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GO Term History: Displaying 500 audit records for all terms for the date 2008-08-18

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Updated TERM regulation of transcription during S-phase of mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Updated TERM regulation of transcription during G2-phase of mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Updated TERM regulation of transcription during G2/M-phase of mitotic cell cycle
2008-08-18 GO:0000767 cell morphogenesis involved in conjugation Updated TERM cell morphogenesis during conjugation
2008-08-18 GO:0000904 cell morphogenesis involved in differentiation Updated TERM cell morphogenesis during differentiation
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Updated TERM serine-type carboxypeptidase activity
2008-08-18 GO:0004298 threonine-type endopeptidase activity Updated TERM threonine-type endopeptidase activity
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Updated TERM regulation of transcription of G1/S-phase of mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Updated TERM regulation of transcription during G1 phase of mitotic cell cycle
2008-08-18 GO:0060281 regulation of oocyte development Added TERM regulation of oocyte development
2008-08-18 GO:0060282 positive regulation of oocyte development Added TERM positive regulation of oocyte development
2008-08-18 GO:0060283 negative regulation of oocyte development Added TERM negative regulation of oocyte development
2008-08-18 GO:0060284 regulation of cell development Added TERM regulation of cell development
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added TERM negative regulation of transcription during G1 phase of mitotic cell cycle
2008-08-18 GO:0060278 regulation of ovulation Added TERM regulation of ovulation
2008-08-18 GO:0060279 positive regulation of ovulation Added TERM positive regulation of ovulation
2008-08-18 GO:0060280 negative regulation of ovulation Added TERM negative regulation of ovulation
2008-08-18 GO:0070001 aspartic-type peptidase activity Added TERM aspartic-type peptidase activity
2008-08-18 GO:0070002 glutamic-type peptidase activity Added TERM glutamic-type peptidase activity
2008-08-18 GO:0070003 threonine-type peptidase activity Added TERM threonine-type peptidase activity
2008-08-18 GO:0070004 cysteine-type exopeptidase activity Added TERM cysteine-type exopeptidase activity
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added TERM cysteine-type aminopeptidase activity
2008-08-18 GO:0070006 metalloaminopeptidase activity Added TERM metalloaminopeptidase activity
2008-08-18 GO:0070007 glutamic-type endopeptidase activity Added TERM glutamic-type endopeptidase activity
2008-08-18 GO:0070008 serine-type exopeptidase activity Added TERM serine-type exopeptidase activity
2008-08-18 GO:0070009 serine-type aminopeptidase activity Added TERM serine-type aminopeptidase activity
2008-08-18 GO:0070010 peptidase activity, acting on D-amino acid peptides Added TERM peptidase activity, acting on D-amino acid peptides
2008-08-18 GO:0070011 peptidase activity, acting on L-amino acid peptides Added TERM peptidase activity, acting on L-amino acid peptides
2008-08-18 GO:0070012 oligopeptidase activity Added TERM oligopeptidase activity
2008-08-18 GO:0008236 serine-type peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004188 serine-type Pro-X carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0008991 serine-type signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism.
2008-08-18 GO:0004195 renin activity Deleted DEFINITION Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
2008-08-18 GO:0008992 repressor LexA activity Deleted DEFINITION Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA.
2008-08-18 GO:0009003 signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor.
2008-08-18 GO:0009004 signal peptidase I activity Deleted DEFINITION Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor.
2008-08-18 GO:0009005 signal peptidase II activity Deleted DEFINITION Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group.
2008-08-18 GO:0042499 signal peptide peptidase activity Deleted DEFINITION Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein.
2008-08-18 GO:0017093 sterol regulatory element-binding protein protease activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
2008-08-18 GO:0017094 sterol regulatory element-binding protein site 1 protease activity Deleted DEFINITION Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves.
2008-08-18 GO:0004248 stromelysin 1 activity Deleted DEFINITION Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
2008-08-18 GO:0030303 stromelysin 2 activity Deleted DEFINITION Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak.
2008-08-18 GO:0004291 subtilisin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
2008-08-18 GO:0017092 sterol regulatory element-binding protein site 2 protease activity Deleted DEFINITION Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus.
2008-08-18 GO:0004247 saccharolysin activity Deleted DEFINITION Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
2008-08-18 GO:0004196 saccharopepsin activity Deleted DEFINITION Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
2008-08-18 GO:0046560 scytalidopepsin B activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin.
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0009377 HslUV protease activity Deleted DEFINITION Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins.
2008-08-18 GO:0031389 Rad17 RFC-like complex Deleted DEFINITION A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17,nRfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
2008-08-18 GO:0001509 legumain activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
2008-08-18 GO:0003802 coagulation factor VIIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
2008-08-18 GO:0003803 coagulation factor IXa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
2008-08-18 GO:0003804 coagulation factor Xa activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
2008-08-18 GO:0003805 coagulation factor XIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
2008-08-18 GO:0003806 coagulation factor XIIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
2008-08-18 GO:0003807 plasma kallikrein activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
2008-08-18 GO:0003808 protein C (activated) activity Added DEFINITION OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.
2008-08-18 GO:0003809 thrombin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
2008-08-18 GO:0003815 complement component C1r activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
2008-08-18 GO:0003816 complement component C1s activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
2008-08-18 GO:0003817 complement factor D activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
2008-08-18 GO:0003818 complement factor I activity Added DEFINITION OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
2008-08-18 GO:0004175 endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2008-08-18 GO:0004177 aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
2008-08-18 GO:0004178 leucyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
2008-08-18 GO:0004180 carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2008-08-18 GO:0004181 metallocarboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0004182 carboxypeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
2008-08-18 GO:0004183 carboxypeptidase E activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
2008-08-18 GO:0004184 lysine carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004186 carboxypeptidase C activity Added DEFINITION OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
2008-08-18 GO:0004187 carboxypeptidase D activity Added DEFINITION OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
2008-08-18 GO:0004188 serine-type Pro-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0004189 tubulinyl-Tyr carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
2008-08-18 GO:0004190 aspartic-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 GO:0004191 barrierpepsin activity Added DEFINITION OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
2008-08-18 GO:0004192 cathepsin D activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
2008-08-18 GO:0004193 cathepsin E activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
2008-08-18 GO:0004194 pepsin A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
2008-08-18 GO:0004195 renin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
2008-08-18 GO:0004196 saccharopepsin activity Added DEFINITION OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
2008-08-18 GO:0004197 cysteine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0004198 calcium-dependent cysteine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 GO:0004213 cathepsin B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
2008-08-18 GO:0004215 cathepsin H activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
2008-08-18 GO:0004216 cathepsin K activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
2008-08-18 GO:0004217 cathepsin L activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
2008-08-18 GO:0004218 cathepsin S activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
2008-08-18 GO:0004219 pyroglutamyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
2008-08-18 GO:0004222 metalloendopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0004226 Gly-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
2008-08-18 GO:0004228 gelatinase A activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
2008-08-18 GO:0004229 gelatinase B activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
2008-08-18 GO:0004230 glutamyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
2008-08-18 GO:0004231 insulysin activity Added DEFINITION OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
2008-08-18 GO:0004232 interstitial collagenase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 GO:0004234 macrophage elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
2008-08-18 GO:0004235 matrilysin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
2008-08-18 GO:0004237 membrane dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides.
2008-08-18 GO:0004238 meprin A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
2008-08-18 GO:0004239 methionyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
2008-08-18 GO:0004240 mitochondrial processing peptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
2008-08-18 GO:0004244 mitochondrial inner membrane peptidase activity Added DEFINITION OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
2008-08-18 GO:0004245 neprilysin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
2008-08-18 GO:0004246 peptidyl-dipeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
2008-08-18 GO:0004247 saccharolysin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
2008-08-18 GO:0004248 stromelysin 1 activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
2008-08-18 GO:0004249 stromelysin 3 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0004250 aminopeptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
2008-08-18 GO:0004251 X-Pro dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
2008-08-18 GO:0004252 serine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004253 gamma-renin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
2008-08-18 GO:0004254 acylaminoacyl-peptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
2008-08-18 GO:0004261 cathepsin G activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
2008-08-18 GO:0019131 tripeptidyl-peptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH.
