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GO Term History: Displaying 38 audit records for all terms for the date 2004-03-24

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2004-03-24 GO:0048207 vesicle targeting, rough ER to cis-Golgi Updated DEFINITION Targeting of a transport vesicle from the rough endoplasmic reticulum to the cis-Golgi.
2004-03-24 GO:0048221 rough ER to cis-Golgi vesicle-mediated transport Updated DEFINITION Transport of a vesicle from the rough endoplasmic reticulum to the cis-Golgi.
2004-03-24 GO:0045045 secretory pathway Updated DEFINITION The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.
2004-03-24 GO:0005787 signal peptidase complex Updated DEFINITION A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.
2004-03-24 GO:0005790 smooth endoplasmic reticulum Updated DEFINITION The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
2004-03-24 GO:0006614 SRP-dependent cotranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2004-03-24 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation Updated DEFINITION The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
2004-03-24 GO:0030133 transport vesicle Updated DEFINITION Any of the vesicles of the constitutive secretory pathway, which carry cargo from theendoplasmic reticulumR to the Golgi, between Golgi cisternae, and to destinations within or outside the cell.
2004-03-24 GO:0046788 egress of virus within host cell Updated DEFINITION The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell.
2004-03-24 GO:0005642 annulate lamellae Updated DEFINITION Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
2004-03-24 GO:0048220 cis-Golgi to rough ER vesicle-mediated transport Updated DEFINITION The directed movement of substances from the Golgi apparatus to the rough endoplasmic reticulum, mediated by vesicles.
2004-03-24 GO:0045057 cisternal progression Updated DEFINITION The process by which a new cis-Golgi stack physically moves from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna.
2004-03-24 GO:0030137 COPI-coated vesicle Updated DEFINITION A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
2004-03-24 GO:0006613 cotranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner.
2004-03-24 GO:0006488 dolichol-linked oligosaccharide biosynthetic process Updated DEFINITION The formation from simpler components of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
2004-03-24 GO:0045052 protein insertion into ER membrane by GPI attachment sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule.
2004-03-24 GO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences.
2004-03-24 GO:0045049 protein insertion into ER membrane by N-terminal cleaved signal sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER.
2004-03-24 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
2004-03-24 GO:0046764 virus budding from ER membrane Updated DEFINITION The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus.
2004-03-24 GO:0046751 viral budding from ER membrane by viral capsid envelopment Updated DEFINITION The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope.
2004-03-24 GO:0046748 virus budding from ER membrane by viral capsid re-envelopment Updated DEFINITION The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope.
2004-03-24 GO:0046923 ER retention sequence binding Updated DEFINITION Interacting selectively with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.
2004-03-24 GO:0006888 ER to Golgi vesicle-mediated transport Updated DEFINITION The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
2004-03-24 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Updated DEFINITION A body found in cells where the endoplasmic reticulum is located several micrometers from the Golgi complex, formed from COP II coated vesicles that fuse with each other shortly after their formation.
2004-03-24 GO:0012507 ER to Golgi transport vesicle membrane Updated DEFINITION The membrane surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
2004-03-24 GO:0046909 intermembrane transport Updated DEFINITION The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside.
2004-03-24 GO:0046757 lytic virus budding from ER membrane Updated DEFINITION A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis.
2004-03-24 GO:0046762 viral budding from ER membrane Updated DEFINITION A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis.
2004-03-24 GO:0008250 oligosaccharyltransferase complex Updated DEFINITION A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast.
2004-03-24 GO:0009510 plasmodesmatal desmotubule Updated DEFINITION A narrow cylindrical tubule that runs through the center of a plasmodesma connecting two cells. The latter appears to be continuous with elements of the endoplasmic reticulum membrane of the interconnected cells.
2004-03-24 GO:0006620 posttranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
2004-03-24 GO:0016254 preassembly of GPI anchor in ER membrane Updated DEFINITION The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.
2004-03-24 GO:0045048 protein insertion into ER membrane Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
2004-03-24 GO:0006621 protein retention in ER lumen Updated DEFINITION The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. KDEL receptors retrieve proteins with the KDEL recognition sequence that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
2004-03-24 GO:0045047 protein targeting to ER Updated DEFINITION The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
2004-03-24 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER Updated DEFINITION The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by COP I vesicles.
