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GO Term History: Displaying 51 audit records for all terms for the date 2004-01-08

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serine proteinase inhibitor activity
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serpin activity
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Added SYNONYM aspartic protease inhibitor activity
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Deleted SYNONYM serine proteinase inhibitor
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Deleted SYNONYM serpin
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartic endopeptidase activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartic protease activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartyl protease activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM carboxyl protease activity
2004-01-08 GO:0004252 serine-type endopeptidase activity Added SYNONYM serine protease activity
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Updated TERM serine-type endopeptidase inhibitor activity
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Updated TERM aspartic-type endopeptidase inhibitor activity
2004-01-08 GO:0048276 gastrulation (sensu Vertebrata) Added TERM gastrulation (sensu Vertebrata)
2004-01-08 GO:0030161 calpain inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.
2004-01-08 GO:0030415 carboxypeptidase A inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme carboxypeptidase A.
2004-01-08 GO:0004866 endopeptidase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2004-01-08 GO:0048276 gastrulation (sensu Vertebrata) Added DEFINITION The process of gastrulation as is characteristic in vertebrates.
2004-01-08 GO:0005096 GTPase activator activity Updated DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2004-01-08 GO:0016173 ice nucleation inhibitor activity Added DEFINITION Inhibits the the formation of ice crystals.
2004-01-08 GO:0019209 kinase activator activity Added DEFINITION Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0019210 kinase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0019207 kinase regulator activity Added DEFINITION Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0008191 metalloendopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2004-01-08 GO:0008439 monophenol monooxygenase activator activity Added DEFINITION Increases the activity of the enzyme monophenol monooxygenase.
2004-01-08 GO:0019211 phosphatase activator activity Added DEFINITION Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0019212 phosphatase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0019208 phosphatase regulator activity Added DEFINITION Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity Updated DEFINITION Modulates the activity of the enzyme phosphatidylinositol 3-kinase activity (GO:0016303).
2004-01-08 GO:0035014 phosphatidylinositol 3-kinase regulator activity Updated DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2004-01-08 GO:0016005 phospholipase A2 activator activity Added DEFINITION Increases the activity of the enzyme phospholipase A2.
2004-01-08 GO:0019834 phospholipase A2 inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme phospholipase A2.
2004-01-08 GO:0016004 phospholipase activator activity Added DEFINITION Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
2004-01-08 GO:0004859 phospholipase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
2004-01-08 GO:0016504 peptidase activator activity Added DEFINITION Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2004-01-08 GO:0030414 peptidase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2004-01-08 GO:0030296 protein tyrosine kinase activator activity Added DEFINITION Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
2004-01-08 GO:0008160 protein tyrosine phosphatase activator activity Added DEFINITION Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.
2004-01-08 GO:0008428 ribonuclease inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA.
2004-01-08 GO:0046863 ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity Updated DEFINITION Increases the activity of rubisco (GO:0016984) by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2004-01-08 GO:0016230 sphingomyelin phosphodiesterase activator activity Added DEFINITION Increases the activity of the enzyme sphingomyelin phosphodiesterase.
2004-01-08 GO:0016176 superoxide-generating NADPH oxidase activator activity Added DEFINITION Increases the activity of the enzyme superoxide-generating NADPH oxidase.
2004-01-08 GO:0030304 trypsin inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the serine endopeptidase trypsin.
2004-01-08 GO:0016483 tryptophan hydroxylase activator activity Added DEFINITION Increases the activity of the enzyme tryptophase hydroxylase.
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2004-01-08 GO:0030295 protein kinase activator activity Added DEFINITION Increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0008426 protein kinase C inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.
2004-01-08 GO:0004860 protein kinase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0019887 protein kinase regulator activity Added DEFINITION Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0004864 protein phosphatase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins.
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serine protease inhibitor activity

Terms

Timestamp GO ID GO Term Name Action Category Detail
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Updated TERM serine-type endopeptidase inhibitor activity
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Updated TERM aspartic-type endopeptidase inhibitor activity
2004-01-08 GO:0048276 gastrulation (sensu Vertebrata) Added TERM gastrulation (sensu Vertebrata)