2008-08-18 GO:0004294 tripeptidyl-peptidase II activity Deleted DEFINITION Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
2008-08-18 GO:0004295 trypsin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
2008-08-18 GO:0030019 tryptase activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin.
2008-08-18 GO:0004298 threonine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-08-18 GO:0003809 thrombin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
2008-08-18 GO:0004189 tubulinyl-Tyr carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
2008-08-18 GO:0004293 tissue kallikrein activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
2008-08-18 GO:0008769 X-His dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Xaa-His dipeptides.
2008-08-18 GO:0008451 X-Pro aminopeptidase activity Deleted DEFINITION Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.
2008-08-18 GO:0004251 X-Pro dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
2008-08-18 GO:0017088 X-Pro dipeptidyl-peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.
2008-08-18 GO:0009983 tyrosine aminopeptidase activity Deleted DEFINITION Catalysis of the release of N-terminal tyrosine from a peptide.
2008-08-18 GO:0008581 ubiquitin-specific protease 5 activity Deleted DEFINITION Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.
2008-08-18 GO:0004243 mitochondrial intermediate peptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
2008-08-18 GO:0030602 chymosin activity Deleted DEFINITION Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein.
2008-08-18 GO:0004263 chymotrypsin activity Deleted DEFINITION Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
2008-08-18 GO:0008931 murein DD-endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008944 oligopeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5.
2008-08-18 GO:0008945 oligopeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline.
2008-08-18 GO:0008947 omptin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys.
2008-08-18 GO:0008956 peptidyl-dipeptidase Dcp activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly.
2008-08-18 GO:0008975 pitrilysin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon.
2008-08-18 GO:0008978 prepilin peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.
2008-08-18 GO:0008981 protease IV activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008991 serine-type signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism.
2008-08-18 GO:0008992 repressor LexA activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA.
2008-08-18 GO:0009003 signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor.
2008-08-18 GO:0009004 signal peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor.
2008-08-18 GO:0009005 signal peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group.
2008-08-18 GO:0009049 aspartic-type signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism.
2008-08-18 GO:0009377 HslUV protease activity Added DEFINITION OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins.
2008-08-18 GO:0009980 glutamate carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
2008-08-18 GO:0009983 tyrosine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide.
2008-08-18 GO:0010466 negative regulation of peptidase activity Added DEFINITION Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
2008-08-18 GO:0016284 alanine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide.
2008-08-18 GO:0016285 cytosol alanyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
2008-08-18 GO:0016511 endothelin-converting enzyme activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0016512 endothelin-converting enzyme 1 activity Added DEFINITION OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor.
2008-08-18 GO:0016804 prolyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide.
2008-08-18 GO:0016807 cysteine-type carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0016808 proprotein convertase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0016919 nardilysin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys.
2008-08-18 GO:0016921 pyroglutamyl-peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides.
2008-08-18 GO:0016946 cathepsin F activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2.
2008-08-18 GO:0017026 procollagen C-endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III.
2008-08-18 GO:0017039 dipeptidyl-peptidase III activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides.
2008-08-18 GO:0017074 procollagen N-endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln.
2008-08-18 GO:0017088 X-Pro dipeptidyl-peptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.
2008-08-18 GO:0017092 sterol regulatory element-binding protein site 2 protease activity Added DEFINITION OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus.
2008-08-18 GO:0004262 cerevisin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
2008-08-18 GO:0004263 chymotrypsin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
2008-08-18 GO:0030271 chymase activity Deleted DEFINITION Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.
2008-08-18 GO:0043859 cyanophycinase activity Deleted DEFINITION Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
2008-08-18 GO:0019132 C-terminal processing peptidase activity Deleted DEFINITION Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
2008-08-18 GO:0016807 cysteine-type carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0004197 cysteine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0008234 cysteine-type peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0051404 clostripain activity Deleted DEFINITION Catalysis of the cleavage of Arg-Xaa bonds.
2008-08-18 GO:0004198 calcium-dependent cysteine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 GO:0003803 coagulation factor IXa activity Deleted DEFINITION Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
2008-08-18 GO:0003802 coagulation factor VIIa activity Deleted DEFINITION Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
2008-08-18 GO:0003805 coagulation factor XIa activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
2008-08-18 GO:0003806 coagulation factor XIIa activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
2008-08-18 GO:0016285 cytosol alanyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
2008-08-18 GO:0042315 cytosol nonspecific dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
2008-08-18 GO:0004182 carboxypeptidase A activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
2008-08-18 GO:0004180 carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2008-08-18 GO:0050425 carboxypeptidase B activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid.
2008-08-18 GO:0004186 carboxypeptidase C activity Deleted DEFINITION Catalysis of the release of a C-terminal amino acid with a broad specificity.
2008-08-18 GO:0004187 carboxypeptidase D activity Deleted DEFINITION Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
2008-08-18 GO:0004183 carboxypeptidase E activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
2008-08-18 GO:0003815 complement component C1r activity Deleted DEFINITION Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
2008-08-18 GO:0003817 complement factor D activity Deleted DEFINITION Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
2008-08-18 GO:0003818 complement factor I activity Deleted DEFINITION Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
2008-08-18 GO:0030693 caspase activity Deleted DEFINITION Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.
2008-08-18 GO:0004262 cerevisin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
2008-08-18 GO:0004213 cathepsin B activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
2008-08-18 GO:0004192 cathepsin D activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
2008-08-18 GO:0004193 cathepsin E activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
2008-08-18 GO:0016946 cathepsin F activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2.
2008-08-18 GO:0004261 cathepsin G activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
2008-08-18 GO:0004215 cathepsin H activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
2008-08-18 GO:0004216 cathepsin K activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
2008-08-18 GO:0017093 sterol regulatory element-binding protein protease activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
2008-08-18 GO:0017094 sterol regulatory element-binding protein site 1 protease activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves.
2008-08-18 GO:0017165 dipeptidase E activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.
2008-08-18 GO:0019131 tripeptidyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH.
2008-08-18 GO:0019132 C-terminal processing peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.
2008-08-18 GO:0019828 aspartic-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0030019 tryptase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin.
2008-08-18 GO:0030271 chymase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.
2008-08-18 GO:0030303 stromelysin 2 activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak.
2008-08-18 GO:0030402 matrilysin-2 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030403 collagenase 4 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030404 collagenase 3 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030405 matrix metalloproteinase 19 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030406 matrix metalloproteinase 25 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030601 aminopeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
2008-08-18 GO:0030602 chymosin activity Added DEFINITION OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein.
2008-08-18 GO:0030693 caspase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.
2008-08-18 GO:0031079 picornain 3C activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
2008-08-18 GO:0031368 Pro-X metallocarboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0031389 Rad17 RFC-like complex Added DEFINITION A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
2008-08-18 GO:0033264 bontoxilysin activity Added DEFINITION OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
2008-08-18 GO:0042029 fibrolase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen.
2008-08-18 GO:0042315 cytosol nonspecific dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
2008-08-18 GO:0042499 signal peptide peptidase activity Added DEFINITION OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein.
2008-08-18 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.
2008-08-18 GO:0042576 aspartyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
2008-08-18 GO:0042708 elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of elastin.
2008-08-18 GO:0043275 glutamate carboxypeptidase II activity Added DEFINITION OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.
2008-08-18 GO:0043859 cyanophycinase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
2008-08-18 GO:0045024 peptidyl-glutamyl peptide hydrolyzing enzyme activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.
2008-08-18 GO:0046560 scytalidopepsin B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin.
2008-08-18 GO:0046561 penicillopepsin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen.
2008-08-18 GO:0050424 alanine carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups.
2008-08-18 GO:0003816 complement component C1s activity Deleted DEFINITION Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
2008-08-18 GO:0004217 cathepsin L activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
2008-08-18 GO:0004218 cathepsin S activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
2008-08-18 GO:0008423 bleomycin hydrolase activity Deleted DEFINITION Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
2008-08-18 GO:0033264 bontoxilysin activity Deleted DEFINITION Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
2008-08-18 GO:0004238 meprin A activity Deleted DEFINITION Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
2008-08-18 GO:0004184 lysine carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
2008-08-18 GO:0004181 metallocarboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-08-18 GO:0008472 metallocarboxypeptidase D activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid.
