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GO Term History: Displaying 167 audit records for all terms for the date 2005-05-26

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2005-05-26 GO:0050851 antigen receptor-mediated signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0042113 B cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0031296 B cell costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.
2005-05-26 GO:0030183 B cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell.
2005-05-26 GO:0042101 T cell receptor complex Updated DEFINITION A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation.
2005-05-26 GO:0050852 T cell receptor signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0045058 T cell selection Updated DEFINITION The processes through which T cells that express T cell receptors which are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
2005-05-26 GO:0045063 T-helper 1 cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2005-05-26 GO:0045064 T-helper 2 cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell.
2005-05-26 GO:0045061 thymic T cell selection Updated DEFINITION Processes of T cell selection that occur in the thymus.
2005-05-26 GO:0048538 thymus development Updated DEFINITION The process aimed at the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
2005-05-26 GO:0001806 type IV hypersensitivity Updated DEFINITION An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
2005-05-26 GO:0031428 box C/D snoRNP complex Updated DEFINITION A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type.
2005-05-26 GO:0048540 bursa of Fabricius development Updated DEFINITION The process aimed at the progression of the bursa over time, from its formation to the mature structure. The bursa is an organ found in birds involved in B cell differentiation.
2005-05-26 GO:0005175 CD27 receptor binding Updated DEFINITION Interacting selectively with a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
2005-05-26 GO:0042609 CD4 receptor binding Updated DEFINITION Interacting selectively with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
2005-05-26 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage.
2005-05-26 GO:0043367 CD4-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive T cell.
2005-05-26 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process be which an immature T cell becomes committed to becoming a CD4-positive T cell.
2005-05-26 GO:0042614 CD70 receptor binding Updated DEFINITION Interacting selectively with a CD70, a receptor found on the surface of most activated B cells and some activated T cells.
2005-05-26 GO:0043374 CD8-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive T cell.
2005-05-26 GO:0043375 CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process be which an immature T cell becomes committed to becoming a CD8-positive T cell.
2005-05-26 GO:0043316 cytotoxic T cell degranulation Updated DEFINITION The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
2005-05-26 GO:0045065 cytotoxic T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
2005-05-26 GO:0001769 establishment of B cell polarity Updated DEFINITION The directed orientation of B cell signaling molecules and associated lipid rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
2005-05-26 GO:0001768 establishment of T cell polarity Updated DEFINITION The directed orientation of T cell signaling molecules and associated lipid rafts towards a chemokine gradient or a contact point with antigen presenting cell.
2005-05-26 GO:0045062 extrathymic T cell selection Updated DEFINITION Processes of T cell selection that occur in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus.
2005-05-26 GO:0046629 gamma-delta T cell activation Updated DEFINITION The change in morphology and behavior of gamma-delta T cells resulting from exposure to a mitogen or to an antigen to which they have been primed.
2005-05-26 GO:0042492 gamma-delta T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell.
2005-05-26 GO:0046630 gamma-delta T cell proliferation Updated DEFINITION The rapid expansion of a gamma-delta T cell population by cell division.
2005-05-26 GO:0030373 high molecular weight B cell growth factor receptor activity Updated DEFINITION Combining with a high molecular weight B cell growth factor to initiate a change in cell activity.
2005-05-26 GO:0030372 high molecular weight B cell growth factor receptor binding Updated DEFINITION Interacting selectively with the high molecular weight B cell growth factor receptor.
2005-05-26 GO:0001782 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism are stable over time in the absence of an outside stimulus.
2005-05-26 GO:0019724 B cell mediated immunity Updated DEFINITION The promotion of an immune response by B cells through the secretion of antibodies and cytokines, and through antigen presentation to T cells.
2005-05-26 GO:0042100 B cell proliferation Updated DEFINITION The rapid expansion of a B cell population by cell division. Follows B cell activation.
2005-05-26 GO:0050853 B cell receptor signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001923 B-1 B cell differentiation Updated DEFINITION Processes whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0001922 B-1 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0043366 beta selection Updated DEFINITION The signaling from the pre-T cell receptor complex indicative of successful recombination of a T cell receptor beta chain into a translatable protein coding sequence and the resulting processes which lead to the rescue from apoptosis and subsequent proliferation of an immature T cell.
2005-05-26 GO:0046014 negative regulation of T cell homeostatic proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.
