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GO Term History: Displaying 125 audit records for all terms for the date 2006-09-19

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2006-09-19 GO:0048245 eosinophil chemotaxis Updated DEFINITION The movement of an eosinophil in response to an external stimulus.
2006-09-19 GO:0032256 establishment of dense core granule localization Added DEFINITION The directed movement of a dense core granule to a specific location.
2006-09-19 GO:0032254 establishment of secretory granule localization Added DEFINITION The directed movement of a secretory granule to a specific location.
2006-09-19 GO:0035101 FACT complex Updated DEFINITION An abundant nuclear complex, which was identified as a chromatin-specific factor required for transcription elongation on chromatin templates. In S. cerevisiae, the complex is composed of three proteins: Spt16 (120 kDa), Pob3 (63 kDa), and Nhp6 (11 kDa). FACT subunits are highly conserved among eukaryotes. However, in metazoans the Pob3 and Nhp6 orthologs are fused to form the SSRP1 protein.
2006-09-19 GO:0001771 immunological synapse formation Updated DEFINITION The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
2006-09-19 GO:0046631 alpha-beta T cell activation Updated DEFINITION The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2006-09-19 GO:0019732 antifungal humoral response Updated DEFINITION An immune response against a fungus mediated through a body fluid.
2006-09-19 GO:0006966 antifungal humoral response (sensu Protostomia) Updated DEFINITION An immune response against a fungus mediated through a body fluid. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317).
2006-09-19 GO:0019734 antifungal humoral response (sensu Vertebrata) Updated DEFINITION An immune response against a fungus mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).
2006-09-19 GO:0019882 antigen processing and presentation Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0019883 antigen processing and presentation of endogenous antigen Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0004422 hypoxanthine phosphoribosyltransferase activity Updated DEFINITION Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
2006-09-19 GO:0006955 immune response Updated DEFINITION Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2006-09-19 GO:0016064 immunoglobulin mediated immune response Updated DEFINITION An immune response mediated by immunoglobulins, whether cell-bound or in solution.
2006-09-19 GO:0048305 immunoglobulin secretion Updated DEFINITION The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.
2006-09-19 GO:0012504 induction of non-apoptotic programmed cell death by other organism Added DEFINITION A process which directly activates any of the steps required for non-apoptotic programmed cell death in another organism.
2006-09-19 GO:0045321 leukocyte activation Updated DEFINITION A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030595 leukocyte chemotaxis Updated DEFINITION The movement of a leukocyte in response to an external stimulus.
2006-09-19 GO:0043299 leukocyte degranulation Updated DEFINITION The regulated exocytosis of secretory granules by a leukocyte.
2006-09-19 GO:0001776 leukocyte homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0001909 leukocyte mediated cytotoxicity Updated DEFINITION The directed killing of a target cell by a leukocyte.
2006-09-19 GO:0050900 leukocyte migration Updated DEFINITION The movement of leukocytes within or between different tissues and organs of the body.
2006-09-19 GO:0048542 lymph gland development Updated DEFINITION The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656).
2006-09-19 GO:0042116 macrophage activation Updated DEFINITION A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0048246 macrophage chemotaxis Updated DEFINITION The movement of a macrophage in response to an external stimulus.
2006-09-19 GO:0032257 maintenance of dense core granule location Added DEFINITION The processes by which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere.
2006-09-19 GO:0032255 maintenance of secretory granule location Added DEFINITION The processes by which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere.
2006-09-19 GO:0045283 fumarate reductase complex Updated DEFINITION A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
2006-09-19 GO:0045284 plasma membrane fumarate reductase complex Updated DEFINITION A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2006-09-19 GO:0046629 gamma-delta T cell activation Updated DEFINITION The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2006-09-19 GO:0021930 cerebellar granule cell precursor proliferation Updated DEFINITION The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-09-19 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I Updated DEFINITION The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
2006-09-19 GO:0019884 antigen processing and presentation of exogenous antigen Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Updated DEFINITION The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
2006-09-19 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Updated DEFINITION The process by which an antigen-presenting cell expresses an peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
2006-09-19 GO:0000400 four-way junction DNA binding Updated DEFINITION Interacting selectively with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
2006-09-19 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0045281 succinate dehydrogenase complex Updated DEFINITION A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones.
2006-09-19 GO:0045282 plasma membrane succinate dehydrogenase complex Updated DEFINITION A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2006-09-19 GO:0043029 T cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0048002 antigen processing and presentation of peptide antigen Updated DEFINITION The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
2006-09-19 GO:0048006 antigen processing and presentation, endogenous lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0045058 T cell selection Updated DEFINITION The process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
2006-09-19 GO:0042088 T-helper 1 type immune response Added DEFINITION An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
2006-09-19 GO:0042092 type 2 immune response Added DEFINITION An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.