2008-08-18 GO:0004222 metalloendopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 GO:0008191 metalloendopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 GO:0008235 metalloexopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 GO:0004234 macrophage elastase activity Deleted DEFINITION Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
2008-08-18 GO:0004274 dipeptidyl-peptidase IV activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
2008-08-18 GO:0004275 enteropeptidase activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
2008-08-18 GO:0004276 furin activity Added DEFINITION OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
2008-08-18 GO:0004239 methionyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
2008-08-18 GO:0008439 monophenol monooxygenase activator activity Deleted DEFINITION Increases the activity of the enzyme monophenol monooxygenase.
2008-08-18 GO:0051405 microbial collagenase activity Deleted DEFINITION Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds.
2008-08-18 GO:0001509 legumain activity Deleted DEFINITION Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
2008-08-18 GO:0004244 mitochondrial inner membrane peptidase activity Deleted DEFINITION Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
2008-08-18 GO:0004235 matrilysin activity Deleted DEFINITION Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
2008-08-18 GO:0004243 mitochondrial intermediate peptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
2008-08-18 GO:0004240 mitochondrial processing peptidase activity Deleted DEFINITION Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
2008-08-18 GO:0004290 kexin activity Deleted DEFINITION Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
2008-08-18 GO:0004237 membrane dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides.
2008-08-18 GO:0005882 intermediate filament Deleted DEFINITION A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells.
2008-08-18 GO:0004232 interstitial collagenase activity Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 GO:0009980 glutamate carboxypeptidase activity Deleted DEFINITION Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
2008-08-18 GO:0043275 glutamate carboxypeptidase II activity Deleted DEFINITION Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.
2008-08-18 GO:0004230 glutamyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
2008-08-18 GO:0050425 carboxypeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid.
2008-08-18 GO:0050426 peptidyl-glycinamidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide.
2008-08-18 GO:0051397 N-terminal basic amino acid aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051398 N-terminal lysine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051399 N-terminal arginine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051404 clostripain activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds.
2008-08-18 GO:0051405 microbial collagenase activity Added DEFINITION OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds.
2008-08-18 GO:0052547 regulation of peptidase activity Added DEFINITION Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
2008-08-18 GO:0052548 regulation of endopeptidase activity Added DEFINITION Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added DEFINITION Any process that stop, prevents or decreases transcription during the G1 phase of the mitotic cell cycle.
2008-08-18 GO:0060278 regulation of ovulation Added DEFINITION Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060279 positive regulation of ovulation Added DEFINITION Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060280 negative regulation of ovulation Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extentnof ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060281 regulation of oocyte development Added DEFINITION Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060282 positive regulation of oocyte development Added DEFINITION Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060283 negative regulation of oocyte development Added DEFINITION Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060284 regulation of cell development Added DEFINITION Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2008-08-18 GO:0070001 aspartic-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 GO:0070002 glutamic-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
2008-08-18 GO:0070003 threonine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070004 cysteine-type exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070006 metalloaminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0070007 glutamic-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
2008-08-18 GO:0070008 serine-type exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0070009 serine-type aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0070010 peptidase activity, acting on D-amino acid peptides Added DEFINITION Catalysis of the hydrolysis of peptide bonds formed between D-amino acids.
2008-08-18 GO:0070011 peptidase activity, acting on L-amino acid peptides Added DEFINITION Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
2008-08-18 GO:0070012 oligopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.
2008-08-18 GO:0004226 Gly-X carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
2008-08-18 GO:0008464 gamma-glutamyl hydrolase activity Deleted DEFINITION Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid.
2008-08-18 GO:0004253 gamma-renin activity Deleted DEFINITION Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
2008-08-18 GO:0004231 insulysin activity Deleted DEFINITION Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
2008-08-18 GO:0004228 gelatinase A activity Deleted DEFINITION Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
2008-08-18 GO:0004229 gelatinase B activity Deleted DEFINITION Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
2008-08-18 GO:0004277 granzyme A activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
2008-08-18 GO:0046561 penicillopepsin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen.
2008-08-18 GO:0004194 pepsin A activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
2008-08-18 GO:0008233 peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-08-18 GO:0004246 peptidyl-dipeptidase A activity Deleted DEFINITION Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
2008-08-18 GO:0008956 peptidyl-dipeptidase Dcp activity Deleted DEFINITION Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly.
2008-08-18 GO:0045024 peptidyl-glutamyl peptide hydrolyzing enzyme activity Deleted DEFINITION Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.
2008-08-18 GO:0050426 peptidyl-glycinamidase activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide.
2008-08-18 GO:0031079 picornain 3C activity Deleted DEFINITION Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
2008-08-18 GO:0008975 pitrilysin activity Deleted DEFINITION Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon.
2008-08-18 GO:0004278 granzyme B activity Deleted DEFINITION Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
2008-08-18 GO:0003807 plasma kallikrein activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
2008-08-18 GO:0004283 plasmin activity Deleted DEFINITION Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
2008-08-18 GO:0008243 plasminogen activator activity Deleted DEFINITION Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.
2008-08-18 GO:0008132 pancreatic elastase activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including elastin.
2008-08-18 GO:0008125 pancreatic elastase I activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.
2008-08-18 GO:0004281 pancreatic elastase II activity Deleted DEFINITION Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
2008-08-18 GO:0004245 neprilysin activity Deleted DEFINITION Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
2008-08-18 GO:0051399 N-terminal arginine aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051397 N-terminal basic amino acid aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051398 N-terminal lysine aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0008450 O-sialoglycoprotein endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.
2008-08-18 GO:0016919 nardilysin activity Deleted DEFINITION Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys.
2008-08-18 GO:0008130 neutrophil collagenase activity Deleted DEFINITION Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
2008-08-18 GO:0008944 oligopeptidase A activity Deleted DEFINITION Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5.
2008-08-18 GO:0008945 oligopeptidase B activity Deleted DEFINITION Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline.
2008-08-18 GO:0008947 omptin activity Deleted DEFINITION Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys.
2008-08-18 GO:0010466 negative regulation of peptidase activity Deleted DEFINITION Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide linkages within proteins.
2008-08-18 GO:0042708 elastase activity Deleted DEFINITION Catalysis of the hydrolysis of elastin.
2008-08-18 GO:0008238 exopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-08-18 GO:0004276 furin activity Deleted DEFINITION Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
2008-08-18 GO:0017165 dipeptidase E activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
2008-08-18 GO:0017039 dipeptidyl-peptidase III activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides.
2008-08-18 GO:0004274 dipeptidyl-peptidase IV activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
2008-08-18 GO:0004175 endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-08-18 GO:0008462 endopeptidase Clp activity Deleted DEFINITION Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs).
2008-08-18 GO:0004866 endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-08-18 GO:0008846 endopeptidase La activity Deleted DEFINITION Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP.
2008-08-18 GO:0016512 endothelin-converting enzyme 1 activity Deleted DEFINITION Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor.
2008-08-18 GO:0004275 enteropeptidase activity Deleted DEFINITION Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
2008-08-18 GO:0042029 fibrolase activity Deleted DEFINITION Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen.
2008-08-18 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-08-18 GO:0004190 aspartic-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0019828 aspartic-type endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0009049 aspartic-type signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism.
2008-08-18 GO:0042576 aspartyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
2008-08-18 GO:0004277 granzyme A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
2008-08-18 GO:0004278 granzyme B activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
2008-08-18 GO:0004283 plasmin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
2008-08-18 GO:0004284 acrosin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
2008-08-18 GO:0004285 proprotein convertase 1 activity Added DEFINITION OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004286 proprotein convertase 2 activity Added DEFINITION OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004287 prolyl oligopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
2008-08-18 GO:0004289 subtilase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0004290 kexin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
2008-08-18 GO:0004291 subtilisin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
2008-08-18 GO:0004293 tissue kallikrein activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
2008-08-18 GO:0004294 tripeptidyl-peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
2008-08-18 GO:0004295 trypsin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
2008-08-18 GO:0004298 threonine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 GO:0004866 endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2008-08-18 GO:0004867 serine-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 GO:0008533 astacin activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
2008-08-18 GO:0008129 actinidain activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'.