2005-05-26 GO:0001915 negative regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
2005-05-26 GO:0042130 negative regulation of T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
2005-05-26 GO:0050860 negative regulation of T cell receptor signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0043383 negative T cell selection Updated DEFINITION The process of elimination of immature T cells which react strongly with self-antigens.
2005-05-26 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD8-positive T cell differentiation.
2005-05-26 GO:0043317 regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation.
2005-05-26 GO:0045583 regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation.
2005-05-26 GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of CD8-positive T cell differentiation.
2005-05-26 GO:0043319 positive regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that activates or increases the rate of cytotoxic T cell degranulation.
2005-05-26 GO:0045585 positive regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that activates or increases the rate of cytotoxic T cell differentiation.
2005-05-26 GO:0046645 positive regulation of gamma-delta T cell activation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell activation.
2005-05-26 GO:0045588 positive regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell differentiation.
2005-05-26 GO:0046648 positive regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell proliferation.
2005-05-26 GO:0051251 positive regulation of lymphocyte activation Updated DEFINITION Any process that activates or increases the rate of lymphocyte activation.
2005-05-26 GO:0043382 positive regulation of memory T cell differentiation Updated DEFINITION Any process that activates or increases the rate of memory T cell differentiation.
2005-05-26 GO:0051135 positive regulation of NK T cell activation Updated DEFINITION Any process that activates or increases the rate of natural killer T cell activation.
2005-05-26 GO:0051138 positive regulation of NK T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell differentiation.
2005-05-26 GO:0051142 positive regulation of NK T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell proliferation.
2005-05-26 GO:0045591 positive regulation of regulatory T cell differentiation Updated DEFINITION Any process that activates or increases the rate of differentiation of regulatory T cells.
2005-05-26 GO:0050870 positive regulation of T cell activation Updated DEFINITION Any process that activates or increases the rate of T cell activation.
2005-05-26 GO:0045582 positive regulation of T cell differentiation Updated DEFINITION Any process that activates or increases the rate of T cell differentiation.
2005-05-26 GO:0042103 positive regulation of T cell homeostatic proliferation Updated DEFINITION Any process that activates or increases the rate or extent of resting T cell proliferation.
2005-05-26 GO:0001916 positive regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that activates or increases the rate of T cell mediated cytotoxicity.
2005-05-26 GO:0042102 positive regulation of T cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of T cell proliferation.
2005-05-26 GO:0050862 positive regulation of T cell receptor signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0043368 positive T cell selection Updated DEFINITION The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0045059 positive thymic T cell selection Updated DEFINITION The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0043384 pre-T cell receptor complex Updated DEFINITION A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.
2005-05-26 GO:0006924 activation-induced cell death of T cells Updated DEFINITION The process of apoptosis in activated T cells.
2005-05-26 GO:0001783 B cell apoptotic process Updated DEFINITION The process of apoptosis in B cells.
2005-05-26 GO:0018190 protein octanoylation Updated DEFINITION The modification of a protein amino acid by formation of an ester or amide with octanoic acid.
2005-05-26 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives Updated DEFINITION Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
2005-05-26 GO:0046006 regulation of activated T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of activated T cell proliferation.
2005-05-26 GO:0046634 regulation of alpha-beta T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.
2005-05-26 GO:0046637 regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation.
2005-05-26 GO:0046640 regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation.
2005-05-26 GO:0050854 regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050864 regulation of B cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell activation.
2005-05-26 GO:0045577 regulation of B cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell differentiation.
2005-05-26 GO:0030888 regulation of B cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell proliferation.
2005-05-26 GO:0050855 regulation of B cell receptor signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001924 regulation of B-1 B cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive T cell differentiation.
2005-05-26 GO:0046643 regulation of gamma-delta T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell activation.
2005-05-26 GO:0045586 regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.
2005-05-26 GO:0046646 regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation.
2005-05-26 GO:0043380 regulation of memory T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of memory T cell differentiation.
2005-05-26 GO:0051133 regulation of NK T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell activation.
2005-05-26 GO:0051136 regulation of NK T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell differentiation.
2005-05-26 GO:0051140 regulation of NK T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell proliferation.
2005-05-26 GO:0045589 regulation of regulatory T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
2005-05-26 GO:0050863 regulation of T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell activation.
2005-05-26 GO:0045580 regulation of T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell differentiation.
2005-05-26 GO:0046013 regulation of T cell homeostatic proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of resting T cell proliferation.
