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GO Term History: Displaying 20 audit records for all terms for the date 2004-04-15

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2004-04-15 GO:0008536 Ran GTPase binding Added DEFINITION Interacting selectively with RAN, a conserved Ras-like GTP- binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
2004-04-15 GO:0042661 regulation of mesodermal cell fate specification Updated DEFINITION Any process that modulates the frequency\\, rate or extent of mesoderm cell fate specification.
2004-04-15 GO:0008538 proteasome activator activity Added DEFINITION Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.
2004-04-15 GO:0015664 nicotinamide mononucleotide permease activity Added DEFINITION Catalysis of the transport of nicotinic acid across biological membranes
2004-04-15 GO:0042662 negative regulation of mesodermal cell fate specification Updated DEFINITION Any process that stops\\, prevents or reduces the rate of mesoderm cell fate specification.
2004-04-15 GO:0007064 mitotic sister chromatid cohesion Added DEFINITION The physical attachment between sister chromatids that is established during S phase of the mitotic cycle at discrete sites along the entire chromosome, maintained until the metaphase-anaphase transition, and dissolved when sisters separate to opposite poles. This cohesion cycle is critical for high fidelity chromosome transmission.
2004-04-15 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity Added DEFINITION Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins
2004-04-15 GO:0004693 cyclin-dependent protein serine/threonine kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)
2004-04-15 GO:0005621 cellular bud scar Added DEFINITION Crater-like ring of chitinous scar tissue located on the surface of the mother cell, as seen in budding fungi. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age.
2004-04-15 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2004-04-15 GO:0005769 early endosome Added DEFINITION Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered
2004-04-15 GO:0000076 DNA replication checkpoint Added DEFINITION A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
2004-04-15 GO:0007093 mitotic cell cycle checkpoint Added DEFINITION A signal transduction based surveillance mechanism that ensures accurate chromosome segregation by preventing premature passage through and exit from mitosis. Events that are monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle.
2004-04-15 GO:0001707 mesoderm formation Updated DEFINITION Biological processes that contribute to the act of giving rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
2004-04-15 GO:0007498 mesoderm development Updated DEFINITION Biological processes specifically aimed at the progression of the mesoderm over time\\, from its initial formation to a mature structure. Mesoderm is the middle germ layer that develops into muscle\\, bone\\, cartilage\\, blood and connective tissue.
2004-04-15 GO:0008640 ubiquitin-like conjugating enzyme activity Added DEFINITION Catalysis of the covalent attachment of ubiquitin-like proteins to lysine residues on the target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2004-04-15 GO:0016233 telomere capping Added DEFINITION A process in which specific single-stranded telomeric DNA binding proteins interact with the ends of linear chromosomes, ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA.
2004-04-15 GO:0016929 SUMO-specific protease activity Added DEFINITION Catalysis of the hydrolysis of SUMO, a small ubiquitin- related modifier, from previously sumoylated substrates
2004-04-15 GO:0019948 SUMO activating enzyme activity Added DEFINITION Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier, SUMO, through the formation of an ATP-dependent high-energy thioester bond.
2004-04-15 GO:0019789 SUMO transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy terminal glycine residues of the small ubiquitin- related modifier, SUMO, and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2004-04-15 GO:0008536 Ran GTPase binding Added DEFINITION Interacting selectively with RAN, a conserved Ras-like GTP- binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
2004-04-15 GO:0042661 regulation of mesodermal cell fate specification Updated DEFINITION Any process that modulates the frequency\\, rate or extent of mesoderm cell fate specification.
2004-04-15 GO:0008538 proteasome activator activity Added DEFINITION Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.
2004-04-15 GO:0015664 nicotinamide mononucleotide permease activity Added DEFINITION Catalysis of the transport of nicotinic acid across biological membranes
2004-04-15 GO:0042662 negative regulation of mesodermal cell fate specification Updated DEFINITION Any process that stops\\, prevents or reduces the rate of mesoderm cell fate specification.
2004-04-15 GO:0007064 mitotic sister chromatid cohesion Added DEFINITION The physical attachment between sister chromatids that is established during S phase of the mitotic cycle at discrete sites along the entire chromosome, maintained until the metaphase-anaphase transition, and dissolved when sisters separate to opposite poles. This cohesion cycle is critical for high fidelity chromosome transmission.
2004-04-15 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity Added DEFINITION Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins
2004-04-15 GO:0004693 cyclin-dependent protein serine/threonine kinase activity Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)
2004-04-15 GO:0005621 cellular bud scar Added DEFINITION Crater-like ring of chitinous scar tissue located on the surface of the mother cell, as seen in budding fungi. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age.
2004-04-15 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2004-04-15 GO:0005769 early endosome Added DEFINITION Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered
2004-04-15 GO:0000076 DNA replication checkpoint Added DEFINITION A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
2004-04-15 GO:0007093 mitotic cell cycle checkpoint Added DEFINITION A signal transduction based surveillance mechanism that ensures accurate chromosome segregation by preventing premature passage through and exit from mitosis. Events that are monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle.
2004-04-15 GO:0001707 mesoderm formation Updated DEFINITION Biological processes that contribute to the act of giving rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
2004-04-15 GO:0007498 mesoderm development Updated DEFINITION Biological processes specifically aimed at the progression of the mesoderm over time\\, from its initial formation to a mature structure. Mesoderm is the middle germ layer that develops into muscle\\, bone\\, cartilage\\, blood and connective tissue.
2004-04-15 GO:0008640 ubiquitin-like conjugating enzyme activity Added DEFINITION Catalysis of the covalent attachment of ubiquitin-like proteins to lysine residues on the target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2004-04-15 GO:0016233 telomere capping Added DEFINITION A process in which specific single-stranded telomeric DNA binding proteins interact with the ends of linear chromosomes, ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA.
2004-04-15 GO:0016929 SUMO-specific protease activity Added DEFINITION Catalysis of the hydrolysis of SUMO, a small ubiquitin- related modifier, from previously sumoylated substrates
2004-04-15 GO:0019948 SUMO activating enzyme activity Added DEFINITION Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier, SUMO, through the formation of an ATP-dependent high-energy thioester bond.
2004-04-15 GO:0019789 SUMO transferase activity Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy terminal glycine residues of the small ubiquitin- related modifier, SUMO, and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.
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