2008-08-18 GO:0004177 aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides.
2008-08-18 GO:0030601 aminopeptidase B activity Deleted DEFINITION Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
2008-08-18 GO:0004250 aminopeptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
2008-08-18 GO:0004254 acylaminoacyl-peptidase activity Deleted DEFINITION Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
2008-08-18 GO:0004191 barrierpepsin activity Deleted DEFINITION Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
2008-08-18 GO:0016284 alanine aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide.
2008-08-18 GO:0050424 alanine carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups.
2008-08-18 GO:0004284 acrosin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Deleted DEFINITION Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
2008-08-18 GO:0008978 prepilin peptidase activity Deleted DEFINITION Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.
2008-08-18 GO:0052547 regulation of peptidase activity Deleted DEFINITION Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide linkages within proteins.
2008-08-18 GO:0008322 Pro-X carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.
2008-08-18 GO:0004281 pancreatic elastase II activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
2008-08-18 GO:0031368 Pro-X metallocarboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0017026 procollagen C-endopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III.
2008-08-18 GO:0017074 procollagen N-endopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln.
2008-08-18 GO:0016804 prolyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of a N-terminal proline from a peptide.
2008-08-18 GO:0004287 prolyl oligopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
2008-08-18 GO:0004285 proprotein convertase 1 activity Deleted DEFINITION Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004286 proprotein convertase 2 activity Deleted DEFINITION Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0003808 protein C (activated) activity Deleted DEFINITION Catalysis of the degradation of blood coagulation factors Va and VIIIa.
2008-08-18 GO:0052548 regulation of endopeptidase activity Deleted DEFINITION Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide linkages within proteins.
2008-08-18 GO:0004219 pyroglutamyl-peptidase I activity Deleted DEFINITION Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
2008-08-18 GO:0016921 pyroglutamyl-peptidase II activity Deleted DEFINITION Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides.
2008-08-18 GO:0004252 serine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004867 serine-type endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 GO:0005882 intermediate filament Added DEFINITION A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filamentss; and Type V, lamins.
2008-08-18 GO:0008125 pancreatic elastase I activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.
2008-08-18 GO:0008129 actinidain activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'.
2008-08-18 GO:0008130 neutrophil collagenase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
2008-08-18 GO:0008132 pancreatic elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin.
2008-08-18 GO:0008133 collagenase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0008191 metalloendopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 GO:0008233 peptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2008-08-18 GO:0008234 cysteine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0008235 metalloexopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0008236 serine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0008237 metallopeptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0008238 exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
2008-08-18 GO:0008243 plasminogen activator activity Added DEFINITION OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.
2008-08-18 GO:0008319 prenyl protein specific endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008322 Pro-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.
2008-08-18 GO:0008423 bleomycin hydrolase activity Added DEFINITION OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
2008-08-18 GO:0008439 monophenol monooxygenase activator activity Added DEFINITION OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase.
2008-08-18 GO:0008450 O-sialoglycoprotein endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.
2008-08-18 GO:0008451 X-Pro aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.
2008-08-18 GO:0008462 endopeptidase Clp activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs).
2008-08-18 GO:0008464 gamma-glutamyl hydrolase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid.
2008-08-18 GO:0008472 metallocarboxypeptidase D activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid.
2008-08-18 GO:0008487 prenyl-dependent CAAX protease activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008533 astacin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
2008-08-18 GO:0008581 ubiquitin-specific protease 5 activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.
2008-08-18 GO:0008717 D-alanyl-D-alanine endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008769 X-His dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides.
2008-08-18 GO:0008846 endopeptidase La activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP.
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Added SYNONYM G1/S-specific transcription in mitotic cell cycle
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM G1-specific transcription in mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle>
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Added SYNONYM S-phase-specific transcription in mitotic cell cycle
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle
2008-08-18 GO:0008233 peptidase activity Added SYNONYM proteinase activity
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Added SYNONYM G2-specific transcription in mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Added SYNONYM G2/M-specific transcription in mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added SYNONYM serine carboxypeptidase activity
2008-08-18 GO:0004298 threonine-type endopeptidase activity Added SYNONYM threonine endopeptidase activity
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added XREF EC:3.4.18
2008-08-18 GO:0070008 serine-type exopeptidase activity Added XREF EC:3.4.21
2008-08-18 GO:0001509 legumain activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)
2008-08-18 GO:0001509 legumain activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003809 thrombin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003815 complement component C1r activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003815 complement component C1r activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003816 complement component C1s activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003816 complement component C1s activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003817 complement factor D activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003817 complement factor D activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003818 complement factor I activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003818 complement factor I activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004175 endopeptidase activity Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 GO:0004175 endopeptidase activity Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 GO:0004176 ATP-dependent peptidase activity Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 GO:0004176 ATP-dependent peptidase activity Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted RELATION is a GO:0004177 (aminopeptidase activity)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted RELATION is a GO:0016284 (alanine aminopeptidase activity)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004182 carboxypeptidase A activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004182 carboxypeptidase A activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004183 carboxypeptidase E activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004183 carboxypeptidase E activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004184 lysine carboxypeptidase activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004184 lysine carboxypeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Deleted RELATION is a GO:0008236 (serine-type peptidase activity)
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added RELATION is a GO:0070008 (serine-type exopeptidase activity)
2008-08-18 GO:0004186 carboxypeptidase C activity Deleted RELATION is a GO:0004185 (serine-type carboxypeptidase activity)
2008-08-18 GO:0004186 carboxypeptidase C activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004187 carboxypeptidase D activity Deleted RELATION is a GO:0004185 (serine-type carboxypeptidase activity)
2008-08-18 GO:0004187 carboxypeptidase D activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003802 coagulation factor VIIa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003802 coagulation factor VIIa activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003803 coagulation factor IXa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003803 coagulation factor IXa activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted RELATION is a GO:0030567 (thrombin activator activity)
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0004193 cathepsin E activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004193 cathepsin E activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004194 pepsin A activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004194 pepsin A activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004195 renin activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004195 renin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004196 saccharopepsin activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004196 saccharopepsin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004213 cathepsin B activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)
2008-08-18 GO:0004213 cathepsin B activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted RELATION is a GO:0008239 (dipeptidyl-peptidase activity)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted RELATION is a GO:0008234 (cysteine-type peptidase activity)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004215 cathepsin H activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)

Terms

Timestamp GO ID GO Term Name Action Category Detail
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Updated TERM regulation of transcription during S-phase of mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Updated TERM regulation of transcription during G2-phase of mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Updated TERM regulation of transcription during G2/M-phase of mitotic cell cycle
2008-08-18 GO:0000767 cell morphogenesis involved in conjugation Updated TERM cell morphogenesis during conjugation
2008-08-18 GO:0000904 cell morphogenesis involved in differentiation Updated TERM cell morphogenesis during differentiation
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Updated TERM serine-type carboxypeptidase activity
2008-08-18 GO:0004298 threonine-type endopeptidase activity Updated TERM threonine-type endopeptidase activity
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Updated TERM regulation of transcription of G1/S-phase of mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Updated TERM regulation of transcription during G1 phase of mitotic cell cycle
2008-08-18 GO:0060281 regulation of oocyte development Added TERM regulation of oocyte development
2008-08-18 GO:0060282 positive regulation of oocyte development Added TERM positive regulation of oocyte development
2008-08-18 GO:0060283 negative regulation of oocyte development Added TERM negative regulation of oocyte development
2008-08-18 GO:0060284 regulation of cell development Added TERM regulation of cell development
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added TERM negative regulation of transcription during G1 phase of mitotic cell cycle
2008-08-18 GO:0060278 regulation of ovulation Added TERM regulation of ovulation
2008-08-18 GO:0060279 positive regulation of ovulation Added TERM positive regulation of ovulation
2008-08-18 GO:0060280 negative regulation of ovulation Added TERM negative regulation of ovulation
2008-08-18 GO:0070001 aspartic-type peptidase activity Added TERM aspartic-type peptidase activity
2008-08-18 GO:0070002 glutamic-type peptidase activity Added TERM glutamic-type peptidase activity
2008-08-18 GO:0070003 threonine-type peptidase activity Added TERM threonine-type peptidase activity
2008-08-18 GO:0070004 cysteine-type exopeptidase activity Added TERM cysteine-type exopeptidase activity
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added TERM cysteine-type aminopeptidase activity
2008-08-18 GO:0070006 metalloaminopeptidase activity Added TERM metalloaminopeptidase activity
2008-08-18 GO:0070007 glutamic-type endopeptidase activity Added TERM glutamic-type endopeptidase activity
2008-08-18 GO:0070008 serine-type exopeptidase activity Added TERM serine-type exopeptidase activity
2008-08-18 GO:0070009 serine-type aminopeptidase activity Added TERM serine-type aminopeptidase activity
2008-08-18 GO:0070010 peptidase activity, acting on D-amino acid peptides Added TERM peptidase activity, acting on D-amino acid peptides
2008-08-18 GO:0070011 peptidase activity, acting on L-amino acid peptides Added TERM peptidase activity, acting on L-amino acid peptides
2008-08-18 GO:0070012 oligopeptidase activity Added TERM oligopeptidase activity

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2008-08-18 GO:0008236 serine-type peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004188 serine-type Pro-X carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0008991 serine-type signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism.