2005-05-26 GO:0001914 regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
2005-05-26 GO:0042129 regulation of T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell proliferation.
2005-05-26 GO:0050856 regulation of T cell receptor signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0003994 aconitate hydratase activity Updated DEFINITION Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate, i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
2005-05-26 GO:0050798 activated T cell proliferation Updated DEFINITION The rapid expansion of a T cell population following activation by an antigenic stimulus.
2005-05-26 GO:0046631 alpha-beta T cell activation Updated DEFINITION The change in morphology and behavior of alpha-beta T cells resulting from exposure to a mitogen or to an antigen to which they have been primed.
2005-05-26 GO:0042722 alpha-beta T cell activation by superantigen Updated DEFINITION The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region.
2005-05-26 GO:0046632 alpha-beta T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell.
2005-05-26 GO:0046633 alpha-beta T cell proliferation Updated DEFINITION The rapid expansion of an alpha-beta T cell population by cell division.
2005-05-26 GO:0001913 T cell mediated cytotoxicity Updated DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2005-05-26 GO:0042098 T cell proliferation Updated DEFINITION The rapid expansion of a T cell population by cell division. Follows T cell activation.
2005-05-26 GO:0042608 T cell receptor binding Updated DEFINITION Interacting selectively with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
2005-05-26 GO:0031418 L-ascorbic acid binding Updated DEFINITION Interacting selectivzely with L-ascorbic acid, a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs.
2005-05-26 GO:0031294 lymphocyte costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.
2005-05-26 GO:0030098 lymphocyte differentiation Updated DEFINITION The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells.
2005-05-26 GO:0031382 mating projection assembly Updated DEFINITION Formation of a projection by unicellular fungi in response to mating pheromone.
2005-05-26 GO:0043379 memory T cell differentiation Updated DEFINITION The process whereby a newly activated T cell acquires specialized features of a memory T cell.
2005-05-26 GO:0045068 negative extrathymic T cell selection Updated DEFINITION The process of elimination of extrathymically maturing T cells which react strongly with self-antigens.
2005-05-26 GO:0046007 negative regulation of activated T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
2005-05-26 GO:0046636 negative regulation of alpha-beta T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell activation.
2005-05-26 GO:0046639 negative regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell differentiation.
2005-05-26 GO:0046642 negative regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell proliferation.
2005-05-26 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050869 negative regulation of B cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of B cell activation.
2005-05-26 GO:0045578 negative regulation of B cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of B cell differentiation.
2005-05-26 GO:0030889 negative regulation of B cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
2005-05-26 GO:0050859 negative regulation of B cell receptor signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0030053 obsolete immunophilin Updated DEFINITION OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin.
2005-05-26 GO:0030073 insulin secretion Updated DEFINITION The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.
2005-05-26 GO:0045190 isotype switching Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048290 isotype switching to IgA isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048292 isotype switching to IgD isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048289 isotype switching to IgE isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048291 isotype switching to IgG isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0045066 regulatory T cell differentiation Updated DEFINITION The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
2005-05-26 GO:0016446 somatic hypermutation of immunoglobulin genes Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.
2005-05-26 GO:0042110 T cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0031295 T cell costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
2005-05-26 GO:0030217 T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell.
2005-05-26 GO:0043029 T cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism are stable over time in the absence of an outside stimulus.
2005-05-26 GO:0001777 T cell homeostatic proliferation Updated DEFINITION The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
2005-05-26 GO:0045060 negative thymic T cell selection Updated DEFINITION The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
2005-05-26 GO:0051132 NK T cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0001865 NK T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a natural killer T cell.
2005-05-26 GO:0001866 NK T cell proliferation Updated DEFINITION The expansion of a natural killer T cell population by cell division.
2005-05-26 GO:0045067 positive extrathymic T cell selection Updated DEFINITION The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0042104 positive regulation of activated T cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of activated T cell proliferation.
2005-05-26 GO:0046635 positive regulation of alpha-beta T cell activation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell activation.
2005-05-26 GO:0046638 positive regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell differentiation.
2005-05-26 GO:0046641 positive regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell proliferation.
2005-05-26 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050871 positive regulation of B cell activation Updated DEFINITION Any process that activates or increases the rate of B cell activation.
2005-05-26 GO:0045579 positive regulation of B cell differentiation Updated DEFINITION Any process that activates or increases the rate of B cell differentiation.
2005-05-26 GO:0030890 positive regulation of B cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of B cell proliferation.