2006-09-19 GO:0032203 telomere formation via telomerase Updated DEFINITION The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase.
2006-09-19 GO:0016068 type I hypersensitivity Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2006-09-19 GO:0001795 type IIb hypersensitivity Updated DEFINITION An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
2006-09-19 GO:0000403 Y-form DNA binding Updated DEFINITION Interacting selectively with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
2006-09-19 GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0050851 antigen receptor-mediated signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.
2006-09-19 GO:0001782 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0019724 B cell mediated immunity Updated DEFINITION Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
2006-09-19 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.
2006-09-19 GO:0043367 CD4-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
2006-09-19 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.
2006-09-19 GO:0043374 CD8-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
2006-09-19 GO:0043375 CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.
2006-09-19 GO:0045123 cellular extravasation Updated DEFINITION The migration of leukocytes from the blood vessels into the surrounding tissue.
2006-09-19 GO:0032258 CVT pathway Added DEFINITION A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast.
2006-09-19 GO:0001816 cytokine production Updated DEFINITION The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2006-09-19 GO:0042742 defense response to bacterium Updated DEFINITION Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2006-09-19 GO:0009816 defense response to bacterium, incompatible interaction Updated DEFINITION A response of an organism to a bacterium that prevents the occurrence or spread of disease.
2006-09-19 GO:0050832 defense response to fungus Updated DEFINITION Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2006-09-19 GO:0009817 defense response to fungus, incompatible interaction Updated DEFINITION A response of an organism to a fungus that prevents the occurrence or spread of disease.
2006-09-19 GO:0050829 defense response to Gram-negative bacterium Updated DEFINITION Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2006-09-19 GO:0050830 defense response to Gram-positive bacterium Updated DEFINITION Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2006-09-19 GO:0042832 defense response to protozoan Updated DEFINITION Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
2006-09-19 GO:0009818 defense response to protozoan, incompatible interaction Updated DEFINITION A response of an organism to a protozoan that prevents the occurrence or spread of disease.
2006-09-19 GO:0032253 dense core granule localization Added DEFINITION The processes by which a dense core granule is transported to, and/or maintained in, a specific location within the cell.
2006-09-19 GO:0009604 detection of symbiotic bacterium Updated DEFINITION The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal.
2006-09-19 GO:0009603 detection of symbiotic fungus Updated DEFINITION The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal.
2006-09-19 GO:0000408 EKC/KEOPS complex Added DEFINITION A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
2006-09-19 GO:0042118 endothelial cell activation Updated DEFINITION The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0043307 eosinophil activation Updated DEFINITION The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0009610 response to symbiotic fungus Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism.
2006-09-19 GO:0032252 secretory granule localization Added DEFINITION The processes by which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
2006-09-19 GO:0032158 septin band Updated DEFINITION A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.
2006-09-19 GO:0016445 somatic diversification of immunoglobulins Updated DEFINITION The somatic process by means of which sequence diversity of immunoglobulins is generated.
2006-09-19 GO:0016446 somatic hypermutation of immunoglobulin genes Updated DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2006-09-19 GO:0016447 somatic recombination of immunoglobulin gene segments Updated DEFINITION The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
2006-09-19 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043302 positive regulation of leukocyte degranulation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.
2006-09-19 GO:0001912 positive regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030887 positive regulation of myeloid dendritic cell activation Updated DEFINITION Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
2006-09-19 GO:0000411 positive regulation of transcription by galactose Added DEFINITION Any process involving galactose that activates or increases the rate of transcription.
2006-09-19 GO:0032195 post-lysosomal vacuole Updated DEFINITION A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
2006-09-19 GO:0000407 pre-autophagosomal structure Added DEFINITION A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.
2006-09-19 GO:0002084 protein depalmitoylation Added DEFINITION The removal of palymitoyl groups from a lipoprotein.
2006-09-19 GO:0050691 regulation of defense response to virus by host Updated DEFINITION Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
2006-09-19 GO:0050690 regulation of defense response to virus by virus Updated DEFINITION Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
2006-09-19 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043300 regulation of leukocyte degranulation Updated DEFINITION Any process that modulates the frequency, rate, or extent of leukocyte degranulation.
2006-09-19 GO:0001910 regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030885 regulation of myeloid dendritic cell activation Updated DEFINITION Any process that modulates the frequency or rate of myeloid dendritic cell activation.
2006-09-19 GO:0000409 regulation of transcription by galactose Added DEFINITION Any process involving galactose that modulates the frequency, rate or extent or transcription.
