Cardiovascular Gene Ontology Annotation Initiative

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Gene Symbol	UniProt Accession	Alternative Gene Symbols and Protein names
A
ABCA1	O95477	ABCA1, ABC1, CERP: ATP-binding cassette sub-family A member 1
ABCG1	P45844	ABCG1, ABC8, WHT1: ATP-binding cassette sub-family G member 1
ACE	P12821	ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor
ACE2	Q9BYF1	ACE2, UNQ868/PRO1885: Angiotensin-converting enzyme 2 precursor
ADAM17	P78536	ADAM17, CSVP, TACE: ADAM 17 precursor
ADAM9	Q13443	ADAM9, KIAA0021, MCMP, MDC9, MLTNG: ADAM 9 precursor
ADD1	P35611	ADD1, ADDA: Alpha-adducin
ADIPOQ	Q15848	ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor
ADRA1A	P35348	ADRA1A, ADRA1C: Alpha-1A adrenergic receptor
ADRA2A	P08913	ADRA2A, ADRA2R, ADRAR: Alpha-2A adrenergic receptor
ADRA2B	P18089	ADRA2B, ADRA2L1, ADRA2RL1: Alpha-2B adrenergic receptor
ADRB1	P08588	ADRB1, ADRB1R, B1AR: Beta-1 adrenergic receptor
ADRB2	P07550	ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor
ADRBK1	P25098	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1
AGT	P01019	AGT, SERPINA8: Angiotensinogen precursor
AGTR1	P30556	AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor
AGTR2	P50052	AGTR2: Type-2 angiotensin II receptor
ANGPTL3	Q9Y5C1	ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor
APOA1	P02647	APOA1: Apolipoprotein A-I precursor
APOA2	P02652	APOA2: Apolipoprotein A-II precursor
APOA4	P06727	APOA4: Apolipoprotein A-IV precursor
APOA5	Q6Q788	APOA5, RAP3, UNQ411/PRO773: Apolipoprotein A-V precursor
APOB	P04114	APOB: Apolipoprotein B-100 precursor
APOC2	P02655	APOC2, APC2: Apolipoprotein C-II precursor
APOC3	P02656	APOC3: Apolipoprotein C-III precursor
APOE	P02649	APOE: Apolipoprotein E precursor
APOH	P02749	APOH, B2G1: Beta-2-glycoprotein 1 precursor
APOL1	O14791	APOL1, APOL: Apolipoprotein-L1 precursor
ATP2A2	P16615	ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
AXIN1	O15169	AXIN1, AXIN: Axin-1
B
BBS1	Q8NFJ9	BBS1, BBS2L2: Bardet-Biedl syndrome 1 protein
BBS2	Q9BXC9	BBS2: Bardet-Biedl syndrome 2 protein
BBS4	Q96RK4	BBS4: Bardet-Biedl syndrome 4 protein
BBS5	Q8N3I7	BBS5: Bardet-Biedl syndrome 5 protein
BMP10	O95393	BMP10: Bone morphogenetic protein 10 precursor
BMPR2	Q13873	BMPR2, PPH1: Bone morphogenetic protein receptor type-2 precursor
C
CALR	P27797	CALR, CRTC: Calreticulin precursor
CAPN10	Q9HC96	CAPN10, KIAA1845: Calpain-10
CAV1	Q03135	CAV1, CAV: Caveolin-1
CAV3	P56539	CAV3: Caveolin-3
CDH13	P55290	CDH13, CDHH: Cadherin-13 precursor
CDK6	Q00534	CDK6: Cell division protein kinase 6
CDKAL1	Q5VV42	CDKAL1: CDK5 regulatory subunit-associated protein 1-like 1.
