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GO Term History: Displaying 50 audit records for all terms for the date 2008-11-27

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2008-11-27 GO:0070160 occluding junction Added RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0030055 cell-substrate junction Deleted DEFINITION A specialized region of connection between a cell and the extracellular matrix.
2008-11-27 GO:0014704 intercalated disc Added RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0014704 intercalated disc Deleted RELATION is a GO:0030054 (cell junction)
2008-11-27 GO:0030057 desmosome Added RELATION is a GO:0070161 (anchoring junction)
2008-11-27 GO:0030057 desmosome Deleted RELATION part of GO:0014704 (intercalated disc)
2008-11-27 GO:0005912 adherens junction Added RELATION is a GO:0070161 (anchoring junction)
2008-11-27 GO:0005912 adherens junction Deleted RELATION is a GO:0030054 (cell junction)
2008-11-27 GO:0005918 septate junction Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 GO:0005918 septate junction Deleted RELATION is a GO:0005913 (cell-cell adherens junction)
2008-11-27 GO:0005921 gap junction Deleted RELATION part of GO:0014704 (intercalated disc)
2008-11-27 GO:0005923 tight junction Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 GO:0005923 tight junction Deleted RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0005925 focal adhesion Deleted SYNONYM hemi-adherens junction
2008-11-27 GO:0010280 UDP-L-rhamnose synthase activity Deleted SYNONYM UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity
2008-11-27 GO:0005921 gap junction Deleted DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2008-11-27 GO:0014704 intercalated disc Deleted DEFINITION Specialised type of cell-cell junction in cardiac muscle, which mediates mechanical and electrochemical integration between the individual cardiomyocytes. Consist of three different kinds of substructures: adherens junctions, desmosomes and gap junctions.
2008-11-27 GO:0005911 cell-cell junction Deleted DEFINITION A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals.
2008-11-27 GO:0033010 paranodal junction Deleted DEFINITION A highly specialized junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
2008-11-27 GO:0005916 fascia adherens Deleted DEFINITION An electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains gap junctions and desmosomes. Most of the disc is formed of a convoluted fascia adherens type of junction into which the actin filaments of the terminal sarcomeres insert (or in the case of muscle cells, myofibrils), desmosomes are also present. The lateral portion of the stepped disc contains gap junctions that couple the cells electrically and thus coordinate the contraction.
2008-11-27 GO:0030057 desmosome Deleted DEFINITION A specialised type of cell junction into which intermediate filaments of adjacent cells are inserted. This type of cell junction is characteristic of epithelia. Desmosomes are particularly conspicuous in tissues such as skin that have to withstand mechanical stress.
2008-11-27 GO:0030054 cell junction Deleted DEFINITION A specialized region of connection between two cells or between a cell and the extracellular matrix.
2008-11-27 GO:0005912 adherens junction Deleted DEFINITION A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2008-11-27 GO:0005911 cell-cell junction Added DEFINITION A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.
2008-11-27 GO:0005912 adherens junction Added DEFINITION A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
2008-11-27 GO:0005915 zonula adherens Added DEFINITION A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
2008-11-27 GO:0005916 fascia adherens Added DEFINITION A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
2008-11-27 GO:0005918 septate junction Added DEFINITION A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates.
2008-11-27 GO:0005921 gap junction Added DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2P4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2008-11-27 GO:0005923 tight junction Added DEFINITION An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2008-11-27 GO:0005915 zonula adherens Added SYNONYM adhesion belt
2008-11-27 GO:0005925 focal adhesion Added SYNONYM hemi-adherens junction
2008-11-27 GO:0010280 UDP-L-rhamnose synthase activity Added SYNONYM UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity
2008-11-27 GO:0030056 hemidesmosome Added SYNONYM hemi-adherens junction
2008-11-27 GO:0043296 apical junction complex Added SYNONYM apical cell junction complex
2008-11-27 GO:0070160 occluding junction Added SYNONYM occluding cell junction
2008-11-27 GO:0070161 anchoring junction Added SYNONYM anchoring cell junction
2008-11-27 GO:0014704 intercalated disc Added DEFINITION A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2008-11-27 GO:0030054 cell junction Added DEFINITION A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
2008-11-27 GO:0030055 cell-substrate junction Added DEFINITION A cell junction that forms a connection between a cell and the extracellular matrix.
2008-11-27 GO:0030057 desmosome Added DEFINITION A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
2008-11-27 GO:0033010 paranodal junction Added DEFINITION A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
2008-11-27 GO:0070160 occluding junction Added DEFINITION A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
2008-11-27 GO:0070161 anchoring junction Added DEFINITION A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
2008-11-27 GO:0005918 septate junction Deleted DEFINITION Invertebrate-specific cell-cell junctions which form a band around the apical borders of epithelial cells and attach to actin filaments.
2008-11-27 GO:0070160 occluding junction Added TERM occluding junction
2008-11-27 GO:0070161 anchoring junction Added TERM anchoring junction
2008-11-27 GO:0005923 tight junction Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-11-27 GO:0005915 zonula adherens Deleted DEFINITION Cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
2008-11-27 GO:0070161 anchoring junction Added RELATION is a GO:0030054 (cell junction)