2008-08-18 GO:0004195 renin activity Deleted DEFINITION Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
2008-08-18 GO:0008992 repressor LexA activity Deleted DEFINITION Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA.
2008-08-18 GO:0009003 signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor.
2008-08-18 GO:0009004 signal peptidase I activity Deleted DEFINITION Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor.
2008-08-18 GO:0009005 signal peptidase II activity Deleted DEFINITION Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group.
2008-08-18 GO:0042499 signal peptide peptidase activity Deleted DEFINITION Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein.
2008-08-18 GO:0017093 sterol regulatory element-binding protein protease activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
2008-08-18 GO:0017094 sterol regulatory element-binding protein site 1 protease activity Deleted DEFINITION Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves.
2008-08-18 GO:0004248 stromelysin 1 activity Deleted DEFINITION Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
2008-08-18 GO:0030303 stromelysin 2 activity Deleted DEFINITION Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak.
2008-08-18 GO:0004291 subtilisin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
2008-08-18 GO:0017092 sterol regulatory element-binding protein site 2 protease activity Deleted DEFINITION Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus.
2008-08-18 GO:0004247 saccharolysin activity Deleted DEFINITION Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
2008-08-18 GO:0004196 saccharopepsin activity Deleted DEFINITION Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
2008-08-18 GO:0046560 scytalidopepsin B activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin.
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0009377 HslUV protease activity Deleted DEFINITION Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins.
2008-08-18 GO:0031389 Rad17 RFC-like complex Deleted DEFINITION A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17,nRfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
2008-08-18 GO:0001509 legumain activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
2008-08-18 GO:0003802 coagulation factor VIIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
2008-08-18 GO:0003803 coagulation factor IXa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
2008-08-18 GO:0003804 coagulation factor Xa activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
2008-08-18 GO:0003805 coagulation factor XIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
2008-08-18 GO:0003806 coagulation factor XIIa activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
2008-08-18 GO:0003807 plasma kallikrein activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
2008-08-18 GO:0003808 protein C (activated) activity Added DEFINITION OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.
2008-08-18 GO:0003809 thrombin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
2008-08-18 GO:0003815 complement component C1r activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
2008-08-18 GO:0003816 complement component C1s activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
2008-08-18 GO:0003817 complement factor D activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
2008-08-18 GO:0003818 complement factor I activity Added DEFINITION OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
2008-08-18 GO:0004175 endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2008-08-18 GO:0004177 aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
2008-08-18 GO:0004178 leucyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
2008-08-18 GO:0004180 carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2008-08-18 GO:0004181 metallocarboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0004182 carboxypeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
2008-08-18 GO:0004183 carboxypeptidase E activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
2008-08-18 GO:0004184 lysine carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004186 carboxypeptidase C activity Added DEFINITION OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.
2008-08-18 GO:0004187 carboxypeptidase D activity Added DEFINITION OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
2008-08-18 GO:0004188 serine-type Pro-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0004189 tubulinyl-Tyr carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
2008-08-18 GO:0004190 aspartic-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 GO:0004191 barrierpepsin activity Added DEFINITION OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
2008-08-18 GO:0004192 cathepsin D activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
2008-08-18 GO:0004193 cathepsin E activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
2008-08-18 GO:0004194 pepsin A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
2008-08-18 GO:0004195 renin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.
2008-08-18 GO:0004196 saccharopepsin activity Added DEFINITION OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.
2008-08-18 GO:0004197 cysteine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0004198 calcium-dependent cysteine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 GO:0004213 cathepsin B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
2008-08-18 GO:0004215 cathepsin H activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
2008-08-18 GO:0004216 cathepsin K activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
2008-08-18 GO:0004217 cathepsin L activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
2008-08-18 GO:0004218 cathepsin S activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
2008-08-18 GO:0004219 pyroglutamyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
2008-08-18 GO:0004222 metalloendopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0004226 Gly-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
2008-08-18 GO:0004228 gelatinase A activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
2008-08-18 GO:0004229 gelatinase B activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
2008-08-18 GO:0004230 glutamyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
2008-08-18 GO:0004231 insulysin activity Added DEFINITION OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
2008-08-18 GO:0004232 interstitial collagenase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 GO:0004234 macrophage elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
2008-08-18 GO:0004235 matrilysin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
2008-08-18 GO:0004237 membrane dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides.
2008-08-18 GO:0004238 meprin A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
2008-08-18 GO:0004239 methionyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
2008-08-18 GO:0004240 mitochondrial processing peptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
2008-08-18 GO:0004244 mitochondrial inner membrane peptidase activity Added DEFINITION OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
2008-08-18 GO:0004245 neprilysin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
2008-08-18 GO:0004246 peptidyl-dipeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
2008-08-18 GO:0004247 saccharolysin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.
2008-08-18 GO:0004248 stromelysin 1 activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.
2008-08-18 GO:0004249 stromelysin 3 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0004250 aminopeptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
2008-08-18 GO:0004251 X-Pro dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
2008-08-18 GO:0004252 serine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004253 gamma-renin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
2008-08-18 GO:0004254 acylaminoacyl-peptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
2008-08-18 GO:0004261 cathepsin G activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
2008-08-18 GO:0019131 tripeptidyl-peptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH.
2008-08-18 GO:0004294 tripeptidyl-peptidase II activity Deleted DEFINITION Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
2008-08-18 GO:0004295 trypsin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
2008-08-18 GO:0030019 tryptase activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin.
2008-08-18 GO:0004298 threonine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-08-18 GO:0003809 thrombin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
2008-08-18 GO:0004189 tubulinyl-Tyr carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.
2008-08-18 GO:0004293 tissue kallikrein activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
2008-08-18 GO:0008769 X-His dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Xaa-His dipeptides.
2008-08-18 GO:0008451 X-Pro aminopeptidase activity Deleted DEFINITION Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.
2008-08-18 GO:0004251 X-Pro dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
2008-08-18 GO:0017088 X-Pro dipeptidyl-peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.
2008-08-18 GO:0009983 tyrosine aminopeptidase activity Deleted DEFINITION Catalysis of the release of N-terminal tyrosine from a peptide.
2008-08-18 GO:0008581 ubiquitin-specific protease 5 activity Deleted DEFINITION Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.
2008-08-18 GO:0004243 mitochondrial intermediate peptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
2008-08-18 GO:0030602 chymosin activity Deleted DEFINITION Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein.
2008-08-18 GO:0004263 chymotrypsin activity Deleted DEFINITION Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
2008-08-18 GO:0008931 murein DD-endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008944 oligopeptidase A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5.
2008-08-18 GO:0008945 oligopeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline.
2008-08-18 GO:0008947 omptin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys.
