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GO Term History: Displaying 83 audit records for all terms for the date 2003-11-30

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Introduction

This page displays the differences recorded in the full Gene Ontology OBO v1.2 file as audited by the UniProt-GOA database during its daily update cycle.
If there is any delay in uploading the current OBO file, the changes displayed and the date recorded for these changes may not correspond to when the changes to the OBO file were committed.

All changes

Timestamp GO ID GO Term Name Action Category Detail
2003-11-30 GO:0050755 chemokine metabolic process Added TERM chemokine metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added TERM fractalkine metabolism
2003-11-30 GO:0050757 thymidylate synthase biosynthetic process Added TERM thymidylate synthase biosynthesis
2003-11-30 GO:0050758 regulation of thymidylate synthase biosynthetic process Added TERM regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0050759 positive regulation of thymidylate synthase biosynthetic process Added TERM positive regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0050760 negative regulation of thymidylate synthase biosynthetic process Added TERM negative regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0030877 beta-catenin destruction complex Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Updated DEFINITION Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).
2003-11-30 GO:0050755 chemokine metabolic process Added DEFINITION The chemical reactions and physical changes involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.
2003-11-30 GO:0030882 lipid antigen binding Added TERM lipid antigen binding
2003-11-30 GO:0030883 endogenous lipid antigen binding Added TERM endogenous lipid antigen binding
2003-11-30 GO:0030884 exogenous lipid antigen binding Added TERM exogenous lipid antigen binding
2003-11-30 GO:0030885 regulation of myeloid dendritic cell activation Added TERM regulation of dendritic cell activation
2003-11-30 GO:0030886 negative regulation of myeloid dendritic cell activation Added TERM negative regulation of dendritic cell activation
2003-11-30 GO:0030887 positive regulation of myeloid dendritic cell activation Added TERM positive regulation of dendritic cell activation
2003-11-30 GO:0030888 regulation of B cell proliferation Added TERM regulation of B-cell proliferation
2003-11-30 GO:0030889 negative regulation of B cell proliferation Added TERM negative regulation of B-cell proliferation
2003-11-30 GO:0030890 positive regulation of B cell proliferation Added TERM positive regulation of B-cell proliferation
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Updated TERM biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added SYNONYM regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added SYNONYM regulation of neurotactin biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added SYNONYM negative regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added SYNONYM negative regulation of neurotactin biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added SYNONYM positive regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added SYNONYM positive regulation of neurotactin biosynthesis
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM ABCD-3 metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM CX3C membrane-anchored chemokine metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM CX3CL1 metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM neurotactin metabolism
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Added SYNONYM biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
2003-11-30 GO:0030169 low-density lipoprotein particle binding Added SYNONYM LDL binding
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added SYNONYM LDL receptor binding
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM ABCD-3 biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM CX3C membrane-anchored chemokine biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM CX3CL1 biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM neurotactin biosynthesis
2003-11-30 GO:0004907 interleukin receptor activity Added DEFINITION The function of combining with an interleukin to initiate a change in cell function.
2003-11-30 GO:0030882 lipid antigen binding Added DEFINITION Interacting selectively with a lipid antigen.
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added DEFINITION Interacting selectively with a low density lipoprotein receptor.
2003-11-30 GO:0030879 mammary gland development Updated DEFINITION Development of the mammary gland; a large compound sebaceous gland that in female mammals is modified to secrete milk.
2003-11-30 GO:0048275 N-terminal peptidyl-arginine acetylation Added DEFINITION The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase.
2003-11-30 GO:0030889 negative regulation of B cell proliferation Added DEFINITION Any process that stops, prevents or reduces the rate or extent of B-cell proliferation.
2003-11-30 GO:0030886 negative regulation of myeloid dendritic cell activation Added DEFINITION Any process that stops, prevents or reduces the rate of dendritic cell activation.