Terms

Timestamp GO ID GO Term Name Action Category Detail
2008-11-27 GO:0070160 occluding junction Added TERM occluding junction
2008-11-27 GO:0070161 anchoring junction Added TERM anchoring junction

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2008-11-27 GO:0030055 cell-substrate junction Deleted DEFINITION A specialized region of connection between a cell and the extracellular matrix.
2008-11-27 GO:0005925 focal adhesion Deleted SYNONYM hemi-adherens junction
2008-11-27 GO:0010280 UDP-L-rhamnose synthase activity Deleted SYNONYM UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity
2008-11-27 GO:0005921 gap junction Deleted DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2008-11-27 GO:0014704 intercalated disc Deleted DEFINITION Specialised type of cell-cell junction in cardiac muscle, which mediates mechanical and electrochemical integration between the individual cardiomyocytes. Consist of three different kinds of substructures: adherens junctions, desmosomes and gap junctions.
2008-11-27 GO:0005911 cell-cell junction Deleted DEFINITION A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals.
2008-11-27 GO:0033010 paranodal junction Deleted DEFINITION A highly specialized junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
2008-11-27 GO:0005916 fascia adherens Deleted DEFINITION An electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains gap junctions and desmosomes. Most of the disc is formed of a convoluted fascia adherens type of junction into which the actin filaments of the terminal sarcomeres insert (or in the case of muscle cells, myofibrils), desmosomes are also present. The lateral portion of the stepped disc contains gap junctions that couple the cells electrically and thus coordinate the contraction.
2008-11-27 GO:0030057 desmosome Deleted DEFINITION A specialised type of cell junction into which intermediate filaments of adjacent cells are inserted. This type of cell junction is characteristic of epithelia. Desmosomes are particularly conspicuous in tissues such as skin that have to withstand mechanical stress.
2008-11-27 GO:0030054 cell junction Deleted DEFINITION A specialized region of connection between two cells or between a cell and the extracellular matrix.
2008-11-27 GO:0005912 adherens junction Deleted DEFINITION A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2008-11-27 GO:0005911 cell-cell junction Added DEFINITION A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.
2008-11-27 GO:0005912 adherens junction Added DEFINITION A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
2008-11-27 GO:0005915 zonula adherens Added DEFINITION A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
2008-11-27 GO:0005916 fascia adherens Added DEFINITION A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
2008-11-27 GO:0005918 septate junction Added DEFINITION A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates.
2008-11-27 GO:0005921 gap junction Added DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2P4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2008-11-27 GO:0005923 tight junction Added DEFINITION An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2008-11-27 GO:0005915 zonula adherens Added SYNONYM adhesion belt
2008-11-27 GO:0005925 focal adhesion Added SYNONYM hemi-adherens junction
2008-11-27 GO:0010280 UDP-L-rhamnose synthase activity Added SYNONYM UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity
2008-11-27 GO:0030056 hemidesmosome Added SYNONYM hemi-adherens junction
2008-11-27 GO:0043296 apical junction complex Added SYNONYM apical cell junction complex
2008-11-27 GO:0070160 occluding junction Added SYNONYM occluding cell junction
2008-11-27 GO:0070161 anchoring junction Added SYNONYM anchoring cell junction
2008-11-27 GO:0014704 intercalated disc Added DEFINITION A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2008-11-27 GO:0030054 cell junction Added DEFINITION A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
2008-11-27 GO:0030055 cell-substrate junction Added DEFINITION A cell junction that forms a connection between a cell and the extracellular matrix.
2008-11-27 GO:0030057 desmosome Added DEFINITION A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
2008-11-27 GO:0033010 paranodal junction Added DEFINITION A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
2008-11-27 GO:0070160 occluding junction Added DEFINITION A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
2008-11-27 GO:0070161 anchoring junction Added DEFINITION A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
2008-11-27 GO:0005918 septate junction Deleted DEFINITION Invertebrate-specific cell-cell junctions which form a band around the apical borders of epithelial cells and attach to actin filaments.
2008-11-27 GO:0005923 tight junction Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-11-27 GO:0005915 zonula adherens Deleted DEFINITION Cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

Relationships

Timestamp GO ID GO Term Name Action Category Detail
2008-11-27 GO:0070160 occluding junction Added RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0014704 intercalated disc Added RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0014704 intercalated disc Deleted RELATION is a GO:0030054 (cell junction)
2008-11-27 GO:0030057 desmosome Added RELATION is a GO:0070161 (anchoring junction)
2008-11-27 GO:0030057 desmosome Deleted RELATION part of GO:0014704 (intercalated disc)
2008-11-27 GO:0005912 adherens junction Added RELATION is a GO:0070161 (anchoring junction)
2008-11-27 GO:0005912 adherens junction Deleted RELATION is a GO:0030054 (cell junction)
2008-11-27 GO:0005918 septate junction Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 GO:0005918 septate junction Deleted RELATION is a GO:0005913 (cell-cell adherens junction)
2008-11-27 GO:0005921 gap junction Deleted RELATION part of GO:0014704 (intercalated disc)
2008-11-27 GO:0005923 tight junction Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 GO:0005923 tight junction Deleted RELATION is a GO:0005911 (cell-cell junction)
2008-11-27 GO:0070161 anchoring junction Added RELATION is a GO:0030054 (cell junction)
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