2005-05-26 GO:0050861 positive regulation of B cell receptor signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001926 positive regulation of B-1 B cell differentiation Updated DEFINITION Any process that activates or increases the rate of B-1 B cell differentiation.
2005-05-26 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of CD4-positive T cell differentiation.
2005-05-26 GO:0001925 negative regulation of B-1 B cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.
2005-05-26 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive T cell differentiation.
2005-05-26 GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of CD8-positive T cell differentiation.
2005-05-26 GO:0050866 negative regulation of cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of cell activation.
2005-05-26 GO:0043318 negative regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
2005-05-26 GO:0045584 negative regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of cytotoxic T cell differentiation.
2005-05-26 GO:0046644 negative regulation of gamma-delta T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell activation.
2005-05-26 GO:0045587 negative regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell differentiation.
2005-05-26 GO:0046647 negative regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell proliferation.
2005-05-26 GO:0043381 negative regulation of memory T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of memory T cell differentiation.
2005-05-26 GO:0051134 negative regulation of NK T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell activation.
2005-05-26 GO:0051137 negative regulation of NK T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell differentiation.
2005-05-26 GO:0051141 negative regulation of NK T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell proliferation.
2005-05-26 GO:0045590 negative regulation of regulatory T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.
2005-05-26 GO:0050868 negative regulation of T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of T cell activation.
2005-05-26 GO:0045581 negative regulation of T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of T cell differentiation.

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2005-05-26 GO:0050851 antigen receptor-mediated signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0042113 B cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0031296 B cell costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.
2005-05-26 GO:0030183 B cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell.
2005-05-26 GO:0042101 T cell receptor complex Updated DEFINITION A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation.
2005-05-26 GO:0050852 T cell receptor signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0045058 T cell selection Updated DEFINITION The processes through which T cells that express T cell receptors which are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
2005-05-26 GO:0045063 T-helper 1 cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell.
2005-05-26 GO:0045064 T-helper 2 cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell.
2005-05-26 GO:0045061 thymic T cell selection Updated DEFINITION Processes of T cell selection that occur in the thymus.
2005-05-26 GO:0048538 thymus development Updated DEFINITION The process aimed at the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
2005-05-26 GO:0001806 type IV hypersensitivity Updated DEFINITION An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
2005-05-26 GO:0031428 box C/D snoRNP complex Updated DEFINITION A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type.
2005-05-26 GO:0048540 bursa of Fabricius development Updated DEFINITION The process aimed at the progression of the bursa over time, from its formation to the mature structure. The bursa is an organ found in birds involved in B cell differentiation.
2005-05-26 GO:0005175 CD27 receptor binding Updated DEFINITION Interacting selectively with a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
2005-05-26 GO:0042609 CD4 receptor binding Updated DEFINITION Interacting selectively with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
2005-05-26 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage.
2005-05-26 GO:0043367 CD4-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive T cell.
2005-05-26 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process be which an immature T cell becomes committed to becoming a CD4-positive T cell.
2005-05-26 GO:0042614 CD70 receptor binding Updated DEFINITION Interacting selectively with a CD70, a receptor found on the surface of most activated B cells and some activated T cells.
2005-05-26 GO:0043374 CD8-positive, alpha-beta T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive T cell.
2005-05-26 GO:0043375 CD8-positive, alpha-beta T cell lineage commitment Updated DEFINITION The process be which an immature T cell becomes committed to becoming a CD8-positive T cell.
2005-05-26 GO:0043316 cytotoxic T cell degranulation Updated DEFINITION The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
2005-05-26 GO:0045065 cytotoxic T cell differentiation Updated DEFINITION The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
2005-05-26 GO:0001769 establishment of B cell polarity Updated DEFINITION The directed orientation of B cell signaling molecules and associated lipid rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
2005-05-26 GO:0001768 establishment of T cell polarity Updated DEFINITION The directed orientation of T cell signaling molecules and associated lipid rafts towards a chemokine gradient or a contact point with antigen presenting cell.
2005-05-26 GO:0045062 extrathymic T cell selection Updated DEFINITION Processes of T cell selection that occur in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus.
2005-05-26 GO:0046629 gamma-delta T cell activation Updated DEFINITION The change in morphology and behavior of gamma-delta T cells resulting from exposure to a mitogen or to an antigen to which they have been primed.
2005-05-26 GO:0042492 gamma-delta T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell.