CDKN2A	P42771	CDKN2A, CDKN2, MTS1: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
CDKN2AIP	Q9NYH0
CDKN2B	P42772	CDKN2B, MTS2: Cyclin-dependent kinase 4 inhibitor B
CDKN2C	P42773	CDKN2C, CDKN6: Cyclin-dependent kinase 4 inhibitor C
CDKN2D	P55273	CDKN2D: Cyclin-dependent kinase 4 inhibitor D
CELSR2	Q9HCU4	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3: Cadherin EGF LAG seven-pass G-type receptor 2 precursor
CETP	P11597	CETP: Cholesteryl ester transfer protein precursor
CHD7	Q9P2D1	CHD7, KIAA1416: Chromodomain-helicase-DNA-binding protein 7
CHRD	Q9H2X0	CHRD, UNQ217/PRO243: Chordin precursor
CHRNA1	P02708	CHRNA1, ACHRA, CHNRA: Acetylcholine receptor subunit alpha precursor
CIDEA	O60543	CIDEA: Cell death activator CIDE-A
CILP2	Q8IUL8	CILP2: Cartilage intermediate layer protein 2 precursor
CITED2	Q99967	CITED2, MRG1: Cbp/p300-interacting transactivator 2
CLPTM1	O96005	CLPTM1: Cleft lip and palate transmembrane protein 1
COL2A1	P02458	COL2A1: Collagen alpha-1(II) chain precursor
CRKL	P46109	CRKL: Crk-like protein
CRP	P02741	CRP, PTX1: C-reactive protein precursor [Contains: C-reactive protein(1-205)]
CST3	P01034	CST3: Cystatin-C precursor
CXCL12	P48061	CXCL12, SDF1, SDF1A, SDF1B: Stromal cell-derived factor 1 precursor
CXCR4	P61073	CXCR4: C-X-C chemokine receptor type 4
CYBA	P13498	CYBA: Cytochrome b-245 light chain
CYP11B1	P15538	CYP11B1, S11BH: Cytochrome P450 11B1, mitochondrial precursor
CYP11B2	P19099	CYP11B2: Cytochrome P450 11B2, mitochondrial precursor
CYP26B1	Q9NR63	CYP26B1, CYP26A2, P450RAI2: Cytochrome P450 26B1
CYP26C1	Q6V0L0	CYP26C1: Cytochrome P450 26C1
D
DOCK7	Q96N67	DOCK7, KIAA1771: Dedicator of cytokinesis protein 7
DRD1	P21728	DRD1: D(1A) dopamine receptor
DRD2	P14416	DRD2: D(2) dopamine receptor
DRD3	P35462	DRD3: D(3) dopamine receptor
DRD4	P21917	DRD4: D(4) dopamine receptor
DVL1	O14640	DVL1: Segment polarity protein dishevelled homolog DVL-1
E
ECE1	P42892	ECE1: Endothelin-converting enzyme 1
EDN1	P05305	EDN1: Endothelin-1 precursor
EDN2	P20800	EDN2: Endothelin-2 precursor
EGFR	P00533	EGFR, ERBB1: Epidermal growth factor receptor precursor
ELN	P15502	ELN: Elastin precursor
ENG	P17813	ENG, END: Endoglin precursor
ENPP1	P22413	ENPP1, M6S1, NPPS, PC1, PDNP1: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
ERBB2	P04626	ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor
ERBB3	P21860	ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor
EVC	P57679	EVC: Ellis-van Creveld syndrome protein
EXT2	Q93063	EXT2: Exostosin-2
F
F12	P00748	F12: Coagulation factor XII precursor
F2R	P25116	F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor
FGF8	P55075	FGF8, AIGF: Fibroblast growth factor 8 precursor
FKBP1A	P62942	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A
FKBP1B	P68106	FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4: FK506-binding protein 1B
FLNA	P21333	FLNA, FLN, FLN1: Filamin-A
FMN2	Q9NZ56	FMN2: Formin-2
FOXC1	Q12948	FOXC1, FKHL7, FREAC3: Forkhead box protein C1
FOXJ1	Q92949	FOXJ1, FKHL13, HFH4: Forkhead box protein J1
FURIN	P09958	FURIN, FUR, PACE, PCSK3: Furin precursor
FXN	Q16595	FXN, FRDA, X25: Frataxin, mitochondrial precursor