2008-08-18 GO:0008956 peptidyl-dipeptidase Dcp activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly.
2008-08-18 GO:0008975 pitrilysin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon.
2008-08-18 GO:0008978 prepilin peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.
2008-08-18 GO:0008981 protease IV activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008991 serine-type signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism.
2008-08-18 GO:0008992 repressor LexA activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA.
2008-08-18 GO:0009003 signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor.
2008-08-18 GO:0009004 signal peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor.
2008-08-18 GO:0009005 signal peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group.
2008-08-18 GO:0009049 aspartic-type signal peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism.
2008-08-18 GO:0009377 HslUV protease activity Added DEFINITION OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins.
2008-08-18 GO:0009980 glutamate carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
2008-08-18 GO:0009983 tyrosine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide.
2008-08-18 GO:0010466 negative regulation of peptidase activity Added DEFINITION Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
2008-08-18 GO:0016284 alanine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide.
2008-08-18 GO:0016285 cytosol alanyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
2008-08-18 GO:0016511 endothelin-converting enzyme activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0016512 endothelin-converting enzyme 1 activity Added DEFINITION OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor.
2008-08-18 GO:0016804 prolyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide.
2008-08-18 GO:0016807 cysteine-type carboxypeptidase activity Added DEFINITION Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0016808 proprotein convertase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0016919 nardilysin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys.
2008-08-18 GO:0016921 pyroglutamyl-peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides.
2008-08-18 GO:0016946 cathepsin F activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2.
2008-08-18 GO:0017026 procollagen C-endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III.
2008-08-18 GO:0017039 dipeptidyl-peptidase III activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides.
2008-08-18 GO:0017074 procollagen N-endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln.
2008-08-18 GO:0017088 X-Pro dipeptidyl-peptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.
2008-08-18 GO:0017092 sterol regulatory element-binding protein site 2 protease activity Added DEFINITION OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus.
2008-08-18 GO:0004262 cerevisin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
2008-08-18 GO:0004263 chymotrypsin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.
2008-08-18 GO:0030271 chymase activity Deleted DEFINITION Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.
2008-08-18 GO:0043859 cyanophycinase activity Deleted DEFINITION Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
2008-08-18 GO:0019132 C-terminal processing peptidase activity Deleted DEFINITION Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.
2008-08-18 GO:0016807 cysteine-type carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0004197 cysteine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0008234 cysteine-type peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-08-18 GO:0051404 clostripain activity Deleted DEFINITION Catalysis of the cleavage of Arg-Xaa bonds.
2008-08-18 GO:0004198 calcium-dependent cysteine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 GO:0003803 coagulation factor IXa activity Deleted DEFINITION Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.
2008-08-18 GO:0003802 coagulation factor VIIa activity Deleted DEFINITION Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).
2008-08-18 GO:0003805 coagulation factor XIa activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.
2008-08-18 GO:0003806 coagulation factor XIIa activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
2008-08-18 GO:0016285 cytosol alanyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
2008-08-18 GO:0042315 cytosol nonspecific dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
2008-08-18 GO:0004182 carboxypeptidase A activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
2008-08-18 GO:0004180 carboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2008-08-18 GO:0050425 carboxypeptidase B activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid.
2008-08-18 GO:0004186 carboxypeptidase C activity Deleted DEFINITION Catalysis of the release of a C-terminal amino acid with a broad specificity.
2008-08-18 GO:0004187 carboxypeptidase D activity Deleted DEFINITION Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.
2008-08-18 GO:0004183 carboxypeptidase E activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.
2008-08-18 GO:0003815 complement component C1r activity Deleted DEFINITION Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).
2008-08-18 GO:0003817 complement factor D activity Deleted DEFINITION Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).
2008-08-18 GO:0003818 complement factor I activity Deleted DEFINITION Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
2008-08-18 GO:0030693 caspase activity Deleted DEFINITION Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.
2008-08-18 GO:0004262 cerevisin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.
2008-08-18 GO:0004213 cathepsin B activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
2008-08-18 GO:0004192 cathepsin D activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
2008-08-18 GO:0004193 cathepsin E activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.
2008-08-18 GO:0016946 cathepsin F activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2.
2008-08-18 GO:0004261 cathepsin G activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.
2008-08-18 GO:0004215 cathepsin H activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.
2008-08-18 GO:0004216 cathepsin K activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
2008-08-18 GO:0017093 sterol regulatory element-binding protein protease activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
2008-08-18 GO:0017094 sterol regulatory element-binding protein site 1 protease activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves.
2008-08-18 GO:0017165 dipeptidase E activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.
2008-08-18 GO:0019131 tripeptidyl-peptidase I activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH.
2008-08-18 GO:0019132 C-terminal processing peptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.
2008-08-18 GO:0019828 aspartic-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0030019 tryptase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin.
2008-08-18 GO:0030271 chymase activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.
2008-08-18 GO:0030303 stromelysin 2 activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak.
2008-08-18 GO:0030402 matrilysin-2 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030403 collagenase 4 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030404 collagenase 3 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030405 matrix metalloproteinase 19 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030406 matrix metalloproteinase 25 activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0030601 aminopeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
2008-08-18 GO:0030602 chymosin activity Added DEFINITION OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein.
2008-08-18 GO:0030693 caspase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.
2008-08-18 GO:0031079 picornain 3C activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
2008-08-18 GO:0031368 Pro-X metallocarboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0031389 Rad17 RFC-like complex Added DEFINITION A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.
2008-08-18 GO:0033264 bontoxilysin activity Added DEFINITION OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
2008-08-18 GO:0042029 fibrolase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen.
2008-08-18 GO:0042315 cytosol nonspecific dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
2008-08-18 GO:0042499 signal peptide peptidase activity Added DEFINITION OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein.
2008-08-18 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.
2008-08-18 GO:0042576 aspartyl aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
2008-08-18 GO:0042708 elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of elastin.
2008-08-18 GO:0043275 glutamate carboxypeptidase II activity Added DEFINITION OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.
2008-08-18 GO:0043859 cyanophycinase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
2008-08-18 GO:0045024 peptidyl-glutamyl peptide hydrolyzing enzyme activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.
2008-08-18 GO:0046560 scytalidopepsin B activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin.
2008-08-18 GO:0046561 penicillopepsin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen.
2008-08-18 GO:0050424 alanine carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups.
2008-08-18 GO:0003816 complement component C1s activity Deleted DEFINITION Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
2008-08-18 GO:0004217 cathepsin L activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
2008-08-18 GO:0004218 cathepsin S activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.
2008-08-18 GO:0008423 bleomycin hydrolase activity Deleted DEFINITION Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
2008-08-18 GO:0033264 bontoxilysin activity Deleted DEFINITION Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
2008-08-18 GO:0004238 meprin A activity Deleted DEFINITION Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
2008-08-18 GO:0004184 lysine carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
2008-08-18 GO:0004181 metallocarboxypeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-08-18 GO:0008472 metallocarboxypeptidase D activity Deleted DEFINITION Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid.
2008-08-18 GO:0004222 metalloendopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 GO:0008191 metalloendopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 GO:0008235 metalloexopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 GO:0004234 macrophage elastase activity Deleted DEFINITION Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.
2008-08-18 GO:0004274 dipeptidyl-peptidase IV activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
2008-08-18 GO:0004275 enteropeptidase activity Added DEFINITION OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
2008-08-18 GO:0004276 furin activity Added DEFINITION OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
2008-08-18 GO:0004239 methionyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
2008-08-18 GO:0008439 monophenol monooxygenase activator activity Deleted DEFINITION Increases the activity of the enzyme monophenol monooxygenase.
2008-08-18 GO:0051405 microbial collagenase activity Deleted DEFINITION Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds.
2008-08-18 GO:0001509 legumain activity Deleted DEFINITION Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.
2008-08-18 GO:0004244 mitochondrial inner membrane peptidase activity Deleted DEFINITION Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.
2008-08-18 GO:0004235 matrilysin activity Deleted DEFINITION Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
2008-08-18 GO:0004243 mitochondrial intermediate peptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.