2005-05-26 GO:0046630 gamma-delta T cell proliferation Updated DEFINITION The rapid expansion of a gamma-delta T cell population by cell division.
2005-05-26 GO:0030373 high molecular weight B cell growth factor receptor activity Updated DEFINITION Combining with a high molecular weight B cell growth factor to initiate a change in cell activity.
2005-05-26 GO:0030372 high molecular weight B cell growth factor receptor binding Updated DEFINITION Interacting selectively with the high molecular weight B cell growth factor receptor.
2005-05-26 GO:0001782 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism are stable over time in the absence of an outside stimulus.
2005-05-26 GO:0019724 B cell mediated immunity Updated DEFINITION The promotion of an immune response by B cells through the secretion of antibodies and cytokines, and through antigen presentation to T cells.
2005-05-26 GO:0042100 B cell proliferation Updated DEFINITION The rapid expansion of a B cell population by cell division. Follows B cell activation.
2005-05-26 GO:0050853 B cell receptor signaling pathway Updated DEFINITION A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001923 B-1 B cell differentiation Updated DEFINITION Processes whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0001922 B-1 B cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0043366 beta selection Updated DEFINITION The signaling from the pre-T cell receptor complex indicative of successful recombination of a T cell receptor beta chain into a translatable protein coding sequence and the resulting processes which lead to the rescue from apoptosis and subsequent proliferation of an immature T cell.
2005-05-26 GO:0046014 negative regulation of T cell homeostatic proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.
2005-05-26 GO:0001915 negative regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
2005-05-26 GO:0042130 negative regulation of T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
2005-05-26 GO:0050860 negative regulation of T cell receptor signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0043383 negative T cell selection Updated DEFINITION The process of elimination of immature T cells which react strongly with self-antigens.
2005-05-26 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD8-positive T cell differentiation.
2005-05-26 GO:0043317 regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation.
2005-05-26 GO:0045583 regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation.
2005-05-26 GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of CD8-positive T cell differentiation.
2005-05-26 GO:0043319 positive regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that activates or increases the rate of cytotoxic T cell degranulation.
2005-05-26 GO:0045585 positive regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that activates or increases the rate of cytotoxic T cell differentiation.
2005-05-26 GO:0046645 positive regulation of gamma-delta T cell activation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell activation.
2005-05-26 GO:0045588 positive regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell differentiation.
2005-05-26 GO:0046648 positive regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that activates or increases the rate of gamma-delta T cell proliferation.
2005-05-26 GO:0051251 positive regulation of lymphocyte activation Updated DEFINITION Any process that activates or increases the rate of lymphocyte activation.
2005-05-26 GO:0043382 positive regulation of memory T cell differentiation Updated DEFINITION Any process that activates or increases the rate of memory T cell differentiation.
2005-05-26 GO:0051135 positive regulation of NK T cell activation Updated DEFINITION Any process that activates or increases the rate of natural killer T cell activation.
2005-05-26 GO:0051138 positive regulation of NK T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell differentiation.
2005-05-26 GO:0051142 positive regulation of NK T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell proliferation.
2005-05-26 GO:0045591 positive regulation of regulatory T cell differentiation Updated DEFINITION Any process that activates or increases the rate of differentiation of regulatory T cells.
2005-05-26 GO:0050870 positive regulation of T cell activation Updated DEFINITION Any process that activates or increases the rate of T cell activation.
2005-05-26 GO:0045582 positive regulation of T cell differentiation Updated DEFINITION Any process that activates or increases the rate of T cell differentiation.
2005-05-26 GO:0042103 positive regulation of T cell homeostatic proliferation Updated DEFINITION Any process that activates or increases the rate or extent of resting T cell proliferation.
2005-05-26 GO:0001916 positive regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that activates or increases the rate of T cell mediated cytotoxicity.
2005-05-26 GO:0042102 positive regulation of T cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of T cell proliferation.
2005-05-26 GO:0050862 positive regulation of T cell receptor signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0043368 positive T cell selection Updated DEFINITION The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0045059 positive thymic T cell selection Updated DEFINITION The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0043384 pre-T cell receptor complex Updated DEFINITION A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.
2005-05-26 GO:0006924 activation-induced cell death of T cells Updated DEFINITION The process of apoptosis in activated T cells.
2005-05-26 GO:0001783 B cell apoptotic process Updated DEFINITION The process of apoptosis in B cells.