2006-09-19 GO:0045728 respiratory burst after phagocytosis Updated DEFINITION A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.
2006-09-19 GO:0009609 response to symbiotic bacterium Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.
2006-09-19 GO:0042119 neutrophil activation Updated DEFINITION The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0001780 neutrophil homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0001865 NK T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a NK T cell.
2006-09-19 GO:0001866 NK T cell proliferation Updated DEFINITION The expansion of a NK T cell population by cell division.
2006-09-19 GO:0000401 open form four-way junction DNA binding Updated DEFINITION Interacting selectively with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.
2006-09-19 GO:0046968 peptide antigen transport Updated DEFINITION The directed movement of a peptide antigen into, out of, within or between cells. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
2006-09-19 GO:0009271 phage shock Updated DEFINITION A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage.
2006-09-19 GO:0006963 positive regulation of antibacterial peptide biosynthetic process Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
2006-09-19 GO:0006967 positive regulation of antifungal peptide biosynthetic process Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
2006-09-19 GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-negative bacteria.
2006-09-19 GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-positive bacteria.
2006-09-19 GO:0050831 male-specific defense response to bacterium Updated DEFINITION A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism.
2006-09-19 GO:0006969 melanotic tumor response Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2006-09-19 GO:0001774 microglial cell activation Updated DEFINITION The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0042117 monocyte activation Updated DEFINITION The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030099 myeloid cell differentiation Updated DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
2006-09-19 GO:0001773 myeloid dendritic cell activation Updated DEFINITION The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030101 natural killer cell activation Updated DEFINITION The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0008348 negative regulation of antimicrobial humoral response Updated DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
2006-09-19 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043301 negative regulation of leukocyte degranulation Updated DEFINITION Any process that stops, prevents, or reduces the rate of leukocyte degranulation.
2006-09-19 GO:0001911 negative regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030886 negative regulation of myeloid dendritic cell activation Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell activation.
2006-09-19 GO:0016065 humoral defense mechanism (sensu Protostomia) Updated DEFINITION OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317).

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2006-09-19 GO:0048245 eosinophil chemotaxis Updated DEFINITION The movement of an eosinophil in response to an external stimulus.
2006-09-19 GO:0032256 establishment of dense core granule localization Added DEFINITION The directed movement of a dense core granule to a specific location.
2006-09-19 GO:0032254 establishment of secretory granule localization Added DEFINITION The directed movement of a secretory granule to a specific location.
2006-09-19 GO:0035101 FACT complex Updated DEFINITION An abundant nuclear complex, which was identified as a chromatin-specific factor required for transcription elongation on chromatin templates. In S. cerevisiae, the complex is composed of three proteins: Spt16 (120 kDa), Pob3 (63 kDa), and Nhp6 (11 kDa). FACT subunits are highly conserved among eukaryotes. However, in metazoans the Pob3 and Nhp6 orthologs are fused to form the SSRP1 protein.
2006-09-19 GO:0001771 immunological synapse formation Updated DEFINITION The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
2006-09-19 GO:0046631 alpha-beta T cell activation Updated DEFINITION The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2006-09-19 GO:0019732 antifungal humoral response Updated DEFINITION An immune response against a fungus mediated through a body fluid.
2006-09-19 GO:0006966 antifungal humoral response (sensu Protostomia) Updated DEFINITION An immune response against a fungus mediated through a body fluid. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317).
2006-09-19 GO:0019734 antifungal humoral response (sensu Vertebrata) Updated DEFINITION An immune response against a fungus mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).
2006-09-19 GO:0019882 antigen processing and presentation Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0019883 antigen processing and presentation of endogenous antigen Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0004422 hypoxanthine phosphoribosyltransferase activity Updated DEFINITION Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
2006-09-19 GO:0006955 immune response Updated DEFINITION Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2006-09-19 GO:0016064 immunoglobulin mediated immune response Updated DEFINITION An immune response mediated by immunoglobulins, whether cell-bound or in solution.
2006-09-19 GO:0048305 immunoglobulin secretion Updated DEFINITION The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.
2006-09-19 GO:0012504 induction of non-apoptotic programmed cell death by other organism Added DEFINITION A process which directly activates any of the steps required for non-apoptotic programmed cell death in another organism.
2006-09-19 GO:0045321 leukocyte activation Updated DEFINITION A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030595 leukocyte chemotaxis Updated DEFINITION The movement of a leukocyte in response to an external stimulus.
2006-09-19 GO:0043299 leukocyte degranulation Updated DEFINITION The regulated exocytosis of secretory granules by a leukocyte.