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the rate of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050748 negative regulation of lipoprotein metabolic process Added DEFINITION Any process that stops, prevents or reduces the rate of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050760 negative regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the rate of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0005049 nuclear export signal receptor activity Added DEFINITION The function of combining with a nuclear export signal to initiate a change in cell function.
2003-11-30 GO:0016502 nucleotide receptor activity Added DEFINITION The function of combining with a nucleotide to initiate a change in cell function. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
2003-11-30 GO:0030890 positive regulation of B cell proliferation Added DEFINITION Any process that activates or increases the rate or extent of B-cell proliferation.
2003-11-30 GO:0030887 positive regulation of myeloid dendritic cell activation Added DEFINITION Any process that stimulates, induces or increases the rate of dendritic cell activation.
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added DEFINITION Any process that activates or increases the rate of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050747 positive regulation of lipoprotein metabolic process Added DEFINITION Any process that activates or increases the rate of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050759 positive regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that activates or increases the rate of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0030888 regulation of B cell proliferation Added DEFINITION Any process that modulates the frequency, rate or extent of B-cell proliferation.
2003-11-30 GO:0030885 regulation of myeloid dendritic cell activation Added DEFINITION Any process that modulates the frequency or rate of dendritic cell activation.
2003-11-30 GO:0030878 thyroid gland development Updated DEFINITION Development of the thyroid gland; an endoderm-derived gland that produces thyroid hormone.
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050746 regulation of lipoprotein metabolic process Added DEFINITION Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050758 regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0007172 signal complex assembly Added DEFINITION Formation of a complex by dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors; the resulting complex is capable of relaying a signal within a cell.
2003-11-30 GO:0050757 thymidylate synthase biosynthetic process Added DEFINITION The formation from simpler components of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
2003-11-30 GO:0005868 cytoplasmic dynein complex Updated DEFINITION Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subuniots associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains.
2003-11-30 GO:0030883 endogenous lipid antigen binding Added DEFINITION Interacting selectively with an endogenous cellular lipid antigen.
2003-11-30 GO:0004900 erythropoietin receptor activity Added DEFINITION The function of combining with erythropoietin to initiate a change in cell function.
2003-11-30 GO:0030884 exogenous lipid antigen binding Added DEFINITION Interacting selectively with an exogenous lipid antigen (examples include microbial lipids and glycolipids).
2003-11-30 GO:0050751 fractalkine biosynthetic process Added DEFINITION The formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1.
2003-11-30 GO:0050756 fractalkine metabolic process Added DEFINITION The chemical reactions and physical changes involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1.
2003-11-30 GO:0042021 granulocyte macrophage colony-stimulating factor complex binding Added DEFINITION Interacting selectively with the granulocyte macrophage colony-stimulating factor complex.
2003-11-30 GO:0004903 growth hormone receptor activity Added DEFINITION The function of combining with growth hormone to initiate a change in cell function.
2003-11-30 GO:0019961 interferon binding Added DEFINITION Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.
2003-11-30 GO:0004904 interferon receptor activity Added DEFINITION The function of combining with an interferon to initiate a change in cell function.
2003-11-30 GO:0004906 interferon-gamma receptor activity Added DEFINITION The function of combining with interferon-gamma to initiate a change in cell function.
2003-11-30 GO:0050749 apolipoprotein E receptor binding Added DEFINITION Interacting selectively with an apolipoprotein E receptor.
2003-11-30 GO:0048275 N-terminal peptidyl-arginine acetylation Added TERM N-terminal peptidyl-arginine acetylation
2003-11-30 GO:0050746 regulation of lipoprotein metabolic process Added TERM regulation of lipoprotein metabolism
2003-11-30 GO:0050747 positive regulation of lipoprotein metabolic process Added TERM positive regulation of lipoprotein metabolism
2003-11-30 GO:0050748 negative regulation of lipoprotein metabolic process Added TERM negative regulation of lipoprotein metabolism
2003-11-30 GO:0050749 apolipoprotein E receptor binding Added TERM apolipoprotein E receptor binding
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added TERM low-density lipoprotein receptor binding
2003-11-30 GO:0050751 fractalkine biosynthetic process Added TERM fractalkine biosynthesis
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added TERM regulation of fractalkine biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added TERM negative regulation of fractalkine biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added TERM positive regulation of fractalkine biosynthesis

