spacer
EBIInformationEventsTACBAC 07

Therapeutic Applications of Computational Biology and Chemistry 2007

11th - 13th March, 2007
The EMBL-European Bioinformatics Institute, Nature Biotechnology and Nature Reviews Drug Discovery are delighted to invite you to Therapeutic Applications of Computational Biology and Chemistry 2007 (TACBAC 07), which will take place from 11 to 13 March 2007 at the Wellcome Trust Conference Centre, Hinxton, Cambs, UK. The scientific programme is chaired by Janet Thornton (EBI), Simon Campbell (Royal Society of Chemistry) and Jim Wells (University of California San Francisco).

The purpose of this broad and multidisciplinary meeting is to explore the major challenges in drug discovery and development where innovation in computational approaches and tools can really make a significant contribution towards providing solutions. You should attend this conference if you are developing or using computational approaches to therapeutics development, or if you are a key decision maker in a pharmaceutical or biotechnology company.

Each of the five sessions, which progress from identifying disease mechanisms to implementing new therapeutic and diagnostic approaches in the clinic, will bring together experts in both the biomedical and the computational aspects of the topic under discussion.

With thanks to support from:

EMBL-EBI

EMBL-EBI Industry Programme

Molecular Medicine at the EMBL

EMBL Centre for Disease Mechanisms

The Department of Trade and Industry

UK Department of Trade and Industry Biosciences Unit



Quick Guide to Therapeutic Applications of Computational Biology and Chemistry :




Chairs and Organisers

This conference is co-hosted by the EBI, Nature Biotechnology and Nature Reviews Drug Discovery.

Conference co-chairs

  • Janet Thornton, EMBL-EBI, UK
  • Simon Campbell, Royal Society of Chemistry, UK
  • Jim Wells, University of California, San Francisco, USA

Conference session-chairs

    Target identification and disease relevance
    • Alan Sachs, Merck, USA
    • Stephen Frye, GSK, USA
    Predictive systems for clinical efficacy
    • David Searls, GSK, USA
    • Paul Workman, Cancer Research UK Centre for Cancer Therapeutics, The Institute for Cancer Research, Sutton, UK
    Predictive systems for safety and ADME
    • Lee Babiss, Roche, USA
    • Michael Bolger, Life Sciences Simulations Plus Inc., USA
    Target to lead generation and exploitation
    • Louise Johnson, Univ. of Oxford, UK
    • Chris Lipinski, Pfizer, USA
    Bioinformatics in the clinic
    • Philip Quirke, Univ. of Leeds, UK
    • Richard Begent, Royal Free and University College Medical School, UK

Organising Committee

  • Kathy Aschheim, Nature Biotechnology, USA
  • Cath Brooksbank, EMBL-EBI, UK
  • Liz Ford, EMBL-EBI, UK
  • Sara Girard, Nature Publishing Group, USA
  • Peter Kirkpatrick, Nature Review Drug Discovery, UK
  • Andrew Marshall, Nature Biotechnology, USA
  • Paul Matthews, EMBL-EBI, UK
Top


Programme

Programme - Final

The programme will include a combination of invited talks, discussion sessions and posters. Printable Therapeutic Applications of Computational Biology ProgrammeClick here to view a printable version of the programme.


