spacer

GO Term History: Displaying 191 audit records for all terms for the date 2007-05-27

From (YYYY-MM-DD):
To (YYYY-MM-DD):
Period:
Category:
Terms:
Limit:
Date Specification

You can specify an explicit date range that you are interested in by setting the "From" and "To" parameters; this will limit the data displayed to those changes that were recorded within that (inclusive) date range.

Alternatively, you can use the "Period" parameter to view the GO term changes that occurred over a specific number of Day(s), Week(s), Month(s) or Year(s) before a specified date.

If you do not enter a "To" date, then the period will be relative to the current date. If, however, you do specify a "To" value, then the "Period" value will display records in the timeframe up to and including that specified date.

Category

You can use this field to specify what types of term changes you are interested in seeing.

Terms

You can enter a list of GO Terms in this field to limit the changes displayed. Please note that only changes made to directly listed terms will be displayed, not term descendants.

Limit

The default number of records returned is 500, however you can increase or decrease this limit. In order to prevent possible browser problems, the maximum upper limit is 10,000.

Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2007-05-27 GO:0016474 sodium ion-transporting V-type ATPase complex Added DEFINITION A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis.
2007-05-27 GO:0033190 solanapyrone synthase activity Added DEFINITION Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A.
2007-05-27 GO:0060133 somatotropin secreting cell development Added DEFINITION The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
2007-05-27 GO:0060126 somatotropin secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
2007-05-27 GO:0033188 sphingomyelin synthase activity Added DEFINITION Catalysis of the reaction: a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
2007-05-27 GO:0051256 mitotic spindle midzone assembly Updated DEFINITION The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of mitosis.
2007-05-27 GO:0060104 surface coat of collagen and cuticulin-based cuticle extracellular matrix Updated DEFINITION An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion.
2007-05-27 GO:0042101 T cell receptor complex Updated DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2007-05-27 GO:0000347 THO complex Updated DEFINITION The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0000445 THO complex part of transcription export complex Added DEFINITION The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0060130 thyroid-stimulating hormone-secreting cell development Added DEFINITION The process whose specific outcome is the progression of a thyroid stimulating hormone secreting cell over time, from its formation to the mature structure. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin.
2007-05-27 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropi hormone secreting cell. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin.
2007-05-27 GO:0033219 urea binding Added DEFINITION Interacting selectively with urea, a water-soluble carboxamide with the structure H2N-CO-NH2.
2007-05-27 GO:0033221 urea-transporting ATPase activity Added DEFINITION Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in).
2007-05-27 GO:0016471 vacuolar proton-transporting V-type ATPase complex Updated DEFINITION A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
2007-05-27 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain Updated DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
2007-05-27 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain Updated DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
2007-05-27 GO:0060118 vestibular receptor cell development Added DEFINITION The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060115 vestibular receptor cell fate commitment Added DEFINITION The process by which a cell becomes committed to become a vestibular receptor cell.
2007-05-27 GO:0060116 vestibular receptor cell morphogenesis Added DEFINITION Any process that alters the mass volume or shape of a vestibular receptor cell.
2007-05-27 GO:0060121 vestibular receptor cell stereocilium organization Added DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells.
2007-05-27 GO:0005891 voltage-gated calcium channel complex Updated DEFINITION A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2007-05-27 GO:0033222 xylose binding Added DEFINITION Interacting selectively with the D- or L-enantiomer of xylose.
2007-05-27 GO:0016035 zeta DNA polymerase complex Updated DEFINITION A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
2007-05-27 GO:0033204 ribonuclease P RNA binding Added DEFINITION Interacting selectively with the RNA subunit of ribonuclease P.
2007-05-27 GO:0009551 secondary plasmodesma Added DEFINITION A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata.
2007-05-27 GO:0010431 seed maturation Added DEFINITION A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.
2007-05-27 GO:0001739 sex chromatin Updated DEFINITION A condensed mass of compacted chromatin that represents an inactivated X chromosome.
2007-05-27 GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex Added DEFINITION A protein complex that possesses single-stranded DNA-dependent DNA helicase activity.
2007-05-27 GO:0016473 sodium ion-transporting F-type ATPase complex Added DEFINITION A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism.
2007-05-27 GO:0016472 sodium ion-transporting two-sector ATPase complex Updated DEFINITION A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis.
2007-05-27 GO:0051257 meiotic spindle midzone assembly Updated DEFINITION The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of meiosis.
2007-05-27 GO:0045259 proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
2007-05-27 GO:0016469 proton-transporting two-sector ATPase complex Updated DEFINITION A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
2007-05-27 GO:0033176 proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.
2007-05-27 GO:0033179 proton-transporting V-type ATPase, V0 domain Added DEFINITION A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.
2007-05-27 GO:0033180 proton-transporting V-type ATPase, V1 domain Added DEFINITION A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.
2007-05-27 GO:0010422 regulation of brassinosteroid biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids.
