator activity Added TERM ubiquitin-specific protease activator activity
2011-04-20 GO:0035801 adrenal cortex development Added TERM adrenal cortex development
2011-04-20 GO:0035802 adrenal cortex formation Added TERM adrenal cortex formation
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Updated TERM ATP:2-methylpropanoate phosphotransferase activity
2011-04-20 GO:0051459 regulation of corticotropin secretion Updated TERM regulation of corticotropin secretion
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Updated TERM negative regulation of corticotropin secretion
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Updated TERM positive regulation of corticotropin secretion
2011-04-20 GO:0051458 corticotropin secretion Updated TERM corticotropin secretion
2011-04-20 GO:0004978 corticotropin receptor activity Updated TERM corticotropin receptor activity
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Updated TERM corticotropin-releasing hormone activity
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted TERM adrenocorticotropin-releasing hormone binding
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted TERM adrenocorticotropin-releasing hormone receptor activity
2011-04-20 GO:0031780 corticotropin hormone receptor binding Updated TERM corticotropin hormone receptor binding

Terms

Timestamp GO ID GO Term Name Action Category Detail
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Updated TERM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Updated TERM corticotropin hormone secreting cell development
2011-04-20 GO:0071856 corticotropin receptor binding Updated TERM corticotropin receptor binding
2011-04-20 GO:0035800 deubiquitinase activator activity Added TERM ubiquitin-specific protease activator activity
2011-04-20 GO:0035801 adrenal cortex development Added TERM adrenal cortex development
2011-04-20 GO:0035802 adrenal cortex formation Added TERM adrenal cortex formation
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Updated TERM ATP:2-methylpropanoate phosphotransferase activity
2011-04-20 GO:0051459 regulation of corticotropin secretion Updated TERM regulation of corticotropin secretion
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Updated TERM negative regulation of corticotropin secretion
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Updated TERM positive regulation of corticotropin secretion
2011-04-20 GO:0051458 corticotropin secretion Updated TERM corticotropin secretion
2011-04-20 GO:0004978 corticotropin receptor activity Updated TERM corticotropin receptor activity
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Updated TERM corticotropin-releasing hormone activity
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted TERM adrenocorticotropin-releasing hormone binding
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted TERM adrenocorticotropin-releasing hormone receptor activity
2011-04-20 GO:0031780 corticotropin hormone receptor binding Updated TERM corticotropin hormone receptor binding