Terms

Timestamp GO ID GO Term Name Action Category Detail
2003-11-30 GO:0050755 chemokine metabolic process Added TERM chemokine metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added TERM fractalkine metabolism
2003-11-30 GO:0050757 thymidylate synthase biosynthetic process Added TERM thymidylate synthase biosynthesis
2003-11-30 GO:0050758 regulation of thymidylate synthase biosynthetic process Added TERM regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0050759 positive regulation of thymidylate synthase biosynthetic process Added TERM positive regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0050760 negative regulation of thymidylate synthase biosynthetic process Added TERM negative regulation of thymidylate synthase biosynthesis
2003-11-30 GO:0030882 lipid antigen binding Added TERM lipid antigen binding
2003-11-30 GO:0030883 endogenous lipid antigen binding Added TERM endogenous lipid antigen binding
2003-11-30 GO:0030884 exogenous lipid antigen binding Added TERM exogenous lipid antigen binding
2003-11-30 GO:0030885 regulation of myeloid dendritic cell activation Added TERM regulation of dendritic cell activation
2003-11-30 GO:0030886 negative regulation of myeloid dendritic cell activation Added TERM negative regulation of dendritic cell activation
2003-11-30 GO:0030887 positive regulation of myeloid dendritic cell activation Added TERM positive regulation of dendritic cell activation
2003-11-30 GO:0030888 regulation of B cell proliferation Added TERM regulation of B-cell proliferation
2003-11-30 GO:0030889 negative regulation of B cell proliferation Added TERM negative regulation of B-cell proliferation
2003-11-30 GO:0030890 positive regulation of B cell proliferation Added TERM positive regulation of B-cell proliferation
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Updated TERM biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
2003-11-30 GO:0048275 N-terminal peptidyl-arginine acetylation Added TERM N-terminal peptidyl-arginine acetylation
2003-11-30 GO:0050746 regulation of lipoprotein metabolic process Added TERM regulation of lipoprotein metabolism
2003-11-30 GO:0050747 positive regulation of lipoprotein metabolic process Added TERM positive regulation of lipoprotein metabolism
2003-11-30 GO:0050748 negative regulation of lipoprotein metabolic process Added TERM negative regulation of lipoprotein metabolism
2003-11-30 GO:0050749 apolipoprotein E receptor binding Added TERM apolipoprotein E receptor binding
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added TERM low-density lipoprotein receptor binding
2003-11-30 GO:0050751 fractalkine biosynthetic process Added TERM fractalkine biosynthesis
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added TERM regulation of fractalkine biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added TERM negative regulation of fractalkine biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added TERM positive regulation of fractalkine biosynthesis