2006-09-19 GO:0001776 leukocyte homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0001909 leukocyte mediated cytotoxicity Updated DEFINITION The directed killing of a target cell by a leukocyte.
2006-09-19 GO:0050900 leukocyte migration Updated DEFINITION The movement of leukocytes within or between different tissues and organs of the body.
2006-09-19 GO:0048542 lymph gland development Updated DEFINITION The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656).
2006-09-19 GO:0042116 macrophage activation Updated DEFINITION A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0048246 macrophage chemotaxis Updated DEFINITION The movement of a macrophage in response to an external stimulus.
2006-09-19 GO:0032257 maintenance of dense core granule location Added DEFINITION The processes by which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere.
2006-09-19 GO:0032255 maintenance of secretory granule location Added DEFINITION The processes by which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere.
2006-09-19 GO:0045283 fumarate reductase complex Updated DEFINITION A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
2006-09-19 GO:0045284 plasma membrane fumarate reductase complex Updated DEFINITION A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2006-09-19 GO:0046629 gamma-delta T cell activation Updated DEFINITION The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2006-09-19 GO:0021930 cerebellar granule cell precursor proliferation Updated DEFINITION The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-09-19 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I Updated DEFINITION The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
2006-09-19 GO:0019884 antigen processing and presentation of exogenous antigen Updated DEFINITION The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.
2006-09-19 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Updated DEFINITION The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
2006-09-19 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Updated DEFINITION The process by which an antigen-presenting cell expresses an peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
2006-09-19 GO:0000400 four-way junction DNA binding Updated DEFINITION Interacting selectively with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
2006-09-19 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0045281 succinate dehydrogenase complex Updated DEFINITION A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones.
2006-09-19 GO:0045282 plasma membrane succinate dehydrogenase complex Updated DEFINITION A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).
2006-09-19 GO:0043029 T cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0048002 antigen processing and presentation of peptide antigen Updated DEFINITION The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
2006-09-19 GO:0048006 antigen processing and presentation, endogenous lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0045058 T cell selection Updated DEFINITION The process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
2006-09-19 GO:0042088 T-helper 1 type immune response Added DEFINITION An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
2006-09-19 GO:0042092 type 2 immune response Added DEFINITION An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.
2006-09-19 GO:0032203 telomere formation via telomerase Updated DEFINITION The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase.
2006-09-19 GO:0016068 type I hypersensitivity Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2006-09-19 GO:0001795 type IIb hypersensitivity Updated DEFINITION An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
2006-09-19 GO:0000403 Y-form DNA binding Updated DEFINITION Interacting selectively with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.
2006-09-19 GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib Updated DEFINITION The process by which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
2006-09-19 GO:0050851 antigen receptor-mediated signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.
2006-09-19 GO:0001782 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0019724 B cell mediated immunity Updated DEFINITION Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
2006-09-19 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.
2006-09-19 GO:0043367 CD4-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
2006-09-19 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.
2006-09-19 GO:0043374 CD8-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.
2006-09-19 GO:0043375 CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.
2006-09-19 GO:0045123 cellular extravasation Updated DEFINITION The migration of leukocytes from the blood vessels into the surrounding tissue.
2006-09-19 GO:0032258 CVT pathway Added DEFINITION A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast.
2006-09-19 GO:0001816 cytokine production Updated DEFINITION The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2006-09-19 GO:0042742 defense response to bacterium Updated DEFINITION Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2006-09-19 GO:0009816 defense response to bacterium, incompatible interaction Updated DEFINITION A response of an organism to a bacterium that prevents the occurrence or spread of disease.
2006-09-19 GO:0050832 defense response to fungus Updated DEFINITION Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2006-09-19 GO:0009817 defense response to fungus, incompatible interaction Updated DEFINITION A response of an organism to a fungus that prevents the occurrence or spread of disease.
2006-09-19 GO:0050829 defense response to Gram-negative bacterium Updated DEFINITION Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2006-09-19 GO:0050830 defense response to Gram-positive bacterium Updated DEFINITION Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2006-09-19 GO:0042832 defense response to protozoan Updated DEFINITION Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
2006-09-19 GO:0009818 defense response to protozoan, incompatible interaction Updated DEFINITION A response of an organism to a protozoan that prevents the occurrence or spread of disease.
2006-09-19 GO:0032253 dense core granule localization Added DEFINITION The processes by which a dense core granule is transported to, and/or maintained in, a specific location within the cell.
2006-09-19 GO:0009604 detection of symbiotic bacterium Updated DEFINITION The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal.
2006-09-19 GO:0009603 detection of symbiotic fungus Updated DEFINITION The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal.