G
G6PD	P11413	G6PD: Glucose-6-phosphate 1-dehydrogenase
GAA	P10253	GAA: Lysosomal alpha-glucosidase precursor
GALNT2	Q10471	GALNT2: Polypeptide N-acetylgalactosaminyltransferase 2
GATA4	P43694	GATA4: Transcription factor GATA-4
GATA6	Q92908	GATA6: Transcription factor GATA-6
GBX2	P52951	GBX2: Homeobox protein GBX-2
GHR	P10912	GHR: Growth hormone receptor precursor
GHRHR	Q02643	GHRHR: Growth hormone-releasing hormone receptor precursor
GJA1	P17302	GJA1, GJAL: Gap junction alpha-1 protein
GJA5	P36382	GJA5: Gap junction alpha-5 protein
GNB3	P16520	GNB3: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
GPX1	P07203	GPX1: Glutathione peroxidase 1
GYS1	P13807	GYS1, GYS: Glycogen [starch] synthase, muscle
H
HAS2	Q92819	HAS2: Hyaluronan synthase 2
HBEGF	Q99075	HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Contains: Heparin-binding EGF-like growth factor
HES1	Q14469	HES1, HL, HRY: Transcription factor HES-1
HHEX	Q03014	HHEX, HEX, PRH, PRHX: Hematopoietically-expressed homeobox protein HHEX
HIC1	Q14526	HIC1, ZBTB29: Hypermethylated in cancer 1 protein
HIC2	Q14526	HIC1, ZBTB29: Hypermethylated in cancer 1 protein
HIF1A	Q16665	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha
HIRA	P54198	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA
HMOX1	P09601	HMOX1, HO, HO1: Heme oxygenase 1
HNF1A	P20823	HNF1A, TCF1: Hepatocyte nuclear factor 1-alpha
HNF1B	P35680	HNF1B, TCF2: Hepatocyte nuclear factor 1-beta
HNF4A	P41235	HNF4A, HNF4, NR2A1, TCF14: Hepatocyte nuclear factor 4-alpha
I
ICAM1	P05362	ICAM1: Intercellular adhesion molecule 1 precursor
IFT80	Q9P2H3	IFT80, KIAA1374, WDR56: Intraflagellar transport protein 80 homolog
IGF1	P05019	IGF1, IBP1: Insulin-like growth factor IB precursor
IGF2BP2	A0A4Z0	IGF2BP2: Insulin-like growth factor 2 mRNA binding protein 2
IL1B	P01584	IL1B, IL1F2: Interleukin-1 beta precursor
IL6R	P08887	IL6R: Interleukin-6 receptor subunit alpha precursor
IL6ST	P40189	IL6ST: Interleukin-6 receptor subunit beta precursor
INS	P01308	INS: Insulin precursor [Contains: Insulin B chain; Insulin A chain]
INSR	P06213	INSR: Insulin receptor precursor
ISL1	P61371	ISL1: Insulin gene enhancer protein ISL-1
J
JAG1	P78504	JAG1, JAGL1: Protein jagged-1 precursor
JMJD6	Q6NYC1	JMJD6, KIAA0585, PTDSR: Histone arginine demethylase JMJD6
JUP	P14923	JUP, CTNNG, DP3: Junction plakoglobin
K
KCNJ11	Q14654	KCNJ11: ATP-sensitive inward rectifier potassium channel 11
KDR	P35968	KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor
KL	Q9UEF7	KL: Klotho precursor
KRIT1	O00522	KRIT1, CCM1: Krev interaction trapped protein 1
L
LBP	P18428	LBP: Lipopolysaccharide-binding protein precursor
LDLR	P01130	LDLR: Low-density lipoprotein receptor precursor
LEFTY2	O00292	LEFTY2, EBAF, PSEC0024, LEFTA, LEFTYA, TGFB4: Left-right determination factor 2 precursor
LEP	P41159	LEP, OB, OBS: Leptin precursor
LEPR	P48357	LEPR, DB, OBR: Leptin receptor precursor
LPA	P08519	LPA: Apolipoprotein(a) precursor
LPL	P06858	LPL, LIPD: Lipoprotein lipase precursor
M
MAPK7	Q13164	MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7
MEF2C	Q06413	MEF2C: Myocyte-specific enhancer factor 2C