2005-05-26 GO:0018190 protein octanoylation Updated DEFINITION The modification of a protein amino acid by formation of an ester or amide with octanoic acid.
2005-05-26 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives Updated DEFINITION Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
2005-05-26 GO:0046006 regulation of activated T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of activated T cell proliferation.
2005-05-26 GO:0046634 regulation of alpha-beta T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.
2005-05-26 GO:0046637 regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation.
2005-05-26 GO:0046640 regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation.
2005-05-26 GO:0050854 regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050864 regulation of B cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell activation.
2005-05-26 GO:0045577 regulation of B cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell differentiation.
2005-05-26 GO:0030888 regulation of B cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of B cell proliferation.
2005-05-26 GO:0050855 regulation of B cell receptor signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001924 regulation of B-1 B cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
2005-05-26 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive T cell differentiation.
2005-05-26 GO:0046643 regulation of gamma-delta T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell activation.
2005-05-26 GO:0045586 regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.
2005-05-26 GO:0046646 regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation.
2005-05-26 GO:0043380 regulation of memory T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of memory T cell differentiation.
2005-05-26 GO:0051133 regulation of NK T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell activation.
2005-05-26 GO:0051136 regulation of NK T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell differentiation.
2005-05-26 GO:0051140 regulation of NK T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of natural killer T cell proliferation.
2005-05-26 GO:0045589 regulation of regulatory T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
2005-05-26 GO:0050863 regulation of T cell activation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell activation.
2005-05-26 GO:0045580 regulation of T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell differentiation.
2005-05-26 GO:0046013 regulation of T cell homeostatic proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of resting T cell proliferation.
2005-05-26 GO:0001914 regulation of T cell mediated cytotoxicity Updated DEFINITION Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
2005-05-26 GO:0042129 regulation of T cell proliferation Updated DEFINITION Any process that modulates the frequency, rate or extent of T cell proliferation.
2005-05-26 GO:0050856 regulation of T cell receptor signaling pathway Updated DEFINITION Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-05-26 GO:0003994 aconitate hydratase activity Updated DEFINITION Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate, i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
2005-05-26 GO:0050798 activated T cell proliferation Updated DEFINITION The rapid expansion of a T cell population following activation by an antigenic stimulus.
2005-05-26 GO:0046631 alpha-beta T cell activation Updated DEFINITION The change in morphology and behavior of alpha-beta T cells resulting from exposure to a mitogen or to an antigen to which they have been primed.
2005-05-26 GO:0042722 alpha-beta T cell activation by superantigen Updated DEFINITION The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region.
2005-05-26 GO:0046632 alpha-beta T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell.
2005-05-26 GO:0046633 alpha-beta T cell proliferation Updated DEFINITION The rapid expansion of an alpha-beta T cell population by cell division.
2005-05-26 GO:0001913 T cell mediated cytotoxicity Updated DEFINITION The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2005-05-26 GO:0042098 T cell proliferation Updated DEFINITION The rapid expansion of a T cell population by cell division. Follows T cell activation.
2005-05-26 GO:0042608 T cell receptor binding Updated DEFINITION Interacting selectively with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
2005-05-26 GO:0031418 L-ascorbic acid binding Updated DEFINITION Interacting selectivzely with L-ascorbic acid, a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs.
2005-05-26 GO:0031294 lymphocyte costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.
2005-05-26 GO:0030098 lymphocyte differentiation Updated DEFINITION The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells.
2005-05-26 GO:0031382 mating projection assembly Updated DEFINITION Formation of a projection by unicellular fungi in response to mating pheromone.
2005-05-26 GO:0043379 memory T cell differentiation Updated DEFINITION The process whereby a newly activated T cell acquires specialized features of a memory T cell.
2005-05-26 GO:0045068 negative extrathymic T cell selection Updated DEFINITION The process of elimination of extrathymically maturing T cells which react strongly with self-antigens.
2005-05-26 GO:0046007 negative regulation of activated T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
2005-05-26 GO:0046636 negative regulation of alpha-beta T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell activation.
2005-05-26 GO:0046639 negative regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell differentiation.
2005-05-26 GO:0046642 negative regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of alpha-beta T cell proliferation.
2005-05-26 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050869 negative regulation of B cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of B cell activation.
2005-05-26 GO:0045578 negative regulation of B cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of B cell differentiation.