2004-03-24 GO:0005791 rough endoplasmic reticulum Updated DEFINITION The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2004-03-24 GO:0048207 vesicle targeting, rough ER to cis-Golgi Updated DEFINITION Targeting of a transport vesicle from the rough endoplasmic reticulum to the cis-Golgi.
2004-03-24 GO:0048221 rough ER to cis-Golgi vesicle-mediated transport Updated DEFINITION Transport of a vesicle from the rough endoplasmic reticulum to the cis-Golgi.
2004-03-24 GO:0045045 secretory pathway Updated DEFINITION The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.
2004-03-24 GO:0005787 signal peptidase complex Updated DEFINITION A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.
2004-03-24 GO:0005790 smooth endoplasmic reticulum Updated DEFINITION The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
2004-03-24 GO:0006614 SRP-dependent cotranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2004-03-24 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation Updated DEFINITION The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
2004-03-24 GO:0030133 transport vesicle Updated DEFINITION Any of the vesicles of the constitutive secretory pathway, which carry cargo from theendoplasmic reticulumR to the Golgi, between Golgi cisternae, and to destinations within or outside the cell.
2004-03-24 GO:0046788 egress of virus within host cell Updated DEFINITION The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell.
2004-03-24 GO:0005642 annulate lamellae Updated DEFINITION Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
2004-03-24 GO:0048220 cis-Golgi to rough ER vesicle-mediated transport Updated DEFINITION The directed movement of substances from the Golgi apparatus to the rough endoplasmic reticulum, mediated by vesicles.
2004-03-24 GO:0045057 cisternal progression Updated DEFINITION The process by which a new cis-Golgi stack physically moves from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna.
2004-03-24 GO:0030137 COPI-coated vesicle Updated DEFINITION A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
2004-03-24 GO:0006613 cotranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner.
2004-03-24 GO:0006488 dolichol-linked oligosaccharide biosynthetic process Updated DEFINITION The formation from simpler components of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
2004-03-24 GO:0045052 protein insertion into ER membrane by GPI attachment sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule.
2004-03-24 GO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences.
2004-03-24 GO:0045049 protein insertion into ER membrane by N-terminal cleaved signal sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER.
2004-03-24 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
2004-03-24 GO:0046764 virus budding from ER membrane Updated DEFINITION The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus.
2004-03-24 GO:0046751 viral budding from ER membrane by viral capsid envelopment Updated DEFINITION The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope.
2004-03-24 GO:0046748 virus budding from ER membrane by viral capsid re-envelopment Updated DEFINITION The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope.
2004-03-24 GO:0046923 ER retention sequence binding Updated DEFINITION Interacting selectively with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.
2004-03-24 GO:0006888 ER to Golgi vesicle-mediated transport Updated DEFINITION The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
2004-03-24 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Updated DEFINITION A body found in cells where the endoplasmic reticulum is located several micrometers from the Golgi complex, formed from COP II coated vesicles that fuse with each other shortly after their formation.
2004-03-24 GO:0012507 ER to Golgi transport vesicle membrane Updated DEFINITION The membrane surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
2004-03-24 GO:0046909 intermembrane transport Updated DEFINITION The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside.
2004-03-24 GO:0046757 lytic virus budding from ER membrane Updated DEFINITION A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis.
2004-03-24 GO:0046762 viral budding from ER membrane Updated DEFINITION A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis.
2004-03-24 GO:0008250 oligosaccharyltransferase complex Updated DEFINITION A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast.
2004-03-24 GO:0009510 plasmodesmatal desmotubule Updated DEFINITION A narrow cylindrical tubule that runs through the center of a plasmodesma connecting two cells. The latter appears to be continuous with elements of the endoplasmic reticulum membrane of the interconnected cells.
2004-03-24 GO:0006620 posttranslational protein targeting to membrane Updated DEFINITION The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
2004-03-24 GO:0016254 preassembly of GPI anchor in ER membrane Updated DEFINITION The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.
2004-03-24 GO:0045048 protein insertion into ER membrane Updated DEFINITION The insertion of integral proteins into the endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
2004-03-24 GO:0006621 protein retention in ER lumen Updated DEFINITION The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. KDEL receptors retrieve proteins with the KDEL recognition sequence that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
2004-03-24 GO:0045047 protein targeting to ER Updated DEFINITION The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
2004-03-24 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER Updated DEFINITION The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by COP I vesicles.
2004-03-24 GO:0005791 rough endoplasmic reticulum Updated DEFINITION The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
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