Time TACBAC 2007 Programme
DAY 1 Sunday 11th March, 2007
10:00 Registation open
12:00 Lunch
14:00 Janet Thornton (EMBL-EBI, Hinxton, UK) and Andrew Marshall (Nature Biotechnology, New York, USA): Welcome address
14:15 Simon Campbell (Royal Society of Chemistry, UK) Opening keynote: The future for drug discovery, a voice from the past
SESSION 1 - TARGET IDENTIFICATION AND DISEASE RELEVANCE
15:00 Douglas Bassett (Merck & Co., Inc., Seattle, WA, USA) Molecular profiling, pathway analysis and implications for the future of oncology healthcare
15:30 Stephen Frye (GlaxoSmithKline, Research Triangle Park, NC, USA) Target identification and validation in the context of gene families
16:00 Tea
16:30 Marc Vidal (Dana Farber Cancer Institute, Boston, MA, USA) Interactome networks
17:00 Alexander Tropsha (University of North Carolina at Chapel Hill, USA) Can primary high-throughput screening data be analysed in a meaningful way?
17:30 Steve Brown (MRC Mammalian Genetics Unit, Harwell, UK) Comprehensive functional annotation of the mouse genome – computational challenges in phenotyping and ontologies
18:30 Welcome reception sponsored by Chemical Computing
19:30 Dinner
DAY 2 Monday 12th March, 2007
SESSION 2 - PREDICTIVE SYSTEMS FOR CLINICAL EFFICACY
09:00 David Searls (GlaxoSmithKline, Philadelphia, PA, USA) Darwin and drug discovery
09:30 John Overington (Inpharmatica, London, UK) The druggable genome revisited
10:00 Brian Shoichet (University of California, San Francisco, CA, USA) Relating protein pharmacology by ligand chemistry
10:30 Coffee
11:00 Aram Adourian (BG Medicine, Inc., Waltham, MA, USA) Systems as drug targets
11:30 David Reif (Vanderbilt University, Nashville, TN, USA) Detection and characterization of gene–gene and gene–environment interactions in common human diseases and complex clinical endpoints
12:00 Douglas Kell (University of Manchester, UK) Novel metabolomic biomarkers: what and how?
12:30 Lunch sponsored by Ingenuity Systems
SESSION 3: PREDICTIVE SYSTEMS FOR SAFETY AND ADME
14:00 Manfred Kansy (F. Hoffmann-La Roche Ltd, Basel, Switzerland): Examining the Impact of in silico techniques on the R&D process: current status and future perspectives
14:30 Gilles Klopman (MULTICASE, Inc., Beachwood, OH, USA): Machine intelligence in the design of safer chemicals
15:00 Mark Cronin (Liverpool John Moore’s University, UK) Computational prediction of toxicity and metabolic transformation
15:30 Tea break and Product Demo: Ingenuity Systems
16:00 Michael Bolger (Simulations Plus, Inc., Lancaster, CA, USA) In silico prediction of fraction absorbed
16:30 Neil Parrott (F. Hoffmann-La Roche Ltd, Basel, Switzerland) Application of physiologically based modelling in pre-clinical to clinical prediction of pharmacokinetics and pharmacodynamics
17:00 Robert Sheridan (Merck & Co., Inc., Rahway, NJ, USA) Empirical and semiempirical models for regioselectivity in human CYPs: ignoring mechanisms can be a good thing
17:30 Peter Goodfellow: special keynote – Integrating time and information
18:15 Drinks and poster session
19:45 Dinner
DAY 3 Tuesday 13th March, 2007
SESSION 4 - TARGET TO LEAD GENERATION AND EXPLOITATION
09:00 Chris Lipinski (Melior Discovery, Waterford, CT, USA) The complexity of screening libraries: balancing competing and contradictory criteria
09:30 Martin Noble (University of Oxford, UK) Structural bioinformatics in kinase inhibitor design
10:00 Philip Hajduk (Abbott Laboratories, Abbott Park, IL, USA) Protein–ligand interactions: lessons from a decade of NMR-based screening
10:30 Coffee break and Product Demo: BIOBASE GmbH
11:00 Gisbert Schneider (University of Frankfurt, Germany) Computational de novo design of drug-like molecules
11:30 Alexander Kiselyov (ChemDiv., Inc., San Diego, CA, USA) Focused diversity: application to identification of specific inhibitors for the Hh signalling pathway
12:00 Christopher Murray (Astex Therapeutics, Cambridge, UK) Fragment-based drug design
12:30 Lunch
SESSION 5: BIOINFORMATICS IN THE CLINIC
13:30 Richard Begent (University College London, UK and National Cancer Research Institute, UK) Coordinating cancer biomedical informatics
14:00 Phil Quirke (Leeds University, UK) Image analysis in disease diagnosis
14:30 Kenneth Buetow (National Cancer Institute, Bethesda, MD, USA) Towards understanding the genetics of cancer susceptibility
15:00 Tea break
15:30 Peter van der Spek (Erasmus Medical Center, Rotterdam, The Netherlands) From molecular phenotyping to clinical benefit
16:00 Paul Workman (Cancer Research UK Centre for Cancer Therapeutics, The Institute for Cancer Research, Sutton, UK) Combinatorial drugging of multiple cancer genome targets
16:30 James Wells (University of California, San Francisco, CA, USA): closing keynote – Challenges for early-stage drug discovery
17:15 Janet Thornton (EMBL-EBI): Closing remarks
17:30 Depart


Top


Poster Abstracts

Abstract submissions are now closed.
  • Abstract submission deadline: Monday 12th February 2007


Top


Sponsors and Exhibitors



Top


Location

Conference Location

The conference will take place at the Wellcome Trust Conference Centre located on the Wellcome Trust Genome Campus, which houses the European Bioinformatics Institute, and the Wellcome Trust Sanger Institute.