2006-09-19 GO:0000408 EKC/KEOPS complex Added DEFINITION A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
2006-09-19 GO:0042118 endothelial cell activation Updated DEFINITION The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0043307 eosinophil activation Updated DEFINITION The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0009610 response to symbiotic fungus Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism.
2006-09-19 GO:0032252 secretory granule localization Added DEFINITION The processes by which a secretory granule is transported to, and/or maintained in, a specific location within the cell.
2006-09-19 GO:0032158 septin band Updated DEFINITION A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.
2006-09-19 GO:0016445 somatic diversification of immunoglobulins Updated DEFINITION The somatic process by means of which sequence diversity of immunoglobulins is generated.
2006-09-19 GO:0016446 somatic hypermutation of immunoglobulin genes Updated DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2006-09-19 GO:0016447 somatic recombination of immunoglobulin gene segments Updated DEFINITION The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
2006-09-19 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043302 positive regulation of leukocyte degranulation Updated DEFINITION Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.
2006-09-19 GO:0001912 positive regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030887 positive regulation of myeloid dendritic cell activation Updated DEFINITION Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
2006-09-19 GO:0000411 positive regulation of transcription by galactose Added DEFINITION Any process involving galactose that activates or increases the rate of transcription.
2006-09-19 GO:0032195 post-lysosomal vacuole Updated DEFINITION A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.
2006-09-19 GO:0000407 pre-autophagosomal structure Added DEFINITION A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.
2006-09-19 GO:0002084 protein depalmitoylation Added DEFINITION The removal of palymitoyl groups from a lipoprotein.
2006-09-19 GO:0050691 regulation of defense response to virus by host Updated DEFINITION Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
2006-09-19 GO:0050690 regulation of defense response to virus by virus Updated DEFINITION Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
2006-09-19 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043300 regulation of leukocyte degranulation Updated DEFINITION Any process that modulates the frequency, rate, or extent of leukocyte degranulation.
2006-09-19 GO:0001910 regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030885 regulation of myeloid dendritic cell activation Updated DEFINITION Any process that modulates the frequency or rate of myeloid dendritic cell activation.
2006-09-19 GO:0000409 regulation of transcription by galactose Added DEFINITION Any process involving galactose that modulates the frequency, rate or extent or transcription.
2006-09-19 GO:0045728 respiratory burst after phagocytosis Updated DEFINITION A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.
2006-09-19 GO:0009609 response to symbiotic bacterium Updated DEFINITION A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.
2006-09-19 GO:0042119 neutrophil activation Updated DEFINITION The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0001780 neutrophil homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2006-09-19 GO:0001865 NK T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a NK T cell.
2006-09-19 GO:0001866 NK T cell proliferation Updated DEFINITION The expansion of a NK T cell population by cell division.
2006-09-19 GO:0000401 open form four-way junction DNA binding Updated DEFINITION Interacting selectively with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.
2006-09-19 GO:0046968 peptide antigen transport Updated DEFINITION The directed movement of a peptide antigen into, out of, within or between cells. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
2006-09-19 GO:0009271 phage shock Updated DEFINITION A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage.
2006-09-19 GO:0006963 positive regulation of antibacterial peptide biosynthetic process Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
2006-09-19 GO:0006967 positive regulation of antifungal peptide biosynthetic process Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
2006-09-19 GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-negative bacteria.
2006-09-19 GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria Updated DEFINITION Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-positive bacteria.
2006-09-19 GO:0050831 male-specific defense response to bacterium Updated DEFINITION A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism.
2006-09-19 GO:0006969 melanotic tumor response Added DEFINITION OBSOLETE (was not defined before being made obsolete).
2006-09-19 GO:0001774 microglial cell activation Updated DEFINITION The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0042117 monocyte activation Updated DEFINITION The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030099 myeloid cell differentiation Updated DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
2006-09-19 GO:0001773 myeloid dendritic cell activation Updated DEFINITION The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0030101 natural killer cell activation Updated DEFINITION The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
2006-09-19 GO:0008348 negative regulation of antimicrobial humoral response Updated DEFINITION Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
2006-09-19 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation.
2006-09-19 GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.
2006-09-19 GO:0043301 negative regulation of leukocyte degranulation Updated DEFINITION Any process that stops, prevents, or reduces the rate of leukocyte degranulation.
2006-09-19 GO:0001911 negative regulation of leukocyte mediated cytotoxicity Updated DEFINITION Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
2006-09-19 GO:0030886 negative regulation of myeloid dendritic cell activation Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell activation.
2006-09-19 GO:0016065 humoral defense mechanism (sensu Protostomia) Updated DEFINITION OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317).
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