2007-05-27 GO:0060123 regulation of growth hormone secretion Added DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.
2007-05-27 GO:0033182 regulation of histone ubiquitination Added DEFINITION Any process that modulates the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032107 regulation of response to nutrient levels Added DEFINITION Any process that modulates the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0033217 regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Added DEFINITION Modulation of the frequency, rate or extent of transcription from an from RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions.
2007-05-27 GO:0008231 repressor ecdysone receptor complex Added DEFINITION A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.
2007-05-27 GO:0033195 response to alkyl hydroperoxide Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group.
2007-05-27 GO:0033198 response to ATP Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
2007-05-27 GO:0033194 response to hydroperoxide Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
2007-05-27 GO:0033189 response to vitamin A Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
2007-05-27 GO:0033197 response to vitamin E Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
2007-05-27 GO:0005753 mitochondrial proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the mitochondrial membrane.
2007-05-27 GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core Updated DEFINITION The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.
2007-05-27 GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity Updated DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2007-05-27 GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity Updated DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
2007-05-27 GO:0009327 NAD(P)+ transhydrogenase complex (AB-specific) Added DEFINITION A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified.
2007-05-27 GO:0010423 negative regulation of brassinosteroid biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids.
2007-05-27 GO:0002719 negative regulation of cytokine production involved in immune response Updated DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production during an immune response.
2007-05-27 GO:0060125 negative regulation of growth hormone secretion Added DEFINITION Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.
2007-05-27 GO:0033183 negative regulation of histone ubiquitination Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032108 negative regulation of response to nutrient levels Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0005892 acetylcholine-gated channel complex Added DEFINITION A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily.
2007-05-27 GO:0031618 nuclear pericentric heterochromatin Updated DEFINITION A region of heterochromatin located near the centromere of a chromosome in the nucleus.
2007-05-27 GO:0000446 nucleoplasmic THO complex Added DEFINITION The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0016581 NuRD complex Updated DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2007-05-27 GO:0009654 photosystem II oxygen evolving complex Added DEFINITION A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ).
2007-05-27 GO:0016409 palmitoyltransferase activity Updated DEFINITION Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.
2007-05-27 GO:0007202 activation of phospholipase C activity Updated DEFINITION The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2007-05-27 GO:0045260 plasma membrane proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the plasma membrane.
2007-05-27 GO:0033181 plasma membrane proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex found in the plasma membrane.
2007-05-27 GO:0000222 plasma membrane proton-transporting V-type ATPase, V0 domain Added DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
2007-05-27 GO:0000223 plasma membrane proton-transporting V-type ATPase, V1 domain Added DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
2007-05-27 GO:0009546 plasmodesmatal cytoplasmic sleeve Added DEFINITION The space between the plasma membrane and the desmotubule of a plasmodesma.
2007-05-27 GO:0009510 plasmodesmatal desmotubule Updated DEFINITION A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell.
2007-05-27 GO:0009548 plasmodesmatal plasma membrane Added DEFINITION The portion of the plasma membrane surrounding a plasmodesma.
2007-05-27 GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate).
2007-05-27 GO:0033184 positive regulation of histone ubiquitination Added DEFINITION Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032109 positive regulation of response to nutrient levels Added DEFINITION Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0060134 prepulse inhibition Added DEFINITION The process by which a startle magnitude is reduced when the startling stimulus is preceeded by a low-intensity prepulse.
2007-05-27 GO:0009550 primary plasmodesma Added DEFINITION A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis.
2007-05-27 GO:0060132 prolactin secreting cell development Added DEFINITION The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin.
2007-05-27 GO:0060127 prolactin secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin.
2007-05-27 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain Added DEFINITION A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.
2007-05-27 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain Added DEFINITION A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.
2007-05-27 GO:0008932 lytic endotransglycosylase activity Added DEFINITION Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends.
2007-05-27 GO:0008933 lytic transglycosylase activity Added DEFINITION Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.
2007-05-27 GO:0033191 macrophomate synthase activity Added DEFINITION Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate.
2007-05-27 GO:0016615 malate dehydrogenase activity Updated DEFINITION Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
2007-05-27 GO:0020036 Maurer's cleft Added DEFINITION A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton.
2007-05-27 GO:0008327 methyl-CpG binding Updated DEFINITION Interacting selectively with a methylated cytosine/guanine dinucleotide.
2007-05-27 GO:0010428 methyl-CpNpG binding Added DEFINITION Interacting selectively with a methylated cytosine/unspecified/guanine trinucleotide.
2007-05-27 GO:0010429 methyl-CpNpN binding Added DEFINITION Interacting selectively with a methylated cytosine/unspecified/unspecified trinucleotide.
2007-05-27 GO:0000818 nuclear MIS12/MIND complex Updated DEFINITION A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. The MIND complex is nuclear localized as the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
2007-05-27 GO:0000444 MIS12/MIND type complex Added DEFINITION A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. In S. cerevisiae, this complex consists of Mtw1p, Nnf1p, Nsl1p, and Dsn1.
