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GO Term History: Displaying 500 audit records for all terms for the date 2006-08-18

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2006-08-18 GO:0021819 layer formation in cerebral cortex Added DEFINITION The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
2006-08-18 GO:0021502 neural fold elevation formation Added DEFINITION The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.
2006-08-18 GO:0021505 neural fold folding Added DEFINITION The process of folding the neuroepithelium around the medial hinge point to create the neural elevations and around the lateral hinge points to produce convergence of the folds.
2006-08-18 GO:0021504 neural fold hinge point formation Added DEFINITION The formation of the median and lateral hinge points in the neural folds created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends the entire length of the neural tube, while the lateral hinge points do not form in the spinal cord region of the neural tube.
2006-08-18 GO:0021999 neural plate anterior/posterior regionalization Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
2006-08-18 GO:0021990 neural plate formation Added DEFINITION The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
2006-08-18 GO:0021998 neural plate mediolateral regionalization Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.
2006-08-18 GO:0021997 neural plate axis specification Added DEFINITION The process whereby the axes of the nervous system are established.
2006-08-18 GO:0021991 neural plate thickening Added DEFINITION The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode.
2006-08-18 GO:0021915 neural tube development Added DEFINITION The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
2006-08-18 GO:0021532 neural tube patterning Added DEFINITION The process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.
2006-08-18 GO:0021863 forebrain neuroblast differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblast that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021851 neuroblast division in dorsal lateral ganglionic eminence Added DEFINITION The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb.
2006-08-18 GO:0022017 neuroblast division in pallium Added DEFINITION The division of neuroblast in the pallium. Neuroblasts are precursor cells that give rise to neurons.
2006-08-18 GO:0021848 neuroblast division in subpallium Added DEFINITION The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially.
2006-08-18 GO:0021849 neuroblast division in subventricular zone Added DEFINITION The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially.
2006-08-18 GO:0021847 ventricular zone neuroblast division Added DEFINITION The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.
2006-08-18 GO:0022008 neurogenesis Added DEFINITION Generation of cells within the nervous system.
2006-08-18 GO:0021867 neuron-producing asymmetric radial glial cell division in forebrain Added DEFINITION The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor.
2006-08-18 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration Added DEFINITION The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021944 neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration Added DEFINITION The changes in adhesion between neuronal cells and glial cells as a component of the process of hindbrain glial-mediated radial cell migration.
2006-08-18 GO:0021985 neurohypophysis development Added DEFINITION The progression of the neurophysis over time from its initial formation until its mature state. The neurophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.
2006-08-18 GO:0021995 neuropore closure Added DEFINITION The process of joining together the neural folds at either end of the neural tube.
2006-08-18 GO:0021810 neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration.
2006-08-18 GO:0021503 neural fold bending Added DEFINITION The shaping morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.
2006-08-18 GO:0021874 Wnt signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021881 Wnt-activated signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021922 Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division.
2006-08-18 GO:0022006 zona limitans intrathalamica formation Added DEFINITION The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.
2006-08-18 GO:0021582 medulla oblongata maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021579 medulla oblongata morphogenesis Added DEFINITION The process by which the anatomical structure of the medulla oblongata is generated and organized. Morphogenesis pertains to the creation of form. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021581 medulla oblongata structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021976 medulla reticulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord.
2006-08-18 GO:0021739 mesencephalic trigeminal nucleus development Added DEFINITION The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022037 metencephalon development Added DEFINITION The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.
2006-08-18 GO:0021547 midbrain-hindbrain boundary initiation Added DEFINITION The process that gives rise to the midbrain-hindbrain boundary. This process pertains to the initial formation of a structure from unspecified parts. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021732 midbrain-hindbrain boundary maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0022004 midbrain-hindbrain boundary maturation during brain development Added DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0022005 midbrain-hindbrain boundary maturation during neural plate development Added DEFINITION A developmental process involved in neural plate development. This process is independent of morphogenetic (shape) change, and is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021555 midbrain-hindbrain boundary morphogenesis Added DEFINITION The process by which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. Morphogenesis pertains to the creation of form. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021552 midbrain-hindbrain boundary structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration Added DEFINITION Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021818 modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration Added DEFINITION The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021560 abducens nerve development Added DEFINITION The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021599 abducens nerve formation Added DEFINITION The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021601 abducens nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021598 abducens nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the abducens nerve is generated and organized. Morphogenesis pertains to the creation of form. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021600 abducens nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021742 abducens nucleus development Added DEFINITION The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021565 accessory nerve development Added DEFINITION The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021608 accessory nerve formation Added DEFINITION The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021606 accessory nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021783 preganglionic parasympathetic fiber development Added DEFINITION The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
2006-08-18 GO:0021994 progression of neural tube closure Added DEFINITION The process whereby the neural folds are fused extending from the initial closure points.
2006-08-18 GO:0045116 protein neddylation Updated DEFINITION Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
2006-08-18 GO:0042798 protein neddylation during NEDD8 class-dependent protein catabolic process Updated DEFINITION OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism.
2006-08-18 GO:0021925 cerebellar Purkinje cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
2006-08-18 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Added DEFINITION The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation.
2006-08-18 GO:0021758 putamen development Added DEFINITION The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.
2006-08-18 GO:0021860 pyramidal neuron development Added DEFINITION The progression of a pyramidal neuron from its initial formation to its mature state.
2006-08-18 GO:0021859 pyramidal neuron differentiation Added DEFINITION The process whereby a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.
2006-08-18 GO:0021852 pyramidal neuron migration Added DEFINITION The migration of pyramidal neuron precursors from the ventricular zone to the correct layer of the cerebral cortex.
2006-08-18 GO:0021933 radial glia guided migration of cerebellar granule cell Added DEFINITION The inward migration of postmitotic granule cells along radial glial cells from the external granule layer to the internal granule cell layer.
2006-08-18 GO:0021942 radial glia guided migration of Purkinje cell Added DEFINITION The migration of postmitotic Purkinje cells along radial glial cells from the ventricular zone to the Purkinje cell layer.
2006-08-18 GO:0021702 cerebellar Purkinje cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
2006-08-18 GO:0021680 cerebellar Purkinje cell layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021694 cerebellar Purkinje cell layer formation Added DEFINITION The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021691 cerebellar Purkinje cell layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021692 cerebellar Purkinje cell layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. Morphogenesis pertains to the creation of form. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021693 cerebellar Purkinje cell layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021710 cerebellar stellate cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021711 cerebellar unipolar brush cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021549 cerebellum development Added DEFINITION The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021588 cerebellum formation Added DEFINITION The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021590 cerebellum maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021587 cerebellum morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellum is generated and organized. Morphogenesis pertains to the creation of form. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021589 cerebellum structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021861 forebrain radial glial cell differentiation Added DEFINITION The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021531 spinal cord radial glial cell differentiation Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021807 motogenic signaling initiating cell movement in cerebral cortex Added DEFINITION The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex.
2006-08-18 GO:0021838 motogenic signaling involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex.
2006-08-18 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration Added DEFINITION The signaling that results in the stimulation of cell movement in the rostral migratory stream.
2006-08-18 GO:0019788 NEDD8 transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
2006-08-18 GO:0022001 negative regulation of anterior neural cell fate commitment of the neural plate Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate.
2006-08-18 GO:0048692 negative regulation of axon extension involved in regeneration Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in regeneration.
2006-08-18 GO:0021804 negative regulation of cell adhesion in ventricular zone Added DEFINITION The process that results in the loss of attachments of a cell in the ventricular zone.
2006-08-18 GO:0021822 negative regulation of cell motility involved in cerebral cortex radial glia guided migration Added DEFINITION The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex.
2006-08-18 GO:0021821 negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination Added DEFINITION The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021941 negative regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Added DEFINITION A BMP
2006-08-18 GO:0021675 nerve development Added DEFINITION The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
2006-08-18 GO:0021682 nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.
2006-08-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021761 limbic system development Added DEFINITION The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.
2006-08-18 GO:0021703 locus ceruleus development Added DEFINITION The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021705 locus ceruleus formation Added DEFINITION The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021706 locus ceruleus maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021704 locus ceruleus morphogenesis Added DEFINITION The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021708 Lugaro cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021767 mammillary body development Added DEFINITION The progression of the mammilary body over time from its initial formation until its mature state. The mammilary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.
2006-08-18 GO:0021700 developmental maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component, or gene product to attain its fully functional state.
2006-08-18 GO:0022020 medial ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of medial ganglionic eminence cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021526 medial motor column neuron differentiation Added DEFINITION The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021550 medulla oblongata development Added DEFINITION The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021580 medulla oblongata formation Added DEFINITION The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021839 interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex Added DEFINITION The process whereby migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex.
2006-08-18 GO:0021948 inward migration of deep nuclear neurons Added DEFINITION The directed movement of deep nuclear neurons from the rostrodorsal region of the cerebellar plate to their final more ventral position.
2006-08-18 GO:0021996 lamina terminalis formation Added DEFINITION The process whereby the anterior-most portion of the neural axis is formed by closure of the anterior neuropore.
2006-08-18 GO:0043261 laminin-12 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma3.
2006-08-18 GO:0043257 laminin-8 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1.
2006-08-18 GO:0043258 laminin-9 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha4, beta2 and gamma1.
2006-08-18 GO:0022018 lateral ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021771 lateral geniculate nucleus development Added DEFINITION The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.
2006-08-18 GO:0021525 lateral motor column neuron differentiation Added DEFINITION The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021726 lateral reticular nucleus development Added DEFINITION The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021670 lateral ventricle development Added DEFINITION The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.