2008-08-18 GO:0004240 mitochondrial processing peptidase activity Deleted DEFINITION Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
2008-08-18 GO:0004290 kexin activity Deleted DEFINITION Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
2008-08-18 GO:0004237 membrane dipeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides.
2008-08-18 GO:0005882 intermediate filament Deleted DEFINITION A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells.
2008-08-18 GO:0004232 interstitial collagenase activity Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 GO:0009980 glutamate carboxypeptidase activity Deleted DEFINITION Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
2008-08-18 GO:0043275 glutamate carboxypeptidase II activity Deleted DEFINITION Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.
2008-08-18 GO:0004230 glutamyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
2008-08-18 GO:0050425 carboxypeptidase B activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid.
2008-08-18 GO:0050426 peptidyl-glycinamidase activity Added DEFINITION OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide.
2008-08-18 GO:0051397 N-terminal basic amino acid aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051398 N-terminal lysine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051399 N-terminal arginine aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051404 clostripain activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds.
2008-08-18 GO:0051405 microbial collagenase activity Added DEFINITION OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds.
2008-08-18 GO:0052547 regulation of peptidase activity Added DEFINITION Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.
2008-08-18 GO:0052548 regulation of endopeptidase activity Added DEFINITION Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added DEFINITION Any process that stop, prevents or decreases transcription during the G1 phase of the mitotic cell cycle.
2008-08-18 GO:0060278 regulation of ovulation Added DEFINITION Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060279 positive regulation of ovulation Added DEFINITION Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060280 negative regulation of ovulation Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extentnof ovulation, the release of a mature ovum/oocyte from an ovary.
2008-08-18 GO:0060281 regulation of oocyte development Added DEFINITION Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060282 positive regulation of oocyte development Added DEFINITION Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060283 negative regulation of oocyte development Added DEFINITION Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2008-08-18 GO:0060284 regulation of cell development Added DEFINITION Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2008-08-18 GO:0070001 aspartic-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 GO:0070002 glutamic-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
2008-08-18 GO:0070003 threonine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070004 cysteine-type exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0070006 metalloaminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0070007 glutamic-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
2008-08-18 GO:0070008 serine-type exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0070009 serine-type aminopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0070010 peptidase activity, acting on D-amino acid peptides Added DEFINITION Catalysis of the hydrolysis of peptide bonds formed between D-amino acids.
2008-08-18 GO:0070011 peptidase activity, acting on L-amino acid peptides Added DEFINITION Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
2008-08-18 GO:0070012 oligopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.
2008-08-18 GO:0004226 Gly-X carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.
2008-08-18 GO:0008464 gamma-glutamyl hydrolase activity Deleted DEFINITION Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid.
2008-08-18 GO:0004253 gamma-renin activity Deleted DEFINITION Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.
2008-08-18 GO:0004231 insulysin activity Deleted DEFINITION Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.
2008-08-18 GO:0004228 gelatinase A activity Deleted DEFINITION Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.
2008-08-18 GO:0004229 gelatinase B activity Deleted DEFINITION Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.
2008-08-18 GO:0004277 granzyme A activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
2008-08-18 GO:0046561 penicillopepsin activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen.
2008-08-18 GO:0004194 pepsin A activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.
2008-08-18 GO:0008233 peptidase activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-08-18 GO:0004246 peptidyl-dipeptidase A activity Deleted DEFINITION Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
2008-08-18 GO:0008956 peptidyl-dipeptidase Dcp activity Deleted DEFINITION Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly.
2008-08-18 GO:0045024 peptidyl-glutamyl peptide hydrolyzing enzyme activity Deleted DEFINITION Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.
2008-08-18 GO:0050426 peptidyl-glycinamidase activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide.
2008-08-18 GO:0031079 picornain 3C activity Deleted DEFINITION Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
2008-08-18 GO:0008975 pitrilysin activity Deleted DEFINITION Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon.
2008-08-18 GO:0004278 granzyme B activity Deleted DEFINITION Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
2008-08-18 GO:0003807 plasma kallikrein activity Deleted DEFINITION Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.
2008-08-18 GO:0004283 plasmin activity Deleted DEFINITION Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
2008-08-18 GO:0008243 plasminogen activator activity Deleted DEFINITION Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.
2008-08-18 GO:0008132 pancreatic elastase activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including elastin.
2008-08-18 GO:0008125 pancreatic elastase I activity Deleted DEFINITION Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.
2008-08-18 GO:0004281 pancreatic elastase II activity Deleted DEFINITION Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
2008-08-18 GO:0004245 neprilysin activity Deleted DEFINITION Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
2008-08-18 GO:0051399 N-terminal arginine aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051397 N-terminal basic amino acid aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0051398 N-terminal lysine aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain.
2008-08-18 GO:0008450 O-sialoglycoprotein endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.
2008-08-18 GO:0016919 nardilysin activity Deleted DEFINITION Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys.
2008-08-18 GO:0008130 neutrophil collagenase activity Deleted DEFINITION Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
2008-08-18 GO:0008944 oligopeptidase A activity Deleted DEFINITION Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5.
2008-08-18 GO:0008945 oligopeptidase B activity Deleted DEFINITION Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline.
2008-08-18 GO:0008947 omptin activity Deleted DEFINITION Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys.
2008-08-18 GO:0010466 negative regulation of peptidase activity Deleted DEFINITION Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide linkages within proteins.
2008-08-18 GO:0042708 elastase activity Deleted DEFINITION Catalysis of the hydrolysis of elastin.
2008-08-18 GO:0008238 exopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-08-18 GO:0004276 furin activity Deleted DEFINITION Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
2008-08-18 GO:0017165 dipeptidase E activity Deleted DEFINITION Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.
2008-08-18 GO:0017039 dipeptidyl-peptidase III activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides.
2008-08-18 GO:0004274 dipeptidyl-peptidase IV activity Deleted DEFINITION Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.
2008-08-18 GO:0004175 endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-08-18 GO:0008462 endopeptidase Clp activity Deleted DEFINITION Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs).
2008-08-18 GO:0004866 endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-08-18 GO:0008846 endopeptidase La activity Deleted DEFINITION Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP.
2008-08-18 GO:0016512 endothelin-converting enzyme 1 activity Deleted DEFINITION Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor.
2008-08-18 GO:0004275 enteropeptidase activity Deleted DEFINITION Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.
2008-08-18 GO:0042029 fibrolase activity Deleted DEFINITION Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen.
2008-08-18 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane.
2008-08-18 GO:0004190 aspartic-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0019828 aspartic-type endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 GO:0009049 aspartic-type signal peptidase activity Deleted DEFINITION Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism.
2008-08-18 GO:0042576 aspartyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
2008-08-18 GO:0004277 granzyme A activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.
2008-08-18 GO:0004278 granzyme B activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.
2008-08-18 GO:0004283 plasmin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
2008-08-18 GO:0004284 acrosin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
2008-08-18 GO:0004285 proprotein convertase 1 activity Added DEFINITION OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004286 proprotein convertase 2 activity Added DEFINITION OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004287 prolyl oligopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
2008-08-18 GO:0004289 subtilase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0004290 kexin activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.
2008-08-18 GO:0004291 subtilisin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
2008-08-18 GO:0004293 tissue kallikrein activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.
2008-08-18 GO:0004294 tripeptidyl-peptidase II activity Added DEFINITION OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.
2008-08-18 GO:0004295 trypsin activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.
2008-08-18 GO:0004298 threonine-type endopeptidase activity Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 GO:0004866 endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2008-08-18 GO:0004867 serine-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 GO:0008533 astacin activity Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
2008-08-18 GO:0008129 actinidain activity Deleted DEFINITION Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'.
2008-08-18 GO:0004177 aminopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides.
2008-08-18 GO:0030601 aminopeptidase B activity Deleted DEFINITION Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
2008-08-18 GO:0004250 aminopeptidase I activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.
2008-08-18 GO:0004254 acylaminoacyl-peptidase activity Deleted DEFINITION Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.
2008-08-18 GO:0004191 barrierpepsin activity Deleted DEFINITION Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.
2008-08-18 GO:0016284 alanine aminopeptidase activity Deleted DEFINITION Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide.
2008-08-18 GO:0050424 alanine carboxypeptidase activity Deleted DEFINITION Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups.