Definition/synonyms

Timestamp GO ID GO Term Name Action Category Detail
2003-11-30 GO:0030877 beta-catenin destruction complex Updated DEFINITION A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein Axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Updated DEFINITION Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).
2003-11-30 GO:0050755 chemokine metabolic process Added DEFINITION The chemical reactions and physical changes involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added SYNONYM regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added SYNONYM regulation of neurotactin biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added SYNONYM negative regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added SYNONYM negative regulation of neurotactin biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added SYNONYM positive regulation of CX3CL1 biosynthesis
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added SYNONYM positive regulation of neurotactin biosynthesis
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM ABCD-3 metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM CX3C membrane-anchored chemokine metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM CX3CL1 metabolism
2003-11-30 GO:0050756 fractalkine metabolic process Added SYNONYM neurotactin metabolism
2003-11-30 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Added SYNONYM biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity
2003-11-30 GO:0030169 low-density lipoprotein particle binding Added SYNONYM LDL binding
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added SYNONYM LDL receptor binding
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM ABCD-3 biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM CX3C membrane-anchored chemokine biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM CX3CL1 biosynthesis
2003-11-30 GO:0050751 fractalkine biosynthetic process Added SYNONYM neurotactin biosynthesis
2003-11-30 GO:0004907 interleukin receptor activity Added DEFINITION The function of combining with an interleukin to initiate a change in cell function.
2003-11-30 GO:0030882 lipid antigen binding Added DEFINITION Interacting selectively with a lipid antigen.
2003-11-30 GO:0050750 low-density lipoprotein particle receptor binding Added DEFINITION Interacting selectively with a low density lipoprotein receptor.
2003-11-30 GO:0030879 mammary gland development Updated DEFINITION Development of the mammary gland; a large compound sebaceous gland that in female mammals is modified to secrete milk.
2003-11-30 GO:0048275 N-terminal peptidyl-arginine acetylation Added DEFINITION The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase.
2003-11-30 GO:0030889 negative regulation of B cell proliferation Added DEFINITION Any process that stops, prevents or reduces the rate or extent of B-cell proliferation.
2003-11-30 GO:0030886 negative regulation of myeloid dendritic cell activation Added DEFINITION Any process that stops, prevents or reduces the rate of dendritic cell activation.
2003-11-30 GO:0050753 negative regulation of fractalkine biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the rate of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050748 negative regulation of lipoprotein metabolic process Added DEFINITION Any process that stops, prevents or reduces the rate of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050760 negative regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that stops, prevents or reduces the rate of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0005049 nuclear export signal receptor activity Added DEFINITION The function of combining with a nuclear export signal to initiate a change in cell function.
2003-11-30 GO:0016502 nucleotide receptor activity Added DEFINITION The function of combining with a nucleotide to initiate a change in cell function. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
2003-11-30 GO:0030890 positive regulation of B cell proliferation Added DEFINITION Any process that activates or increases the rate or extent of B-cell proliferation.
2003-11-30 GO:0030887 positive regulation of myeloid dendritic cell activation Added DEFINITION Any process that stimulates, induces or increases the rate of dendritic cell activation.
2003-11-30 GO:0050754 positive regulation of fractalkine biosynthetic process Added DEFINITION Any process that activates or increases the rate of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050747 positive regulation of lipoprotein metabolic process Added DEFINITION Any process that activates or increases the rate of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050759 positive regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that activates or increases the rate of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0030888 regulation of B cell proliferation Added DEFINITION Any process that modulates the frequency, rate or extent of B-cell proliferation.
2003-11-30 GO:0030885 regulation of myeloid dendritic cell activation Added DEFINITION Any process that modulates the frequency or rate of dendritic cell activation.
2003-11-30 GO:0030878 thyroid gland development Updated DEFINITION Development of the thyroid gland; an endoderm-derived gland that produces thyroid hormone.
2003-11-30 GO:0050752 regulation of fractalkine biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation.
2003-11-30 GO:0050746 regulation of lipoprotein metabolic process Added DEFINITION Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.
2003-11-30 GO:0050758 regulation of thymidylate synthase biosynthetic process Added DEFINITION Any process that modulates the frequency, rate or extent of the formation from simpler components of the enzyme thymidylate synthase.
2003-11-30 GO:0007172 signal complex assembly Added DEFINITION Formation of a complex by dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors; the resulting complex is capable of relaying a signal within a cell.
2003-11-30 GO:0050757 thymidylate synthase biosynthetic process Added DEFINITION The formation from simpler components of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
2003-11-30 GO:0005868 cytoplasmic dynein complex Updated DEFINITION Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subuniots associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains.
2003-11-30 GO:0030883 endogenous lipid antigen binding Added DEFINITION Interacting selectively with an endogenous cellular lipid antigen.
2003-11-30 GO:0004900 erythropoietin receptor activity Added DEFINITION The function of combining with erythropoietin to initiate a change in cell function.
2003-11-30 GO:0030884 exogenous lipid antigen binding Added DEFINITION Interacting selectively with an exogenous lipid antigen (examples include microbial lipids and glycolipids).
2003-11-30 GO:0050751 fractalkine biosynthetic process Added DEFINITION The formation from simpler components of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1.
2003-11-30 GO:0050756 fractalkine metabolic process Added DEFINITION The chemical reactions and physical changes involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1.
2003-11-30 GO:0042021 granulocyte macrophage colony-stimulating factor complex binding Added DEFINITION Interacting selectively with the granulocyte macrophage colony-stimulating factor complex.
2003-11-30 GO:0004903 growth hormone receptor activity Added DEFINITION The function of combining with growth hormone to initiate a change in cell function.
2003-11-30 GO:0019961 interferon binding Added DEFINITION Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.
2003-11-30 GO:0004904 interferon receptor activity Added DEFINITION The function of combining with an interferon to initiate a change in cell function.
2003-11-30 GO:0004906 interferon-gamma receptor activity Added DEFINITION The function of combining with interferon-gamma to initiate a change in cell function.
2003-11-30 GO:0050749 apolipoprotein E receptor binding Added DEFINITION Interacting selectively with an apolipoprotein E receptor.
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