2006-08-18 GO:0021664 rhombomere 5 morphogenesis Added DEFINITION The process by which the anatomical structures of rhombomere 5 are generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021665 rhombomere 5 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021572 rhombomere 6 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021669 rhombomere 6 formation Added DEFINITION The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021667 rhombomere 6 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 6 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021864 radial glial cell division in forebrain Added DEFINITION The mitotic division of radial glial cells in the developing forebrain.
2006-08-18 GO:0022015 radial glial cell division in pallium Added DEFINITION The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.
2006-08-18 GO:0022014 radial glial cell division in subpallium Added DEFINITION The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.
2006-08-18 GO:0022023 radial glial cell fate commitment in forebrain Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell.
2006-08-18 GO:0048690 regulation of axon extension involved in regeneration Updated DEFINITION Any process that modulates the frequency, rate or extent of axon extension involved in regeneration.
2006-08-18 GO:0021921 regulation of cell proliferation in dorsal spinal cord Added DEFINITION The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.
2006-08-18 GO:0021936 regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that modulates the frequency, rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021909 regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021918 regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis.
2006-08-18 GO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord.
2006-08-18 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord.
2006-08-18 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.
2006-08-18 GO:0021911 retinoic acid metabolic process in spinal cord anterior-posterior patterning Added DEFINITION The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021908 retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation Added DEFINITION The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021774 retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
2006-08-18 GO:0021723 medullary reticular formation development Added DEFINITION The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata.
2006-08-18 GO:0021567 rhombomere 1 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021652 rhombomere 1 formation Added DEFINITION The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021651 rhombomere 1 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 1 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021653 rhombomere 1 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021568 rhombomere 2 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021845 neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration Added DEFINITION The response of migrating cells to neurotransmitters that alter electrical activity in cells in calcium dependent manner.
2006-08-18 GO:0021809 neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021876 Notch signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021880 Notch signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration Added DEFINITION The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021768 nucleus accumbens development Added DEFINITION The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.
2006-08-18 GO:0021745 nucleus ambiguus development Added DEFINITION The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.
2006-08-18 GO:0032132 O6-alkylguanine-DNA binding Added DEFINITION Interacting selectively with O6-alkylguanine adducts in DNA.
2006-08-18 GO:0021645 vagus nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
2006-08-18 GO:0021749 ventral cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021517 ventral spinal cord development Added DEFINITION The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.
2006-08-18 GO:0021514 ventral spinal cord interneuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021521 ventral spinal cord interneuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021952 central nervous system projection neuron axonogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2006-08-18 GO:0021597 central nervous system structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0022009 central nervous system vasculogenesis Added DEFINITION The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.
2006-08-18 GO:0021709 cerebellar basket cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021695 cerebellar cortex development Added DEFINITION The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021697 cerebellar cortex formation Added DEFINITION The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021699 cerebellar cortex maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021696 cerebellar cortex morphogenesis Added DEFINITION The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021982 pineal gland development Added DEFINITION The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms.
2006-08-18 GO:0021983 pituitary gland development Added DEFINITION The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
2006-08-18 GO:0021548 pons development Added DEFINITION The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021584 pons formation Added DEFINITION The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021586 pons maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021583 pons morphogenesis Added DEFINITION The process by which the anatomical structure of the pons is generated and organized. Morphogenesis pertains to the creation of form. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021975 pons reticulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord.
2006-08-18 GO:0021585 pons structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021740 principal sensory nucleus of trigeminal nerve development Added DEFINITION The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0048691 positive regulation of axon extension involved in regeneration Updated DEFINITION Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
2006-08-18 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that activates or increases the rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021961 posterior commissure morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon.
2006-08-18 GO:0021507 posterior neuropore closure Added DEFINITION The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete.
2006-08-18 GO:0021784 postganglionic parasympathetic fiber development Added DEFINITION The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
2006-08-18 GO:0021827 postnatal olfactory bulb interneuron migration Added DEFINITION The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth.
2006-08-18 GO:0021501 prechordal plate formation Added DEFINITION The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
2006-08-18 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration Added DEFINITION The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.
2006-08-18 GO:0021950 chemorepulsion involved in precerebellar neuron migration Added DEFINITION The creation and reception of signals that repel precerebellar neurons as a component of the process of tangential migration.
2006-08-18 GO:0021793 chemorepulsion of branchiomotor axon Added DEFINITION The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021790 chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme Added DEFINITION The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021787 chemorepulsion of branchiomotor neuron axon in neural tube Added DEFINITION The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021765 cingulate gyrus development Added DEFINITION The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum.
2006-08-18 GO:0021747 cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021528 commissural neuron differentiation in spinal cord Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain Added DEFINITION The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.
2006-08-18 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain Added DEFINITION The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain.
2006-08-18 GO:0022007 convergent extension involved in neural plate elongation Added DEFINITION The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.
2006-08-18 GO:0021668 rhombomere 6 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021573 rhombomere 7 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021673 rhombomere 7 formation Added DEFINITION The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021671 rhombomere 7 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 7 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021672 rhombomere 7 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021574 rhombomere 8 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0019783 ubiquitin-like protein-specific protease activity Updated DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups.
2006-08-18 GO:0008641 small protein activating enzyme activity Updated DEFINITION Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
2006-08-18 GO:0008639 small protein conjugating enzyme activity Updated DEFINITION Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2006-08-18 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells.
2006-08-18 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2006-08-18 GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
2006-08-18 GO:0021746 solitary nucleus development Added DEFINITION The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021802 somal translocation Added DEFINITION The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.
2006-08-18 GO:0021523 somatic motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021591 ventricular system development Added DEFINITION The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
2006-08-18 GO:0021900 ventricular zone cell fate commitment Added DEFINITION The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons.
2006-08-18 GO:0021868 ventricular zone cell-producing asymmetric radial glial cell division in forebrain Added DEFINITION The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell.
2006-08-18 GO:0021750 vestibular nucleus development Added DEFINITION The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021562 vestibulocochlear nerve development Added DEFINITION The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021650 vestibulocochlear nerve formation Added DEFINITION The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021647 vestibulocochlear nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021648 vestibulocochlear nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the vestibulocochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021649 vestibulocochlear nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021962 vestibulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord.
2006-08-18 GO:0021524 visceral motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0022002 negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway Added DEFINITION The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell.
2006-08-18 GO:0021701 cerebellar Golgi cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021681 cerebellar granular layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021684 cerebellar granular layer formation Added DEFINITION The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021686 cerebellar granular layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021683 cerebellar granular layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar granular layer is generated and organized. Morphogenesis pertains to the creation of form. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021685 cerebellar granular layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021707 cerebellar granule cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021679 cerebellar molecular layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021688 cerebellar molecular layer formation Added DEFINITION The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021690 cerebellar molecular layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021687 cerebellar molecular layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar molecular layer is generated and organized. Morphogenesis pertains to the creation of form. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021689 cerebellar molecular layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021795 cerebral cortex cell migration Added DEFINITION The orderly movement of cells from one site to another in the cerebral cortex.
2006-08-18 GO:0021655 rhombomere 2 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 2 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021656 rhombomere 2 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021569 rhombomere 3 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021660 rhombomere 3 formation Added DEFINITION The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021658 rhombomere 3 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 3 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021659 rhombomere 3 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021570 rhombomere 4 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021663 rhombomere 4 formation Added DEFINITION The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021661 rhombomere 4 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 4 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021662 rhombomere 4 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021571 rhombomere 5 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021666 rhombomere 5 formation Added DEFINITION The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0019787 ubiquitin-like protein transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.
2006-08-18 GO:0021612 facial nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021754 facial nucleus development Added DEFINITION The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021738 fastigial nucleus development Added DEFINITION The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022003 negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway Added DEFINITION The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2006-08-18 GO:0021875 fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021907 fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021899 fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0043680 filiform apparatus Added DEFINITION A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells.
2006-08-18 GO:0021508 floor plate formation Added DEFINITION The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.
2006-08-18 GO:0021797 forebrain anterior/posterior pattern specification Added DEFINITION The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.
2006-08-18 GO:0043259 laminin-10 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta1 and gamma1.
2006-08-18 GO:0043260 laminin-11 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta2 and gamma1.
2006-08-18 GO:0021897 forebrain astrocyte development Added DEFINITION The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2006-08-18 GO:0021896 forebrain astrocyte differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2006-08-18 GO:0021878 forebrain astrocyte fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain.
2006-08-18 GO:0021885 forebrain cell migration Added DEFINITION The orderly movement of cells from one site to another at least one of which is located in the forebrain.
2006-08-18 GO:0021798 forebrain dorsal/ventral pattern formation Added DEFINITION The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.
2006-08-18 GO:0022000 forebrain induction by the anterior neural ridge Added DEFINITION The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate.
2006-08-18 GO:0021873 forebrain neuroblast division Added DEFINITION The division of a neuroblast, the neural precursor in the forebrain, giving rise to at least another neuroblast. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).
2006-08-18 GO:0021884 forebrain neuron development Added DEFINITION The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
2006-08-18 GO:0021879 forebrain neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
2006-08-18 GO:0021877 forebrain neuron fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.
2006-08-18 GO:0021871 forebrain regionalization Added DEFINITION The creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.
2006-08-18 GO:0021869 forebrain ventricular zone progenitor cell division Added DEFINITION The mitotic division of a basal progenitor giving rise to two neurons.
2006-08-18 GO:0021905 forebrain-midbrain boundary formation Added DEFINITION The process whose specific outcome is the creation of the forebrain-midbrain boundary.
2006-08-18 GO:0021943 formation of radial glial scaffolds Added DEFINITION The formation of scaffolds from radial glial cells. The scaffolds are used as a substrate for the radial migration of cells.