2008-08-18 GO:0004284 acrosin activity Deleted DEFINITION Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Deleted DEFINITION Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.
2008-08-18 GO:0008978 prepilin peptidase activity Deleted DEFINITION Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.
2008-08-18 GO:0052547 regulation of peptidase activity Deleted DEFINITION Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide linkages within proteins.
2008-08-18 GO:0008322 Pro-X carboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.
2008-08-18 GO:0004281 pancreatic elastase II activity Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.
2008-08-18 GO:0031368 Pro-X metallocarboxypeptidase activity Deleted DEFINITION Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid.
2008-08-18 GO:0017026 procollagen C-endopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III.
2008-08-18 GO:0017074 procollagen N-endopeptidase activity Deleted DEFINITION Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln.
2008-08-18 GO:0016804 prolyl aminopeptidase activity Deleted DEFINITION Catalysis of the release of a N-terminal proline from a peptide.
2008-08-18 GO:0004287 prolyl oligopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.
2008-08-18 GO:0004285 proprotein convertase 1 activity Deleted DEFINITION Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0004286 proprotein convertase 2 activity Deleted DEFINITION Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.
2008-08-18 GO:0003808 protein C (activated) activity Deleted DEFINITION Catalysis of the degradation of blood coagulation factors Va and VIIIa.
2008-08-18 GO:0052548 regulation of endopeptidase activity Deleted DEFINITION Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide linkages within proteins.
2008-08-18 GO:0004219 pyroglutamyl-peptidase I activity Deleted DEFINITION Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.
2008-08-18 GO:0016921 pyroglutamyl-peptidase II activity Deleted DEFINITION Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides.
2008-08-18 GO:0004252 serine-type endopeptidase activity Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0004867 serine-type endopeptidase inhibitor activity Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 GO:0005882 intermediate filament Added DEFINITION A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filamentss; and Type V, lamins.
2008-08-18 GO:0008125 pancreatic elastase I activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.
2008-08-18 GO:0008129 actinidain activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'.
2008-08-18 GO:0008130 neutrophil collagenase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
2008-08-18 GO:0008132 pancreatic elastase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin.
2008-08-18 GO:0008133 collagenase activity Added DEFINITION OBSOLETE. Was not defined before being made obsolete.
2008-08-18 GO:0008191 metalloendopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 GO:0008233 peptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2008-08-18 GO:0008234 cysteine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 GO:0008235 metalloexopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0008236 serine-type peptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 GO:0008237 metallopeptidase activity Added DEFINITION Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-08-18 GO:0008238 exopeptidase activity Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
2008-08-18 GO:0008243 plasminogen activator activity Added DEFINITION OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.
2008-08-18 GO:0008319 prenyl protein specific endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008322 Pro-X carboxypeptidase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.
2008-08-18 GO:0008423 bleomycin hydrolase activity Added DEFINITION OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
2008-08-18 GO:0008439 monophenol monooxygenase activator activity Added DEFINITION OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase.
2008-08-18 GO:0008450 O-sialoglycoprotein endopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.
2008-08-18 GO:0008451 X-Pro aminopeptidase activity Added DEFINITION OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.
2008-08-18 GO:0008462 endopeptidase Clp activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs).
2008-08-18 GO:0008464 gamma-glutamyl hydrolase activity Added DEFINITION OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid.
2008-08-18 GO:0008472 metallocarboxypeptidase D activity Added DEFINITION OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid.
2008-08-18 GO:0008487 prenyl-dependent CAAX protease activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008533 astacin activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
2008-08-18 GO:0008581 ubiquitin-specific protease 5 activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.
2008-08-18 GO:0008717 D-alanyl-D-alanine endopeptidase activity Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2008-08-18 GO:0008769 X-His dipeptidase activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides.
2008-08-18 GO:0008846 endopeptidase La activity Added DEFINITION OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP.
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Added SYNONYM G1/S-specific transcription in mitotic cell cycle
2008-08-18 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM G1-specific transcription in mitotic cell cycle
2008-08-18 GO:0000114 regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle>
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Added SYNONYM S-phase-specific transcription in mitotic cell cycle
2008-08-18 GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle
2008-08-18 GO:0008233 peptidase activity Added SYNONYM proteinase activity
2008-08-18 GO:0060277 negative regulation of transcription involved in G1 phase of mitotic cell cycle Added SYNONYM negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Added SYNONYM G2-specific transcription in mitotic cell cycle
2008-08-18 GO:0000116 regulation of transcription involved in G2-phase of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Added SYNONYM G2/M-specific transcription in mitotic cell cycle
2008-08-18 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle Added SYNONYM regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added SYNONYM serine carboxypeptidase activity
2008-08-18 GO:0004298 threonine-type endopeptidase activity Added SYNONYM threonine endopeptidase activity

Relationships

Timestamp GO ID GO Term Name Action Category Detail
2008-08-18 GO:0001509 legumain activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)
2008-08-18 GO:0001509 legumain activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003809 thrombin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003812 alternative-complement-pathway C3/C5 convertase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003813 classical-complement-pathway C3/C5 convertase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003815 complement component C1r activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003815 complement component C1r activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003816 complement component C1s activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003816 complement component C1s activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003817 complement factor D activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003817 complement factor D activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003818 complement factor I activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003818 complement factor I activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004175 endopeptidase activity Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 GO:0004175 endopeptidase activity Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 GO:0004176 ATP-dependent peptidase activity Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 GO:0004176 ATP-dependent peptidase activity Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Deleted RELATION is a GO:0004177 (aminopeptidase activity)
2008-08-18 GO:0004178 leucyl aminopeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted RELATION is a GO:0016284 (alanine aminopeptidase activity)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Deleted RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-08-18 GO:0004179 membrane alanyl aminopeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004182 carboxypeptidase A activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004182 carboxypeptidase A activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004183 carboxypeptidase E activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004183 carboxypeptidase E activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004184 lysine carboxypeptidase activity Deleted RELATION is a GO:0004181 (metallocarboxypeptidase activity)
2008-08-18 GO:0004184 lysine carboxypeptidase activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Deleted RELATION is a GO:0008236 (serine-type peptidase activity)
2008-08-18 GO:0004185 serine-type carboxypeptidase activity Added RELATION is a GO:0070008 (serine-type exopeptidase activity)
2008-08-18 GO:0004186 carboxypeptidase C activity Deleted RELATION is a GO:0004185 (serine-type carboxypeptidase activity)
2008-08-18 GO:0004186 carboxypeptidase C activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004187 carboxypeptidase D activity Deleted RELATION is a GO:0004185 (serine-type carboxypeptidase activity)
2008-08-18 GO:0004187 carboxypeptidase D activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003802 coagulation factor VIIa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003802 coagulation factor VIIa activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003803 coagulation factor IXa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0003803 coagulation factor IXa activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted RELATION is a GO:0030567 (thrombin activator activity)
2008-08-18 GO:0003804 coagulation factor Xa activity Deleted RELATION is a GO:0004252 (serine-type endopeptidase activity)
2008-08-18 GO:0004193 cathepsin E activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004193 cathepsin E activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004194 pepsin A activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004194 pepsin A activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004195 renin activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004195 renin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004196 saccharopepsin activity Deleted RELATION is a GO:0004190 (aspartic-type endopeptidase activity)
2008-08-18 GO:0004196 saccharopepsin activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004213 cathepsin B activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)
2008-08-18 GO:0004213 cathepsin B activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted RELATION is a GO:0008239 (dipeptidyl-peptidase activity)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Deleted RELATION is a GO:0008234 (cysteine-type peptidase activity)
2008-08-18 GO:0004214 dipeptidyl-peptidase I activity Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 GO:0004215 cathepsin H activity Deleted RELATION is a GO:0004197 (cysteine-type endopeptidase activity)

Cross-references

Timestamp GO ID GO Term Name Action Category Detail
2008-08-18 GO:0070005 cysteine-type aminopeptidase activity Added XREF EC:3.4.18
2008-08-18 GO:0070008 serine-type exopeptidase activity Added XREF EC:3.4.21
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