MEN1	O00255	MEN1, SCG2: Menin
MIA3	Q5JRA6	MIA3, KIAA0268, UNQ6077/PRO20088: Melanoma inhibitory activity protein 3 precursor
MLXIPL	Q9NP71	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosomal region 14 protein
MTHFD1L	Q6UB35	MTHFD1L, FTHFSDC1: Monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
MTHFR	P42898	MTHFR: Methylenetetrahydrofolate reductase
MYBPC3	Q14896	MYBPC3: Myosin-binding protein C, cardiac-type
MYL1	P05976	MYL1: Myosin light chain 1, skeletal muscle isoform
MYL2	P10916	MYL2: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
MYL3	P08590	MYL3: Myosin light chain 3
MYLK2	Q9H1R3	MYLK2: Myosin light chain kinase 2, skeletal/cardiac muscle
MYLPF	Q96A32	MYLPF: Myosin regulatory light chain 2, skeletal muscle isoform
N
NEUROD1	Q13562	NEUROD1, NEUROD: Neurogenic differentiation factor 1
NFATC1	O95644	NFATC1, NFAT2, NFATC: Nuclear factor of activated T-cells, cytoplasmic 1
NKX2-5	P52952	NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5
NKX2-6	A6NCS4	NKX2-6, NKX2F: Homeobox protein Nkx-2.6
NODAL	Q96S42	NODAL: Nodal homolog precursor
NOG	Q13253	NOG: Noggin precursor
NOS1	P29475	NOS1: Nitric oxide synthase, brain
NOS2A	P35228	NOS2A, NOS2: Nitric oxide synthase, inducible
NOS3	P29474	NOS3: Nitric oxide synthase, endothelial
NOX1	Q9Y5S8	NOX1, NOH1: NADPH oxidase 1
NPPA	P01160	NPPA, ANP, PND: Atrial natriuretic factor precursor
NPPB	P16860	NPPB: Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide 32
NR2F2	P24468	NR2F2, ARP1, TFCOUP2: COUP transcription factor 2
NRG1	Q02297	NRG1, GGF, HGL, HRGA, NDF, SMDF: Pro-neuregulin-1, membrane-bound isoform precursor
O
OBSL1	O75147	OBSL1, KIAA0657: Obscurin-like protein 1 precursor
p
p19ARF	Q8N726	CDKN2A, CDKN2, MLM: Cyclin-dependent kinase inhibitor 2A, isoform 4
P
P2RX4	Q99571	P2RX4: P2X purinoceptor 4
P2RX7	Q99572	P2RX7: P2X purinoceptor 7
PAFAH1B1	P43034	PAFAH1B1, LIS1, MDCR, MDS, PAFAHA: Platelet-activating factor acetylhydrolase IB subunit alpha
PBX4	Q9BYU1	PBX4: Pre-B-cell leukemia transcription factor 4
PCK1	P35558	PCK1, PEPCK1: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
PCSK2	P16519	PCSK2, NEC2: Neuroendocrine convertase 2 precursor
PCSK5	Q92824	PC5, PCSK5, PC6: Proprotein convertase subtilisin/kexin type 5 precursor
PCSK6	P29122	PCSK6, PACE4: Proprotein convertase subtilisin/kexin type 6 precursor
PDGFA	P04085	PDGFA, PDGF1: Platelet-derived growth factor A chain precursor
PDGFC	Q9NRA1	PDGFC: Fallotein
PDGFRA	P16234	PDGFRA: Alpha-type platelet-derived growth factor receptor precursor
PITX2	Q99697	PITX2, ARP1, RGS, RIEG, RIEG1: Pituitary homeobox 2
PKD1	P98161	PKD1: Polycystin-1 precursor
PLA2G1B	P04054	PLA2G1B, PLA2, PLA2A, PPLA2: Phospholipase A2 precursor
PON1	P27169	PON1, PON: Serum paraoxonase/arylesterase 1
PON3	Q15166	PON3: Serum paraoxonase/lactonase 3
PPARG	P37231	PPARG, NR1C3: Peroxisome proliferator-activated receptor gamma
PRKAG2	Q9UGJ0	PRKAG2: 5''-AMP-activated protein kinase subunit gamma-2
PRKAR1A	P10644	PRKAR1A, PKR1, PRKAR1, TSE1: cAMP-dependent protein kinase type I-alpha regulatory subunit
PROX1	Q92786	PROX1: Prospero homeobox protein 1
PSEN1	P49768	PSEN1, AD3, PS1, PSNL1: Presenilin-1