2006-08-18 GO:0021657 rhombomere 2 formation Added DEFINITION The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021987 cerebral cortex development Added DEFINITION The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
2006-08-18 GO:0021894 cerebral cortex GABAergic interneuron development Added DEFINITION The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.
2006-08-18 GO:0021892 cerebral cortex GABAergic interneuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.
2006-08-18 GO:0021893 cerebral cortex GABAergic interneuron fate commitment Added DEFINITION The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.
2006-08-18 GO:0021698 cerebellar cortex structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021677 rhombomere 8 formation Added DEFINITION The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021674 rhombomere 8 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 8 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021676 rhombomere 8 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021654 rhombomere boundary formation Added DEFINITION The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0022036 rhombomere cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a rhombomere cell.
2006-08-18 GO:0022035 rhombomere cell migration Added DEFINITION The movement of cells within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.
2006-08-18 GO:0022034 rhombomere cell proliferation Added DEFINITION The multiplication or reproduction of rhombomere cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021546 rhombomere development Added DEFINITION The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021594 rhombomere formation Added DEFINITION The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021593 rhombomere morphogenesis Added DEFINITION The process by which the anatomical structure of the rhombomere is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021595 rhombomere structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021509 roof plate formation Added DEFINITION The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.
2006-08-18 GO:0021931 rostral hindbrain neuronal precursor cell proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus.
2006-08-18 GO:0021734 rostral lateral line nerve development Added DEFINITION The progression of the rostral lateral line nerve over time from its initial formation until its mature state. The rostral lateral line nerve is a sensory afferent projecting from the anterior lateral line ganglion to the hindbrain in fishes.
2006-08-18 GO:0021903 rostrocaudal neural tube patterning Added DEFINITION The process by which the neural tube is divided into specific regions along the rostrocaudal axis.
2006-08-18 GO:0021853 cerebral cortex GABAergic interneuron migration Added DEFINITION The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
2006-08-18 GO:0021895 cerebral cortex neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
2006-08-18 GO:0021801 cerebral cortex radial glia guided migration Added DEFINITION The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.
2006-08-18 GO:0021799 cerebral cortex radially oriented cell migration Added DEFINITION The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
2006-08-18 GO:0021796 cerebral cortex regionalization Added DEFINITION The creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.
2006-08-18 GO:0021800 cerebral cortex tangential migration Added DEFINITION The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
2006-08-18 GO:0021824 cerebral cortex tangential migration using cell-axon interactions Added DEFINITION The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons.
2006-08-18 GO:0021823 cerebral cortex tangential migration using cell-cell interactions Added DEFINITION The process whereby neurons interact with each other to promote migration along a tangential plane.
2006-08-18 GO:0021835 chemoattraction involved in embryonic olfactory bulb interneuron precursor migration Added DEFINITION The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb.
2006-08-18 GO:0021841 chemoattraction involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex.
2006-08-18 GO:0021951 chemoattraction involved in precerebellar neuron migration Added DEFINITION The creation and reception of signals that guide precerebellar neurons towards their signals, where this process is involved in tangential migration.
2006-08-18 GO:0021792 chemoattraction of branchiomotor axon Added DEFINITION The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021791 chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme Added DEFINITION The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021788 chemoattraction of branchiomotor neuron axon in neural tube Added DEFINITION The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration Added DEFINITION The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb.
2006-08-18 GO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.
2006-08-18 GO:0021516 dorsal spinal cord development Added DEFINITION The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.
2006-08-18 GO:0021904 dorsal/ventral neural tube patterning Added DEFINITION The process by which the neural tube is regionalized in the dorsoventral axis.
2006-08-18 GO:0021862 early neuron differentiation in forebrain Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021901 early neuron fate commitment in forebrain Added DEFINITION The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain.
2006-08-18 GO:0021737 emboliform nucleus development Added DEFINITION The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021831 embryonic olfactory bulb interneuron precursor migration Added DEFINITION The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.
2006-08-18 GO:0043671 endexine Updated DEFINITION The inner part of the exine, which stains.
2006-08-18 GO:0022026 epidermal growth factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021538 epithalamus development Added DEFINITION The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle.
2006-08-18 GO:0021755 eurydendroid cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.
2006-08-18 GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration Added DEFINITION The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.
2006-08-18 GO:0044420 extracellular matrix component Updated DEFINITION Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
2006-08-18 GO:0021939 extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation Added DEFINITION The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation.
2006-08-18 GO:0021561 facial nerve development Added DEFINITION The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021611 facial nerve formation Added DEFINITION The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021607 accessory nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the accessory nerve is generated and organized. Morphogenesis pertains to the creation of form. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021609 accessory nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021984 adenohypophysis development Added DEFINITION The progression of the adenophysis over time from its initial formation until its mature state. The adenophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
2006-08-18 GO:0032131 alkylated DNA binding Added DEFINITION Interacting selectively with alkylated residues in DNA.
2006-08-18 GO:0021541 ammon gyrus development Added DEFINITION The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.
2006-08-18 GO:0021764 amygdala development Added DEFINITION The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.
2006-08-18 GO:0048646 anatomical structure formation involved in morphogenesis Updated DEFINITION The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
2006-08-18 GO:0021960 anterior commissure morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal processes is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
2006-08-18 GO:0021506 anterior neuropore closure Added DEFINITION The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete.
2006-08-18 GO:0021866 asymmetric radial glial cell division in forebrain Added DEFINITION The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type.
2006-08-18 GO:0021557 oculomotor nerve development Added DEFINITION The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0022029 telencephalon cell migration Added DEFINITION The orderly movement of cells from one site to another at least one of which is located in the telencephalon.
2006-08-18 GO:0021917 somatic motor neuron fate commitment Added DEFINITION The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.
2006-08-18 GO:0021512 spinal cord anterior/posterior patterning Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.
2006-08-18 GO:0021527 spinal cord association neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021519 spinal cord association neuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021518 spinal cord commissural neuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021510 spinal cord development Added DEFINITION The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
2006-08-18 GO:0021513 spinal cord dorsal/ventral patterning Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.
2006-08-18 GO:0021520 spinal cord motor neuron cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021522 spinal cord motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021529 spinal cord oligodendrocyte cell differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021530 spinal cord oligodendrocyte cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021511 spinal cord patterning Added DEFINITION The process that regulates the coordinated growth that establishes the non-random spatial arrangement of the spinal cord.
2006-08-18 GO:0021965 spinal cord ventral commissure morphogenesis Added DEFINITION The process by which the anatomical structures of the spinal cord ventral commissure are generated and organized. Morphogenesis pertains to the creation of form.
2006-08-18 GO:0021741 spinal trigeminal nucleus development Added DEFINITION The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022038 corpus callosum development Added DEFINITION The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
2006-08-18 GO:0021540 corpus callosum morphogenesis Added DEFINITION The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.
2006-08-18 GO:0021967 corticospinal neuron axon guidance through the cerebral cortex Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021973 corticospinal neuron axon decussation Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.
2006-08-18 GO:0021966 corticospinal neuron axon guidance Added DEFINITION The process by which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021970 corticospinal neuron axon guidance through the basilar pons Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021969 corticospinal neuron axon guidance through the cerebral peduncle Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021968 corticospinal neuron axon guidance through the internal capsule Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021971 corticospinal neuron axon guidance through the medullary pyramid Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021972 corticospinal neuron axon guidance through spinal cord Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021957 corticospinal tract morphogenesis Added DEFINITION Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal processes is a member of those that make up the corticospinal tract.
2006-08-18 GO:0021545 cranial nerve development Added DEFINITION The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021603 cranial nerve formation Added DEFINITION The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021605 cranial nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021602 cranial nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021604 cranial nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021959 cuneatus tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb.
2006-08-18 GO:0021808 cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration Added DEFINITION The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021946 deep nuclear neuron cell migration Added DEFINITION The directed movement of deep nuclear neurons from the ventricular zone to the deep hindbrain nuclei.
2006-08-18 GO:0021927 deep nuclear neuron precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons.
2006-08-18 GO:0021964 rubrospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord.
2006-08-18 GO:0021751 salivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022022 septal cell proliferation Added DEFINITION The multiplication or reproduction of septal cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021850 subpallium glioblast cell division Added DEFINITION The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes.
2006-08-18 GO:0021736 globose nucleus development Added DEFINITION The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021759 globus pallidus development Added DEFINITION The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.
2006-08-18 GO:0021563 glossopharyngeal nerve development Added DEFINITION Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021616 glossopharyngeal nerve formation Added DEFINITION The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021614 glossopharyngeal nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021615 glossopharyngeal nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the glossopharyngeal nerve is generated and organized. Morphogenesis pertains to the creation of form. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021617 glossopharyngeal nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021926 Golgi cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus Added DEFINITION The directional movement of gonadotrophin-releasing hormone producing neurons from the nasal placode to the hypothalamus.
2006-08-18 GO:0021958 gracilis tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb.
2006-08-18 GO:0021930 cerebellar granule cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021935 cerebellar granule cell precursor tangential migration Added DEFINITION The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.
2006-08-18 GO:0021811 growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex.
2006-08-18 GO:0021986 habenula development Added DEFINITION The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.
2006-08-18 GO:0021576 hindbrain formation Added DEFINITION The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021578 hindbrain maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021575 hindbrain morphogenesis Added DEFINITION The process by which the anatomical structure of the hindbrain is generated and organized. Morphogenesis pertains to the creation of form. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021932 hindbrain radial glia guided cell migration Added DEFINITION The radially directed movement of cells along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.
2006-08-18 GO:0021577 hindbrain structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021934 hindbrain tangential cell migration Added DEFINITION The migration of cells in the hindbrain in which cells move orthogonal to the direction of radial migration.
2006-08-18 GO:0021906 hindbrain-spinal cord boundary formation Added DEFINITION The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.
2006-08-18 GO:0021766 hippocampus development Added DEFINITION The progression of the hippocampus over time from its initial formation until its mature state.
2006-08-18 GO:0021566 hypoglossal nerve development Added DEFINITION The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
2006-08-18 GO:0021779 oligodendrocyte cell fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte.
2006-08-18 GO:0021778 oligodendrocyte cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2006-08-18 GO:0021829 oligodendrocyte cell migration from the subpallium to the cortex Added DEFINITION The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development.
2006-08-18 GO:0021592 fourth ventricle development Added DEFINITION The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.
2006-08-18 GO:0021858 GABAergic neuron differentiation in basal ganglia Added DEFINITION The process whereby a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.
2006-08-18 GO:0021872 forebrain generation of neurons Added DEFINITION The process by which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.
2006-08-18 GO:0021782 glial cell development Added DEFINITION The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2006-08-18 GO:0021781 glial cell fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
2006-08-18 GO:0021963 spinothalamic tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal processes is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling.
2006-08-18 GO:0021929 stellate cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021773 striatal medium spiny neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.
2006-08-18 GO:0021756 striatum development Added DEFINITION The progression of the striatum over time from its initial formation until its mature state. The striatum is a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking.
2006-08-18 GO:0021980 subpallium cell migration Added DEFINITION The orderly movement of cells from one site to another in the subpallium.
2006-08-18 GO:0022012 subpallium cell proliferation in forebrain Added DEFINITION The multiplication or reproduction of subpallium cells in the forebrain, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021544 subpallium development Added DEFINITION The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.
2006-08-18 GO:0021981 subpallium radially oriented migration Added DEFINITION The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
2006-08-18 GO:0021762 substantia nigra development Added DEFINITION The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
2006-08-18 GO:0021825 substrate-dependent cerebral cortex tangential migration Added DEFINITION The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.
2006-08-18 GO:0021843 substrate-independent telencephalic tangential interneuron migration Added DEFINITION The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates.
2006-08-18 GO:0021826 substrate-independent telencephalic tangential migration Added DEFINITION The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact.
2006-08-18 GO:0021763 subthalamic nucleus development Added DEFINITION The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.
2006-08-18 GO:0021539 subthalamus development Added DEFINITION The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.
2006-08-18 GO:0019789 SUMO transferase activity Updated DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.
2006-08-18 GO:0021718 superior olivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021720 superior olivary nucleus formation Added DEFINITION The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021722 superior olivary nucleus maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021719 superior olivary nucleus morphogenesis Added DEFINITION The process by which the anatomical structure of the superior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021721 superior olivary nucleus structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021725 superior raphe nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure
2006-08-18 GO:0021729 superior reticular formation development Added DEFINITION The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure.
2006-08-18 GO:0021753 superior salivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021865 symmetric radial glial cell division in forebrain Added DEFINITION The mitotic division of a radial glial cell giving rise to two new radial glial cells.
2006-08-18 GO:0022028 tangential migration from the subventricular zone to the olfactory bulb Added DEFINITION The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
2006-08-18 GO:0021542 dentate gyrus development Added DEFINITION The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.
2006-08-18 GO:0021735 dentate nucleus development Added DEFINITION The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021536 diencephalon development Added DEFINITION The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
2006-08-18 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex.
2006-08-18 GO:0021748 dorsal cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022019 dorsal lateral ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021744 dorsal motor nucleus of vagus nerve development Added DEFINITION The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.
2006-08-18 GO:0021757 caudate nucleus development Added DEFINITION The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.
2006-08-18 GO:0021883 cell cycle arrest of committed forebrain neuronal progenitor cell Added DEFINITION The process by which progression through the cell cycle is halted in a cell that has been committed to become a neuron that will reside in the forebrain.
2006-08-18 GO:0021533 cell differentiation in hindbrain Added DEFINITION The process whereby relatively unspecialized cells, acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021515 cell differentiation in spinal cord Added DEFINITION The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration Added DEFINITION The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021535 cell migration in hindbrain Added DEFINITION The orderly movement of cells that will reside in the hindbrain.
2006-08-18 GO:0021805 cell movement involved in somal translocation Added DEFINITION The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface.
2006-08-18 GO:0021534 cell proliferation in hindbrain Added DEFINITION The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain.
2006-08-18 GO:0021924 cell proliferation in external granule layer Added DEFINITION The multiplication or reproduction of neuroblasts resulting in the rapid expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.
2006-08-18 GO:0021846 cell proliferation in forebrain Added DEFINITION The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
2006-08-18 GO:0021923 cell proliferation in hindbrain ventricular zone Added DEFINITION The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity.
2006-08-18 GO:0021992 cell proliferation involved in neural plate elongation Added DEFINITION The process of rapid expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue.
2006-08-18 GO:0021832 cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions Added DEFINITION The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration.
2006-08-18 GO:0021630 olfactory nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021627 olfactory nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the olfactory nerve is generated and organized. Morphogenesis pertains to the creation of form. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021629 olfactory nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Added DEFINITION The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.
2006-08-18 GO:0021833 cell-matrix adhesion involved in tangential migration using cell-cell interactions Added DEFINITION The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex.
2006-08-18 GO:0021556 central nervous system formation Added DEFINITION The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0021956 central nervous system interneuron axonogenesis Added DEFINITION Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.
2006-08-18 GO:0021626 central nervous system maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0021551 central nervous system morphogenesis Added DEFINITION The process by which the anatomical structure of the central nervous system is generated and organized. Morphogenesis pertains to the creation of form. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0022010 central nervous system myelination Added DEFINITION The process during which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2006-08-18 GO:0021955 central nervous system neuron axonogenesis Added DEFINITION Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
2006-08-18 GO:0021954 central nervous system neuron development Added DEFINITION The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
2006-08-18 GO:0021953 central nervous system neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
2006-08-18 GO:0021620 hypoglossal nerve formation Added DEFINITION The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
2006-08-18 GO:0021537 telencephalon development Added DEFINITION The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
2006-08-18 GO:0022030 telencephalon glial cell migration Added DEFINITION The orderly movement of glial cells through the telencephalon.
2006-08-18 GO:0022033 telencephalon microglial cell migration Added DEFINITION The orderly movement of microglial cells through the telencephalon.
2006-08-18 GO:0022032 telencephalon oligodendrocyte cell migration Added DEFINITION The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021978 telencephalon regionalization Added DEFINITION The creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.
2006-08-18 GO:0021794 thalamus development Added DEFINITION The process by which the thalamus changes over time, from its initial formation to its mature state.
2006-08-18 GO:0021678 third ventricle development Added DEFINITION The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.
2006-08-18 GO:0016563 transcription activator activity Updated DEFINITION Any transcription regulator activity required for initiation or upregulation of transcription.
2006-08-18 GO:0021731 trigeminal motor nucleus development Added DEFINITION The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021559 trigeminal nerve development Added DEFINITION The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0021638 trigeminal nerve formation Added DEFINITION The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0021635 trigeminal nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0048846 axon extension involved in axon guidance Added DEFINITION The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
2006-08-18 GO:0048676 axon extension involved in development Updated DEFINITION Long distance growth of a single axon process involved in cellular development.
2006-08-18 GO:0048677 axon extension involved in regeneration Updated DEFINITION Long distance growth of a single axon process involved in regeneration of the neuron.
2006-08-18 GO:0021928 basket cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Added DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord..
2006-08-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Added DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate
2006-08-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021623 oculomotor nerve formation Added DEFINITION The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021625 oculomotor nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021622 oculomotor nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the oculomotor nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021624 oculomotor nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021772 olfactory bulb development Added DEFINITION The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
2006-08-18 GO:0021891 olfactory bulb interneuron development Added DEFINITION The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.
2006-08-18 GO:0021889 olfactory bulb interneuron differentiation Added DEFINITION The process whereby a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.
2006-08-18 GO:0021890 olfactory bulb interneuron fate commitment Added DEFINITION The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb.
2006-08-18 GO:0021989 olfactory cortex development Added DEFINITION The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors.
2006-08-18 GO:0021988 olfactory lobe development Added DEFINITION The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.
2006-08-18 GO:0021553 olfactory nerve development Added DEFINITION The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021628 olfactory nerve formation Added DEFINITION The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021613 facial nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021610 facial nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the facial nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021977 tectospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord.
2006-08-18 GO:0022031 telencephalon astrocyte cell migration Added DEFINITION The orderly movement of astrocyte cells through the telencephalon.
2006-08-18 GO:0021780 glial cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2006-08-18 GO:0022016 pallium glioblast division Added DEFINITION The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells.

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2006-08-18 GO:0021819 layer formation in cerebral cortex Added DEFINITION The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
2006-08-18 GO:0021502 neural fold elevation formation Added DEFINITION The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.
2006-08-18 GO:0021505 neural fold folding Added DEFINITION The process of folding the neuroepithelium around the medial hinge point to create the neural elevations and around the lateral hinge points to produce convergence of the folds.
2006-08-18 GO:0021504 neural fold hinge point formation Added DEFINITION The formation of the median and lateral hinge points in the neural folds created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends the entire length of the neural tube, while the lateral hinge points do not form in the spinal cord region of the neural tube.
2006-08-18 GO:0021999 neural plate anterior/posterior regionalization Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
2006-08-18 GO:0021990 neural plate formation Added DEFINITION The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
2006-08-18 GO:0021998 neural plate mediolateral regionalization Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.
2006-08-18 GO:0021997 neural plate axis specification Added DEFINITION The process whereby the axes of the nervous system are established.
2006-08-18 GO:0021991 neural plate thickening Added DEFINITION The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode.
2006-08-18 GO:0021915 neural tube development Added DEFINITION The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
2006-08-18 GO:0021532 neural tube patterning Added DEFINITION The process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.
2006-08-18 GO:0021863 forebrain neuroblast differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblast that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021851 neuroblast division in dorsal lateral ganglionic eminence Added DEFINITION The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb.
2006-08-18 GO:0022017 neuroblast division in pallium Added DEFINITION The division of neuroblast in the pallium. Neuroblasts are precursor cells that give rise to neurons.
2006-08-18 GO:0021848 neuroblast division in subpallium Added DEFINITION The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially.
2006-08-18 GO:0021849 neuroblast division in subventricular zone Added DEFINITION The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially.
2006-08-18 GO:0021847 ventricular zone neuroblast division Added DEFINITION The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.
2006-08-18 GO:0022008 neurogenesis Added DEFINITION Generation of cells within the nervous system.
2006-08-18 GO:0021867 neuron-producing asymmetric radial glial cell division in forebrain Added DEFINITION The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor.
2006-08-18 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration Added DEFINITION The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021944 neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration Added DEFINITION The changes in adhesion between neuronal cells and glial cells as a component of the process of hindbrain glial-mediated radial cell migration.
2006-08-18 GO:0021985 neurohypophysis development Added DEFINITION The progression of the neurophysis over time from its initial formation until its mature state. The neurophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.
2006-08-18 GO:0021995 neuropore closure Added DEFINITION The process of joining together the neural folds at either end of the neural tube.
2006-08-18 GO:0021810 neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration.
2006-08-18 GO:0021503 neural fold bending Added DEFINITION The shaping morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.
2006-08-18 GO:0021874 Wnt signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021881 Wnt-activated signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021922 Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division.
2006-08-18 GO:0022006 zona limitans intrathalamica formation Added DEFINITION The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.
2006-08-18 GO:0021582 medulla oblongata maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021579 medulla oblongata morphogenesis Added DEFINITION The process by which the anatomical structure of the medulla oblongata is generated and organized. Morphogenesis pertains to the creation of form. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021581 medulla oblongata structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021976 medulla reticulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord.
2006-08-18 GO:0021739 mesencephalic trigeminal nucleus development Added DEFINITION The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022037 metencephalon development Added DEFINITION The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.
2006-08-18 GO:0021547 midbrain-hindbrain boundary initiation Added DEFINITION The process that gives rise to the midbrain-hindbrain boundary. This process pertains to the initial formation of a structure from unspecified parts. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021732 midbrain-hindbrain boundary maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0022004 midbrain-hindbrain boundary maturation during brain development Added DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0022005 midbrain-hindbrain boundary maturation during neural plate development Added DEFINITION A developmental process involved in neural plate development. This process is independent of morphogenetic (shape) change, and is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021555 midbrain-hindbrain boundary morphogenesis Added DEFINITION The process by which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. Morphogenesis pertains to the creation of form. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021552 midbrain-hindbrain boundary structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration Added DEFINITION Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021818 modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration Added DEFINITION The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021560 abducens nerve development Added DEFINITION The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021599 abducens nerve formation Added DEFINITION The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021601 abducens nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021598 abducens nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the abducens nerve is generated and organized. Morphogenesis pertains to the creation of form. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021600 abducens nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.
2006-08-18 GO:0021742 abducens nucleus development Added DEFINITION The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021565 accessory nerve development Added DEFINITION The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021608 accessory nerve formation Added DEFINITION The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021606 accessory nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021783 preganglionic parasympathetic fiber development Added DEFINITION The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
2006-08-18 GO:0021994 progression of neural tube closure Added DEFINITION The process whereby the neural folds are fused extending from the initial closure points.
2006-08-18 GO:0045116 protein neddylation Updated DEFINITION Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
2006-08-18 GO:0042798 protein neddylation during NEDD8 class-dependent protein catabolic process Updated DEFINITION OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism.
2006-08-18 GO:0021925 cerebellar Purkinje cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
2006-08-18 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Added DEFINITION The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation.
2006-08-18 GO:0021758 putamen development Added DEFINITION The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.
2006-08-18 GO:0021860 pyramidal neuron development Added DEFINITION The progression of a pyramidal neuron from its initial formation to its mature state.
2006-08-18 GO:0021859 pyramidal neuron differentiation Added DEFINITION The process whereby a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.
2006-08-18 GO:0021852 pyramidal neuron migration Added DEFINITION The migration of pyramidal neuron precursors from the ventricular zone to the correct layer of the cerebral cortex.
2006-08-18 GO:0021933 radial glia guided migration of cerebellar granule cell Added DEFINITION The inward migration of postmitotic granule cells along radial glial cells from the external granule layer to the internal granule cell layer.
2006-08-18 GO:0021942 radial glia guided migration of Purkinje cell Added DEFINITION The migration of postmitotic Purkinje cells along radial glial cells from the ventricular zone to the Purkinje cell layer.
2006-08-18 GO:0021702 cerebellar Purkinje cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
2006-08-18 GO:0021680 cerebellar Purkinje cell layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021694 cerebellar Purkinje cell layer formation Added DEFINITION The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021691 cerebellar Purkinje cell layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021692 cerebellar Purkinje cell layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. Morphogenesis pertains to the creation of form. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021693 cerebellar Purkinje cell layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
2006-08-18 GO:0021710 cerebellar stellate cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021711 cerebellar unipolar brush cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021549 cerebellum development Added DEFINITION The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021588 cerebellum formation Added DEFINITION The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021590 cerebellum maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021587 cerebellum morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellum is generated and organized. Morphogenesis pertains to the creation of form. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021589 cerebellum structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2006-08-18 GO:0021861 forebrain radial glial cell differentiation Added DEFINITION The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021531 spinal cord radial glial cell differentiation Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021807 motogenic signaling initiating cell movement in cerebral cortex Added DEFINITION The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex.
2006-08-18 GO:0021838 motogenic signaling involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex.
2006-08-18 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration Added DEFINITION The signaling that results in the stimulation of cell movement in the rostral migratory stream.
2006-08-18 GO:0019788 NEDD8 transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
2006-08-18 GO:0022001 negative regulation of anterior neural cell fate commitment of the neural plate Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate.
2006-08-18 GO:0048692 negative regulation of axon extension involved in regeneration Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in regeneration.
2006-08-18 GO:0021804 negative regulation of cell adhesion in ventricular zone Added DEFINITION The process that results in the loss of attachments of a cell in the ventricular zone.
2006-08-18 GO:0021822 negative regulation of cell motility involved in cerebral cortex radial glia guided migration Added DEFINITION The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex.
2006-08-18 GO:0021821 negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination Added DEFINITION The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021941 negative regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Added DEFINITION A BMP
2006-08-18 GO:0021675 nerve development Added DEFINITION The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
2006-08-18 GO:0021682 nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.
2006-08-18 GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021761 limbic system development Added DEFINITION The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.
2006-08-18 GO:0021703 locus ceruleus development Added DEFINITION The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021705 locus ceruleus formation Added DEFINITION The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021706 locus ceruleus maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021704 locus ceruleus morphogenesis Added DEFINITION The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
2006-08-18 GO:0021708 Lugaro cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021767 mammillary body development Added DEFINITION The progression of the mammilary body over time from its initial formation until its mature state. The mammilary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.
2006-08-18 GO:0021700 developmental maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component, or gene product to attain its fully functional state.
2006-08-18 GO:0022020 medial ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of medial ganglionic eminence cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021526 medial motor column neuron differentiation Added DEFINITION The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021550 medulla oblongata development Added DEFINITION The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021580 medulla oblongata formation Added DEFINITION The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.
2006-08-18 GO:0021839 interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex Added DEFINITION The process whereby migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex.
2006-08-18 GO:0021948 inward migration of deep nuclear neurons Added DEFINITION The directed movement of deep nuclear neurons from the rostrodorsal region of the cerebellar plate to their final more ventral position.
2006-08-18 GO:0021996 lamina terminalis formation Added DEFINITION The process whereby the anterior-most portion of the neural axis is formed by closure of the anterior neuropore.
2006-08-18 GO:0043261 laminin-12 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma3.
2006-08-18 GO:0043257 laminin-8 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1.
2006-08-18 GO:0043258 laminin-9 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha4, beta2 and gamma1.
2006-08-18 GO:0022018 lateral ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021771 lateral geniculate nucleus development Added DEFINITION The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.
2006-08-18 GO:0021525 lateral motor column neuron differentiation Added DEFINITION The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021726 lateral reticular nucleus development Added DEFINITION The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021670 lateral ventricle development Added DEFINITION The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.
2006-08-18 GO:0021664 rhombomere 5 morphogenesis Added DEFINITION The process by which the anatomical structures of rhombomere 5 are generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021665 rhombomere 5 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021572 rhombomere 6 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021669 rhombomere 6 formation Added DEFINITION The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021667 rhombomere 6 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 6 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021864 radial glial cell division in forebrain Added DEFINITION The mitotic division of radial glial cells in the developing forebrain.
2006-08-18 GO:0022015 radial glial cell division in pallium Added DEFINITION The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.
2006-08-18 GO:0022014 radial glial cell division in subpallium Added DEFINITION The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.
2006-08-18 GO:0022023 radial glial cell fate commitment in forebrain Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell.
2006-08-18 GO:0048690 regulation of axon extension involved in regeneration Updated DEFINITION Any process that modulates the frequency, rate or extent of axon extension involved in regeneration.
2006-08-18 GO:0021921 regulation of cell proliferation in dorsal spinal cord Added DEFINITION The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.
2006-08-18 GO:0021936 regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that modulates the frequency, rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021909 regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021918 regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis.
2006-08-18 GO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord.
2006-08-18 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord.
2006-08-18 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.
2006-08-18 GO:0021911 retinoic acid metabolic process in spinal cord anterior-posterior patterning Added DEFINITION The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021908 retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation Added DEFINITION The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021774 retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
2006-08-18 GO:0021723 medullary reticular formation development Added DEFINITION The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata.
2006-08-18 GO:0021567 rhombomere 1 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021652 rhombomere 1 formation Added DEFINITION The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021651 rhombomere 1 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 1 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021653 rhombomere 1 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021568 rhombomere 2 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021845 neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration Added DEFINITION The response of migrating cells to neurotransmitters that alter electrical activity in cells in calcium dependent manner.
2006-08-18 GO:0021809 neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021876 Notch signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021880 Notch signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration Added DEFINITION The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.
2006-08-18 GO:0021768 nucleus accumbens development Added DEFINITION The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.
2006-08-18 GO:0021745 nucleus ambiguus development Added DEFINITION The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.
2006-08-18 GO:0032132 O6-alkylguanine-DNA binding Added DEFINITION Interacting selectively with O6-alkylguanine adducts in DNA.
2006-08-18 GO:0021645 vagus nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
2006-08-18 GO:0021749 ventral cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021517 ventral spinal cord development Added DEFINITION The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.
2006-08-18 GO:0021514 ventral spinal cord interneuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021521 ventral spinal cord interneuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021952 central nervous system projection neuron axonogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2006-08-18 GO:0021597 central nervous system structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0022009 central nervous system vasculogenesis Added DEFINITION The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.
2006-08-18 GO:0021709 cerebellar basket cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021695 cerebellar cortex development Added DEFINITION The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021697 cerebellar cortex formation Added DEFINITION The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021699 cerebellar cortex maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021696 cerebellar cortex morphogenesis Added DEFINITION The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021982 pineal gland development Added DEFINITION The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms.
2006-08-18 GO:0021983 pituitary gland development Added DEFINITION The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
2006-08-18 GO:0021548 pons development Added DEFINITION The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021584 pons formation Added DEFINITION The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021586 pons maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021583 pons morphogenesis Added DEFINITION The process by which the anatomical structure of the pons is generated and organized. Morphogenesis pertains to the creation of form. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021975 pons reticulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord.
2006-08-18 GO:0021585 pons structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
2006-08-18 GO:0021740 principal sensory nucleus of trigeminal nerve development Added DEFINITION The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0048691 positive regulation of axon extension involved in regeneration Updated DEFINITION Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
2006-08-18 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation Added DEFINITION The process that activates or increases the rate or extent of granule cell precursor proliferation.
2006-08-18 GO:0021961 posterior commissure morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon.
2006-08-18 GO:0021507 posterior neuropore closure Added DEFINITION The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete.
2006-08-18 GO:0021784 postganglionic parasympathetic fiber development Added DEFINITION The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
2006-08-18 GO:0021827 postnatal olfactory bulb interneuron migration Added DEFINITION The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth.
2006-08-18 GO:0021501 prechordal plate formation Added DEFINITION The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
2006-08-18 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration Added DEFINITION The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.
2006-08-18 GO:0021950 chemorepulsion involved in precerebellar neuron migration Added DEFINITION The creation and reception of signals that repel precerebellar neurons as a component of the process of tangential migration.
2006-08-18 GO:0021793 chemorepulsion of branchiomotor axon Added DEFINITION The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021790 chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme Added DEFINITION The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021787 chemorepulsion of branchiomotor neuron axon in neural tube Added DEFINITION The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021765 cingulate gyrus development Added DEFINITION The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum.
2006-08-18 GO:0021747 cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021528 commissural neuron differentiation in spinal cord Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain Added DEFINITION The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.
2006-08-18 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain Added DEFINITION The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain.
2006-08-18 GO:0022007 convergent extension involved in neural plate elongation Added DEFINITION The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.
2006-08-18 GO:0021668 rhombomere 6 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021573 rhombomere 7 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021673 rhombomere 7 formation Added DEFINITION The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021671 rhombomere 7 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 7 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021672 rhombomere 7 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021574 rhombomere 8 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0019783 ubiquitin-like protein-specific protease activity Updated DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups.
2006-08-18 GO:0008641 small protein activating enzyme activity Updated DEFINITION Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
2006-08-18 GO:0008639 small protein conjugating enzyme activity Updated DEFINITION Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2006-08-18 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells.
2006-08-18 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
2006-08-18 GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification Added DEFINITION The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
2006-08-18 GO:0021746 solitary nucleus development Added DEFINITION The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021802 somal translocation Added DEFINITION The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.
2006-08-18 GO:0021523 somatic motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021591 ventricular system development Added DEFINITION The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
2006-08-18 GO:0021900 ventricular zone cell fate commitment Added DEFINITION The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons.
2006-08-18 GO:0021868 ventricular zone cell-producing asymmetric radial glial cell division in forebrain Added DEFINITION The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell.
2006-08-18 GO:0021750 vestibular nucleus development Added DEFINITION The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021562 vestibulocochlear nerve development Added DEFINITION The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021650 vestibulocochlear nerve formation Added DEFINITION The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021647 vestibulocochlear nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021648 vestibulocochlear nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the vestibulocochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021649 vestibulocochlear nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2006-08-18 GO:0021962 vestibulospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord.
2006-08-18 GO:0021524 visceral motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0022002 negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway Added DEFINITION The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell.
2006-08-18 GO:0021701 cerebellar Golgi cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021681 cerebellar granular layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021684 cerebellar granular layer formation Added DEFINITION The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021686 cerebellar granular layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021683 cerebellar granular layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar granular layer is generated and organized. Morphogenesis pertains to the creation of form. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021685 cerebellar granular layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
2006-08-18 GO:0021707 cerebellar granule cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021679 cerebellar molecular layer development Added DEFINITION The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021688 cerebellar molecular layer formation Added DEFINITION The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021690 cerebellar molecular layer maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021687 cerebellar molecular layer morphogenesis Added DEFINITION The process by which the anatomical structure of the cerebellar molecular layer is generated and organized. Morphogenesis pertains to the creation of form. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021689 cerebellar molecular layer structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
2006-08-18 GO:0021795 cerebral cortex cell migration Added DEFINITION The orderly movement of cells from one site to another in the cerebral cortex.
2006-08-18 GO:0021655 rhombomere 2 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 2 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021656 rhombomere 2 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021569 rhombomere 3 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021660 rhombomere 3 formation Added DEFINITION The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021658 rhombomere 3 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 3 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021659 rhombomere 3 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021570 rhombomere 4 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021663 rhombomere 4 formation Added DEFINITION The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021661 rhombomere 4 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 4 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021662 rhombomere 4 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021571 rhombomere 5 development Added DEFINITION The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021666 rhombomere 5 formation Added DEFINITION The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0019787 ubiquitin-like protein transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.
2006-08-18 GO:0021612 facial nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021754 facial nucleus development Added DEFINITION The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021738 fastigial nucleus development Added DEFINITION The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022003 negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway Added DEFINITION The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2006-08-18 GO:0021875 fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain.
2006-08-18 GO:0021907 fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.
2006-08-18 GO:0021899 fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0043680 filiform apparatus Added DEFINITION A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells.
2006-08-18 GO:0021508 floor plate formation Added DEFINITION The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.
2006-08-18 GO:0021797 forebrain anterior/posterior pattern specification Added DEFINITION The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.
2006-08-18 GO:0043259 laminin-10 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta1 and gamma1.
2006-08-18 GO:0043260 laminin-11 complex Updated DEFINITION A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta2 and gamma1.
2006-08-18 GO:0021897 forebrain astrocyte development Added DEFINITION The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2006-08-18 GO:0021896 forebrain astrocyte differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2006-08-18 GO:0021878 forebrain astrocyte fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain.
2006-08-18 GO:0021885 forebrain cell migration Added DEFINITION The orderly movement of cells from one site to another at least one of which is located in the forebrain.
2006-08-18 GO:0021798 forebrain dorsal/ventral pattern formation Added DEFINITION The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.
2006-08-18 GO:0022000 forebrain induction by the anterior neural ridge Added DEFINITION The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate.
2006-08-18 GO:0021873 forebrain neuroblast division Added DEFINITION The division of a neuroblast, the neural precursor in the forebrain, giving rise to at least another neuroblast. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).
2006-08-18 GO:0021884 forebrain neuron development Added DEFINITION The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
2006-08-18 GO:0021879 forebrain neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.
2006-08-18 GO:0021877 forebrain neuron fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.
2006-08-18 GO:0021871 forebrain regionalization Added DEFINITION The creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.
2006-08-18 GO:0021869 forebrain ventricular zone progenitor cell division Added DEFINITION The mitotic division of a basal progenitor giving rise to two neurons.
2006-08-18 GO:0021905 forebrain-midbrain boundary formation Added DEFINITION The process whose specific outcome is the creation of the forebrain-midbrain boundary.
2006-08-18 GO:0021943 formation of radial glial scaffolds Added DEFINITION The formation of scaffolds from radial glial cells. The scaffolds are used as a substrate for the radial migration of cells.
2006-08-18 GO:0021657 rhombomere 2 formation Added DEFINITION The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021987 cerebral cortex development Added DEFINITION The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
2006-08-18 GO:0021894 cerebral cortex GABAergic interneuron development Added DEFINITION The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.
2006-08-18 GO:0021892 cerebral cortex GABAergic interneuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.
2006-08-18 GO:0021893 cerebral cortex GABAergic interneuron fate commitment Added DEFINITION The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.