2007-05-27 GO:0009377 obsolete HslUV protease activity Added DEFINITION A protein complex that possesses ATP-dependent protease activity; as characterized in E. coli, the complex contains six identical subunits of both ClpY and ClpQ that self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, to form a dumbbell shape complex.
2007-05-27 GO:0009376 HslUV protease complex Added DEFINITION A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex.
2007-05-27 GO:0010421 hydrogen peroxide-mediated programmed cell death Added DEFINITION Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes.
2007-05-27 GO:0008262 importin-alpha export receptor activity Added DEFINITION Interacting selectively with importin-alpha to mediate its transfer across the nuclear membrane to the cytoplasm.
2007-05-27 GO:0060119 inner ear receptor cell development Added DEFINITION The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060113 inner ear receptor cell differentiation Updated DEFINITION The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.
2007-05-27 GO:0060120 inner ear receptor cell fate commitment Added DEFINITION The process by which a cell becomes committed to become an inner ear receptor cell.
2007-05-27 GO:0060122 inner ear receptor stereocilium organization Added DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
2007-05-27 GO:0033199 obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
2007-05-27 GO:0033200 inositol heptakisphosphate 5-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
2007-05-27 GO:0033187 obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
2007-05-27 GO:0033212 iron assimilation Added DEFINITION A process by which iron is solubilized and transported into a cell.
2007-05-27 GO:0033213 iron assimilation by capture and transport Added DEFINITION A process by which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell.
2007-05-27 GO:0033214 iron assimilation by chelation and transport Added DEFINITION A process by which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.
2007-05-27 GO:0033215 iron assimilation by reduction and transport Added DEFINITION A process by which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.
2007-05-27 GO:0033210 leptin-mediated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor.
2007-05-27 GO:0033193 Lsd1/2 complex Added DEFINITION A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
2007-05-27 GO:0046611 lysosomal proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.
2007-05-27 GO:0046610 lysosomal proton-transporting V-type ATPase, V0 domain Added DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
2007-05-27 GO:0046612 lysosomal proton-transporting V-type ATPase, V1 domain Added DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
2007-05-27 GO:0032835 glomerulus development Added DEFINITION The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
2007-05-27 GO:0006096 glycolytic process Updated DEFINITION The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle.
2007-05-27 GO:0009379 Holliday junction helicase complex Added DEFINITION A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA .
2007-05-27 GO:0048476 Holliday junction resolvase complex Updated DEFINITION A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage.
2007-05-27 GO:0033174 chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) Added DEFINITION The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the choroplast thylakoid membrane when the entire ATP synthase is assembled. The choroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.
2007-05-27 GO:0033175 chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) Added DEFINITION All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins.
2007-05-27 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2007-05-27 GO:0033206 meiotic cytokinesis Added DEFINITION The processes resulting in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.
2007-05-27 GO:0033205 cell cycle cytokinesis Added DEFINITION The set of processes that occur in the context of cell cycle progression and result in the division of the cytoplasm of a cell and its separation into two daughter cells.
2007-05-27 GO:0010424 DNA methylation on cytosine within a CG sequence Added DEFINITION The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule.
2007-05-27 GO:0010425 DNA methylation on cytosine within a CNG sequence Added DEFINITION The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide.
2007-05-27 GO:0010426 DNA methylation on cytosine within a CHH sequence Added DEFINITION The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNN sequence in a DNA molecule. N stands for any nucleotide.
2007-05-27 GO:0005856 cytoskeleton Updated DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2007-05-27 GO:0042729 DASH complex Updated DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2007-05-27 GO:0033203 DNA helicase A complex Added DEFINITION A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.
2007-05-27 GO:0003678 DNA helicase activity Updated DEFINITION Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix.
2007-05-27 GO:0033202 DNA helicase complex Added DEFINITION A protein complex that possesses DNA helicase activity.
2007-05-27 GO:0009360 DNA polymerase III complex Added DEFINITION A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.
2007-05-27 GO:0009355 DNA polymerase V complex Added DEFINITION A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis.
2007-05-27 GO:0006269 DNA replication, synthesis of RNA primer Updated DEFINITION The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
2007-05-27 GO:0033185 dolichol-phosphate-mannose synthase complex Added DEFINITION A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.
2007-05-27 GO:0008622 epsilon DNA polymerase complex Updated DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2007-05-27 GO:0010430 fatty acid omega-oxidation Added DEFINITION The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the omega-carbon in a fatty acid (the carbon furthest in the alkyl chain from the carboxylic acid) is progressively oxidized first to an alcohol and then to a carboxylic acid, creating a molecule with a carboxylic acid on both ends.
2007-05-27 GO:0033196 tryparedoxin peroxidase activity Added DEFINITION Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O.
2007-05-27 GO:0033209 tumor necrosis factor-mediated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2007-05-27 GO:0033208 UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity Added DEFINITION Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide.
2007-05-27 GO:0033216 ferric iron import Added DEFINITION The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle.
2007-05-27 GO:0042106 gamma-delta T cell receptor complex Added DEFINITION A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.
2007-05-27 GO:0007514 garland cell differentiation Updated DEFINITION The process whereby a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis.
2007-05-27 GO:0009356 aminodeoxychorismate synthase complex Added DEFINITION A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity.
2007-05-27 GO:0055048 anastral spindle assembly Added DEFINITION The formation of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins.
2007-05-27 GO:0033167 ARC complex Updated DEFINITION A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
2007-05-27 GO:0055049 astral spindle assembly Added DEFINITION The formation of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes.
2007-05-27 GO:0055050 astral spindle assembly involved in male meiosis Added DEFINITION The formation of the astral spindle in male meiotic cells.
2007-05-27 GO:0043190 ATP-binding cassette (ABC) transporter complex Updated DEFINITION A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
2007-05-27 GO:0055051 ATP-binding cassette (ABC) transporter complex, integrated substrate binding Added DEFINITION A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a "half transporter". Two "half-transporters" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
2007-05-27 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Added DEFINITION A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
2007-05-27 GO:0008282 ATP-sensitive potassium channel complex Added DEFINITION A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity.
2007-05-27 GO:0060117 auditory receptor cell development Added DEFINITION The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060088 auditory receptor cell stereocilium organization Updated DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
2007-05-27 GO:0033207 beta-1,4-N-acetylgalactosaminyltransferase activity Added DEFINITION Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage.
2007-05-27 GO:0010432 bract development Added DEFINITION The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence.
2007-05-27 GO:0010434 bract formation Added DEFINITION The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence.
2007-05-27 GO:0010433 bract morphogenesis Added DEFINITION The process by which the anatomical structure of bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. Morphogenesis pertains to the creation of form.
2007-05-27 GO:0033186 CAF-1 complex Added DEFINITION A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.
2007-05-27 GO:0009931 calcium-dependent protein serine/threonine kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions.
2007-05-27 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity Updated DEFINITION Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions.
2007-05-27 GO:0004683 calmodulin-dependent protein kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin.
2007-05-27 GO:0033192 calmodulin-dependent protein phosphatase activity Added DEFINITION Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
2007-05-27 GO:0006755 obsolete carbamoyl phosphate-ADP transphosphorylation Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2007-05-27 GO:0005951 carbamoyl-phosphate synthase complex Updated DEFINITION A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
2007-05-27 GO:0031668 cellular response to extracellular stimulus Added DEFINITION A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
2007-05-27 GO:0005721 pericentric heterochromatin Updated DEFINITION A region of heterochromatin located near the centromere of a chromosome.
2007-05-27 GO:0045320 chloroplast proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation.
2007-05-27 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex Updated DEFINITION A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits.
2007-05-27 GO:0043723 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity Added DEFINITION Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NH3.
2007-05-27 GO:0043729 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2007-05-27 GO:0043724 2-keto-3-deoxygalactonate aldolase activity Added DEFINITION Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate.
2007-05-27 GO:0043725 2-keto-3-deoxygluconate aldolase activity Added DEFINITION Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate.
2007-05-27 GO:0043728 2-keto-4-methylthiobutyrate aminotransferase activity Added DEFINITION Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine.
2007-05-27 GO:0043727 5-amino-4-imidazole carboxylate lyase activity Added DEFINITION Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate.
2007-05-27 GO:0043726 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity Added DEFINITION Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate.
2007-05-27 GO:0043730 5-ureido-4-imidazole carboxylate hydrolase activity Added DEFINITION Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2.
2007-05-27 GO:0043731 6-hydroxynicotinate 3-monooxygenase activity Added DEFINITION Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD.
2007-05-27 GO:0043732 6-hydroxynicotinate dehydrogenase activity Added DEFINITION Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O.
2007-05-27 GO:0010427 abscisic acid binding Added DEFINITION Interacting selectively with abscisic acid, plant hormones that regulate aspects of plant growth.
2007-05-27 GO:0008232 activator ecdysone receptor complex Added DEFINITION A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.
2007-05-27 GO:0033211 adiponectin-activated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor.
2007-05-27 GO:0060131 corticotropin hormone secreting cell development Added DEFINITION The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2007-05-27 GO:0060128 corticotropin hormone secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2007-05-27 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Updated DEFINITION A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.
2007-05-27 GO:0033201 alpha-1,4-glucan synthase activity Added DEFINITION Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP.
2007-05-27 GO:0042105 alpha-beta T cell receptor complex Added DEFINITION A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.
2007-05-27 GO:0033218 amide binding Added DEFINITION Interacting selectively with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
2007-05-27 GO:0033220 amide-transporting ATPase activity Added DEFINITION Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in).
2007-05-27 GO:0009971 anastral spindle assembly involved in male meiosis Updated DEFINITION The formation of the anastral spindle in male meiotic cells.
2007-05-27 GO:0003844 1,4-alpha-glucan branching enzyme activity Updated DEFINITION Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
2007-05-27 GO:0005943 phosphatidylinositol 3-kinase complex, class IA Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is a member of a family of related proteins often called p85 proteins.