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serine proteinase inhibitor activity
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serpin activity
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Added SYNONYM aspartic protease inhibitor activity
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Deleted SYNONYM serine proteinase inhibitor
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Deleted SYNONYM serpin
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartic endopeptidase activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartic protease activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM aspartyl protease activity
2004-01-08 GO:0004190 aspartic-type endopeptidase activity Added SYNONYM carboxyl protease activity
2004-01-08 GO:0004252 serine-type endopeptidase activity Added SYNONYM serine protease activity
2004-01-08 GO:0030161 calpain inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.
2004-01-08 GO:0030415 carboxypeptidase A inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme carboxypeptidase A.
2004-01-08 GO:0004866 endopeptidase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2004-01-08 GO:0048276 gastrulation (sensu Vertebrata) Added DEFINITION The process of gastrulation as is characteristic in vertebrates.
2004-01-08 GO:0005096 GTPase activator activity Updated DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2004-01-08 GO:0016173 ice nucleation inhibitor activity Added DEFINITION Inhibits the the formation of ice crystals.
2004-01-08 GO:0019209 kinase activator activity Added DEFINITION Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0019210 kinase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0019207 kinase regulator activity Added DEFINITION Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2004-01-08 GO:0008191 metalloendopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2004-01-08 GO:0008439 monophenol monooxygenase activator activity Added DEFINITION Increases the activity of the enzyme monophenol monooxygenase.
2004-01-08 GO:0019211 phosphatase activator activity Added DEFINITION Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0019212 phosphatase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0019208 phosphatase regulator activity Added DEFINITION Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
2004-01-08 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity Updated DEFINITION Modulates the activity of the enzyme phosphatidylinositol 3-kinase activity (GO:0016303).
2004-01-08 GO:0035014 phosphatidylinositol 3-kinase regulator activity Updated DEFINITION Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks) (GO:0035004). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
2004-01-08 GO:0016005 phospholipase A2 activator activity Added DEFINITION Increases the activity of the enzyme phospholipase A2.
2004-01-08 GO:0019834 phospholipase A2 inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the enzyme phospholipase A2.
2004-01-08 GO:0016004 phospholipase activator activity Added DEFINITION Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
2004-01-08 GO:0004859 phospholipase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
2004-01-08 GO:0016504 peptidase activator activity Added DEFINITION Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2004-01-08 GO:0030414 peptidase inhibitor activity Updated DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2004-01-08 GO:0030296 protein tyrosine kinase activator activity Added DEFINITION Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
2004-01-08 GO:0008160 protein tyrosine phosphatase activator activity Added DEFINITION Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.
2004-01-08 GO:0008428 ribonuclease inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA.
2004-01-08 GO:0046863 ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity Updated DEFINITION Increases the activity of rubisco (GO:0016984) by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2004-01-08 GO:0016230 sphingomyelin phosphodiesterase activator activity Added DEFINITION Increases the activity of the enzyme sphingomyelin phosphodiesterase.
2004-01-08 GO:0016176 superoxide-generating NADPH oxidase activator activity Added DEFINITION Increases the activity of the enzyme superoxide-generating NADPH oxidase.
2004-01-08 GO:0030304 trypsin inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of the serine endopeptidase trypsin.
2004-01-08 GO:0016483 tryptophan hydroxylase activator activity Added DEFINITION Increases the activity of the enzyme tryptophase hydroxylase.
2004-01-08 GO:0019828 aspartic-type endopeptidase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2004-01-08 GO:0030295 protein kinase activator activity Added DEFINITION Increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0008426 protein kinase C inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.
2004-01-08 GO:0004860 protein kinase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0019887 protein kinase regulator activity Added DEFINITION Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.
2004-01-08 GO:0004864 protein phosphatase inhibitor activity Added DEFINITION Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins.
2004-01-08 GO:0004867 serine-type endopeptidase inhibitor activity Added SYNONYM serine protease inhibitor activity
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