2006-08-18 GO:0021698 cerebellar cortex structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2006-08-18 GO:0021677 rhombomere 8 formation Added DEFINITION The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0021674 rhombomere 8 morphogenesis Added DEFINITION The process by which the anatomical structure of rhombomere 8 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021676 rhombomere 8 structural organization Added DEFINITION The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
2006-08-18 GO:0021654 rhombomere boundary formation Added DEFINITION The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
2006-08-18 GO:0022036 rhombomere cell differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a rhombomere cell.
2006-08-18 GO:0022035 rhombomere cell migration Added DEFINITION The movement of cells within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.
2006-08-18 GO:0022034 rhombomere cell proliferation Added DEFINITION The multiplication or reproduction of rhombomere cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021546 rhombomere development Added DEFINITION The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021594 rhombomere formation Added DEFINITION The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021593 rhombomere morphogenesis Added DEFINITION The process by which the anatomical structure of the rhombomere is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021595 rhombomere structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.
2006-08-18 GO:0021509 roof plate formation Added DEFINITION The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.
2006-08-18 GO:0021931 rostral hindbrain neuronal precursor cell proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus.
2006-08-18 GO:0021734 rostral lateral line nerve development Added DEFINITION The progression of the rostral lateral line nerve over time from its initial formation until its mature state. The rostral lateral line nerve is a sensory afferent projecting from the anterior lateral line ganglion to the hindbrain in fishes.
2006-08-18 GO:0021903 rostrocaudal neural tube patterning Added DEFINITION The process by which the neural tube is divided into specific regions along the rostrocaudal axis.
2006-08-18 GO:0021853 cerebral cortex GABAergic interneuron migration Added DEFINITION The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
2006-08-18 GO:0021895 cerebral cortex neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
2006-08-18 GO:0021801 cerebral cortex radial glia guided migration Added DEFINITION The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.
2006-08-18 GO:0021799 cerebral cortex radially oriented cell migration Added DEFINITION The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
2006-08-18 GO:0021796 cerebral cortex regionalization Added DEFINITION The creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.
2006-08-18 GO:0021800 cerebral cortex tangential migration Added DEFINITION The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
2006-08-18 GO:0021824 cerebral cortex tangential migration using cell-axon interactions Added DEFINITION The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons.
2006-08-18 GO:0021823 cerebral cortex tangential migration using cell-cell interactions Added DEFINITION The process whereby neurons interact with each other to promote migration along a tangential plane.
2006-08-18 GO:0021835 chemoattraction involved in embryonic olfactory bulb interneuron precursor migration Added DEFINITION The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb.
2006-08-18 GO:0021841 chemoattraction involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex.
2006-08-18 GO:0021951 chemoattraction involved in precerebellar neuron migration Added DEFINITION The creation and reception of signals that guide precerebellar neurons towards their signals, where this process is involved in tangential migration.
2006-08-18 GO:0021792 chemoattraction of branchiomotor axon Added DEFINITION The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021791 chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme Added DEFINITION The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021788 chemoattraction of branchiomotor neuron axon in neural tube Added DEFINITION The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2006-08-18 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration Added DEFINITION The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb.
2006-08-18 GO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.
2006-08-18 GO:0021516 dorsal spinal cord development Added DEFINITION The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.
2006-08-18 GO:0021904 dorsal/ventral neural tube patterning Added DEFINITION The process by which the neural tube is regionalized in the dorsoventral axis.
2006-08-18 GO:0021862 early neuron differentiation in forebrain Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021901 early neuron fate commitment in forebrain Added DEFINITION The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain.
2006-08-18 GO:0021737 emboliform nucleus development Added DEFINITION The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021831 embryonic olfactory bulb interneuron precursor migration Added DEFINITION The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.
2006-08-18 GO:0043671 endexine Updated DEFINITION The inner part of the exine, which stains.
2006-08-18 GO:0022026 epidermal growth factor signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021538 epithalamus development Added DEFINITION The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle.
2006-08-18 GO:0021755 eurydendroid cell differentiation Added DEFINITION The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.
2006-08-18 GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration Added DEFINITION The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.
2006-08-18 GO:0044420 extracellular matrix component Updated DEFINITION Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
2006-08-18 GO:0021939 extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation Added DEFINITION The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation.
2006-08-18 GO:0021561 facial nerve development Added DEFINITION The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021611 facial nerve formation Added DEFINITION The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021607 accessory nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the accessory nerve is generated and organized. Morphogenesis pertains to the creation of form. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021609 accessory nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
2006-08-18 GO:0021984 adenohypophysis development Added DEFINITION The progression of the adenophysis over time from its initial formation until its mature state. The adenophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
2006-08-18 GO:0032131 alkylated DNA binding Added DEFINITION Interacting selectively with alkylated residues in DNA.
2006-08-18 GO:0021541 ammon gyrus development Added DEFINITION The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.
2006-08-18 GO:0021764 amygdala development Added DEFINITION The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.
2006-08-18 GO:0048646 anatomical structure formation involved in morphogenesis Updated DEFINITION The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
2006-08-18 GO:0021960 anterior commissure morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal processes is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
2006-08-18 GO:0021506 anterior neuropore closure Added DEFINITION The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete.
2006-08-18 GO:0021866 asymmetric radial glial cell division in forebrain Added DEFINITION The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type.
2006-08-18 GO:0021557 oculomotor nerve development Added DEFINITION The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0022029 telencephalon cell migration Added DEFINITION The orderly movement of cells from one site to another at least one of which is located in the telencephalon.
2006-08-18 GO:0021917 somatic motor neuron fate commitment Added DEFINITION The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.
2006-08-18 GO:0021512 spinal cord anterior/posterior patterning Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.
2006-08-18 GO:0021527 spinal cord association neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021519 spinal cord association neuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021518 spinal cord commissural neuron specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021510 spinal cord development Added DEFINITION The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
2006-08-18 GO:0021513 spinal cord dorsal/ventral patterning Added DEFINITION The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.
2006-08-18 GO:0021520 spinal cord motor neuron cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021522 spinal cord motor neuron differentiation Added DEFINITION The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021529 spinal cord oligodendrocyte cell differentiation Added DEFINITION The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021530 spinal cord oligodendrocyte cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.
2006-08-18 GO:0021511 spinal cord patterning Added DEFINITION The process that regulates the coordinated growth that establishes the non-random spatial arrangement of the spinal cord.
2006-08-18 GO:0021965 spinal cord ventral commissure morphogenesis Added DEFINITION The process by which the anatomical structures of the spinal cord ventral commissure are generated and organized. Morphogenesis pertains to the creation of form.
2006-08-18 GO:0021741 spinal trigeminal nucleus development Added DEFINITION The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022038 corpus callosum development Added DEFINITION The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
2006-08-18 GO:0021540 corpus callosum morphogenesis Added DEFINITION The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.
2006-08-18 GO:0021967 corticospinal neuron axon guidance through the cerebral cortex Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021973 corticospinal neuron axon decussation Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.
2006-08-18 GO:0021966 corticospinal neuron axon guidance Added DEFINITION The process by which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021970 corticospinal neuron axon guidance through the basilar pons Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021969 corticospinal neuron axon guidance through the cerebral peduncle Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021968 corticospinal neuron axon guidance through the internal capsule Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021971 corticospinal neuron axon guidance through the medullary pyramid Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021972 corticospinal neuron axon guidance through spinal cord Added DEFINITION The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.
2006-08-18 GO:0021957 corticospinal tract morphogenesis Added DEFINITION Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal processes is a member of those that make up the corticospinal tract.
2006-08-18 GO:0021545 cranial nerve development Added DEFINITION The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021603 cranial nerve formation Added DEFINITION The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021605 cranial nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021602 cranial nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021604 cranial nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2006-08-18 GO:0021959 cuneatus tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb.
2006-08-18 GO:0021808 cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration Added DEFINITION The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021946 deep nuclear neuron cell migration Added DEFINITION The directed movement of deep nuclear neurons from the ventricular zone to the deep hindbrain nuclei.
2006-08-18 GO:0021927 deep nuclear neuron precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons.
2006-08-18 GO:0021964 rubrospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord.
2006-08-18 GO:0021751 salivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022022 septal cell proliferation Added DEFINITION The multiplication or reproduction of septal cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021850 subpallium glioblast cell division Added DEFINITION The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes.
2006-08-18 GO:0021736 globose nucleus development Added DEFINITION The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021759 globus pallidus development Added DEFINITION The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.
2006-08-18 GO:0021563 glossopharyngeal nerve development Added DEFINITION Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021616 glossopharyngeal nerve formation Added DEFINITION The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021614 glossopharyngeal nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021615 glossopharyngeal nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the glossopharyngeal nerve is generated and organized. Morphogenesis pertains to the creation of form. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021617 glossopharyngeal nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
2006-08-18 GO:0021926 Golgi cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus Added DEFINITION The directional movement of gonadotrophin-releasing hormone producing neurons from the nasal placode to the hypothalamus.
2006-08-18 GO:0021958 gracilis tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb.
2006-08-18 GO:0021930 cerebellar granule cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021935 cerebellar granule cell precursor tangential migration Added DEFINITION The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.
2006-08-18 GO:0021811 growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration Added DEFINITION Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex.
2006-08-18 GO:0021986 habenula development Added DEFINITION The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.
2006-08-18 GO:0021576 hindbrain formation Added DEFINITION The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021578 hindbrain maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021575 hindbrain morphogenesis Added DEFINITION The process by which the anatomical structure of the hindbrain is generated and organized. Morphogenesis pertains to the creation of form. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021932 hindbrain radial glia guided cell migration Added DEFINITION The radially directed movement of cells along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.
2006-08-18 GO:0021577 hindbrain structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2006-08-18 GO:0021934 hindbrain tangential cell migration Added DEFINITION The migration of cells in the hindbrain in which cells move orthogonal to the direction of radial migration.