2007-05-27 GO:0005944 phosphatidylinositol 3-kinase complex, class IB Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes.
2007-05-27 GO:0060124 positive regulation of growth hormone secretion Added DEFINITION Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2007-05-27 GO:0016474 sodium ion-transporting V-type ATPase complex Added DEFINITION A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis.
2007-05-27 GO:0033190 solanapyrone synthase activity Added DEFINITION Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A.
2007-05-27 GO:0060133 somatotropin secreting cell development Added DEFINITION The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
2007-05-27 GO:0060126 somatotropin secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
2007-05-27 GO:0033188 sphingomyelin synthase activity Added DEFINITION Catalysis of the reaction: a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
2007-05-27 GO:0051256 mitotic spindle midzone assembly Updated DEFINITION The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of mitosis.
2007-05-27 GO:0060104 surface coat of collagen and cuticulin-based cuticle extracellular matrix Updated DEFINITION An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion.
2007-05-27 GO:0042101 T cell receptor complex Updated DEFINITION A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2007-05-27 GO:0000347 THO complex Updated DEFINITION The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0000445 THO complex part of transcription export complex Added DEFINITION The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0060130 thyroid-stimulating hormone-secreting cell development Added DEFINITION The process whose specific outcome is the progression of a thyroid stimulating hormone secreting cell over time, from its formation to the mature structure. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin.
2007-05-27 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropi hormone secreting cell. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin.
2007-05-27 GO:0033219 urea binding Added DEFINITION Interacting selectively with urea, a water-soluble carboxamide with the structure H2N-CO-NH2.
2007-05-27 GO:0033221 urea-transporting ATPase activity Added DEFINITION Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in).
2007-05-27 GO:0016471 vacuolar proton-transporting V-type ATPase complex Updated DEFINITION A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
2007-05-27 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain Updated DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
2007-05-27 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain Updated DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
2007-05-27 GO:0060118 vestibular receptor cell development Added DEFINITION The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060115 vestibular receptor cell fate commitment Added DEFINITION The process by which a cell becomes committed to become a vestibular receptor cell.
2007-05-27 GO:0060116 vestibular receptor cell morphogenesis Added DEFINITION Any process that alters the mass volume or shape of a vestibular receptor cell.
2007-05-27 GO:0060121 vestibular receptor cell stereocilium organization Added DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells.
2007-05-27 GO:0005891 voltage-gated calcium channel complex Updated DEFINITION A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2007-05-27 GO:0033222 xylose binding Added DEFINITION Interacting selectively with the D- or L-enantiomer of xylose.
2007-05-27 GO:0016035 zeta DNA polymerase complex Updated DEFINITION A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
2007-05-27 GO:0033204 ribonuclease P RNA binding Added DEFINITION Interacting selectively with the RNA subunit of ribonuclease P.
2007-05-27 GO:0009551 secondary plasmodesma Added DEFINITION A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata.
2007-05-27 GO:0010431 seed maturation Added DEFINITION A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.
2007-05-27 GO:0001739 sex chromatin Updated DEFINITION A condensed mass of compacted chromatin that represents an inactivated X chromosome.
2007-05-27 GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex Added DEFINITION A protein complex that possesses single-stranded DNA-dependent DNA helicase activity.
2007-05-27 GO:0016473 sodium ion-transporting F-type ATPase complex Added DEFINITION A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism.
2007-05-27 GO:0016472 sodium ion-transporting two-sector ATPase complex Updated DEFINITION A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis.
2007-05-27 GO:0051257 meiotic spindle midzone assembly Updated DEFINITION The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of meiosis.
2007-05-27 GO:0045259 proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
2007-05-27 GO:0016469 proton-transporting two-sector ATPase complex Updated DEFINITION A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
2007-05-27 GO:0033176 proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.
2007-05-27 GO:0033179 proton-transporting V-type ATPase, V0 domain Added DEFINITION A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.
2007-05-27 GO:0033180 proton-transporting V-type ATPase, V1 domain Added DEFINITION A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.
2007-05-27 GO:0010422 regulation of brassinosteroid biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids.
2007-05-27 GO:0060123 regulation of growth hormone secretion Added DEFINITION Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.
2007-05-27 GO:0033182 regulation of histone ubiquitination Added DEFINITION Any process that modulates the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032107 regulation of response to nutrient levels Added DEFINITION Any process that modulates the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0033217 regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Added DEFINITION Modulation of the frequency, rate or extent of transcription from an from RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions.
2007-05-27 GO:0008231 repressor ecdysone receptor complex Added DEFINITION A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.
2007-05-27 GO:0033195 response to alkyl hydroperoxide Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group.
2007-05-27 GO:0033198 response to ATP Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
2007-05-27 GO:0033194 response to hydroperoxide Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
2007-05-27 GO:0033189 response to vitamin A Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
2007-05-27 GO:0033197 response to vitamin E Added DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
2007-05-27 GO:0005753 mitochondrial proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the mitochondrial membrane.
2007-05-27 GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core Updated DEFINITION The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.
2007-05-27 GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity Updated DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2007-05-27 GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity Updated DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
2007-05-27 GO:0009327 NAD(P)+ transhydrogenase complex (AB-specific) Added DEFINITION A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified.
2007-05-27 GO:0010423 negative regulation of brassinosteroid biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids.
2007-05-27 GO:0002719 negative regulation of cytokine production involved in immune response Updated DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production during an immune response.
2007-05-27 GO:0060125 negative regulation of growth hormone secretion Added DEFINITION Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.
2007-05-27 GO:0033183 negative regulation of histone ubiquitination Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032108 negative regulation of response to nutrient levels Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0005892 acetylcholine-gated channel complex Added DEFINITION A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily.
2007-05-27 GO:0031618 nuclear pericentric heterochromatin Updated DEFINITION A region of heterochromatin located near the centromere of a chromosome in the nucleus.
2007-05-27 GO:0000446 nucleoplasmic THO complex Added DEFINITION The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
2007-05-27 GO:0016581 NuRD complex Updated DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2007-05-27 GO:0009654 photosystem II oxygen evolving complex Added DEFINITION A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ).
2007-05-27 GO:0016409 palmitoyltransferase activity Updated DEFINITION Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.
2007-05-27 GO:0007202 activation of phospholipase C activity Updated DEFINITION The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2007-05-27 GO:0045260 plasma membrane proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the plasma membrane.
2007-05-27 GO:0033181 plasma membrane proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex found in the plasma membrane.
2007-05-27 GO:0000222 plasma membrane proton-transporting V-type ATPase, V0 domain Added DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.
2007-05-27 GO:0000223 plasma membrane proton-transporting V-type ATPase, V1 domain Added DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.
2007-05-27 GO:0009546 plasmodesmatal cytoplasmic sleeve Added DEFINITION The space between the plasma membrane and the desmotubule of a plasmodesma.
2007-05-27 GO:0009510 plasmodesmatal desmotubule Updated DEFINITION A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell.
2007-05-27 GO:0009548 plasmodesmatal plasma membrane Added DEFINITION The portion of the plasma membrane surrounding a plasmodesma.
2007-05-27 GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate).
2007-05-27 GO:0033184 positive regulation of histone ubiquitination Added DEFINITION Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein.
2007-05-27 GO:0032109 positive regulation of response to nutrient levels Added DEFINITION Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.
2007-05-27 GO:0060134 prepulse inhibition Added DEFINITION The process by which a startle magnitude is reduced when the startling stimulus is preceeded by a low-intensity prepulse.
2007-05-27 GO:0009550 primary plasmodesma Added DEFINITION A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis.
2007-05-27 GO:0060132 prolactin secreting cell development Added DEFINITION The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin.
2007-05-27 GO:0060127 prolactin secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin.
2007-05-27 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain Added DEFINITION A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.
2007-05-27 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain Added DEFINITION A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.
2007-05-27 GO:0008932 lytic endotransglycosylase activity Added DEFINITION Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends.
2007-05-27 GO:0008933 lytic transglycosylase activity Added DEFINITION Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.
2007-05-27 GO:0033191 macrophomate synthase activity Added DEFINITION Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate.
2007-05-27 GO:0016615 malate dehydrogenase activity Updated DEFINITION Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
2007-05-27 GO:0020036 Maurer's cleft Added DEFINITION A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton.
2007-05-27 GO:0008327 methyl-CpG binding Updated DEFINITION Interacting selectively with a methylated cytosine/guanine dinucleotide.
2007-05-27 GO:0010428 methyl-CpNpG binding Added DEFINITION Interacting selectively with a methylated cytosine/unspecified/guanine trinucleotide.
2007-05-27 GO:0010429 methyl-CpNpN binding Added DEFINITION Interacting selectively with a methylated cytosine/unspecified/unspecified trinucleotide.
2007-05-27 GO:0000818 nuclear MIS12/MIND complex Updated DEFINITION A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. The MIND complex is nuclear localized as the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
2007-05-27 GO:0000444 MIS12/MIND type complex Added DEFINITION A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. In S. cerevisiae, this complex consists of Mtw1p, Nnf1p, Nsl1p, and Dsn1.
2007-05-27 GO:0009377 obsolete HslUV protease activity Added DEFINITION A protein complex that possesses ATP-dependent protease activity; as characterized in E. coli, the complex contains six identical subunits of both ClpY and ClpQ that self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, to form a dumbbell shape complex.
2007-05-27 GO:0009376 HslUV protease complex Added DEFINITION A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex.
2007-05-27 GO:0010421 hydrogen peroxide-mediated programmed cell death Added DEFINITION Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes.
2007-05-27 GO:0008262 importin-alpha export receptor activity Added DEFINITION Interacting selectively with importin-alpha to mediate its transfer across the nuclear membrane to the cytoplasm.