2005-05-26 GO:0030889 negative regulation of B cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
2005-05-26 GO:0050859 negative regulation of B cell receptor signaling pathway Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0030053 obsolete immunophilin Updated DEFINITION OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin.
2005-05-26 GO:0030073 insulin secretion Updated DEFINITION The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.
2005-05-26 GO:0045190 isotype switching Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048290 isotype switching to IgA isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048292 isotype switching to IgD isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048289 isotype switching to IgE isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0048291 isotype switching to IgG isotypes Updated DEFINITION The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.
2005-05-26 GO:0045066 regulatory T cell differentiation Updated DEFINITION The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
2005-05-26 GO:0016446 somatic hypermutation of immunoglobulin genes Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.
2005-05-26 GO:0042110 T cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0031295 T cell costimulation Updated DEFINITION The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
2005-05-26 GO:0030217 T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell.
2005-05-26 GO:0043029 T cell homeostasis Updated DEFINITION The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism are stable over time in the absence of an outside stimulus.
2005-05-26 GO:0001777 T cell homeostatic proliferation Updated DEFINITION The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
2005-05-26 GO:0045060 negative thymic T cell selection Updated DEFINITION The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
2005-05-26 GO:0051132 NK T cell activation Updated DEFINITION The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2005-05-26 GO:0001865 NK T cell differentiation Updated DEFINITION Processes whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a natural killer T cell.
2005-05-26 GO:0001866 NK T cell proliferation Updated DEFINITION The expansion of a natural killer T cell population by cell division.
2005-05-26 GO:0045067 positive extrathymic T cell selection Updated DEFINITION The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
2005-05-26 GO:0042104 positive regulation of activated T cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of activated T cell proliferation.
2005-05-26 GO:0046635 positive regulation of alpha-beta T cell activation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell activation.
2005-05-26 GO:0046638 positive regulation of alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell differentiation.
2005-05-26 GO:0046641 positive regulation of alpha-beta T cell proliferation Updated DEFINITION Any process that activates or increases the rate of alpha-beta T cell proliferation.
2005-05-26 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
2005-05-26 GO:0050871 positive regulation of B cell activation Updated DEFINITION Any process that activates or increases the rate of B cell activation.
2005-05-26 GO:0045579 positive regulation of B cell differentiation Updated DEFINITION Any process that activates or increases the rate of B cell differentiation.
2005-05-26 GO:0030890 positive regulation of B cell proliferation Updated DEFINITION Any process that activates or increases the rate or extent of B cell proliferation.
2005-05-26 GO:0050861 positive regulation of B cell receptor signaling pathway Updated DEFINITION Any process that activates or increases the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2005-05-26 GO:0001926 positive regulation of B-1 B cell differentiation Updated DEFINITION Any process that activates or increases the rate of B-1 B cell differentiation.
2005-05-26 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that activates or increases the rate of CD4-positive T cell differentiation.
2005-05-26 GO:0001925 negative regulation of B-1 B cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.
2005-05-26 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that modulates the frequency, rate, or extent of CD4-positive T cell differentiation.
2005-05-26 GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of CD8-positive T cell differentiation.
2005-05-26 GO:0050866 negative regulation of cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of cell activation.
2005-05-26 GO:0043318 negative regulation of cytotoxic T cell degranulation Updated DEFINITION Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
2005-05-26 GO:0045584 negative regulation of cytotoxic T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of cytotoxic T cell differentiation.
2005-05-26 GO:0046644 negative regulation of gamma-delta T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell activation.
2005-05-26 GO:0045587 negative regulation of gamma-delta T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell differentiation.
2005-05-26 GO:0046647 negative regulation of gamma-delta T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of gamma-delta T cell proliferation.
2005-05-26 GO:0043381 negative regulation of memory T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of memory T cell differentiation.
2005-05-26 GO:0051134 negative regulation of NK T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell activation.
2005-05-26 GO:0051137 negative regulation of NK T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell differentiation.
2005-05-26 GO:0051141 negative regulation of NK T cell proliferation Updated DEFINITION Any process that stops, prevents or reduces the rate of natural killer T cell proliferation.
2005-05-26 GO:0045590 negative regulation of regulatory T cell differentiation Updated DEFINITION Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.
2005-05-26 GO:0050868 negative regulation of T cell activation Updated DEFINITION Any process that stops, prevents or reduces the rate of T cell activation.
2005-05-26 GO:0045581 negative regulation of T cell differentiation Updated DEFINITION Any process that stops, prevents or reduces the rate of T cell differentiation.
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