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:2-methylpropanoate 1-phosphotransferase activity
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Added SYNONYM corticotropin hormone secreting cell development
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Added SYNONYM negative regulation of adrenocorticotropin secretion
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM branched-chain-fatty-acid kinase activity
2011-04-20 GO:0071856 corticotropin receptor binding Added SYNONYM adrenocorticotropin receptor binding
2011-04-20 GO:0035801 adrenal cortex development Added SYNONYM adrenal gland cortex development
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:isobutyrate 1-phosphotransferase activity
2011-04-20 GO:0043404 corticotropin-releasing hormone receptor activity Added SYNONYM adrenocorticotropin-releasing hormone receptor activity
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM isobutyrate kinase activity
2011-04-20 GO:0051458 corticotropin secretion Deleted SYNONYM corticotropin secretion
2011-04-20 GO:0051459 regulation of corticotropin secretion Deleted SYNONYM regulation of corticotropin secretion
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Deleted SYNONYM corticotropin-releasing hormone
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Deleted SYNONYM branched-chain-fatty-acid kinase activity
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Deleted SYNONYM negative regulation of corticotropin secretion
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Deleted SYNONYM isobutyrate kinase activity
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Deleted SYNONYM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Deleted SYNONYM corticotropin hormone secreting cell development
2011-04-20 GO:0004978 corticotropin receptor activity Added SYNONYM adrenocorticotropin receptor activity
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM ATP:2-methylpropanoate kinase activity
2011-04-20 GO:0031780 corticotropin hormone receptor binding Added SYNONYM adrenocorticotropin hormone receptor binding
2011-04-20 GO:0051459 regulation of corticotropin secretion Added SYNONYM regulation of adrenocorticotropin secretion
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Added SYNONYM corticotropin hormone secreting cell differentiation
2011-04-20 GO:0047758 ATP:2-methylpropanoate phosphotransferase activity Added SYNONYM branched-chain fatty acid kinase activity
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Added SYNONYM adrenocorticotropin-releasing hormone
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Added SYNONYM positive regulation of adrenocorticotropin secretion
2011-04-20 GO:0051458 corticotropin secretion Added SYNONYM adrenocorticotropin secretion
2011-04-20 GO:0035802 adrenal cortex formation Added SYNONYM adrenal gland cortex formation
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted DEFINITION Interacting selectively and non-covalently with adrenocorticotropin-releasing hormone.
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted DEFINITION Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity.
2011-04-20 GO:0043396 corticotropin-releasing hormone secretion Deleted DEFINITION The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.
2011-04-20 GO:0071856 corticotropin receptor binding Deleted DEFINITION Interacting selectively and non-covalently with an adrenocorticotropin receptor.
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells.
2011-04-20 GO:0051459 regulation of corticotropin secretion Deleted DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Deleted DEFINITION The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2011-04-20 GO:0051458 corticotropin secretion Deleted DEFINITION The regulated release of adrenocorticotropin hormone, also known as corticotropin, by a cell or group of cells. Adrenocorticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.
2011-04-20 GO:0004978 corticotropin receptor activity Deleted DEFINITION Combining with adrenocorticotropin to initiate a change in cell activity.
2011-04-20 GO:0051430 corticotropin-releasing hormone receptor 1 binding Deleted DEFINITION Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
2011-04-20 GO:0031780 corticotropin hormone receptor binding Deleted DEFINITION Interacting selectively and non-covalently with an adrenocorticotropin hormone receptor.
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Deleted DEFINITION The action characteristic of adrenocorticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of adrenocorticotropin secretion by the anterior pituitary.
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Deleted DEFINITION The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2011-04-20 GO:0051460 negative regulation of corticotropin secretion Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells.
2011-04-20 GO:0060131 corticotropin hormone secreting cell development Added DEFINITION The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.
2011-04-20 GO:0035801 adrenal cortex development Added DEFINITION The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens).
2011-04-20 GO:0043396 corticotropin-releasing hormone secretion Added DEFINITION The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.
2011-04-20 GO:0060128 corticotropin hormone secreting cell differentiation Added DEFINITION The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.
2011-04-20 GO:0031780 corticotropin hormone receptor binding Added DEFINITION Interacting selectively and non-covalently with an corticotropin hormone receptor.
2011-04-20 GO:0004978 corticotropin receptor activity Added DEFINITION Combining with corticotropin to initiate a change in cell activity.
2011-04-20 GO:0071856 corticotropin receptor binding Added DEFINITION Interacting selectively and non-covalently with a corticotropin receptor.
2011-04-20 GO:0035800 deubiquitinase activator activity Added DEFINITION Increases the activity of a ubiquitin-specific protease, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.
2011-04-20 GO:0051430 corticotropin-releasing hormone receptor 1 binding Added DEFINITION Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
2011-04-20 GO:0051461 positive regulation of corticotropin secretion Added DEFINITION Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell or group of cells.
2011-04-20 GO:0017045 corticotropin-releasing hormone activity Added DEFINITION The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.
2011-04-20 GO:0035802 adrenal cortex formation Added DEFINITION The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
2011-04-20 GO:0051459 regulation of corticotropin secretion Added DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell or group of cells.
2011-04-20 GO:0051458 corticotropin secretion Added DEFINITION The regulated release of corticotropin, by a cell or group of cells. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.

Relationships

Timestamp GO ID GO Term Name Action Category Detail
2011-04-20 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Added RELATION part of GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
2011-04-20 GO:0035800 deubiquitinase activator activity Added RELATION is a GO:0016504 (peptidase activator activity)
2011-04-20 GO:0035800 deubiquitinase activator activity Added RELATION part of GO:2000158 (positive regulation of ubiquitin-specific protease activity)
2011-04-20 GO:0035801 adrenal cortex development Added RELATION is a GO:0048856 (anatomical structure development)
2011-04-20 GO:0035801 adrenal cortex development Added RELATION part of GO:0030325 (adrenal gland development)
2011-04-20 GO:0035802 adrenal cortex formation Added RELATION part of GO:0035801 (adrenal cortex development)
2011-04-20 GO:0035802 adrenal cortex formation Added RELATION is a GO:0048646 (anatomical structure formation involved in morphogenesis)
2011-04-20 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process Added RELATION part of GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
2011-04-20 GO:0017047 adrenocorticotropin-releasing hormone binding Deleted RELATION is a GO:0017046 (peptide hormone binding)
2011-04-20 GO:0031636 adrenocorticotropin-releasing hormone receptor activity Deleted RELATION is a GO:0017047 (adrenocorticotropin-releasing hormone binding)

Other

Timestamp GO ID GO Term Name Action Category Detail
2011-04-20 GO:0051424 corticotropin-releasing hormone binding Added SECONDARY GO:0017047 (adrenocorticotropin-releasing hormone binding)
2011-04-20 GO:0043404 corticotropin-releasing hormone receptor activity Added SECONDARY GO:0031636 (adrenocorticotropin-releasing hormone receptor activity)
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