2007-05-27 GO:0060119 inner ear receptor cell development Added DEFINITION The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060113 inner ear receptor cell differentiation Updated DEFINITION The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.
2007-05-27 GO:0060120 inner ear receptor cell fate commitment Added DEFINITION The process by which a cell becomes committed to become an inner ear receptor cell.
2007-05-27 GO:0060122 inner ear receptor stereocilium organization Added DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
2007-05-27 GO:0033199 obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
2007-05-27 GO:0033200 inositol heptakisphosphate 5-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
2007-05-27 GO:0033187 obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity Added DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.
2007-05-27 GO:0033212 iron assimilation Added DEFINITION A process by which iron is solubilized and transported into a cell.
2007-05-27 GO:0033213 iron assimilation by capture and transport Added DEFINITION A process by which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell.
2007-05-27 GO:0033214 iron assimilation by chelation and transport Added DEFINITION A process by which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.
2007-05-27 GO:0033215 iron assimilation by reduction and transport Added DEFINITION A process by which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.
2007-05-27 GO:0033210 leptin-mediated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor.
2007-05-27 GO:0033193 Lsd1/2 complex Added DEFINITION A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
2007-05-27 GO:0046611 lysosomal proton-transporting V-type ATPase complex Added DEFINITION A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.
2007-05-27 GO:0046610 lysosomal proton-transporting V-type ATPase, V0 domain Added DEFINITION The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
2007-05-27 GO:0046612 lysosomal proton-transporting V-type ATPase, V1 domain Added DEFINITION The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.
2007-05-27 GO:0032835 glomerulus development Added DEFINITION The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
2007-05-27 GO:0006096 glycolytic process Updated DEFINITION The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle.
2007-05-27 GO:0009379 Holliday junction helicase complex Added DEFINITION A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA .
2007-05-27 GO:0048476 Holliday junction resolvase complex Updated DEFINITION A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage.
2007-05-27 GO:0033174 chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) Added DEFINITION The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the choroplast thylakoid membrane when the entire ATP synthase is assembled. The choroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.
2007-05-27 GO:0033175 chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) Added DEFINITION All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins.
2007-05-27 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2007-05-27 GO:0033206 meiotic cytokinesis Added DEFINITION The processes resulting in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.
2007-05-27 GO:0033205 cell cycle cytokinesis Added DEFINITION The set of processes that occur in the context of cell cycle progression and result in the division of the cytoplasm of a cell and its separation into two daughter cells.
2007-05-27 GO:0010424 DNA methylation on cytosine within a CG sequence Added DEFINITION The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule.
2007-05-27 GO:0010425 DNA methylation on cytosine within a CNG sequence Added DEFINITION The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide.
2007-05-27 GO:0010426 DNA methylation on cytosine within a CHH sequence Added DEFINITION The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNN sequence in a DNA molecule. N stands for any nucleotide.
2007-05-27 GO:0005856 cytoskeleton Updated DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2007-05-27 GO:0042729 DASH complex Updated DEFINITION A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role spindle attachment, chromosome segregation and spindle stability.
2007-05-27 GO:0033203 DNA helicase A complex Added DEFINITION A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.
2007-05-27 GO:0003678 DNA helicase activity Updated DEFINITION Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix.
2007-05-27 GO:0033202 DNA helicase complex Added DEFINITION A protein complex that possesses DNA helicase activity.
2007-05-27 GO:0009360 DNA polymerase III complex Added DEFINITION A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.
2007-05-27 GO:0009355 DNA polymerase V complex Added DEFINITION A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis.
2007-05-27 GO:0006269 DNA replication, synthesis of RNA primer Updated DEFINITION The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
2007-05-27 GO:0033185 dolichol-phosphate-mannose synthase complex Added DEFINITION A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.
2007-05-27 GO:0008622 epsilon DNA polymerase complex Updated DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2007-05-27 GO:0010430 fatty acid omega-oxidation Added DEFINITION The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the omega-carbon in a fatty acid (the carbon furthest in the alkyl chain from the carboxylic acid) is progressively oxidized first to an alcohol and then to a carboxylic acid, creating a molecule with a carboxylic acid on both ends.
2007-05-27 GO:0033196 tryparedoxin peroxidase activity Added DEFINITION Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O.
2007-05-27 GO:0033209 tumor necrosis factor-mediated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2007-05-27 GO:0033208 UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity Added DEFINITION Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide.
2007-05-27 GO:0033216 ferric iron import Added DEFINITION The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle.
2007-05-27 GO:0042106 gamma-delta T cell receptor complex Added DEFINITION A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.
2007-05-27 GO:0007514 garland cell differentiation Updated DEFINITION The process whereby a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis.
2007-05-27 GO:0009356 aminodeoxychorismate synthase complex Added DEFINITION A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity.
2007-05-27 GO:0055048 anastral spindle assembly Added DEFINITION The formation of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins.
2007-05-27 GO:0033167 ARC complex Updated DEFINITION A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
2007-05-27 GO:0055049 astral spindle assembly Added DEFINITION The formation of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes.