2006-08-18 GO:0021906 hindbrain-spinal cord boundary formation Added DEFINITION The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.
2006-08-18 GO:0021766 hippocampus development Added DEFINITION The progression of the hippocampus over time from its initial formation until its mature state.
2006-08-18 GO:0021566 hypoglossal nerve development Added DEFINITION The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
2006-08-18 GO:0021779 oligodendrocyte cell fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte.
2006-08-18 GO:0021778 oligodendrocyte cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2006-08-18 GO:0021829 oligodendrocyte cell migration from the subpallium to the cortex Added DEFINITION The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development.
2006-08-18 GO:0021592 fourth ventricle development Added DEFINITION The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.
2006-08-18 GO:0021858 GABAergic neuron differentiation in basal ganglia Added DEFINITION The process whereby a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.
2006-08-18 GO:0021872 forebrain generation of neurons Added DEFINITION The process by which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.
2006-08-18 GO:0021782 glial cell development Added DEFINITION The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2006-08-18 GO:0021781 glial cell fate commitment Added DEFINITION The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
2006-08-18 GO:0021963 spinothalamic tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal processes is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling.
2006-08-18 GO:0021929 stellate cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021773 striatal medium spiny neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.
2006-08-18 GO:0021756 striatum development Added DEFINITION The progression of the striatum over time from its initial formation until its mature state. The striatum is a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking.
2006-08-18 GO:0021980 subpallium cell migration Added DEFINITION The orderly movement of cells from one site to another in the subpallium.
2006-08-18 GO:0022012 subpallium cell proliferation in forebrain Added DEFINITION The multiplication or reproduction of subpallium cells in the forebrain, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021544 subpallium development Added DEFINITION The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.
2006-08-18 GO:0021981 subpallium radially oriented migration Added DEFINITION The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.
2006-08-18 GO:0021762 substantia nigra development Added DEFINITION The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
2006-08-18 GO:0021825 substrate-dependent cerebral cortex tangential migration Added DEFINITION The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.
2006-08-18 GO:0021843 substrate-independent telencephalic tangential interneuron migration Added DEFINITION The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates.
2006-08-18 GO:0021826 substrate-independent telencephalic tangential migration Added DEFINITION The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact.
2006-08-18 GO:0021763 subthalamic nucleus development Added DEFINITION The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.
2006-08-18 GO:0021539 subthalamus development Added DEFINITION The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.
2006-08-18 GO:0019789 SUMO transferase activity Updated DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.
2006-08-18 GO:0021718 superior olivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021720 superior olivary nucleus formation Added DEFINITION The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021722 superior olivary nucleus maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021719 superior olivary nucleus morphogenesis Added DEFINITION The process by which the anatomical structure of the superior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021721 superior olivary nucleus structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.
2006-08-18 GO:0021725 superior raphe nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure
2006-08-18 GO:0021729 superior reticular formation development Added DEFINITION The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure.
2006-08-18 GO:0021753 superior salivary nucleus development Added DEFINITION The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021865 symmetric radial glial cell division in forebrain Added DEFINITION The mitotic division of a radial glial cell giving rise to two new radial glial cells.
2006-08-18 GO:0022028 tangential migration from the subventricular zone to the olfactory bulb Added DEFINITION The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
2006-08-18 GO:0021542 dentate gyrus development Added DEFINITION The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.
2006-08-18 GO:0021735 dentate nucleus development Added DEFINITION The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021536 diencephalon development Added DEFINITION The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
2006-08-18 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex Added DEFINITION The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex.
2006-08-18 GO:0021748 dorsal cochlear nucleus development Added DEFINITION The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0022019 dorsal lateral ganglionic eminence cell proliferation Added DEFINITION The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population.
2006-08-18 GO:0021744 dorsal motor nucleus of vagus nerve development Added DEFINITION The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.
2006-08-18 GO:0021757 caudate nucleus development Added DEFINITION The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.
2006-08-18 GO:0021883 cell cycle arrest of committed forebrain neuronal progenitor cell Added DEFINITION The process by which progression through the cell cycle is halted in a cell that has been committed to become a neuron that will reside in the forebrain.
2006-08-18 GO:0021533 cell differentiation in hindbrain Added DEFINITION The process whereby relatively unspecialized cells, acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021515 cell differentiation in spinal cord Added DEFINITION The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2006-08-18 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration Added DEFINITION The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
2006-08-18 GO:0021535 cell migration in hindbrain Added DEFINITION The orderly movement of cells that will reside in the hindbrain.
2006-08-18 GO:0021805 cell movement involved in somal translocation Added DEFINITION The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface.
2006-08-18 GO:0021534 cell proliferation in hindbrain Added DEFINITION The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain.
2006-08-18 GO:0021924 cell proliferation in external granule layer Added DEFINITION The multiplication or reproduction of neuroblasts resulting in the rapid expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.
2006-08-18 GO:0021846 cell proliferation in forebrain Added DEFINITION The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.
2006-08-18 GO:0021923 cell proliferation in hindbrain ventricular zone Added DEFINITION The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity.
2006-08-18 GO:0021992 cell proliferation involved in neural plate elongation Added DEFINITION The process of rapid expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue.
2006-08-18 GO:0021832 cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions Added DEFINITION The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration.
2006-08-18 GO:0021630 olfactory nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021627 olfactory nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the olfactory nerve is generated and organized. Morphogenesis pertains to the creation of form. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021629 olfactory nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration Added DEFINITION The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.
2006-08-18 GO:0021833 cell-matrix adhesion involved in tangential migration using cell-cell interactions Added DEFINITION The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex.
2006-08-18 GO:0021556 central nervous system formation Added DEFINITION The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0021956 central nervous system interneuron axonogenesis Added DEFINITION Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.
2006-08-18 GO:0021626 central nervous system maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0021551 central nervous system morphogenesis Added DEFINITION The process by which the anatomical structure of the central nervous system is generated and organized. Morphogenesis pertains to the creation of form. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2006-08-18 GO:0022010 central nervous system myelination Added DEFINITION The process during which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2006-08-18 GO:0021955 central nervous system neuron axonogenesis Added DEFINITION Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
2006-08-18 GO:0021954 central nervous system neuron development Added DEFINITION The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
2006-08-18 GO:0021953 central nervous system neuron differentiation Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
2006-08-18 GO:0021620 hypoglossal nerve formation Added DEFINITION The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.
2006-08-18 GO:0021537 telencephalon development Added DEFINITION The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
2006-08-18 GO:0022030 telencephalon glial cell migration Added DEFINITION The orderly movement of glial cells through the telencephalon.
2006-08-18 GO:0022033 telencephalon microglial cell migration Added DEFINITION The orderly movement of microglial cells through the telencephalon.
2006-08-18 GO:0022032 telencephalon oligodendrocyte cell migration Added DEFINITION The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the rapid expansion of a cell population.
2006-08-18 GO:0021978 telencephalon regionalization Added DEFINITION The creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.
2006-08-18 GO:0021794 thalamus development Added DEFINITION The process by which the thalamus changes over time, from its initial formation to its mature state.
2006-08-18 GO:0021678 third ventricle development Added DEFINITION The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.
2006-08-18 GO:0016563 transcription activator activity Updated DEFINITION Any transcription regulator activity required for initiation or upregulation of transcription.
2006-08-18 GO:0021731 trigeminal motor nucleus development Added DEFINITION The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure.
2006-08-18 GO:0021559 trigeminal nerve development Added DEFINITION The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0021638 trigeminal nerve formation Added DEFINITION The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0021635 trigeminal nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2006-08-18 GO:0048846 axon extension involved in axon guidance Added DEFINITION The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
2006-08-18 GO:0048676 axon extension involved in development Updated DEFINITION Long distance growth of a single axon process involved in cellular development.
2006-08-18 GO:0048677 axon extension involved in regeneration Updated DEFINITION Long distance growth of a single axon process involved in regeneration of the neuron.
2006-08-18 GO:0021928 basket cell precursor proliferation Added DEFINITION The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
2006-08-18 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning Added DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord..
2006-08-18 GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification Added DEFINITION A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate
2006-08-18 GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment Added DEFINITION The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
2006-08-18 GO:0021623 oculomotor nerve formation Added DEFINITION The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021625 oculomotor nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021622 oculomotor nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the oculomotor nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021624 oculomotor nerve structural organization Added DEFINITION The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2006-08-18 GO:0021772 olfactory bulb development Added DEFINITION The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
2006-08-18 GO:0021891 olfactory bulb interneuron development Added DEFINITION The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.
2006-08-18 GO:0021889 olfactory bulb interneuron differentiation Added DEFINITION The process whereby a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.
2006-08-18 GO:0021890 olfactory bulb interneuron fate commitment Added DEFINITION The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb.
2006-08-18 GO:0021989 olfactory cortex development Added DEFINITION The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors.
2006-08-18 GO:0021988 olfactory lobe development Added DEFINITION The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.
2006-08-18 GO:0021553 olfactory nerve development Added DEFINITION The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021628 olfactory nerve formation Added DEFINITION The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
2006-08-18 GO:0021613 facial nerve maturation Added DEFINITION A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021610 facial nerve morphogenesis Added DEFINITION The process by which the anatomical structure of the facial nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2006-08-18 GO:0021977 tectospinal tract morphogenesis Added DEFINITION Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord.
2006-08-18 GO:0022031 telencephalon astrocyte cell migration Added DEFINITION The orderly movement of astrocyte cells through the telencephalon.
2006-08-18 GO:0021780 glial cell fate specification Added DEFINITION The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2006-08-18 GO:0022016 pallium glioblast division Added DEFINITION The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells.
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