Top


Accommodation-Travel

Please Organise your own Accommodation

If you wish to stay in Hinxton we recommend using Hinxton Hall for accommodation, but please book early as space is limited.
  • Wellcome Trust Genome Campus (Hinxton Hall) - limited accommodation is available.
    Tel: +44(0) 1223 495000 or Fax: +44(0) 1223 495114
    Email: reception@wtconference.org.uk
Other accommodation within a few miles of Hinxton includes:
  • Duxford Lodge Hotel, Ickleton Road, Duxford, (Tel: +44(0) 1223 836444. Fax: +44(0) 1223 832271), £110.00-£135.00 per night with breakfast.

  • The Crown House Hotel, London Road, Great Chesterford, (Tel: +44(0) 1799 530515), £100-£130 per night with breakfast.

  • B&B accommodation near the EBI:
    • Lordship Farm, Mill Lane, Hinxton, (Tel: +44(0) 1799 530242), cost from £25.

    • New Inn House, 10 Brookhampton Street, Ickleton (Tel: +44(0) 1799 530463, jpinternational@nascr.net), cost from £25.

      B&Bs do not accept credit cards, Eurocheques etc. Please pay by cash.
A comprehensive range of accommodation in central cambridge can be found at smoothhound.

A shuttle-bus service will be provided once a day from Cambridge to Hinxton and back.
For schedule see below 'Local Transport Information'

Top


Local Transport Information

Free Shuttle Bus


Time Shuttle Route
Sunday 11th March
21:00 Wellcome Trust Conference Centre – Travelodge, Cambridge Leisure Park, Clifton Way – Cambridge Train Station – Arundel House Hotel, Chesterton Road, Cambridge
21:00 Mini-bus from Wellcome Trust Conference Centre to Duxford Lodge
Monday 12th March
08:15 Cambridge Train Station – 08.30 Travelodge, Cambridge Leisure Park, Clifton Way – Wellcome Trust Conference Centre
08:15 Arundel House Hotel, Chesterton Road, Cambridge – 08:40 Duxford Lodge Hotel – Wellcome Trust Conference Centre
22:00 Wellcome Trust Conference Centre – Travelodge, Cambridge Leisure Park, Clifton Way – Cambridge Train Station – Arundel House Hotel, Chesterton Road, Cambridge
22:00 Mini-bus from Wellcome Trust Conference Centre to Duxford Lodge
Tuesday 13th March
08:15 Cambridge Train Station – 08.30 Travelodge, Cambridge Leisure Park, Clifton Way – Wellcome Trust Conference Centre
08:15 Arundel House Hotel, Chesterton Road, Cambridge – 08:40 Duxford Lodge Hotel – Wellcome Trust Conference Centre
17:30 Wellcome Trust Conference Centre – Travelodge, Cambridge Leisure Park, Clifton Way – Cambridge Train Station – Cambridge Bus Station – Arundel House Hotel, Chesterton Road, Cambridge
17:30 Wellcome Trust Conference Centre – Stansted Airport

Trains

From Cambridge Station you can get direct trains to London Liverpool Street, London King's Cross and Stansted Airport. For train timetables please see: www.nationalrail.co.uk

Public bus between Hinxton and Cambridge

There is a public bus (Line 32) that operates Monday to Saturday. You can obtain a bus timetable from the reception desk of Hinxton Hall Conference Centre.

Taxis

If you require a taxi, please ensure that you book this sufficiently in advance as it can take time for a taxi to reach Hinxton. A taxi from Cambridge to Hinxton costs approximately £25.00.

Contact numbers for some local taxi companies that we use:
  • Abbots Car Service: 01440 766988
  • Mid-Anglia: 01223 836000
  • Mastercab: 01223 566654
  • Kenway Cars: 01223 832515
  • Panther Taxi: 01223 715715


Top


Payment Details


Payment can be made by cheque or bank transfer. Please make cheques payable to 'Industry Workshops' and send them to Liz Ford, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

When paying by bank transfer please make the payment to:
'Industry Workshops',
NatWest, King's Parade Branch, 10 Benet Street, Cambridge CB2 3PU, UK.
Account No. 24066540 Sort Code 60-04-23
IBAN Code GB21NWBK 600423 24066540
SWIFT Code NWBKGB2122N

Please ask your bank to pay the bank charges and to state clearly whom the payment is from.

Industry delegate - £320 GBP
SME delegate - £220 GBP
Academic delegate - £200 GBP


Top


Contact


If you have any enquiries regarding the conference please send an e-mail to tacbac@ebi.ac.uk.

Top






Nature Biotechnology EBINature Reviews

Top































spacer
spacer