2007-05-27 GO:0055050 astral spindle assembly involved in male meiosis Added DEFINITION The formation of the astral spindle in male meiotic cells.
2007-05-27 GO:0043190 ATP-binding cassette (ABC) transporter complex Updated DEFINITION A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
2007-05-27 GO:0055051 ATP-binding cassette (ABC) transporter complex, integrated substrate binding Added DEFINITION A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a "half transporter". Two "half-transporters" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
2007-05-27 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Added DEFINITION A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
2007-05-27 GO:0008282 ATP-sensitive potassium channel complex Added DEFINITION A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity.
2007-05-27 GO:0060117 auditory receptor cell development Added DEFINITION The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2007-05-27 GO:0060088 auditory receptor cell stereocilium organization Updated DEFINITION A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
2007-05-27 GO:0033207 beta-1,4-N-acetylgalactosaminyltransferase activity Added DEFINITION Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage.
2007-05-27 GO:0010432 bract development Added DEFINITION The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence.
2007-05-27 GO:0010434 bract formation Added DEFINITION The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence.
2007-05-27 GO:0010433 bract morphogenesis Added DEFINITION The process by which the anatomical structure of bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. Morphogenesis pertains to the creation of form.
2007-05-27 GO:0033186 CAF-1 complex Added DEFINITION A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.
2007-05-27 GO:0009931 calcium-dependent protein serine/threonine kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions.
2007-05-27 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity Updated DEFINITION Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions.
2007-05-27 GO:0004683 calmodulin-dependent protein kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin.
2007-05-27 GO:0033192 calmodulin-dependent protein phosphatase activity Added DEFINITION Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
2007-05-27 GO:0006755 obsolete carbamoyl phosphate-ADP transphosphorylation Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2007-05-27 GO:0005951 carbamoyl-phosphate synthase complex Updated DEFINITION A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
2007-05-27 GO:0031668 cellular response to extracellular stimulus Added DEFINITION A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
2007-05-27 GO:0005721 pericentric heterochromatin Updated DEFINITION A region of heterochromatin located near the centromere of a chromosome.
2007-05-27 GO:0045320 chloroplast proton-transporting ATP synthase complex Updated DEFINITION A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation.
2007-05-27 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex Updated DEFINITION A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits.
2007-05-27 GO:0043723 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity Added DEFINITION Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NH3.
2007-05-27 GO:0043729 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity Added DEFINITION Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.
2007-05-27 GO:0043724 2-keto-3-deoxygalactonate aldolase activity Added DEFINITION Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate.
2007-05-27 GO:0043725 2-keto-3-deoxygluconate aldolase activity Added DEFINITION Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate.
2007-05-27 GO:0043728 2-keto-4-methylthiobutyrate aminotransferase activity Added DEFINITION Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine.
2007-05-27 GO:0043727 5-amino-4-imidazole carboxylate lyase activity Added DEFINITION Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate.
2007-05-27 GO:0043726 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity Added DEFINITION Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate.
2007-05-27 GO:0043730 5-ureido-4-imidazole carboxylate hydrolase activity Added DEFINITION Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2.
2007-05-27 GO:0043731 6-hydroxynicotinate 3-monooxygenase activity Added DEFINITION Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD.
2007-05-27 GO:0043732 6-hydroxynicotinate dehydrogenase activity Added DEFINITION Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O.
2007-05-27 GO:0010427 abscisic acid binding Added DEFINITION Interacting selectively with abscisic acid, plant hormones that regulate aspects of plant growth.
2007-05-27 GO:0008232 activator ecdysone receptor complex Added DEFINITION A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.
2007-05-27 GO:0033211 adiponectin-activated signaling pathway Added DEFINITION A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor.
2007-05-27 GO:0060131 corticotropin hormone secreting cell development Added DEFINITION The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2007-05-27 GO:0060128 corticotropin hormone secreting cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin.
2007-05-27 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Updated DEFINITION A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.
2007-05-27 GO:0033201 alpha-1,4-glucan synthase activity Added DEFINITION Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP.
2007-05-27 GO:0042105 alpha-beta T cell receptor complex Added DEFINITION A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.
2007-05-27 GO:0033218 amide binding Added DEFINITION Interacting selectively with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
2007-05-27 GO:0033220 amide-transporting ATPase activity Added DEFINITION Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in).
2007-05-27 GO:0009971 anastral spindle assembly involved in male meiosis Updated DEFINITION The formation of the anastral spindle in male meiotic cells.
2007-05-27 GO:0003844 1,4-alpha-glucan branching enzyme activity Updated DEFINITION Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
2007-05-27 GO:0005943 phosphatidylinositol 3-kinase complex, class IA Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is a member of a family of related proteins often called p85 proteins.
2007-05-27 GO:0005944 phosphatidylinositol 3-kinase complex, class IB Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes.
2007-05-27 GO:0060124 positive regulation of growth hormone secretion Added DEFINITION Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells.
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
101ms