PSEN2	P49810	PSEN2, AD4, PS2, PSNL2, STM2: Presenilin-2
PSMD9	O00233	PSMD9: 26S proteasome non-ATPase regulatory subunit 9
PSRC1	Q6PGN9	PSRC1, DDA3, FP3214: Proline/serine-rich coiled-coil protein 1
PTEN	P60484	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
PTPN11	Q06124	PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11
R
RARA	P10276	RARA, NR1B1: Retinoic acid receptor alpha
RARB	P10826	RARB, HAP, NR1B2: Retinoic acid receptor beta
RARG	P13631	RARG, NR1B3: Retinoic acid receptor gamma
RBP4	P02753	RBP4, PRO2222: Plasma retinol-binding protein precursor
REN	P00797	REN: Renin precursor
ROBO1	Q9Y6N7	ROBO1, DUTT1: Roundabout homolog 1 precursor
ROBO2	Q9HCK4	ROBO2, KIAA1568: Roundabout homolog 2 precursor
ROBO3	Q96MS0	ROBO3: Roundabout homolog 3 precursor
ROBO4	Q8WZ75	ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor
RPS19	P39019	RPS19: 40S ribosomal protein S19
RXRA	P19793	RXRA, NR2B1: Retinoic acid receptor RXR-alpha
S
SCD	O00767	SCD: Acyl-CoA desaturase
SELE	P16581	SELE, ELAM1: E-selectin precursor
SELS	Q9BQE4	SELS, VIMP, AD-015, SBBI8: Selenoprotein S
SEMA3C	Q99985	SEMA3C, SEMAE: Semaphorin-3C precursor
SERPINE1	P05121	SERPINE1, PAI1, PLANH1: Plasminogen activator inhibitor 1 precursor
SIRT1	Q96EB6	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1
SLC30A8	Q8IWU4	SLC30A8, ZNT8: Zinc transporter 8
SLC6A4	P31645	SLC6A4, HTT, SERT: Sodium-dependent serotonin transporter
SLIT1	O75093	SLIT1, KIAA0813, MEGF4, SLIL1: Slit homolog 1 protein precursor
SLIT2	O94813	SLIT2, SLIL3: Slit homolog 2 protein precursor
SLIT3	O75094	SLIT3, KIAA0814, UNQ691/PRO1336, MEGF5, SLIL2: Slit homolog 3 protein precursor
SMAD3	P84022	SMAD3, MADH3: Mothers against decapentaplegic homolog 3
SMAD4	Q13485	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4
SOD2	P04179	SOD2: Superoxide dismutase [Mn], mitochondrial precursor
SORT1	Q99523	SORT1: Sortilin precursor
SOX4	Q06945	SOX4: Transcription factor SOX-4
SRF	P11831	SRF: Serum response factor
T
TBL2	Q9Y4P3	TBL2, WBSCR13, UNQ563/PRO1125: Transducin beta-like 2 protein
TBX2	Q13207	TBX2: T-box transcription factor TBX2
TCF7L2	Q9NQB0	TCF7L2, TCF4: Transcription factor 7-like 2
TGFB2	P61812	TGFB2: Transforming growth factor beta-2 precursor
TGFBR2	P37173	TGFBR2: TGF-beta receptor type-2 precursor
TGFBR3	Q03167	TGFBR3: TGF-beta receptor type III precursor
TH	P07101	TH, TYH: Tyrosine 3-monooxygenase
THBS1	P07996	THBS1, TSP, TSP1: Thrombospondin-1 precursor
TMSB4X	P62328	TMSB4X, TB4X, THYB4, TMSB4: Thymosin beta-4
TNF	P01375	TNF, TNFA, TNFSF2: Tumor necrosis factor precursor
TNNC1	P63316	TNNC1, TNNC: Troponin C, slow skeletal and cardiac muscles
TPM1	P09493	TPM1, C15orf13, TMSA: Tropomyosin alpha-1 chain
TRIB1	Q96RU8	TRIB1, C8FW, GIG2, TRB1: Tribbles homolog 1
TTN	Q8WZ42	TTN: Titin
U
USF1	P22415	USF1, USF: Upstream stimulatory factor 1
V
VCAM1	P19320	VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor
VCL	P18206	VCL: Vinculin
VEGFA	P15692	VEGFA, VEGF: Vascular endothelial growth factor A precursor
VNN1	O95497	VNN1: Pantetheinase precursor
W
WFS1	O76024	WFS1: Wolframin
WRN	Q14191	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase